#paralog — Public Fediverse posts

Intriguing: modeling and empirical data support that after whole genome duplication (autotetraploids) genetic variation rises, and mutation load increases because deleterious mutations are masked by additional chromosome copies
https://www.biorxiv.org/content/10.1101/2025.01.12.632621v1
#WholeGenomeDuplication #paralog #MolecularEvolution #PopulationGenetics #Arabidopsis

Very nice preprint on most-diverged vs. less-diverged ortholog among paralog pairs: https://www.biorxiv.org/content/10.1101/2024.10.29.620890v1 @dessimoz #ortholog #paralog #MolecularEvolution

Updated preprint of work by Tina Begum et al showing that paralogs from small-scale duplications have jumps in expression phenotype, much more than orthologs or whole genome duplication paralogs
https://www.biorxiv.org/content/10.1101/2023.12.29.571877v2 #ortholog #paralog #phylogenetics #GeneExpression #MolecularEvolution #FishEvolution

Registrations open to our @SIB course for PhD students in Lausanne 🇨🇭 with @rmwaterhouse and @dessimoz :
Biodiversity bioinformatics: from large-scale phylogenomics to gene families and functions
with @bgeedb, OMA and BUSCO inside
https://www.sib.swiss/training/course/20240828_COMGE #BiodiversityGenomics #MolecularEvolution #ortholog #paralog #bioinformatics

We posted this cool preprint between Xmas and new year, now time for a thread about the results: Begum et al "Phylogenetic modeling provides evidence for sudden shifts in expression after small-scale duplication in vertebrates and strong support for the ortholog conjecture"
https://www.biorxiv.org/content/10.1101/2023.12.29.571877v1
#paralog #ortholog #GeneDuplication #GenomeDuplication #MolecularEvolution #phylogeny #ohnolog

E Lau shows very nicely how bioluminescence in ostracods, fireflies and sea pansies can use very different structures yet convergently recruited homologous enzymes. The number of functional genes varies according to lineage-specific duplications. https://www.biorxiv.org/content/10.1101/2023.04.12.536614v1.abstract #SMBE2023 #ConvergentEvolution #paralog #bioluminescence

Marjorie Liénard: method to express invertebrate opsin proteins in vitro, allowing to show spectral shifts in opsins in butterflies, with notably 2 paralogs of LW providing differentiation in function between the dorsal and ventral parts of the eye https://www.pnas.org/doi/abs/10.1073/pnas.2008986118 #SMBE2023 #opsin #GeneDuplication #paralog

Carlos Cortez shows how a single mutation was sufficient to evolve Hb from a tetramer to a dimer. How does specificity of heterotetramer evolve? 2 deletions and 1 substitution in one of the 2 paralogs are sufficient. Overall, evolving heterotetramer complex from identical at birth paralogs is remarkably simple. #SMBE2023 #paralog #duplication

Announcing #SIB Comparative genomics course, taught by Christophe Dessimoz, Natasha Glover, @rmwaterhouse and myself, 30 August - 01 September in Lausanne #UNIL
• Introduction to molecular evolution & phylogenetics
• Orthology-focused arthropod comparative genomics
• Duplication of genes and genomes, expression
with #SIB resources #OMA, #Orthodb #BUSCO and @bgeedb #ortholog #orthologs #paralog #duplication #MolecularEvolution #Genomics #bioinformatics #training @P_Palagi https://www.sib.swiss/training/course/20230830_COMGE

Bgee used to support the identification of the target gene for depletion experiment in zebrafish: https://elifesciences.org/articles/83652
#zebrafish #cytoskeleton #ortholog #paralog #GeneExpression #SIB @dee_unil @marcrr

@wait_sasha Well “forks” in the sense that an instance is not only its code but also its users & regulations … But actually the post was mostly crafted since @marcrr complaimed about an underused #paralog tag - so some liberties were taken ¯\_(ツ)_/¯

So Mastodon instances are typical examples of whole code duplication events - i.e. #paralog driven #evolution of social network diversity ¯\_(ツ)_/¯

Will be fun to remember this later if #ScienceMastodon takes off: right now my posts seem to be the only hits for #ortholog and #paralog.

Now published in its final form: Parallel evolution of amphioxus and vertebrate small-scale gene duplications by Brasó-Vives et al
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02808-6
#EvoDevo #EvolutionaryBiology #Genomics #Amphioxus #Chordate #ortholog #paralog #GeneDuplication

Very exciting preprint led by Manu Irimia on evolution of tissue-specificity of expression in vertebrates and insects, providing great data, evidence for "low conservation of tissue-specific expression profiles", and tissue-specific gains associated with duplications and with the emergence of unique phenotypes
https://www.biorxiv.org/content/10.1101/2022.11.14.516384v1
#geneexpression #EvolutionaryBiology #TissueSpecifity #ortholog #paralog #DeneDuplication