#2baditspaywalled — Public Fediverse posts

Pros and Cons of APOE4 Homozygosity and Effects on Neuroplasticity, Malnutrition, and Infections in Early Life Adversity, Alzheimer’s Disease, and Alzheimer’s Prevention [2024]
https://doi.org/10.3233/JAD-240888

#Alzheimers #2BadItsPaywalled

Pros and Cons of APOE4 Homozygosity and Effects on Neuroplasticity, Malnutrition, and Infections in Early Life Adversity, Alzheimer’s Disease, and Alzheimer’s Prevention [2024]
https://doi.org/10.3233/JAD-240888

#Alzheimers #2BadItsPaywalled

Pros and Cons of APOE4 Homozygosity and Effects on Neuroplasticity, Malnutrition, and Infections in Early Life Adversity, Alzheimer’s Disease, and Alzheimer’s Prevention [2024]
https://doi.org/10.3233/JAD-240888

#Alzheimers #2BadItsPaywalled

Pros and Cons of APOE4 Homozygosity and Effects on Neuroplasticity, Malnutrition, and Infections in Early Life Adversity, Alzheimer’s Disease, and Alzheimer’s Prevention [2024]
https://doi.org/10.3233/JAD-240888

#Alzheimers #2BadItsPaywalled

Intake of psyllium seed husk reduces white matter damage in a rat model of chronic cerebral hypoperfusion [2019]
https://pubmed.ncbi.nlm.nih.gov/31103857/

#CerebralHypoperfusion #Brain #perfusion #hypoperfusion #psyllium #arabinoxylan #NaturalProducts #FunctionalFoods
#2BadItsPaywalled

Intake of psyllium seed husk reduces white matter damage in a rat model of chronic cerebral hypoperfusion [2019]
https://pubmed.ncbi.nlm.nih.gov/31103857/

#CerebralHypoperfusion #Brain #perfusion #hypoperfusion #psyllium #arabinoxylan #NaturalProducts #FunctionalFoods
#2BadItsPaywalled

Intake of psyllium seed husk reduces white matter damage in a rat model of chronic cerebral hypoperfusion [2019]
https://pubmed.ncbi.nlm.nih.gov/31103857/

#CerebralHypoperfusion #Brain #perfusion #hypoperfusion #psyllium #arabinoxylan #NaturalProducts #FunctionalFoods
#2BadItsPaywalled

Intake of psyllium seed husk reduces white matter damage in a rat model of chronic cerebral hypoperfusion [2019]
https://pubmed.ncbi.nlm.nih.gov/31103857/

#CerebralHypoperfusion #Brain #perfusion #hypoperfusion #psyllium #arabinoxylan #NaturalProducts #FunctionalFoods
#2BadItsPaywalled

@climatenewsnow

Interesting article -
#2badItsPaywalled
(and also, it isn't about climate change)

Here's an open access academic article about toxic airplane cabin air -

Burden of Proof: The Debate Surrounding Aerotoxic Syndrome [2022]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9452852/

"... some manufacturers developed a safer alternative. Boeing Aircraft introduced a new air intake system for the Boeing 787 Dreamliner, which does not use bleed air to supply the cabin; instead, air intakes have been mounted along the root of the front wings, thereby reducing the risk of contamination."

#AerotoxicSyndrome #AirTravel #OccupationalHealth #organophosphates #AirPollution

@climatenewsnow

Interesting article -
#2badItsPaywalled
(and also, it isn't about climate change)

Here's an open access academic article about toxic airplane cabin air -

Burden of Proof: The Debate Surrounding Aerotoxic Syndrome [2022]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9452852/

"... some manufacturers developed a safer alternative. Boeing Aircraft introduced a new air intake system for the Boeing 787 Dreamliner, which does not use bleed air to supply the cabin; instead, air intakes have been mounted along the root of the front wings, thereby reducing the risk of contamination."

#AerotoxicSyndrome #AirTravel #OccupationalHealth #organophosphates #AirPollution

@climatenewsnow

Interesting article -
#2badItsPaywalled
(and also, it isn't about climate change)

Here's an open access academic article about toxic airplane cabin air -

Burden of Proof: The Debate Surrounding Aerotoxic Syndrome [2022]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9452852/

"... some manufacturers developed a safer alternative. Boeing Aircraft introduced a new air intake system for the Boeing 787 Dreamliner, which does not use bleed air to supply the cabin; instead, air intakes have been mounted along the root of the front wings, thereby reducing the risk of contamination."

#AerotoxicSyndrome #AirTravel #OccupationalHealth #organophosphates #AirPollution

@climatenewsnow

Interesting article -
#2badItsPaywalled
(and also, it isn't about climate change)

Here's an open access academic article about toxic airplane cabin air -

Burden of Proof: The Debate Surrounding Aerotoxic Syndrome [2022]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9452852/

"... some manufacturers developed a safer alternative. Boeing Aircraft introduced a new air intake system for the Boeing 787 Dreamliner, which does not use bleed air to supply the cabin; instead, air intakes have been mounted along the root of the front wings, thereby reducing the risk of contamination."

#AerotoxicSyndrome #AirTravel #OccupationalHealth #organophosphates #AirPollution

@ScienceScholar

“To test their findings, the researchers isolated a protein associated with aging in the aortas of mice, and injected it into young mice to observe the results. ..."

The senoprotein tested was Gas6; it is a vitamin K dependent protein and it's activities are dependent on carboxylation. Unfortunately the original research article * is paywalled, so no details on carboxylation ...

* Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures [2025]
https://doi.org/10.1016/j.cell.2025.06.047

#2badItsPaywalled #Gas6 #Aging #VitaminK

@ScienceScholar

“To test their findings, the researchers isolated a protein associated with aging in the aortas of mice, and injected it into young mice to observe the results. ..."

The senoprotein tested was Gas6; it is a vitamin K dependent protein and it's activities are dependent on carboxylation. Unfortunately the original research article * is paywalled, so no details on carboxylation ...

* Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures [2025]
https://doi.org/10.1016/j.cell.2025.06.047

#2badItsPaywalled #Gas6 #Aging #VitaminK

@ScienceScholar

“To test their findings, the researchers isolated a protein associated with aging in the aortas of mice, and injected it into young mice to observe the results. ..."

The senoprotein tested was Gas6; it is a vitamin K dependent protein and it's activities are dependent on carboxylation. Unfortunately the original research article * is paywalled, so no details on carboxylation ...

* Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures [2025]
https://doi.org/10.1016/j.cell.2025.06.047

#2badItsPaywalled #Gas6 #Aging #VitaminK

@ScienceScholar

“To test their findings, the researchers isolated a protein associated with aging in the aortas of mice, and injected it into young mice to observe the results. ..."

The senoprotein tested was Gas6; it is a vitamin K dependent protein and it's activities are dependent on carboxylation. Unfortunately the original research article * is paywalled, so no details on carboxylation ...

* Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures [2025]
https://doi.org/10.1016/j.cell.2025.06.047

#2badItsPaywalled #Gas6 #Aging #VitaminK

Interesting case report:

Early coma in intussusception: Endogenous opioid induced?
https://pubmed.ncbi.nlm.nih.gov/3562307/

Abstract
A decreased level of consciousness with little abdominal pain or gastrointestinal symptoms is an uncommon, but well described, presentation of infantile intussusception. Its etiology is unclear. We describe a 10-month-old male who presented with coma and miosis, reversible with bolus injections of naloxone on three separate occasions. No opiates were involved and an intussusception was subsequently found. We speculate that the coma and miosis were induced by an endogenous opioid which could also mask the abdominal pain, thus explaining this presentation of intussusception. If so, miosis would be a valuable clue for diagnosing such children.

#2badItsPaywalled

Interesting case report:

Early coma in intussusception: Endogenous opioid induced?
https://pubmed.ncbi.nlm.nih.gov/3562307/

Abstract
A decreased level of consciousness with little abdominal pain or gastrointestinal symptoms is an uncommon, but well described, presentation of infantile intussusception. Its etiology is unclear. We describe a 10-month-old male who presented with coma and miosis, reversible with bolus injections of naloxone on three separate occasions. No opiates were involved and an intussusception was subsequently found. We speculate that the coma and miosis were induced by an endogenous opioid which could also mask the abdominal pain, thus explaining this presentation of intussusception. If so, miosis would be a valuable clue for diagnosing such children.

#2badItsPaywalled

Interesting case report:

Early coma in intussusception: Endogenous opioid induced?
https://pubmed.ncbi.nlm.nih.gov/3562307/

Abstract
A decreased level of consciousness with little abdominal pain or gastrointestinal symptoms is an uncommon, but well described, presentation of infantile intussusception. Its etiology is unclear. We describe a 10-month-old male who presented with coma and miosis, reversible with bolus injections of naloxone on three separate occasions. No opiates were involved and an intussusception was subsequently found. We speculate that the coma and miosis were induced by an endogenous opioid which could also mask the abdominal pain, thus explaining this presentation of intussusception. If so, miosis would be a valuable clue for diagnosing such children.

