#ldl — Public Fediverse posts

New research finds that removing senescent macrophages from the liver, which accumulate with age and LDL cholesterol exposure, reduces liver inflammation, liver size, and body weight in mice. Similarities between senescent macrophages in mice and humans suggest this finding has therapeutic value.

Summary: https://www.sciencedaily.com/releases/2026/04/260416071947.htm

Original paper: https://www.nature.com/articles/s43587-026-01101-6

#Science #Health #MASLD #Cholesterol #LDL #LiverDisease

Longevity Cocktail based on Science 👍

Cholesterol (LDL)
-Statin (low dose rosuvastatin)
-Zetia (ezetimibe)

Gut Health
-Psyllium 10-12 gm/day

Muscle (and maybe Brain)
-Creatine

Cognitive/Biologic Aging
-Multivitamin (generic Centrum Silver)

Metabolic, Insulin Resistance, Anti-inflammatory
-Low dose Zepbound/Mounjaro (tirzepatide)

https://substance-over-noise.beehiiv.com/p/the-longevity-stack

#longevity #rosuvastatin #zetia #psyllium #creatine #Zepbound #Mounjaro #tirzepatide #cholesterol #ldl #glp1

For individuals with metabolic syndrome, a two-day calorie-restricted diet of oats produced a 10 percent decrease in LDL. The reduction persisted for 6 weeks. A six-week lower-dose supplementation with oats was not as effective. The gut microbiome shifted to increase metabolism of phenols, and those metabolites may have a role in LDL reduction.

Summary: https://scitechdaily.com/this-simple-48-hour-diet-cut-harmful-cholesterol-by-10-study-finds/

Original paper: https://www.nature.com/articles/s41467-026-68303-9

#Science #Health #Cholesterol #LDL #Diet #Oats #GutMicrobiome

Can we edit cholesterol once and be done for life?

New phase 1 data on CTX310, a CRISPR-based infusion from @CrisprTx, show ~50% drops in LDL & triglycerides after a single dose on top of usual therapy.

Read the full analysis:
https://biotech.industryexaminer.com/one-time-crispr-edit-cholesterol-ctx310/

#CRISPR #GeneEditing #Biotech #Cholesterol #LDL #Cardiology #ClinicalTrials #HealthEconomics #PrecisionMedicine #TechNews

Base & prime editing are moving from hype to timelines.
Scissors-and-tape→✂️📎|Pencil eraser→🩹|Word-processor rewrite→✏️
Where first: #SCD, #LDL/#PCSK9, #CGD.
Risks: off-targets, mismatch-repair tweaks, delivery/immune reactions
https://biotech.industryexaminer.com/base-prime-editing-timelines-patient-impact/
#CRISPR #Biotech #GeneEditing

@arthurdent Prüfung als Schüler alles alleine (non-kooperativ, non-kommunikativ, ohne internet, und ohne seine Aufschriebe) können muss, so dass wir diese Methoden, deren Stärke in dem Erleben von Agency liegt, zurückfahren bis einstampfen müssen. Weil die Prüfungen so verfasst sind, wie sie verfasst sind.
#Prüfungskultur #FediLZ #LdL #PBL #DeeperLearning

« Le vrai scandale, ce ne sont pas les propos d’#HarounBouazzi, mais les tentatives, au #Québec comme dans beaucoup d’autres sociétés occidentales, de faire des immigrants les boucs émissaires des maux sociaux causés par près de 40 ans de saccage néolibéral. »

https://www.ledevoir.com/opinion/idees/824009/idees-taisez-mot-racisme-on-ne-saurait-entendre
#SoutienÀHarounBouazzi #polQC #DroitardsPleurnichards #tartuffes #nationaleux #hypocrites #CommunautésRacisées #LDL

I used #AI to learn how to lower my #LDL #cholesterol by feeding several days of my food log information to #ChatGPT and using the prompt: "Analyze these food logs and suggest changes to dramatically lower LDL cholesterol." The result: I need to lower protein intake by about 25% and increase vegetable intake by 50%. I had to interpolate the results, but It was way easier and more productive than sitting through a 90 minute Zoom class with a dietician.

The #LDL cumulative exposure hypothesis: evidence and practical applications | #Nature Reviews #Cardiology https://www.nature.com/articles/s41569-024-01039-5 “Maintaining low levels of LDL-cholesterol (LDL-C) over time decreases the number of LDL particles trapped within the artery wall, slows the progression of atherosclerosis and, by delaying the age at which mature atherosclerotic plaques develop, substantially reduces the lifetime risk of #ASCVD events.”

Om mättat fett är bra eller dåligt har varit en het diskussion inom ”hälsosfären” under en väldigt lång tid. Det började ordentligt med LCHF för kanske 15 år sedan och så har det fortsatt fram tills idag.

Redan då, för 15 år sedan, så påstod LCHF-arna att vi var mitt i ett paradigmskifte och att ny forskning visade något helt annat. […]

https://traningslara.se/varfor-rekommenderas-vi-att-ata-mindre-mattat-fett/

I'm a believer
In plant based diet

My #LDL dropped 57 points from 1 month of #PlantBasedDiet !
162 -> 105
I only wish I would have started sooner
Think I need to give up peanut butter 😔

Dec 2023 my Dr said he was going to prescribe a statin medication and mentioned many unfavorable side affects.
I went to the library, read these books and followed the guidance
#Engine2Diet - Rip Esselstyn
#PreventAndReverseHeartDisease - Caldwell Esselstyn
#TheChinaStudy - T Colin Campbell - read it!

Consuming #soy flour rich in the #protein B-conglycinin has the potential to reduce #LDL #cholesterol levels and lower the risk of metabolic #diseases such as atherosclerosis and #fatty #liver disease
#NutritionalScience #Medical #sflorg #nutrition
https://www.sflorg.com/2023/01/nut01232301.html

#SayCheese!

#Goednieuws voor de kaasliefhebber. Volvette kaas is #niet ongezonder dan magere voor wat betreft risico op hart-vaatziekten, diabetes en overgewicht. Dat weten we trouwens al jááren.
Ondanks tig onderzoeken blijft het Voedingscentrum echter volhouden: "Kaas is gezonder dan je denkt, maar 30+ blijft het advies" en "volvette 48+ kaas niet in de Schijf van Vijf".

Gaat het hier nu over voedingsadvies of over gezichtsverlies?

#LDL #VerzadigdVet #VoedingsToot
https://www.nu.nl/eten-en-drinken/6246610/kaas-is-gezonder-dan-je-denkt-maar-30-blijft-het-advies.html