#mendelianrandomization — Public Fediverse posts

STATGEN 2024 talk
Identifying GxE through Mendelian Randomization
Xiaofeng Zhu

Statistical power is low and detecting GxE is a challenge.

See:

Aschard H. A perspective on interaction effects in genetic association studies. Genet Epidemiol. 2016 Dec;40(8):678-688. doi: 10.1002/gepi.21989. Epub 2016 Jul 7. PMID: 27390122; PMCID: PMC5132101.

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#Genetics #STATGEN2024 #StatisticalGenetics #MendelianRandomization

STATGEN 2024 talk
An efficient method for network Mendelian randomization allows network structure discovery and effect estimation.
Jean Morrison

Existing methods

* GenomicSEM
* Network deconvolution
Graph-cML
bimmer

Our method

* Network empirical shrinkage Mendelian randomization (NESMR)
- likelihood-based

Assumptions
1. Causal effects between traits are linear with no interactions

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#Genetics #MendelianRandomization #STATGEN2024 #StatisticalGenetics

STATGEN 2024
Pleiotropy-robust methods for high-dimensional multivariable Mendelian randomization (HDMR)
Nathan LaPierre presenting, co-authors: Matthew Stephens, Xin He

In HDMR, we have many genetically correlated exposures, which may be explained by unobserved shared factors. These can be inferred by factor analysis.

Flexible, modular framework: Factor-Augmented MR
1. Factor Analysis
2. Regression/Variable Selection

#Genetics #StatisticalGenetics #MendelianRandomization #STATGEN2024