#proteasome — Public Fediverse posts

🔧 Flexibly assembled: Proteasomes, the cells’ garbage cans, are assembled in different ways
A new study by University Potsdam and the #UniCologne shows that the assembly of the proteasome, a central component of cellular protein quality control, does not follow a rigid program but uses flexible pathways. This discovery challenges established views in research.

Read more▶️ https://uni-koeln.de/en/university/news/news/news-detail/flexibel-montiert-alternative-wege-in-der-proteasom-biogenese-entschluesselt

📰 https://www.nature.com/articles/s41467-026-70525-w

#uniköln #unicologne #Proteasome #ProteinResearch #CellBiology

Derailed Protein Turnover in the Aging Mammalian Brain | presented by Jeffrey Savas, PhD

pulse-chase studies of long-lived proteins in mice

11:34 - distribution of extremely long lived proteins in tissues & organelles

27:44 - protein turnover is reduced in male aged brains, but elevated in female aged brains

30:43 - sex specific distinct cellular components have hampered protein turnover during aging (synapse, mitochondria, myelin sheath)

33:56 - proteasome activity during aging correlates with catalytic subunit turnover

36:00 - proteasome activity highest at 18 months (mice), correlates with turnover of catalytic subunits

https://youtu.be/-K0HjCJXQlg?si=XFakvMV5dv9qgMSU

#aging #brain #proteasome #proteomics #neuroscience #SexDifferences

#Proteasome regulation is disrupted in human #NGLY1 deficiency. @nlehrbach @gary_ruvkun &co find that in NGLY1-deficient #Celegans this depends on #nucleotide availability, suggesting that nucleotide restriction might mitigate such diseases #PLOSBiology https://plos.io/4cViY3y

#ProteinQC pathways play key roles in resistance to #pathogens. @manishgrover_4 @barkoulab &co show that #proteasome regulation keeps #InnateImmune responses against natural pathogens of #Celegans in check in a tissue-specific manner #PLOSBiology https://plos.io/3PhIjLW

Global histone H2B degradation regulates #insulin/#IGF signaling-mediated nutrient stress

The #ubiquitin-#proteasome system regulates #histone #H2B exchange in mammalian cells and in C. elegans during development and starvation.

https://www.embopress.org/doi/full/10.15252/embj.2022113328

In EMBO Journal issue 3:

Host #mucins negotiate peace with #toxigenic #Vibrio
Cytosolic #stressgranules relieve nuclear #ubiquitin-#proteasome system
#Smoothened #cholesterylation and ER exit links in #Hedgehog signaling
Developmental #cellfate decision control by #chromatin reader #TRIM33
Cover by Kimon Lemonides, Helen Walden et al

https://www.embopress.org/toc/14602075/2023/42/3

What happens to the #ubiquitin-#proteasome system in cells that cannot form #stressgranules?
Nico Dantuma & coworkers at Karolinska Institute find surprising #nucleolar relocalization of DRiP #peptides, compromising #proteostasis in the nucleus
https://www.embopress.org/doi/10.15252/embj.2022111802

Check out our recent paper on #vascular cell apoptotic vulnerabilities to #cancer therapeutics, including #radiotherapy, #chemotherapy and targeted agents (e.g. #proteasome inhibitors, #BH3mimetics). We find that #EndothelialCells remain primed for #apoptosis throughout development into adulthood and may represent a “weakest link” vulnerability in multiple tissues for development of toxicities. https://www.science.org/doi/full/10.1126/sciadv.abn6579

#Celldeath #CardioOncology #VigiBase #RadioBiology #BH3Profiling

Check out our recent paper on #vascular cell apoptotic vulnerabilities to #cancer therapeutics, including #radiotherapy, #chemotherapy and targeted agents (e.g. #proteasome inhibitors, #BH3mimetics). We find that #EndothelialCells remain primed for #apoptosis throughout development into adulthood and may represent a “weakest link” vulnerability in multiple tissues for development of toxicities. https://www.science.org/doi/full/10.1126/sciadv.abn6579

#Celldeath #CardioOncology #VigiBase #RadioBiology #BH3Profiling

Check out our recent paper on #vascular cell apoptotic vulnerabilities to #cancer therapeutics, including #radiotherapy, #chemotherapy and targeted agents (e.g. #proteasome inhibitors, #BH3mimetics). We find that #EndothelialCells remain primed for #apoptosis throughout development into adulthood and may represent a “weakest link” vulnerability in multiple tissues for development of toxicities. https://www.science.org/doi/full/10.1126/sciadv.abn6579

#Celldeath #CardioOncology #VigiBase #RadioBiology #BH3Profiling

Check out our recent paper on #vascular cell apoptotic vulnerabilities to #cancer therapeutics, including #radiotherapy, #chemotherapy and targeted agents (e.g. #proteasome inhibitors, #BH3mimetics). We find that #EndothelialCells remain primed for #apoptosis throughout development into adulthood and may represent a “weakest link” vulnerability in multiple tissues for development of toxicities. https://www.science.org/doi/full/10.1126/sciadv.abn6579

#Celldeath #CardioOncology #VigiBase #RadioBiology #BH3Profiling

Check out our recent paper on #vascular cell apoptotic vulnerabilities to #cancer therapeutics, including #radiotherapy, #chemotherapy and targeted agents (e.g. #proteasome inhibitors, #BH3mimetics). We find that #EndothelialCells remain primed for #apoptosis throughout development into adulthood and may represent a “weakest link” vulnerability in multiple tissues for development of toxicities. https://www.science.org/doi/full/10.1126/sciadv.abn6579

#Celldeath #CardioOncology #VigiBase #RadioBiology #BH3Profiling

I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup