#sars-cov2 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #sars-cov2, aggregated by home.social.
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@tomjennings In summary for you:
- A positive is a true positive, from any test.
- A negative result from an expired test is uninformative both because reagents degrade, and old RATs are insensitive to Omicron variants
- unexpired rapid tests will give false negatives in 40-80% of positive cases, so a negative on a fresh test should be taken as a very weak signal that an infection isn't SARS-CoV-2
- test using a cheek and nose swab, and not the way-up-there nasopharyngeal swabbing which is less comfortable and has a higher false negative rate
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RE: https://mastodon.scot/@kim_harding/116998708841301587
@kim_harding hmm, to me this informs the scenario where HEPA filters are spot-placed but not facility-wide, and suggests only that spot cleaning may be ineffective.
And some risk did seem to shift, approximately halving the days on antibiotics, the days with fever, and they days with acute deterioration:
There was evidence of a reduction in the number of symptomatic days with fever and/or delirium and/or acute deterioration in physical ability (aIRR, 0.49; 95% CI, 0.26-0.90, P = .02) and number of days antibiotics were taken (aIRR, 0.57; 95% CI, 0.37-0.87; P = .01) in intervention communal room residents
and - surprising to me - it was underpowered for measuring healthcare worker impact, with a 20% decrease in sick days not being statistically significant:
in the number of staff working days lost to illness or infections (aIRR, 0.80; 95% CI, 0.55-1.16; P = .24
although they tout high compliance, they weren't actually checking robustly:
there was low intervention adherence. However, staff reported that the HEPA filters were usually switched on and were correctly located. We considered and decided against conducting monitoring visits to check intervention compliance
and I would point out that other work found a majority of filters were disabled on spot checks, so that lack of compliance checking, and relying on reports from people who know the filters should have been running, is troublesome.
The filters were lacking at the speed they were set to:
there were also insufficient CADRs
And finally, what I think is the most serious issue with the design and which they don't discuss: by only running HEPAs in some communal rooms (not all, no hallways, etc) and some bedrooms in each intervention facility, it may be the case that once an airborne disease infects enough people in a facility, spot air cleaning is ineffective. In the extreme imagine a facility with 100 residents, 1 with a HEPA in their room, and a HEPA in the dining and TV rooms. Is that 1 person going to have a meaningfully reduced risk, when an airborne disease sweeps through? Of course not; every hallway walk where they pass coughing people easily dominates the risk, and any reduction in the common room and bedroom is irrelevant.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2852235
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#SarsCoV2 Het besmettingsrisico voor Covid19, op basis van de rioolwatermetingen, is nog steeds gering, maar er is al 6 weken een stijgende tendens: een nieuwe coronagolf dient zich aan. Het geschatte aantal infecties in NL was op 14 juli 919 per dag en in week 29 meldde 0,04% van de deelnemers aan @rivm infectieradar een Covid19-infectie.
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Researchers tested undergrads while measuring brain blood flows. Their brain scans looked like people in their 60s:
previously infected students exhibited distinct prefrontal haemodynamic patterns during cognitive engagement, reminiscent of those observed in adults four decades older, and this appeared to be especially true if they reported experiencing brain fog due to COVID-19.
Over a third of them showed objective cognitive impairment:
37.33 % of participants who reported previously having COVID-19 displayed objective cognitive impairment [...] (assessed via computerised testing),
And neuron death is irreversible:
This may indicate microglial hyperactivation, theoretically driven by elevated oxidative stress from dysfunctional mitochondria—a possible contributor to cell death and cognitive impairment
https://www.sciencedirect.com/science/article/pii/S0889159124007311
h/t @PatrickWirth
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Here's the latest variant picture for New Zealand, to early July.
BA.3.2.* "Cicada" was been dominant during June, but fell to finish at 26%.
NB.1.8.1 "Nimbus" rebounded to 53% in early July.
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Here's the latest variant picture for Australia, to the end of June.
NB.1.8.1.* "Nimbus" remained dominant, but fell to 45%.
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#SarsCoV2 Op basis van rioolwatermetingen is het besmettingsrisico voor COVID-19 nog steeds gering, maar sinds het historisch minimum van 347 geschatte infecties per dag op 1 juni is het risico 5 weken achtereen continu gestegen. Op 7 juli waren er naar schatting 961 infecties per dag, bijna drie keer zoveel als in het minimum. Een nieuwe golf is dus begonnen.
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Case detections by jurisdiction & month. The pink dot at the end of a line indicates this ongoing month. June saw ⬆️ #SARSCoV2 detections in several Australian jurisdictions, also a peak in March. Patterns vary by region, though.
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Find's ja witzig, dass gerade der #ADAC noch laufend über die neuesten Corona Varianten berichtet. 😅
https://www.adac.de/news/corona-herbst-test-impfung/
Find's schade, dass die neuesten Varianten in der Presse keine Eilmeldungen mehr wert sind. 😁
Klang immer so lustig.
"Neue Variante XYZ breitet sich aus." 🥹 -
@ducky also EBV seems to be one of the on-ramps to LC:
- summary https://www.mdpi.com/1999-4915/17/7/903
- direct evidence of reactivation in acute phase https://www.medrxiv.org/content/10.64898/2025.12.31.25343091v1
- Long COVID associations
- https://www.nature.com/articles/s41598-026-42952-8
- https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00630-8
- https://www.biorxiv.org/content/10.64898/2026.01.27.701989v1
- https://www.medrxiv.org/content/10.1101/2024.12.30.24319800v1
- summary and mechanistic suggestions https://www.nature.com/articles/s41380-023-02161-5
- summary https://www.sciencedirect.com/science/article/pii/S1684118225000763
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A crystal structure of PLpro exhibits Ubl2 in two distinct conformations: the well characterized closed state, where Ubl2 is positioned near the PLpro domain, and an as yet uncharacterized open state #SARSCoV2 #PapainLikeProteases #Ubl2Domain https://doi.org/10.1107/S2053230X26003699
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New virus catalogue reveals which pathogens pose the greatest threat
