#opsin — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #opsin, aggregated by home.social.
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Cui et al. investigate the evolutionary trajectory leading to dim-light vision in vertebrates, concluding that it evolved via three main stages of molecular adaptation, at the origins of ancestral rhodopsin pigments.
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#Zhongmou wins U.S. #FDA clearance for China's first optogenetic human trials https://www.linkedin.com/pulse/zhongmou-wins-us-fda-clearance-chinas-first-optogenetic-k1vte/ using ZM-02 for treating advanced retinitis pigmentosa; #RP #blindness #opsin #optogenetics #PRISM
"By bypassing damaged rod and cones, this mutation-agonistic approach is being developed for advanced retinal diseases, including retinitis pigmentosa and geographic atrophy (GA) in age-related macular degeneration."
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We thank our postdoc Natalie Roberts for leading a stimulating lab-meeting today on #colour #vision and #opsin genes in damselflies and other insects for members of #SvenssonLab and #TsuboiLab.
In the evening some of the lab members went to Café Ariman in Lund and later to see the movie "The Apprentice" at #Kino in #Lund
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If you too like #opsin evolution, check our new #bioinformatics tool #Matreex to visualize the evolution of complex gene families, illustrated by the evolution of vertebrate red-sensitive visual opsins https://www.biorxiv.org/content/10.1101/2023.02.18.529053v1.full #SMBE2023
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Marjorie Liénard: method to express invertebrate opsin proteins in vitro, allowing to show spectral shifts in opsins in butterflies, with notably 2 paralogs of LW providing differentiation in function between the dorsal and ventral parts of the eye https://www.pnas.org/doi/abs/10.1073/pnas.2008986118 #SMBE2023 #opsin #GeneDuplication #paralog
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Our favourite #Platynereis #opsin now in the mammalian brain as a new #optogenetic tool!
"Here we ... found that the Platynereis dumerilii ciliary opsin ... is an efficient, versatile, light-activated bistable GPCR that can suppress synaptic transmission in mammalian neurons with high temporal precision in-vivo "
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#Matreex can be used for teaching, as here with the classical example of opsin evolution: notice the parallel loss of blue- and green-sensitive opsins in snakes and mammals, the duplications in frugivorous old-world primates, and the duplications and losses in fishes according to habitat. #opsin #MolecularEvolution
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