#geneticcodeexpansion — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #geneticcodeexpansion, aggregated by home.social.
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Amazing talk by Jana Volaric from our Molecular Physiology Department and @LED3hub at #KNCVMCCB2026. She talked about her postdoctoral research in the Ed Tate lab into optical control of S-acyltransferase activity in mammalian cells.
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Interesting paper by the groups of Zhi Zhou and Xiang Sheng in Nature Communications. They developed a system, with which thiophenols can be fed to cells, converted into non-canonical amino acids and directly used for genetic code expansion in protein engineering.
https://www.nature.com/articles/s41467-025-63733-3
#Chemistry #ChemBio #GeneticCodeExpansion -
Monumental paper of unnatural amino acid (UAA) mutagenesis in calcium release channels from Isabella Derler and team! Light-activated calcium release in complexes without STIM1 and tons of insights to structure function.
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Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.
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Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.
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Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.
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Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.
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Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.
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Nice to see this work from Alberto Gonzalez and Teresa Giraldez and collaborators online! My part was small but very happy with how it has turned out. Beautiful state-dependence of crosslinks, fingerprinting movements of the BK channel.
https://www.biorxiv.org/content/10.1101/2022.12.15.520511v1.article-info