#2badItsPaywalled

Interesting case report:

Early coma in intussusception: Endogenous opioid induced?
https://pubmed.ncbi.nlm.nih.gov/3562307/

Abstract
A decreased level of consciousness with little abdominal pain or gastrointestinal symptoms is an uncommon, but well described, presentation of infantile intussusception. Its etiology is unclear. We describe a 10-month-old male who presented with coma and miosis, reversible with bolus injections of naloxone on three separate occasions. No opiates were involved and an intussusception was subsequently found. We speculate that the coma and miosis were induced by an endogenous opioid which could also mask the abdominal pain, thus explaining this presentation of intussusception. If so, miosis would be a valuable clue for diagnosing such children.

#2badItsPaywalled

"Moreover, genipin cross-linked the extracellular matrix (ECM), increased the stiffness of the ECM, reorganized the actin cytoskeleton, and promoted transcription of yes-associated protein–dependent genes."

https://www.science.org/doi/10.1126/scitranslmed.adq2418

#2badItsPaywalled #genipin #NaturalProducts #ExtracellularMatrix

"Moreover, genipin cross-linked the extracellular matrix (ECM), increased the stiffness of the ECM, reorganized the actin cytoskeleton, and promoted transcription of yes-associated protein–dependent genes."

https://www.science.org/doi/10.1126/scitranslmed.adq2418

#2badItsPaywalled #genipin #NaturalProducts #ExtracellularMatrix

"Moreover, genipin cross-linked the extracellular matrix (ECM), increased the stiffness of the ECM, reorganized the actin cytoskeleton, and promoted transcription of yes-associated protein–dependent genes."

https://www.science.org/doi/10.1126/scitranslmed.adq2418

#2badItsPaywalled #genipin #NaturalProducts #ExtracellularMatrix

"Moreover, genipin cross-linked the extracellular matrix (ECM), increased the stiffness of the ECM, reorganized the actin cytoskeleton, and promoted transcription of yes-associated protein–dependent genes."

https://www.science.org/doi/10.1126/scitranslmed.adq2418

#2badItsPaywalled #genipin #NaturalProducts #ExtracellularMatrix

Antianxiety and Antidepressant Activity Guided Isolation and Characterization of Gossypetin from Hibiscus sabdariffa Linn. Calyces
https://doi.org/10.1080/22311866.2019.1615552

I can feel a difference when I drink hibiscus tea. It tastes good, but it's really acidic and I worry about my teeth.

#2badItsPaywalled #NaturalProducts #hibiscus #gossypetin

Antianxiety and Antidepressant Activity Guided Isolation and Characterization of Gossypetin from Hibiscus sabdariffa Linn. Calyces
https://doi.org/10.1080/22311866.2019.1615552

I can feel a difference when I drink hibiscus tea. It tastes good, but it's really acidic and I worry about my teeth.

#2badItsPaywalled #NaturalProducts #hibiscus #gossypetin

Antianxiety and Antidepressant Activity Guided Isolation and Characterization of Gossypetin from Hibiscus sabdariffa Linn. Calyces
https://doi.org/10.1080/22311866.2019.1615552

I can feel a difference when I drink hibiscus tea. It tastes good, but it's really acidic and I worry about my teeth.

#2badItsPaywalled #NaturalProducts #hibiscus #gossypetin

Antianxiety and Antidepressant Activity Guided Isolation and Characterization of Gossypetin from Hibiscus sabdariffa Linn. Calyces
https://doi.org/10.1080/22311866.2019.1615552

I can feel a difference when I drink hibiscus tea. It tastes good, but it's really acidic and I worry about my teeth.

