#infectivity — Public Fediverse posts

{#USA, #Nevada} The Occurrence of Another Highly Pathogenic Avian #Influenza (HPAI) #Spillover from Wild #Birds into Dairy #Cattle, https://etidiohnew.blogspot.com/2025/02/usa-nevada-occurrence-of-another-highly.html

Analysis of hemagglutinin gene of Nevada dairy cattle viruses did not identify changes predicted to impact #infectivity or #adaptation to mammalian hosts. However, a change of #PB2 D701N commonly associated with mammalian adaptation of HPAI virus was identified in viruses sequenced from four separate dairy cattle.

''Compared to the Svalbard avian index case, #PB2 #segment of the walrus sequence contained only 2 aa #substitutions, including #E627K mutation, which is known to enhance #infectivity in #mammals. Interestingly, all avian HPAIV H5N5 from Norway, as well as the walrus sequence, have a set of 6 aa in PB2 that have been reported to favour infection of mammals [Citation11].''

Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R

Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.

#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1

Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.

Characteristics of #JN1-derived #SarsCoV2 #subvariants #SLip, #FLiRT, and #KP2 in neutralization #escape, #infectivity and membrane #fusion http://biorxiv.org/cgi/content/short/2024.05.20.595020v1?rss=1

Interestingly, #antibodies in #XBB15 monovalent vaccinated hamster sera robustly neutralized FLiRT and KP.2 but had reduced efficiency for SLip.

#Omicron #Spike confers enhanced #infectivity and #interferon #resistance to #SARS-CoV-2 in #human nasal tissue https://www.nature.com/articles/s41467-024-45075-8

#Antigenicity and #infectivity characterisation of #SARS-CoV-2 #BA286, Lancet Infect Dis.: https://doi.org/10.1016/S1473-3099(23)00573-X #research #science #covid19

#Transmissibility, #infectivity, and immune #evasion of the #SARS-CoV-2 #BA286 #variant, Lancet Infect Dis.: https://doi.org/10.1016/S1473-3099(23)00575-3 #research #science #VOIs #immunity #antibodies