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  1. LLMs and crystallisation as a form of object relating

    I thought this was interesting from Mari Ruti’s The Summons of Love pg 109:

    Stendhal labels this process “crystallization,” describing it as follows: Leave a lover with his thoughts for twenty-four hours, and this is what will happen. At the salt mines of Salzburg, they throw a leafless wintry bough into one of the abandoned workings. Two or three months later they haul it out covered with a shining deposit of crystals. The smallest twig, no bigger than a tom-tit’s claw, is studded with a galaxy of scintillating diamonds. The original branch is no longer recognizable. What I have called crystallization is a mental process which draws from everything that happens new proofs of the perfection of the loved one. Crystallization endows the beloved with every possible perfection. Through it, the object of our desire, no matter how ordinary, is rendered extraordinary. As Stendhal specifies, crystallization implies “a certain fever of the imagination which translates a normally commonplace object into something unrecognizable, and makes it an entity apart.”

    I don’t think this idealisation is narrowly romantic: it’s a particular mode of object relating in which a subject determinedly renders an object as sublime, seeing in every empirical facet of it evidence of the sublimity they have already ascribed to the object in their psyche. Essentially I think it’s a totalising way of reading back your own initial emotional response to the object into the nature of that object itself, in the process sharpening and entrenching the contours of that response.

    It’s exactly the form of object-relating which I worry that LLMs make much easier. Object relating like this thrives on articulation. It’s through putting reactions to the object into words that those reactions begin to crystallise the object, inviting stronger and deeper expressions of the initial reaction. It’s an auto-catalytic process: the more you do it, the more you’re prone to doing it. The problem isn’t just model sycophancy (they’re much less likely to check this behaviour than a human interlocutor) but rather the epistemic constraints of being entirely text based and reliant on what the user shares with them.

    It also makes me wonder if modes of object relating would be a useful analytical frame to bring towards the suffusion of LLMs into the lifeworld.

    #crystallization #idealisation #LLMs #MariRuti #obesssive #Stendhal
  2. We watch the minerals alter their chemistry. Stripped of silk and power, their heavy greed crystallizes into pure geometry and quiet justice. 💎⚖️ #Crystallization #MineralAlchemy

  3. An acylated GLP-1/GIP analogue peptide forms a uniquely porous spiral crystal structure composed of clockwise-ascending monomers in a square pattern #GLP1 #Peptides #Crystallization doi.org/10.1107/S2053230X26001

  4. Manual Rotary Evaporators EZL-RE21 offer smooth, controlled solvent evaporation for concentration, purification, and sample preparation tasks in chemistry and research labs. Their ergonomic design and easy-to-operate controls support consistent performance for academic, industrial, and analytical workflows.

    [email protected]

    Learn More: ezilab.com/manual-rotary-evapo

    #Ezilab #LaboratoryEvaporators #ManualRotaryEvaporators
    #LabEquipment #crystallization

  5. Features of sample preparation that should be considered prior to biomolecular crystallization experiments are reviewed, as described in the SAMPREP workshop during the 73rd Annual ACA Meeting #Crystallization #XRayCrystallography #StructuralBiology doi.org/10.1107/S2053230X25004

  6. Building an X-Ray Crystallography Machine - X-ray crystallography, like mass spectroscopy and nuclear spectroscopy, is an ext... - hackaday.com/2025/07/07/buildi #x-raycrystallography #x-raydiffraction #crystallization #crystallography #highvoltage #science #x-rays #x-ray

  7. Building an X-Ray Crystallography Machine - X-ray crystallography, like mass spectroscopy and nuclear spectroscopy, is an ext... - hackaday.com/2025/07/07/buildi #x-raycrystallography #x-raydiffraction #crystallization #crystallography #highvoltage #science #x-rays #x-ray

  8. Crystals of His15 acetamide-modified lysozyme had similar unit-cell parameters to the unmodified tetragonal form but refinement was only possible in an orthorhombic system #AcylatedLysozyme #Crystallization #SpaceGroupAnalysis doi.org/10.1107/S2053230X25000

  9. Unlike other serpins, human serpin B9 shows significant structural deviations around helix D, with a larger surface cavity, which could serve as a promising target for small-molecule inhibitors #Serpins #XRayCrystallography #Crystallization t.co/ilB7Aa3Krg

  10. 🧪🔬🧊 Growing sodium chloride #salt #crystals. Here is a flat crystal, ~7.2 millimetres wide, seen with optical microscopy at 10X, 40X, 200X, and 400X. At high magnifications, we can see small crystalline domains in a highly ordered arrangement. #crystallization #science #microscopy #nature

  11. New paper from David Baker's lab: doi.org/10.1038/s41563-023-016
    Computational design of #protein #crystals! 🤯
    Spontaneous #crystallization by mixing two E. coli lysates. 🤯 🤯
    Designed #protein #crystals that survive being autoclaved. 🤯 🤯 🤯

    #crystallography #StructuralBiology

  12. New paper from David Baker's lab: doi.org/10.1038/s41563-023-016
    Computational design of #protein #crystals! 🤯
    Spontaneous #crystallization by mixing two E. coli lysates. 🤯 🤯
    Designed #protein #crystals that survive being autoclaved. 🤯 🤯 🤯

    #crystallography #StructuralBiology

  13. "Garbage In, Garbage Out" - how many times have you heard this expression in structural biology?!?!