#2badItsPaywalled #NaturalProducts #hibiscus #gossypetin

Marital Status and Mortality: The National Longitudinal Mortality Study
https://doi.org/10.1016/S1047-2797(99)00052-6

really annoyed that this study is paywalled since it is a product of the Census Bureau

my taxpayer money is lining the pockets of Elsevier, as usual

#2badItsPaywalled

Marital Status and Mortality: The National Longitudinal Mortality Study
https://doi.org/10.1016/S1047-2797(99)00052-6

really annoyed that this study is paywalled since it is a product of the Census Bureau

my taxpayer money is lining the pockets of Elsevier, as usual

#2badItsPaywalled

Marital Status and Mortality: The National Longitudinal Mortality Study
https://doi.org/10.1016/S1047-2797(99)00052-6

really annoyed that this study is paywalled since it is a product of the Census Bureau

my taxpayer money is lining the pockets of Elsevier, as usual

#2badItsPaywalled

Marital Status and Mortality: The National Longitudinal Mortality Study
https://doi.org/10.1016/S1047-2797(99)00052-6

really annoyed that this study is paywalled since it is a product of the Census Bureau

my taxpayer money is lining the pockets of Elsevier, as usual

#2badItsPaywalled

@brittanytrang @STAT

First sentence in this paywalled article: "Pascal Geldsetzer believes in open access, in disseminating science as quickly as it happens."

I understand good articles cost money to produce, but - it just seems a bit ironic. And I can't help but be disappointed that I can't access this article since it sounds interesting.

#2badItsPaywalled

@brittanytrang @STAT

First sentence in this paywalled article: "Pascal Geldsetzer believes in open access, in disseminating science as quickly as it happens."

I understand good articles cost money to produce, but - it just seems a bit ironic. And I can't help but be disappointed that I can't access this article since it sounds interesting.

#2badItsPaywalled

@brittanytrang @STAT

First sentence in this paywalled article: "Pascal Geldsetzer believes in open access, in disseminating science as quickly as it happens."

I understand good articles cost money to produce, but - it just seems a bit ironic. And I can't help but be disappointed that I can't access this article since it sounds interesting.

#2badItsPaywalled

@brittanytrang @STAT

First sentence in this paywalled article: "Pascal Geldsetzer believes in open access, in disseminating science as quickly as it happens."

I understand good articles cost money to produce, but - it just seems a bit ironic. And I can't help but be disappointed that I can't access this article since it sounds interesting.

#2badItsPaywalled

@brittanytrang @STAT

First sentence in this paywalled article: "Pascal Geldsetzer believes in open access, in disseminating science as quickly as it happens."

I understand good articles cost money to produce, but - it just seems a bit ironic. And I can't help but be disappointed that I can't access this article since it sounds interesting.

#2badItsPaywalled

@PerceptionsToday

Interesting, #2badItsPaywalled

I looked up Cătălina Curceanu and found this recent, open access review article:
https://www.mdpi.com/1099-4300/25/10/1431

#biophotons

@PerceptionsToday

Interesting, #2badItsPaywalled

I looked up Cătălina Curceanu and found this recent, open access review article:
https://www.mdpi.com/1099-4300/25/10/1431

#biophotons

@PerceptionsToday

Interesting, #2badItsPaywalled

I looked up Cătălina Curceanu and found this recent, open access review article:
https://www.mdpi.com/1099-4300/25/10/1431

#biophotons

@PerceptionsToday

Interesting, #2badItsPaywalled

I looked up Cătălina Curceanu and found this recent, open access review article:
https://www.mdpi.com/1099-4300/25/10/1431

#biophotons

@MolecularCell

Interesting, #2badItsPaywalled

Open access review from 2022 on similar topic with overlapping authorship:
https://doi.org/10.1038/s41392-022-01211-8

#Aging

@MolecularCell

Interesting, #2badItsPaywalled

Open access review from 2022 on similar topic with overlapping authorship:
https://doi.org/10.1038/s41392-022-01211-8

#Aging

@MolecularCell

Interesting, #2badItsPaywalled

Open access review from 2022 on similar topic with overlapping authorship:
https://doi.org/10.1038/s41392-022-01211-8

#Aging

@MolecularCell

Interesting, #2badItsPaywalled

Open access review from 2022 on similar topic with overlapping authorship:
https://doi.org/10.1038/s41392-022-01211-8

#Aging

@ScienceMagazine

Very interesting, too bad both articles are paywalled. Lots of potential therapeutic implications.

"Heat shock protein-47 (Hsp47) is a collagen-specific molecular chaperone, which plays an essential role in collagen synthesis and deposition to promote fibrosis"
https://doi.org/10.1038/s41392-022-01119-3

Attacks of familiar Mediterranean fever can be triggered by long duration travel. https://doi.org/10.1007/s00296-012-2453-x

#2badItsPaywalled #MedMastodon

@ScienceMagazine

Very interesting, too bad both articles are paywalled. Lots of potential therapeutic implications.

