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34 results for “breed”
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CW: Adult content
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CW: NSFW
Long dick Breeding dilettante pair Have pleasure
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Use the BRAVE browser // https://brave.com/ -
Struinen over het breedste strand. In de verte een streep van de duinen waarop de vuurtoren staat. Alleen met de wind en leegte.
#peaceful #beach #SilentSunday #schiermonnikoog #vuurtoren #ligthhouse #clouds #reflexiones #MindfulLiving #mindfulness #silence #nature #amsterdam #peaceandcalm
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Violence
Violence
Violence breeds violence
Violence breeds -
First Poster for Horror-Thriller ‘Breeder’ – An eccentric poodle breeder lures a broke college student to her remote ranch with a promise of research funding. But, as he soon learns, there’s a catch. https://www.fxoxo.com/337422/ #Movie #MovieNews #Movies
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#BBC #News #Science #Environment Little tern colony has worst breeding season https://w.st/K8tgv
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No.
Your trusted advisor is not giving you the best of breed.
No.
The leading cybersecurity firm is not giving you the best solution
No.
The software company Y (normally X, but that letter has been polluted) is not providing the best application for your business.
Why?????
Well, it’s as simple as (drums)
BudgetMoney 💴
Always, anywhere money is what is in control
Sad but true.
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I’ve discovered a new dinosaur! Researcher identifies unknown breed
Dr Cassius Morrison FROM an early age he obsessed over the prehistoric reptiles after watching Jurassic Park movies…
#London #Britain #UnitedKingdom #UK #GB #England #Headlines #News #Europe #EU #Camden #Bloomsbury #history #TheCamdenNewJournal #TomFoot
https://www.europesays.com/gbr/london/40103/ -
http://www.amiga-news.de/de/news/AN-2026-10-00083-DE.html
Test: Alien Breed 35th Anniversary Collection. #amiga #amiganews -
The key to fascism, explained by Katherine Hepburn in 1942
This sounds familiar: https://www.youtube.com/watch?v=_abRxAL3hnw Let's see it in practice today: https://www.youtube.com/shorts/DmM-A7GaciA Fox News is a fascist breeding ground. It has created a false reality, then moved into power to enforce its lies. And despite its lies, millions of brainwashed stooges continue to vomit up its fantasies because that's their reality. They will always be dupes: WILMINGTON, Del.—Fox News’s huge payment to Dominion Voting Systems to settle […] -
https://www.europesays.com/gbr/london/40103/ I’ve discovered a new dinosaur! Researcher identifies unknown breed #Bloomsbury #Camden #history #TheCamdenNewJournal #TomFoot
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BoE warns banks to prepare for AI-enabled cyber breaches
The Bank of England is working with banks on deep cyber-recovery options, its deputy governor Sarah Breeden said…
#Economy #Britain #centralbank #CentralBanks #CentralBanksoftheEuropeanSystem #DeutscheBundesbank #ECB #ESCB #Europe #European #EuropeanCentralBank #EuropeanCentralBanks #THEBANKOFENGLAND #TheBankofFrance #TheBankofItaly
https://www.europesays.com/3312750/ -
https://www.europesays.com/uk/1255161/ ‘I’ve had a fair bit of luck with greys, so I’m always trying to breed them’ – catching up with Desert Orchid’s in-form owner #HorseRacing #racing #Sports #UK #UnitedKingdom
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I finally got around to designing Arviris and Stenvar's horses! This is Chaya and Starlight. Chaya is based on Oblivion's black horses and the American Quarter Horse, and Starlight is inspired by Skyrim's grey horses and the Shire horse breed.
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:kirby_prideheart: Ello sweet and lovely Friendos :purple_heart_sparkle:
I just noticed that my mutual aid Toot had not been shared, but ended up in my drafts 🫣
So I just shared it... 😊
My blog post today will be about this topic as well. I've been crying a lot this night, scared of what will happen if Koa and I can't get the help we need so desperately... 😭 I either can't leave the house easily for many years to come. Or I'll need to rehome him through the breeder.
