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matrixscience.com is being overwhelmed by millions of HTTP requests from distributed botnets, essentially a distributed denial of service (DDoS) attack. We are forced to mitigate it by restricting access to certain pages of dynamic content.
https://www.matrixscience.com/whats_new/mitigations-against-uncontrolled-web-crawlers-and-bots.html
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Thunder-DDA-PASEF is an acquisition strategy for capturing more human leukocyte antigen (HLA) class I peptide ligands on Bruker timsTOF instruments. This month's blog shows how you can process Thunder-DDA-PASEF data with Mascot Distiller.
https://www.matrixscience.com/blog/processing-thunder-dda-pasef-data-with-mascot-distiller.html
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Using the blib2msp converter, Mascot Server can now search DDA spectral libraries in BLIB format. Here's an example for identifying mycobacteria.
https://www.matrixscience.com/blog/identifying-mycobacteria-with-custom-spectral-libraries.html
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Mascot Newsletter, February 2026:
Strange software errors? Check your disk space.
Proteomic signatures in human fingertip regeneration.
Customise columns in the search log.
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Mascot Server can create and search NIST MSP formatted spectral libraries but not BLIB -- until now! We have developed an MSP to BLIB to MSP converter that allows Mascot Server to use BLIB libraries.
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Mascot Newsletter, January 2026:
Ion intensity: peak area vs signal to noise?
Duplexing deuterated water-labeled samples for protein turnover rate estimation.
Role-based access with Mascot Security is useful in a variety of cases.
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Proteomics software is prone to filling up the disk with data and temp files, which can cause weird issues. This blog article lists the most common errors in Mascot products and how to free up disk space.
https://www.matrixscience.com/blog/strange-software-failures-check-your-disk-space.html
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Mascot Newsletter, December 2025:
NCBI nr FASTA replacement.
Immunoregulation during pregnancy.
Mascot Server as system service on Linux.
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When raw data is processed into peak lists, there is a choice: how should peak intensity be calculated? Mascot Distiller defaults to peak area. The alternative, signal-to-noise (S/N), can be useful with detecting diagnostic ions.
https://www.matrixscience.com/blog/peak-list-arcana-area-vs-signal-to-noise.html
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Mascot Newsletter, November 2025:
Top-3 quant with DDA-PASEF.
ZooMS peptide markers for South American Xenarthrans.
Migrating from Windows 10 to Linux could extend the lifetime of your hardware.
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The NCBI nr FASTA file of protein sequences is no longer updated. We've summarised instructions for creating it from the BLAST database -- or you may be better off using TrEMBL.
https://www.matrixscience.com/blog/replacements-for-ncbi-nr.html
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Mascot Newsletter, October 2025:
Spectrum-centric DIA scoring.
Molecular mechanisms of SBK2 kinase on the heart.
Windows update issue with IIS (resolved).
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Mascot Daemon can export protein level quant intensities for replicate LFQ, SILAC and iTRAQ/TMT. The latest version can also export intensity values calculated using the "Top-3" method, illustrated here with DDA-PASEF data.
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We are pleased to announce a new distributor for Matrix Science products! Customers in India can now buy Mascot Server through BioInnovations, who provide instruments, software, services and consumables for life sciences and analytical and clinical labs. #proteomics #massspec
https://www.matrixscience.com/whats_new/new-mascot-distributor-in-india-bioinnovations.html
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Probabilistic scoring of DIA matches without spectral deconvolution? Not only is it possible, we're working on implementing it in Mascot DIA.
https://www.matrixscience.com/blog/probabilistic-spectrum-centric-scoring-for-dia.html
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Mascot Newsletter, August 2025:
Precursor detection for spectrum-centric DIA.
Reconstructing mediaeval monastic diets.
Microsoft has announced the end of Windows 10 support; your Mascot Server may be affected.
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CW: Deltarune ch2, Matrix
*unable to decrypt* is literally Matrix' version of Spamtom's [HYPRLINK BLOCKED]
#matrix #deltarune #spamton #unabletodecrypt #spamtongspamton
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#nooneasked for #neo to become a #vampire
#matrix -
@hopidd Entschuldigt die späte Antwort: Momentan ist alles in fester Hand von #Zoom, alternativ nicht weniger proprietär #AdobeConnect und #DFNConf. Die box.hu-berlin.de (#Seafile Pro) ist wenigstens clientseitig #FLOSS. #gnuHU hat die [Arbeitsgruppe Dezentrale Dienste](https://hu.berlin/agdd) als kleines gallisches Dorf gegründet (#Jitsi #Mumble). #BigBlueButton und #Matrix sind zumindest als offizielle HU-Dienste geplant, produktiv genutzt werden sie aber zum Semesterstart noch nicht.
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This month in my newsletter:
New writing about 50 years of street performing at Covent garden, and how a computer incorrectly predicted my future life when I was a kid, along with photography, videos and other stuff!
Hope you love it
#substack #writer #blogger #newsletter #streetperforming #jiigcal #essay
https://matricardo.substack.com/p/you-can-really-hear-the-distance
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Another passion of mine is the history of #Çatalhöyük site - and whether or not it had a #MatriachalSociety!
