#ligand — Public Fediverse posts

Optibrium introduces graphical interface for QuanSA to enhance ligand-based affinity predictions

Optibrium, a leading developer of software and AI solutions for molecular design, today announced a new QuanSA™ plugin…
#NewsBeep #News #Technology #AU #Australia #bindingaffinity #drugdiscovery #Ligand #Molecule #protein #Software
https://www.newsbeep.com/au/562694/

https://www.europesays.com/ie/376772/ Machine learning model predicts chemical reactions to accelerate drug discovery #Catalyst #Compound #DrugDiscovery #Éire #IE #Ireland #Ligand #MachineLearning #medicine #Molecule #Research #Running #Science

Investigating microglia’s role in Alzheimer’s pathology

Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the…
#NewsBeep #News #Health #Agonist #Alzheimer'sdisease #Antibody #Brain #CA #Canada #Cell #CentralNervousSystem #Dementia #language #Ligand #Microglia #MonoclonalAntibody #nervoussystem #neurodegenerativedisorder #Pathology #Receptor #RNA #RNAsequencing #Transcriptomics
https://www.newsbeep.com/ca/508841/

https://www.europesays.com/ie/363426/ Investigating microglia’s role in Alzheimer’s pathology #Agonist #Alzheimer'sDisease #Antibody #Brain #Cell #CentralNervousSystem #dementia #Éire #Health #IE #Ireland #Language #Ligand #microglia #MonoclonalAntibody #NervousSystem #NeurodegenerativeDisorder #Pathology #Receptor #RNA #RNASequencing #Transcriptomics

on some level, all carbenes are kinda insane. but hexaphenylcarbodiphosphorane (technically a carbone) might just be the most insane of all. Formally neutral with not one but _two_ lone pairs??? GTFOH
#chemistry #carbene #ligand

on some level, all carbenes are kinda insane. but hexaphenylcarbodiphosphorane (technically a carbone) might just be the most insane of all. Formally neutral with not one but _two_ lone pairs??? GTFOH
#chemistry #carbene #ligand

on some level, all carbenes are kinda insane. but hexaphenylcarbodiphosphorane (technically a carbone) might just be the most insane of all. Formally neutral with not one but _two_ lone pairs??? GTFOH
#chemistry #carbene #ligand

on some level, all carbenes are kinda insane. but hexaphenylcarbodiphosphorane (technically a carbone) might just be the most insane of all. Formally neutral with not one but _two_ lone pairs??? GTFOH
#chemistry #carbene #ligand

on some level, all carbenes are kinda insane. but hexaphenylcarbodiphosphorane (technically a carbone) might just be the most insane of all. Formally neutral with not one but _two_ lone pairs??? GTFOH
#chemistry #carbene #ligand

https://www.europesays.com/ie/326098/ RNA micelles enable targeted chemotherapy without immune toxicity #cancer #Cell #chemotherapy #Colorectal #ColorectalCancer #Drugs #Éire #Gemcitabine #Gene #Health #IE #ImmuneResponse #Ireland #Ligand #Lungs #Metastasis #Molecule #Nanoparticle #Pharmacology #Research #RNA #siRNA #Technology #Therapeutics #therapy #Tumor

https://www.europesays.com/ie/228601/ New findings show why the human intestine uniquely presents gluten to T cells #Antigen #CeliacDisease #Cell #CellDevelopment #CoeliacDisease #Cytometry #DendriticCell #Éire #FlowCytometry #Gene #Genes #gluten #Glycoprotein #Health #IE #immunity #InVivo #Interferon #InterferonGamma #Ireland #Knockout #Ligand #Necrosis #Organoids #peptides #Protein #Receptor #RetinoicAcid #StemCells #Transcription #TranscriptionFactors #Tumor #TumorNecrosisFactor

SciTech Chronicles. . . . . . . . .Mar 5th, 2025

https://bit.ly/stc030525

#cornea #epithelial #transplantation #18-months #sunspot #earthquake #Prediction #tectonic #hydrosilylation #platinum #silicon #ligand #AI #entanglement #communication #photons #LiDAR #Autonomous #Farming #odometry

SciTech Chronicles. . . . . . . . .Mar 5th, 2025

https://bit.ly/stc030525

#cornea #epithelial #transplantation #18-months #sunspot #earthquake #Prediction #tectonic #hydrosilylation #platinum #silicon #ligand #AI #entanglement #communication #photons #LiDAR #Autonomous #Farming #odometry

SciTech Chronicles. . . . . . . . .Mar 5th, 2025

https://bit.ly/stc030525

#cornea #epithelial #transplantation #18-months #sunspot #earthquake #Prediction #tectonic #hydrosilylation #platinum #silicon #ligand #AI #entanglement #communication #photons #LiDAR #Autonomous #Farming #odometry

SciTech Chronicles. . . . . . . . .Mar 5th, 2025

https://bit.ly/stc030525

#cornea #epithelial #transplantation #18-months #sunspot #earthquake #Prediction #tectonic #hydrosilylation #platinum #silicon #ligand #AI #entanglement #communication #photons #LiDAR #Autonomous #Farming #odometry

SciTech Chronicles. . . . . . . . .Mar 5th, 2025

https://bit.ly/stc030525

#cornea #epithelial #transplantation #18-months #sunspot #earthquake #Prediction #tectonic #hydrosilylation #platinum #silicon #ligand #AI #entanglement #communication #photons #LiDAR #Autonomous #Farming #odometry

My favorite molecular #protein-#ligand #docking method, #DiffDock, has been updated! The new DiffDock-L, provides a significant improvement in performance and generalization capacity.

Importantly., this new method comes with the new #DockGen benchmark, aiming to provide better evaluation metrics and help improve #generalization of #ML docking models by accounting for sequence-dissimilar proteins with very similar binding pockets in training/test splits.

https://arxiv.org/abs/2402.18396

New, and promising, #SurfDock diffusion generative model for #protein-#ligand #docking
https://www.biorxiv.org/content/10.1101/2023.12.13.571408v2.full.pdf+html

Unfortunately, code will only be available after the paper has been published 🙃
https://github.com/CAODH/SurfDock

Has anyone looked at CINS (https://doi.org/10.1371/journal.pcbi.1010468)?

Learns a Bayesian network of cell type dependencies from changes in cell type proportions (#scRNAseq) in case-control studies. Causal ligands from cell-cell edges are predicted by LASSO regression of #ligand and predicted response genes (using NicheNet's ligand-reponse network).
Cool idea, weird lack of validation in their paper... But I guess that's the challenge in #CellCellInteraction prediction - validation is _hard_

Finally read the REMI paper by Alice Yu (aliceomics@twitter) et al. Calculating the partial correlation structure of #ligand #receptor interactions across #scRNAseq samples (cancer, in their case) to _more_specifically_ identify context-dependent interactions. #CellCellInteraction prediction has a specificity problem, and this method outperforms NicheNet, which uses predicted transcriptional response to improve specificity of predictions.

https://twitter.com/PlevritisLab/status/1509196799520620544?s=20&t=6jB2saz7rcO2u-4Gh54C4Q

We used #STRINGdb to build a zebrafish-specific ligand-receptor interactome database. We also added human interactions from IID database from Jurisica group #ligand #receptor 12/n

We used #STRINGdb to build a zebrafish-specific ligand-receptor interactome database. We also added human interactions from IID database from Jurisica group #ligand #receptor 12/n

Nice paper from the Schapira lab identifying potential #ligand binding pockets for future #PROTAC development.

https://www.sciencedirect.com/science/article/pii/S2001037022005049#b0040

I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup

I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup

I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup

I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup

I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup