#mrnadegradation — Public Fediverse posts

This just published from Jeff Chao's lab
@MolecularCell

"Single-molecule imaging reveals translation-dependent destabilization of mRNAs"

#mRNA #mRNADegradation #miRNA #translation #imaging #SingleMolecule #NMD

https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00033-3

When the bioRxiv came out (along with 2 others on similar topic), I wrote about it in my blog:

https://greenfluorescentblog.wordpress.com/2021/07/25/imaging-of-mirna-mediated-translational-repression-and-mrna-decay-at-single-molecule-resolution/

There are several additions in the print version, e.g. adding miR-21. but its just 1st impression. Have to read it.

Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.

They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.

@MolecularCell

https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9

So, after lurking here for a couple of days, I realized that hashtags are important here. So here are a few of my interests:
#RNA
#mRNA
#mRNALocalization
#ribosome #P_bodies #StressGranules
#Transcription #Translation #mRNADegradation
#CellBiology #MolecularBiology
#TunnelingNanotubes
#EndoplasmicReticulum #mitochondria #Peroxisome
#Microscopy #fluorescent #FluorescentProteins
#PeerReview #StaffScientist
#Reproducibility
#LabLife