I feel so ashamed that I can't seem to help him, to raise him right, without the fears. 😢 Stupid boy hormones 😭.
I really hope that the GoFundMe will "lift off", and lift my spirits... As I really want to spend the next 12 years (or more 😇) with my boy! Just without all the stress and anxiety... 😢
Thanks to all for your kindness and support during my "journey through daily life" :bear_love: I really appreciate it :bear_hugs: as it helps me to keep going on bad/harder days! :bear_nuzzle:
:pixy_party: 🫂 🩵 💜 🩷 🐾 :dogeparrot:
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[#TRADESHOW] 15th #Leman #China #Swine #Conference & #World Swine #Industry #Expo 2026 from October 22 to 24, 2026, at Central #China #International #Convention and #Exhibition #Centre in #Zhengzhou. As a leading swine industry trade show and conference in China, the #event brings together #pig #farms, #breeding #companies, animal health suppliers, feed #producers, equipment #manufacturers, researchers, and #purchasing decision-makers across the full #ValueChain. https://cnbusinessforum.com/event/15th-leman-china-swine-conference-world-swine-industry-expo-2026/
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💔 TIL: Fewer than 50 Sumatran #rhinos survive, all in #Indonesia, while roughly 50 Javan rhinos are confined to one park on #Java that sits near converging tectonic plates. Sumatran rhinos are scattered across two islands, so wild individuals may never meet a mate.
#conservation #sumatra #endangered #wildlife #sanctuary #extinction #breeding #nature #animals #science #poaching #habitat
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Thursday already again! Today's on the desk combo is from a local maker, Fantastic Pens, and it truly is, inked with PenBBS Chartreux. Hard to track down ink, but possible and a must-have since we have that breed of cat 🐈⬛️
Paired with the trusty Uniball One P in .38What are you writing with today?
#standardpens #fountainpens #onthedesk #bennyslittlethingsstationery #gelpens
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ITER is more than a fusion reactor. ⚛️
12 supporting systems make the tokamak work: cryogenics for the superconducting magnets, CODAC for control and data, diagnostics, vacuum, external heating, tritium breeding, remote handling, disruption mitigation and more.
About one million components and ten million parts. Systems engineering as much as physics.
https://buff.ly/PnO9LAF
#ITER #FusionEnergy #Physics #Engineering #SciComm -
DATE: October 16, 2026 at 08:00PM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: New compounds target clumping enzyme to protect brain cells in Alzheimer’s models
Researchers have identified a specific enzyme that clumps up and damages cellular powerhouses in the brains of mice with Alzheimer’s disease. Developing chemical compounds to prevent or eliminate these clumps slowed memory loss and brain cell death in the animals. The findings were published in Cell Reports Medicine.
Alzheimer’s disease involves the buildup of misfolded proteins in the brain, most notably beta-amyloid plaques and tau tangles. These proteins interfere with brain cell function and eventually lead to memory loss and cognitive decline.
A lesser-known player in cell survival is an enzyme called G-protein-coupled receptor kinase 2, or GRK2. In healthy cells, this enzyme usually operates in the main fluid of the cell, where it helps regulate cellular communication and stress responses.
When modified by a specific chemical tag in a process called phosphorylation, GRK2 changes its behavior. It can migrate to mitochondria, the microscopic structures that generate energy for cells.
A research team led by Joshua Abd Alla and Ursula Quitterer at ETH Zurich in Switzerland investigated whether abnormal regulation of this enzyme contributes to the brain damage seen in Alzheimer’s disease. Mitochondrial dysfunction is a major feature of the condition, and the researchers suspected that modified GRK2 might be interfering with these cellular powerhouses.
The team first examined the brain tissue of genetically modified mice that develop Alzheimer’s-like symptoms. They looked specifically at older mice that already exhibited heavy beta-amyloid buildup.
They found that a massive portion of the GRK2 in these mice had clumped together into large, dysfunctional aggregates. These clumps were highly concentrated on the mitochondria within the brain cells of the animals.