Ancient city possibly ruled by females living in a "matriarchal society" more than 9,000 years ago, researchers say
By Cara Tabachnick
June 28, 2025Excerpt: "We need to move away from our Western bias that assumes all societies are #patrilineal. Many cultures, including some #IndigenousAustralian groups, pass identity, land rights, and responsibilities through the mother's line — a #matrilineal system,' study co-author Dr. Eline Schotsmans, a research fellow at Australia's University of Wollongong's School of Science, said in a statement.
"These findings come several months after researchers studying social networks in #CelticSociety in Britain before the #RomanInvasion gathered genetic evidence from a late Iron Age cemetery and found that women were closely related, while unrelated men tended to come into the community from elsewhere, likely after marriage.
"Using an examination of ancient DNA recovered from 57 graves in #Dorset in southwest England, their study, published in the journal Nature, shows that two-thirds of the individuals were descended from a single maternal lineage. This suggests that women had some control of land and property, as well as strong social support, researchers said.
"Researchers said upon the release of their findings, 'It is possible that maternal ancestry was the primary shaper of group identities.' "
Read more:
https://www.cbsnews.com/news/ancient-city-ruled-by-females-catalhoyuk/Original paper:
https://www.science.org/doi/10.1126/science.adr2915#History #Histodon #Matrilineal #Matriarchy #AncientHistory #AncientTurkey #Neolithic #Anatolia #MotherGoddess
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Ok, ich bin jetzt seit etlichen Stunden damit beschäftigt #Matrix #Synapse dazu zu bringen #ElementCall zu verwenden... oida, ist das Setup ein scheiß.
Zuvor wurde einfach ein Turn Server mit WebRTC verwendet für Anrufe. Turn Server sind ein Ding für sich, aber irgendwie bekommt man es ja dann doch hin. Doch #ElementX besteht darauf Element Call zu verwenden. Das sind dann zwei weitere Docker Container die laufen müssen, die Nginx Konfiguration muss man umwerfen und anpassen und und und.
Die Entwickler von Synapse sollten langsam lernen ein vernünftiges Setup für Matrix zu ermöglichen. Ich verstehe durchaus, warum sich einige Admins den Mist nicht antun wollen. Man findet zwar alle Infos die man braucht in der Dokumentation, doch bis man die Infos wie Klemmbausteine zusammengesetzt hat, kostet dich das einige Nerven. Man hat 20 Tabs offen für so ziemlich alles was man beachten muss.
Ich habe es bis jetzt zumindestens hinbekommen, dass ElementX weiß, dass man irgendwie anrufen kann. Ob die Anrufe funktionieren, wird sich morgen rausstellen, wenn jemand die auch entgegen nehmen kann.
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Nice. Built my first working instance of Element Call. Everything running on our own servers and under our control, and true end-to-end encryption. Eat that, Zoom!
It's only a test setup for now, but I foresee that Element Call will quickly become the main tool for videoconferencing, not only here but in many ICT environments.
If you have no idea what I mean, visit the public instance and play with it:
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Does anyone know if there's a way to search for #Matrix servers, or search for rooms across multiple servers?
Or... does anyone know if a #naturist or #nudist Matrix server, space or room exists? There's #ElementCall coming out soon which would allow for video chat rooms, ala Zoom or Discord.
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Wondering if you can run @matrix and @xmpp on the same domain (same subdomain) - same hosting, or not - connected with a bridge bot, connecting your personal user on both.
#matrix #xmpp #jabber #chat #integration #compatibility #networked #federationHave you tried?
@nitrokey
@monocles
@chapril
@mailbox_org -
📚🔢 Ah, yet another thrilling bedtime story about matrix calculus—because who doesn't want to dive into a sea of math symbols with more enthusiasm than a toddler in a ball pit? 🙄 With authors who remind us that they have credentials longer than the paper itself, this is basically "Matrix Calculus for Dummies" but with extra academic snooze. 💤
https://explained.ai/matrix-calculus/ #matrixcalculus #bedtimefun #mathhumor #academicwriting #dummiesguide #HackerNews #ngated -
📚🔢 Ah, yet another thrilling bedtime story about matrix calculus—because who doesn't want to dive into a sea of math symbols with more enthusiasm than a toddler in a ball pit? 🙄 With authors who remind us that they have credentials longer than the paper itself, this is basically "Matrix Calculus for Dummies" but with extra academic snooze. 💤
https://explained.ai/matrix-calculus/ #matrixcalculus #bedtimefun #mathhumor #academicwriting #dummiesguide #HackerNews #ngated -
📚🔢 Ah, yet another thrilling bedtime story about matrix calculus—because who doesn't want to dive into a sea of math symbols with more enthusiasm than a toddler in a ball pit? 🙄 With authors who remind us that they have credentials longer than the paper itself, this is basically "Matrix Calculus for Dummies" but with extra academic snooze. 💤
https://explained.ai/matrix-calculus/ #matrixcalculus #bedtimefun #mathhumor #academicwriting #dummiesguide #HackerNews #ngated -
http://financemetrics.scienceontheweb.net Maximising the value of a portfolio. Calculating #Variance, #CoVariance and portfolio Variance using the magic of Matrix Algebra. Calculations feature 5 ftse stocks, BP, Vodafone, UU.L, Tesco and Morrison. Detailed exposition leads one through x transpose multiplied b x. #MatrixAlgebra