    We are running a workshop on sample preparation techniques at the upcoming 2023 American Crystallographic Association meeting July 7, 2023 in Baltimore, MD - register by June 30!

    acameeting.com/workshop2-sam23

    #structural #SAXS #cryoem #crystallization #crystallography #lightscattering #AUC #workshop #structuralbiology

  14. "Garbage In, Garbage Out" - how many times have you heard this expression in structural biology?!?!

    We are running a workshop on sample preparation techniques at the upcoming 2023 American Crystallographic Association meeting July 7, 2023 in Baltimore, MD - register by June 30!

    acameeting.com/workshop2-sam23

    #structural #SAXS #cryoem #crystallization #crystallography #lightscattering #AUC #workshop #structuralbiology

  15. We are excited to announce the Meritorious Users Program at the National Crystallization Center! Are you a structural biologist at a US PUI or MSI? Is your laboratory under-resourced? Take a look at the program for HT 💎 screening! We screen 1536 conditions in one experimental plate! Application deadline May 31 for the 1st round of screening!
    #crystallization #structuralbiology #crystallography #research #access
    getacrystal.org

  16. It's time to see... How HWI is providing scientists with models created to design drugs, vaccines and other treatments for diseases.

    youtube.com/watch?v=_Xo8E5Wqv0

    www.getacrystal.org

    #structuralbiology #crystallization #crystallography

  17. Excited to be presenting a Thermo Fisher Scientific Ask the Experts webinar 3/22/23 11am EDT with Devrim Acehan!

    We'll discuss emerging methods in cryo-EM of microcrystals, as well as our collaborative work as we seek to further develop microcrystal detection and handling methods.

    Register here: tinyurl.com/2p9d9zer

    www.getacrystal.org
    www.cryo-EM.center

    #structuralbiology #crystallization #cryoem #microED #webinar
    @strucbio

  18. Excited to be presenting a Thermo Fisher Scientific Ask the Experts webinar 3/22/23 11am EDT with Devrim Acehan!

    We'll discuss emerging methods in cryo-EM of microcrystals, as well as our collaborative work as we seek to further develop microcrystal detection and handling methods.

    Register here: tinyurl.com/2p9d9zer

    www.getacrystal.org
    www.cryo-EM.center

    #structuralbiology #crystallization #cryoem #microED #webinar
    @strucbio

  19. 📣Andreas Seidel-Morgenstern has been elected as a member of the National Academy of Engineering of the USA for his contributions to #adsorption, #chromatography, #crystallization processes, and the separation of #enantiomer mixtures - congratulations!

    mpi-magdeburg.mpg.de/4385805/2

  20. Announcing the December 2022 Crystals of the Month from the HTX Center!

    We are excited to feature recent results published in JBC from the Stull & Bardwell Groups.

    HT crystallization screening in the HTX Center identified 💎 💎 💎 💎 hits!

    Link to the paper: doi.org/10.1016/j.jbc.2022.102

    getacrystal.org

    1st time posting one of these #crystallization features on #Mastodon!
    #StructuralBiology
    @strucbio

  21. High fashion science going on in the HTX Center at HWI - new lab coats are in!!
    💎 🔬 👩🏻‍🔬

    #research #structuralbiology #crystallography #crystallization

  22. Our new 🦟🤖 has been installed! We will use this in the HT pipeline for growing 💎s in the HTX Center.

    We can't wait to get it setting up samples in the high-throughput pipeline for 💎!

    www.getacrystal.org

    #StructuralBiology #crystallization #crystallography #research

  23. Hi from the National High-Throughput Crystallization (HTX) Center in #Buffalo NY.

    The HTX Center specializes in #crystallization 💎 for #StructuralBiology.

    We are a team of 👩🏻‍🔬👩🏼‍🔬 👩🏽‍🔬 👩🏾‍🔬 and will often post #crystal images, #robot images, and updates for HTX Center users.

    www.getacrystal.org

    #introduction #toot

    #Crystallography #XrayCrystallography #NeutronCrystallography #XFEL #microED

  24. Hi from the National High-Throughput Crystallization (HTX) Center in #Buffalo NY.

    The HTX Center specializes in #crystallization 💎 for #StructuralBiology.

    We are a team of 👩🏻‍🔬👩🏼‍🔬 👩🏽‍🔬 👩🏾‍🔬 and will often post #crystal images, #robot images, and updates for HTX Center users.

    www.getacrystal.org

    #introduction #toot

    #Crystallography #XrayCrystallography #NeutronCrystallography #XFEL #microED

  25. Hi all - new to #Mastodon (fleeing the 🦃 #TwitterMigration).

    I'm an Associate Investigator & #StructuralBiologist at HWI in Buffalo #NY. I direct the National High-Throughput #Crystallization Center 💎.

    My group uses X-ray #crystallography, #microED, #computationalbiology, & other #biophysical tools to study #protein structure & function.

    Especially interested in #metalloproteins & coupling #crystallography & #spectroscopy.

    #Introduction #Science #SciComm #structuralbiology #WomeninSTEM