When the researchers looked at brain tissue samples from a small study of four human patients with dementia likely caused by Alzheimer’s, they observed the exact same pattern of clumped GRK2. In both the mice and the human samples, the accumulation of this enzyme was accompanied by mitochondrial dysfunction and elevated oxidative stress.
The researchers noted that the presence of beta-amyloid and toxic tau proteins actually triggered the initial phosphorylation and clumping of GRK2 in laboratory models. This suggests a destructive cycle where Alzheimer’s hallmark proteins damage mitochondria by causing GRK2 to clump, which in turn accelerates the buildup of more Alzheimer’s proteins.
To understand how the clumped enzyme causes damage, the researchers analyzed which other proteins it bound to in the mouse brains. They discovered that it attached to a protein called TOMM6, which normally helps transport materials across the outer membrane of mitochondria.
The researchers then tested the chemical interaction between GRK2 and TOMM6 in laboratory dishes. They observed that active, healthy GRK2 typically adds a chemical tag to TOMM6, keeping it stable and functional.
The clumped, modified version of GRK2 found in the diseased brains was inactive and failed to modify TOMM6. Without this chemical tag, TOMM6 also began to clump up and lose its ability to interact with the mitochondrial pores.
The scientists next bred new strains of mice to genetically force different versions of the GRK2 enzyme into their brains. When they introduced an inactive, clumping version of GRK2, the mice developed severe mitochondrial damage, rapid beta-amyloid accumulation, and died at an accelerated rate.
Conversely, breeding mice to produce extra active, healthy GRK2 protected the animals against these symptoms and improved their survival. In another genetic test, the researchers engineered mice to produce extra TOMM6 to compensate for the amount lost to clumping.
While extra TOMM6 reduced the large plaques of beta-amyloid, it unexpectedly caused a different, soluble form of beta-amyloid to build up. This soluble buildup was highly toxic to the brain cells, leading to an increased mortality rate in the animals.
Because simply adding TOMM6 was harmful, the team tried a pharmacological approach to fix the root of the problem. They developed a small chemical compound called CPD10, designed to stabilize GRK2 and prevent it from adopting the harmful, clumping shape.
Using computer modeling, the researchers found that CPD10 preferentially attaches to the healthy, unphosphorylated form of GRK2. By binding to this active form, the compound shifts the cellular balance, making it much harder for the enzyme to become phosphorylated and clump together.
They administered this compound to aging Alzheimer’s mice over a six-month period. The compound successfully penetrated the brain and prevented the enzyme from clumping on the mitochondria.
The mice treated with CPD10 had healthier mitochondria, fewer beta-amyloid plaques, less toxic tau protein, and experienced less brain cell loss than untreated mice. Behavioral tests in a water maze showed that the treated mice also retained better spatial memory.
The researchers explored a second chemical strategy aimed at removing the existing clumps rather than preventing new ones. They synthesized another molecule, CPD57, designed to boost the activity of the proteasome, which acts as the garbage disposal system of the cell.
Cells naturally use the proteasome to break down damaged or unnecessary proteins, preventing toxic buildups. The CPD57 compound physically binds to the opening of this disposal system, acting like a gate opener to let more waste inside.
They treated older Alzheimer’s mice with this compound for 14 days and evaluated their brain tissue. The compound increased the cellular garbage disposal activity and successfully degraded the clumped GRK2 and TOMM6 proteins.
When given over a six-month period, this molecule also slowed the accumulation of beta-amyloid plaques and reduced signs of cellular aging. The findings demonstrate that targeting these protein clumps from multiple pharmacological angles can offer neurological protection in animal models.
While these chemical compounds showed promising results in mice, animal models of Alzheimer’s disease do not perfectly replicate the human condition. The human tissue analysis in this study relied on a very limited number of brain samples obtained during surgery for brain tumors.
Because these samples were taken during active operations rather than after death, they provided a rare snapshot of the living brain’s chemistry, but the sample size was inherently small. Larger studies involving more human patients are necessary to confirm how widespread this specific enzyme clumping is in the general population.
