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#acetylation — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #acetylation, aggregated by home.social.

  1. Dan Bose @[email protected] ·

    This allows condensate behaviour to respond to different inputs, such as lysine #acetylation in IDRs in other CBP domains. It can help to explain how #transcription factors binding to different regions of CBP differentially regulate CBP activity. #enhancers #generegulation #llps #chromatin #imaging #biochemistry #molecularbiology #CellBiology

    #acetylation #transcription #enhancers #generegulation #llps #chromatin
  2. CellBioNews @[email protected] ·

    Researchers reveal how #acetylation regulates #centromere dynamics, #chromosome #segregation and #mitotic progression.

    #TIP60 #Bub1

    phys.org/news/2024-05-reveal-a

    #acetylation #centromere #chromosome #segregation #mitotic #tip60
  3. CellBioNews @[email protected] ·

    Researchers reveal how #acetylation regulates #centromere dynamics, #chromosome #segregation and #mitotic progression.

    #TIP60 #Bub1

    phys.org/news/2024-05-reveal-a

    #acetylation #centromere #chromosome #segregation #mitotic #tip60
  4. katch wreck @[email protected] ·

    "CD8+ Teff cells preferentially used #ketone bodies (KBs) over #glucose to fuel the tricarboxylic acid (TCA) cycle in vitro and in vivo. KBs directly boosted the respiratory capacity and TCA cycle-dependent metabolic pathways that fuel CD8+ T cell function. Mechanistically, βOHB was a major substrate for acetyl-CoA production in CD8+ T cells and regulated effector responses through effects on #histone #acetylation"

    cell.com/immunity/fulltext/S10

    #ketone #glucose #histone #acetylation
  5. The EMBO Journal @[email protected] ·

    How does #centrosome #amplification -common in #cancer- promote #cellmigration through confined spaces?
    Susana Godinho and colleagues show that it alters intracellular organization via effects on #tubulin #acetylation and #organelle transport along #microtubules
    embopress.org/doi/full/10.1525

    #centrosome #amplification #cancer #cellmigration #tubulin #acetylation
  6. The EMBO Journal @[email protected] ·

    How does #centrosome #amplification -common in #cancer- promote #cellmigration through confined spaces?
    Susana Godinho and colleagues show that it alters intracellular organization via effects on #tubulin #acetylation and #organelle transport along #microtubules
    embopress.org/doi/full/10.1525

    #centrosome #amplification #cancer #cellmigration #tubulin #acetylation
  7. Alexis Verger @[email protected] ·

    😱

    #Structural insights into p300 regulation and #acetylation-dependent genome organisation
    nature.com/articles/s41467-022

    @strucbio

    - #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

    - #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

    - domain truncation and #mutagenesis support the #computational #models !

    #models #computational #mutagenesis #alphafold #acetylation #structural
  8. Alexis Verger @[email protected] ·

    😱

    #Structural insights into p300 regulation and #acetylation-dependent genome organisation
    nature.com/articles/s41467-022

    @strucbio

    - #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

    - #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

    - domain truncation and #mutagenesis support the #computational #models !

    #structural #models #computational #mutagenesis #alphafold #acetylation