#mutagenesis — Public Fediverse posts

Could Space Radiation Mutate Seeds For The Benefit of Humanity? - Humans have forever been using all manner of techniques to better secure the food ... - https://hackaday.com/2025/07/08/could-space-radiation-mutate-seeds-for-the-benefit-of-humanity/ #spacemutagenesis #hackadaycolumns #cosmicradiation #agriculture #mutagenesis #cosmicrays #radiation #science #iaea

Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R

Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.

Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R

Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.

Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R

Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.

Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R

Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.

Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R

Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.

🍽️You'd be stressed too if you had 10 billion people coming for dinner...😳

Using #CRISPR for targeted #mutagenesis on important #crop species like broomcorn #millet may help meet the growing need for global #FoodSecurity.

https://doi.org/10.1111/jipb.13669
@wileyplantsci
#JIPB #PlantSci #botany

#Epistasis mediates the evolution of #receptor binding mode in recent #human #H3N2 #hemagglutinin, Nat Commun.: https://www.nature.com/articles/s41467-024-49487-4

Combinatorial #mutagenesis reveals that G186D and D190N, along with other natural mutations in recent H3N2 strains, alter compatibility with a common egg-adaptive mutation in seasonal influenza vaccines. Our findings elucidate role of epistasis in shaping recent evolution of human hemagglutinin & substantiate high evolvability of its receptor-binding mode.

😱

#Structural insights into p300 regulation and #acetylation-dependent genome organisation
https://www.nature.com/articles/s41467-022-35375-2

@strucbio

- #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

- #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

- domain truncation and #mutagenesis support the #computational #models !