It remains an open question whether the clumped enzyme on the mitochondria is the primary driver of the brain damage, or if the overall lack of healthy, active GRK2 floating elsewhere in the cell is the real culprit. Future research using organisms entirely deficient in GRK2 will help pinpoint the exact mechanism behind the cellular deterioration.
Extensive safety and efficacy testing will be required before either of the newly developed chemical compounds can be considered for human clinical trials. These findings provide a new pharmacological avenue to protect the aging brain.
The study, “Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models,” was authored by Joshua Abd Alla, Alexander Perhal, Xuebin Fu, Andreas Langer, Yasser el Faramawy, and Ursula Quitterer.
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Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #AlzheimersResearch #GRK2 #Mitochondria #BetaAmyloid #TauTangles #ProteasomeTherapy #CPD10 #CPD57 #Neuroprotection # AlzheimerModel70
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Aptos Font Family by Microsoft Corporation
The Aptos font family is the most successful typeface nobody asked for. Millions of people type in it every day. Almost none can name it. That anonymity is its greatest achievement, and it is also its biggest flaw.
Microsoft swapped Calibri for the Aptos font family in July 2023. Calibri has held the default slot in Word, Excel, PowerPoint, and Outlook since 2007. Since then, I have set memos, tables, and slide decks in the Aptos font family. My verdict is blunt. It works better than its reputation suggests. However, it also signals “Microsoft 365” louder than any brand should want.
The complete font family is available on MyFonts.This guide to the Aptos font family offers a working definition and a four-gate test. It also coins two terms, Default Gravity and Signal Cost, and answers the licensing question directly.
Aptos font family by Microsoft Corporation The complete font family is available on MyFonts.What Is the Aptos Font Family?
Quick definition. The Aptos font family is a neo-grotesque sans serif by type designer Steve Matteson. Microsoft Corporation released it in 2023 as the default font of Microsoft 365. It replaced Calibri in Word, Excel, PowerPoint, and Outlook.
Matteson first called the design Bierstadt, after Mount Bierstadt in Colorado. He later renamed it after Aptos, a small unincorporated town near Santa Cruz, California. Microsoft announced the new name on July 13, 2023. Matteson also drew Segoe and Open Sans, so he knows how a default font behaves in the wild.
Microsoft commissioned five candidates in 2021. Bierstadt, Grandview, Seaford, Skeena, and Tenorite all landed in the Office font picker. Microsoft then weighed user feedback and chose Bierstadt. The other four remain available as options. Only the Aptos font family became the default.
The brief asked for sharp, uniform letterforms that also work as display type. The target was higher-resolution screens. That context matters, because it explains almost every drawing decision in the font family.
Why Does the Aptos Font Family Follow a Rendering-Era Rule?
Microsoft’s type history explains the Aptos font family better than any press release. The MyFonts description of the Microsoft Typography Group tells the story. TrueType arrived with Windows 3.1. Microsoft and Monotype then tuned Arial, Times New Roman, and Courier New for the screen.
The mid-1990s brought new designs. Matthew Carter drew Verdana, Georgia, and Tahoma. Vincent Connare drew Trebuchet and Comic Sans. Microsoft offered these core fonts free on the web until August 2002. Then it ended the downloads and cited abuse of the license terms.
ClearType followed in 1998. It addresses the red, green, and blue subpixels of an LCD screen one by one. Calibri, drawn by Lucas de Groot, belongs to that generation. It became the Office default in 2007.
I call this pattern the Rendering-Era Rule. Microsoft’s default typeface tracks the dominant display technology of its time. ClearType-era screens gave the company Calibri. Dense modern displays gave it the Aptos font family.
The rule also makes a prediction. Microsoft will replace Aptos only when display technology changes again. Taste alone will not push it out.
What Makes the Aptos Font Family Look Different Up Close?
The Tail on the Lowercase “l”
One detail decides whether the Aptos font family works as a document font. It is the tail on the lowercase “l.” Microsoft’s own design post says the tail separates the “l” from the capital “I.”
