#mutagenesis — Public Fediverse posts

https://www.europesays.com/uk/1076886/ Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing #Agriculture #AnimalGeneticsAndGenomics #Biomedicine #CancerResearch #Epigenetics #GeneFunction #general #GeneticEngineering #HumanGenetics #Mutagenesis #Science #UK #UnitedKingdom

https://www.europesays.com/ie/575299/ Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing #Agriculture #AnimalGeneticsAndGenomics #Biomedicine #CancerResearch #Éire #Epigenetics #GeneFunction #general #GeneticEngineering #HumanGenetics #IE #Ireland #Mutagenesis #Science

Random #mutagenesis of #influenza #hemagglutinin identifies new sites which modulate its acid-stability and cleavability, https://etidiohnew.blogspot.com/2025/07/random-mutagenesis-of-influenza.html

Random #mutagenesis of #influenza #hemagglutinin identifies new sites which modulate its acid-stability and cleavability, https://etidiohnew.blogspot.com/2025/07/random-mutagenesis-of-influenza.html

Could Space Radiation Mutate Seeds For The Benefit of Humanity? - Humans have forever been using all manner of techniques to better secure the food ... - https://hackaday.com/2025/07/08/could-space-radiation-mutate-seeds-for-the-benefit-of-humanity/ #spacemutagenesis #hackadaycolumns #cosmicradiation #agriculture #mutagenesis #cosmicrays #radiation #science #iaea

Could Space Radiation Mutate Seeds For The Benefit of Humanity? - Humans have forever been using all manner of techniques to better secure the food ... - https://hackaday.com/2025/07/08/could-space-radiation-mutate-seeds-for-the-benefit-of-humanity/ #spacemutagenesis #hackadaycolumns #cosmicradiation #agriculture #mutagenesis #cosmicrays #radiation #science #iaea

#CRISPR can improve disease resistance in #wheat by giving access to a broader range of solutions beyond random #mutagenesis or intraspecific variation. #Geneediting can unlock new ways to improve crops & speed up #plantbreeding for resistance to crop diseases: https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1542487/

Using the transposon-associated TnpB to improve the efficiency of #CRISPR/Cas-9 #gene editing may prove to be a valuable tool to improve #crop yield and quality of #medicinal #plants
https://doi.org/10.1111/jipb.13758
@wileyplantsci
#PlantScience #JIPB #Arabidopsis #mutagenesis #botany

Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R

Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.

Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R

Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.

Ancient #volcanoes poisoned #ferns for millions of years https://www.earth.com/news/ancient-volcanoes-chaos-poisoned-ferns-for-millions-of-years/

#Climate-forced Hg-remobilization associated with fern #mutagenesis in the aftermath of the end-#Triassic #extinction https://www.nature.com/articles/s41467-024-47922-0

"the initial volcanic eruptions caused a dramatic shift in the planet’s climate. However, the environmental consequences unfolded over millions of years. Mercury contamination lingered in the environment, poisoning ecosystems long after the immediate extinction event."

Ancient #volcanoes poisoned #ferns for millions of years https://www.earth.com/news/ancient-volcanoes-chaos-poisoned-ferns-for-millions-of-years/

#Climate-forced Hg-remobilization associated with fern #mutagenesis in the aftermath of the end-#Triassic #extinction https://www.nature.com/articles/s41467-024-47922-0

"the initial volcanic eruptions caused a dramatic shift in the planet’s climate. However, the environmental consequences unfolded over millions of years. Mercury contamination lingered in the environment, poisoning ecosystems long after the immediate extinction event."

🍽️You'd be stressed too if you had 10 billion people coming for dinner...😳

Using #CRISPR for targeted #mutagenesis on important #crop species like broomcorn #millet may help meet the growing need for global #FoodSecurity.

https://doi.org/10.1111/jipb.13669
@wileyplantsci
#JIPB #PlantSci #botany

#Epistasis mediates the evolution of #receptor binding mode in recent #human #H3N2 #hemagglutinin, Nat Commun.: https://www.nature.com/articles/s41467-024-49487-4

Combinatorial #mutagenesis reveals that G186D and D190N, along with other natural mutations in recent H3N2 strains, alter compatibility with a common egg-adaptive mutation in seasonal influenza vaccines. Our findings elucidate role of epistasis in shaping recent evolution of human hemagglutinin & substantiate high evolvability of its receptor-binding mode.

#Epistasis mediates the evolution of #receptor binding mode in recent #human #H3N2 #hemagglutinin, Nat Commun.: https://www.nature.com/articles/s41467-024-49487-4

Combinatorial #mutagenesis reveals that G186D and D190N, along with other natural mutations in recent H3N2 strains, alter compatibility with a common egg-adaptive mutation in seasonal influenza vaccines. Our findings elucidate role of epistasis in shaping recent evolution of human hemagglutinin & substantiate high evolvability of its receptor-binding mode.

I am constantly amazed that the older folks around here aren't all dead of chemical-caused cancer, given how much Roundup and pesticides are applied to their yards. (These folks pay for monthly chemical dousing, even if there are NO PESTS to apply those chemicals too -- we call it the Visit From The Merchants Of Death). #chemicals #mutagenesis #pesticides

I am constantly amazed that the older folks around here aren't all dead of chemical-caused cancer, given how much Roundup and pesticides are applied to their yards. (These folks pay for monthly chemical dousing, even if there are NO PESTS to apply those chemicals too -- we call it the Visit From The Merchants Of Death). #chemicals #mutagenesis #pesticides

#Organic farming is dishonest when it comes to genetic engineering as it also uses #GMO varieties—namely those developed by #mutagenesis. Costs of #GMOs are driven by approval hurdles, not patents: https://www-topagrar-com.translate.goog/acker/news/prof-qaim-haelt-oekolandbau-fuer-unehrlich-20001615.html?_x_tr_sl=de&_x_tr_tl=en #biotech #patents (1/2)

#CRISPR/Cas9-mediated targeted #mutagenesis of #inulin #biosynthesis in rubber #dandelion.

#Taraxacum #1_FFT

https://phys.org/news/2024-02-crisprcas9-mutagenesis-inulin-biosynthesis-rubber.html

Some #AntiviralDrugs act by triggering viral "Death by #Mutagenesis", but could this accelerate evolution of variants-of-concern? @Gabriela3001 @TPilpel @DrMANowak use a math framework to ask whether such treatments are evolutionarily safe #PLOSBiology https://plos.io/45mSjJe

Some #AntiviralDrugs act by triggering viral "Death by #Mutagenesis", but could this accelerate evolution of variants-of-concern? @Gabriela3001 @TPilpel @DrMANowak use a math framework to ask whether such treatments are evolutionarily safe #PLOSBiology https://plos.io/45mSjJe

RT @EUCourtPress: #ECJ specifies the status of in vitro random #mutagenesis having regard to the #GMO Directive #environment 👉 https://curia.europa.eu/jcms/jcms/Jo2_7052/

🐦🔗: https://n.respublicae.eu/EURLex/status/1622902274040160257

RT @EUCourtPress: #ECJ specifies the status of in vitro random #mutagenesis having regard to the #GMO Directive #environment 👉 https://curia.europa.eu/jcms/jcms/Jo2_7052/

🐦🔗: https://n.respublicae.eu/EURLex/status/1622902274040160257

"We set out to systematically investigate global sequencing databases for a signature of #molnupiravir #mutagenesis. We find that a specific class of long phylogenetic branches appear almost exclusively in sequences from 2022, after the introduction of molnupiravir treatment, and in countries and age-groups with widespread usage of the drug."

#Preprint #COVID19 #Covid #Antiviral #SARSCoV2

https://www.medrxiv.org/content/10.1101/2023.01.26.23284998v1

"We set out to systematically investigate global sequencing databases for a signature of #molnupiravir #mutagenesis. We find that a specific class of long phylogenetic branches appear almost exclusively in sequences from 2022, after the introduction of molnupiravir treatment, and in countries and age-groups with widespread usage of the drug."

#Preprint #COVID19 #Covid #Antiviral #SARSCoV2

https://www.medrxiv.org/content/10.1101/2023.01.26.23284998v1

Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.

#biophysics #IonChannels #physiology #GeneticCodeExpansion

https://www.nature.com/articles/s41467-022-35279-1

😱

#Structural insights into p300 regulation and #acetylation-dependent genome organisation
https://www.nature.com/articles/s41467-022-35375-2

@strucbio

- #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

- #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

- domain truncation and #mutagenesis support the #computational #models !

😱

#Structural insights into p300 regulation and #acetylation-dependent genome organisation
https://www.nature.com/articles/s41467-022-35375-2

@strucbio

- #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

- #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

- domain truncation and #mutagenesis support the #computational #models !

😱

#Structural insights into p300 regulation and #acetylation-dependent genome organisation
https://www.nature.com/articles/s41467-022-35375-2

@strucbio

- #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

- #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

- domain truncation and #mutagenesis support the #computational #models !

😱

#Structural insights into p300 regulation and #acetylation-dependent genome organisation
https://www.nature.com/articles/s41467-022-35375-2

@strucbio

- #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

- #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

- domain truncation and #mutagenesis support the #computational #models !

😱

#Structural insights into p300 regulation and #acetylation-dependent genome organisation
https://www.nature.com/articles/s41467-022-35375-2

@strucbio

- #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

- #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

- domain truncation and #mutagenesis support the #computational #models !