"Heat shock protein-47 (Hsp47) is a collagen-specific molecular chaperone, which plays an essential role in collagen synthesis and deposition to promote fibrosis"
https://doi.org/10.1038/s41392-022-01119-3

Attacks of familiar Mediterranean fever can be triggered by long duration travel. https://doi.org/10.1007/s00296-012-2453-x

#2badItsPaywalled #MedMastodon

@ScienceMagazine

Very interesting, too bad both articles are paywalled. Lots of potential therapeutic implications.

"Heat shock protein-47 (Hsp47) is a collagen-specific molecular chaperone, which plays an essential role in collagen synthesis and deposition to promote fibrosis"
https://doi.org/10.1038/s41392-022-01119-3

Attacks of familiar Mediterranean fever can be triggered by long duration travel. https://doi.org/10.1007/s00296-012-2453-x

#2badItsPaywalled #MedMastodon

@ScienceMagazine

Very interesting, too bad both articles are paywalled. Lots of potential therapeutic implications.

"Heat shock protein-47 (Hsp47) is a collagen-specific molecular chaperone, which plays an essential role in collagen synthesis and deposition to promote fibrosis"
https://doi.org/10.1038/s41392-022-01119-3

Attacks of familiar Mediterranean fever can be triggered by long duration travel. https://doi.org/10.1007/s00296-012-2453-x

#2badItsPaywalled #MedMastodon

@garry

Too bad this review paper referenced in the article is paywalled:

Psychedelics as potent anti-inflammatory therapeutics (2022)
https://doi.org/10.1016/j.neuropharm.2022.109232
"Remarkably, we have discovered that psychedelics are also potent anti-inflammatories and immunomodulators in peripheral tissues."

#2badItsPaywalled

@garry

Too bad this review paper referenced in the article is paywalled:

Psychedelics as potent anti-inflammatory therapeutics (2022)
https://doi.org/10.1016/j.neuropharm.2022.109232
"Remarkably, we have discovered that psychedelics are also potent anti-inflammatories and immunomodulators in peripheral tissues."

#2badItsPaywalled

@garry

Too bad this review paper referenced in the article is paywalled:

Psychedelics as potent anti-inflammatory therapeutics (2022)
https://doi.org/10.1016/j.neuropharm.2022.109232
"Remarkably, we have discovered that psychedelics are also potent anti-inflammatories and immunomodulators in peripheral tissues."

#2badItsPaywalled

@garry

Too bad this review paper referenced in the article is paywalled:

Psychedelics as potent anti-inflammatory therapeutics (2022)
https://doi.org/10.1016/j.neuropharm.2022.109232
"Remarkably, we have discovered that psychedelics are also potent anti-inflammatories and immunomodulators in peripheral tissues."

#2badItsPaywalled

research article (2019):
Puerarin suppresses TRPV1, calcitonin gene-related peptide and substance P to prevent paclitaxel-induced peripheral neuropathic pain in rats
https://doi.org/10.1177/0333102417748563
~
Puerarin is a natural product found in kudzu root. Kudzu root is used to make Japanese kuzu noodles - don't know how much puerarin is in kuzu starch, but it's used traditionally as a digestive aid.

#2badItsPaywalled #CGRP #TRPV1 #NaturalProducts #FunctionalFoods
#puerarin #kuzu #neuropathy #ChronicPain

research article (2019):
Puerarin suppresses TRPV1, calcitonin gene-related peptide and substance P to prevent paclitaxel-induced peripheral neuropathic pain in rats
https://doi.org/10.1177/0333102417748563
~
Puerarin is a natural product found in kudzu root. Kudzu root is used to make Japanese kuzu noodles - don't know how much puerarin is in kuzu starch, but it's used traditionally as a digestive aid.

#2badItsPaywalled #CGRP #TRPV1 #NaturalProducts #FunctionalFoods
#puerarin #kuzu #neuropathy #ChronicPain

research article (2019):
Puerarin suppresses TRPV1, calcitonin gene-related peptide and substance P to prevent paclitaxel-induced peripheral neuropathic pain in rats
https://doi.org/10.1177/0333102417748563
~
Puerarin is a natural product found in kudzu root. Kudzu root is used to make Japanese kuzu noodles - don't know how much puerarin is in kuzu starch, but it's used traditionally as a digestive aid.

#2badItsPaywalled #CGRP #TRPV1 #NaturalProducts #FunctionalFoods
#puerarin #kuzu #neuropathy #ChronicPain