Plain grotesques ignore that problem. Set “Illinois” in Arial, and the first three letters become near-identical vertical strokes. Names, URLs, serial numbers, and passwords all suffer from this. The font family fixes it without drawing attention to itself.
Check it yourself. Type Il1 in Aptos, then in Arial. Print both rows and judge the paper, not the screen preview. I would argue this one tail does more for document safety than any other choice in the font family. A misread character in an invoice costs real money.
The Smaller Signals
Matteson says he added a slight swing to the R and gave the “g” a double-stacked form. Round dots sit on the i and j. The 6 uses a single stroke, and the 8 stacks two ellipses. Stem ends stay clean-cut. Together, these details give the Aptos font family a human edge without softening its structure.
How Is the Aptos Font Family Built?
Microsoft Learn lists 28 font files for the Aptos font family, spread across five cuts. They are Aptos, Aptos Display, Aptos Narrow, Aptos Mono, and Aptos Serif. Aptos Slab also appears in the Microsoft 365 cloud font set.
The main cut climbs six rungs. Light, Regular, SemiBold, Bold, ExtraBold, and Black all come with italics. I call this the Weight Ladder.
Most Office users never climb past Bold. That wastes the Aptos font family. SemiBold is the rung I use most, because it marks table headers and callouts without the heaviness of Bold. I could be wrong about that, and you should test it on your own tables.
The companion cuts serve narrower jobs. Aptos Display targets headlines, while Aptos Narrow tightens dense columns, and Aptos Mono and Aptos Serif let you set code and long reading text without leaving the family.
Aptos Font vs Calibri: Which Works Better?
Calibri’s rounded corners gave documents a friendly softness. The Aptos font family trades that softness for structure. My take is simple. I prefer the Aptos font family on modern displays and in tables. Calibri still looks warmer in long memos. A reasonable reader could disagree, and many do.
Default Gravity explains why the debate barely matters. It describes the pull a default font exerts on every document that nobody restyles. Calibri enjoyed that pull from 2007 to 2023. Aptos has it now. Most files will stay in the font family simply because nobody opens the settings menu.
Microsoft does let you choose your own default. It also kept Calibri pinned at the top of the new web font menu. So the choice is yours. Few people make it.
How Do You Test the Aptos Font Family? The Four-Gate Method
I run four gates on the Aptos font family and on every other Office typeface. Each gate takes about five minutes. A font that fails one gate needs a different job.
Gate 1, Confusables. Type Il1 and O0 at 11 points. Check the “l” tail first. Then compare the zero with the capital O.
Gate 2, Weight Ladder. Set one table header in SemiBold and again in Bold at 9 points. Print both. Decide which one separates the header from the data without shouting.
Gate 3, Numerals. Paste a column of figures into Excel. Look at alignment, then study the 1, 6 and 8 at small sizes. Microsoft redrew the 6 and 8, so these digits deserve a close look.
Gate 4, Fallback. Send the file to a colleague on an older Office install. Watch what replaces Aptos. Microsoft offers a local download for such machines, which solves the problem only if your colleague installs it.
Can You Use the Aptos Font Family in Client Work?
Treat licensing of the Aptos font family as a gate of its own. Microsoft 365 subscribers receive Aptos through cloud fonts inside Office apps. Microsoft Learn also links a download for local installation. A download, however, is not a distribution license.
A subscription licenses the software. It does not license redistribution of the typeface. It also does not cover web embedding or shipping Aptos inside an app. Microsoft Learn points to separate licensing for web developers and redistribution. Read that page before you promise a client anything.
If a project needs a free stand-in, I reach for Inter. It ships under the SIL Open Font License. It is the closest free option I know, though it is no clone.
Signal Cost is the second term I want you to keep. It names what Aptos charges a brand for using it. Readers now associate the Aptos font family with internal Microsoft 365 documents. A logo or campaign set in the Aptos font family spends that association.
