#genipin — Public Fediverse posts

Genipin Rescues Sleep Deficits in a Fruit Fly Model of Parkinson's Disease

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https://1ban.news/genipin-sleep-alpha-synuclein-drosophila-parkinsons/

#1ban #genipin #sleep #alpha #synuclein #neuroscience

Genipin Rescues Sleep Deficits in a Fruit Fly Model of Parkinson's Disease

Like and share if you enjoyed this.

https://1ban.news/genipin-sleep-alpha-synuclein-drosophila-parkinsons/

#1ban #genipin #sleep #alpha #synuclein #neuroscience

"Moreover, genipin cross-linked the extracellular matrix (ECM), increased the stiffness of the ECM, reorganized the actin cytoskeleton, and promoted transcription of yes-associated protein–dependent genes."

https://www.science.org/doi/10.1126/scitranslmed.adq2418

#2badItsPaywalled #genipin #NaturalProducts #ExtracellularMatrix

@AskPippa

"Genipin is being studied as a potential treatment for a rare degenerative nervous system disorder that is caused by a gene mutation. The condition is known as familial dysautonomia, which becomes evident during infancy. The hypothesis of this relatively large cadre of regenerative medicine researchers is that genipin from the humble gardenia plant—known scientifically as Gardenia jasminoides—possesses the secret to effective treatment."

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I wonder if genipin could be used for small fiber neuropathy?

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This genipin stuff looks like it might have helped my father, who had multiple system atrophy and peripheral neuropathy (which I think may have been small fiber neuropathy) -

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage
https://www.nature.com/articles/s41467-023-37561-2

#genipin #NaturalProducts #dysautonomia #SmallFiberNeuropathy
#neuroscience