Institutions already treat defaults as statements. The U.S. State Department switched to Calibri in 2023. In December 2025, it ordered a return to Times New Roman at 14 points.
Where Is the Aptos Font Family Heading?
By 2028, the Aptos font family will carry the same boring-slide stigma that Calibri carries today. Familiarity breeds contempt among designers. I expect agencies to write “no Aptos” into brand briefs within two years.
Microsoft will keep extending the Aptos font family. Slab and Mono already show the direction. Expect more cuts before Microsoft considers a replacement.
Meanwhile, the Rendering-Era Rule suggests the next default arrives with the next display change. Until then, the Aptos font family stays where it is.
Aptos Font Family at a Glance
AttributeDetailDesignerSteve MattesonFoundryMicrosoft CorporationOriginal nameBierstadtClassificationNeo-grotesque sans serifRename announcedJuly 13, 2023ReplacedCalibri (default since 2007)Main cut weightsLight, Regular, SemiBold, Bold, ExtraBold, Black, each with italicCompanion cutsAptos Display, Aptos Narrow, Aptos Mono, Aptos Serif, Aptos SlabFiles on Microsoft Learn28LicenseProprietary, included with Microsoft 365 cloud fontsSignature detailTail on the lowercase lBest forMemos, tables, slide decks, interface textWeak forBrand identity, because of Signal CostClosest free alternative (my pick)InterTerms coined hereRendering-Era Rule, Weight Ladder, Default Gravity, Signal Cost The complete font family is available on MyFonts.Frequently Asked Questions About the Aptos Font Family
Who designed the Aptos font family?
Steve Matteson designed it. Microsoft Corporation published it. Matteson also drew Segoe and Open Sans.
Is the Aptos font family free?
Not in the open-source sense. Microsoft 365 subscribers get the Aptos font family through cloud fonts. Microsoft also offers a local download. Web use and redistribution need a separate license from Microsoft.
Why did Microsoft replace Calibri with the Aptos font family?
Microsoft wanted a sharper, more uniform default for higher-resolution screens. Calibri had served since 2007. Microsoft announced the replacement on July 13, 2023.
What was Aptos called before?
Bierstadt. Matteson named it after Mount Bierstadt in Colorado, then renamed it after the California town of Aptos.
What is the best free alternative to the Aptos font?
I recommend Inter as a stand-in for the Aptos font family. It is free under the SIL Open Font License and suits interface and document text.
Can I still use Calibri?
Yes. Calibri stays available next to the Aptos font family. Office settings let you pick any default.
Does the old Bierstadt name still appear in Office?
Yes. Microsoft kept Bierstadt in the font drop-down for people who have not accepted the new name.
Browse WE AND THE COLOR’s Fonts category for more.
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#Aptos #font #fontFamily #MicrosoftCorporation #MicrosoftTypeface #MSOffice #sansSerif #typeface -
If the numbers show that the Awful Bill benefited the American People, the #TrumpRegime would be shouting it from the top of Trump’s arch. We can be pretty sure that it will show all the benefits went to the ultra rich and the average taxpayer got nada.
#midterms2026 #VoteDemocratic #voteblue #incompetence #corruption #IRS #taxes
https://www.ms.now/opinion/irs-big-beautiful-bill-data-midterms
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The really sad part of this finding is that it’s just SOME #GenZ #voters.
#corruption #incompetence #voteblue #VoteDemocratic #midterms2026
https://www.npr.org/2026/10/16/nx-s1-5993835/gen-z-trump-voting-support
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Do you mean it came from the #Kremlin western offices?
#midterms2026 #VoteDemocratic #voteblue #incompetence #corruption
https://www.huffpost.com/entry/starshield-order-ukraine-white-house_n_6ad1a16ce4b0f62da448978a
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I say the #TrumpRegime shouldn’t be doing crimes that require #leaks.
#corruption #incompetence #voteblue #VoteDemocratic #midterms2026
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“#Responsibility & #Ethics”, two concepts which should never be associated with #Kushner.
#midterms2026 #VoteDemocratic #corruption #voteblue #incompetence
