#mrnadegradation — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #mrnadegradation, aggregated by home.social.
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📣 New on my blog:
Re-opening the discussion on mRNA decay inside P-bodies💥
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Wow! 🔥
Super interesting pre-print from Bin Wu lab featuring new technology to study mRNA decay by live imaging (I remember Bin suggested this approach 10 yrs ago!)
bottom line:
kinetics of mRNA decay *inside* P-bodies!
Cool paper to read on the train back home tonight!this new tech allows rapid decay of *all* mRNAs of a certain transcript within minutes.
So it will be useful for other applications for sure. -
Interesting paper, looking at mRNA cap1 & cap2.
They claim cap2 marks "aged" mRNAs, i.e. long lived mRNA, and it has immunological importance.
From Samie Jaffrey's lab
@Nature"mRNA ageing shapes the Cap2 methylome in mammalian mRNA"
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This just published from Jeff Chao's lab
@MolecularCell"Single-molecule imaging reveals translation-dependent destabilization of mRNAs"
#mRNA #mRNADegradation #miRNA #translation #imaging #SingleMolecule #NMD
https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00033-3
When the bioRxiv came out (along with 2 others on similar topic), I wrote about it in my blog:
There are several additions in the print version, e.g. adding miR-21. but its just 1st impression. Have to read it.
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Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
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Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
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Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
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Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
-
Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
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📣 💥 It took almost 12 years, but the final paper from my PhD is finally published @naturecomms
It is titled “RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway” but the somewhat dry title hides a novel nuclear import mechanism that we discovered.
https://www.nature.com/articles/s41467-022-34417-zA 🧵:
#mRNA #mRNADegradation #GeneExpression #yeast #nucleus #NuclearImport #RiboRegulation
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So, after lurking here for a couple of days, I realized that hashtags are important here. So here are a few of my interests:
#RNA
#mRNA
#mRNALocalization
#ribosome #P_bodies #StressGranules
#Transcription #Translation #mRNADegradation
#CellBiology #MolecularBiology
#TunnelingNanotubes
#EndoplasmicReticulum #mitochondria #Peroxisome
#Microscopy #fluorescent #FluorescentProteins
#PeerReview #StaffScientist
#Reproducibility
#LabLife -
So, after lurking here for a couple of days, I realized that hashtags are important here. So here are a few of my interests:
#RNA
#mRNA
#mRNALocalization
#ribosome #P_bodies #StressGranules
#Transcription #Translation #mRNADegradation
#CellBiology #MolecularBiology
#TunnelingNanotubes
#EndoplasmicReticulum #mitochondria #Peroxisome
#Microscopy #fluorescent #FluorescentProteins
#PeerReview #StaffScientist
#Reproducibility
#LabLife -
So, after lurking here for a couple of days, I realized that hashtags are important here. So here are a few of my interests:
#RNA
#mRNA
#mRNALocalization
#ribosome #P_bodies #StressGranules
#Transcription #Translation #mRNADegradation
#CellBiology #MolecularBiology
#TunnelingNanotubes
#EndoplasmicReticulum #mitochondria #Peroxisome
#Microscopy #fluorescent #FluorescentProteins
#PeerReview #StaffScientist
#Reproducibility
#LabLife -
So, after lurking here for a couple of days, I realized that hashtags are important here. So here are a few of my interests:
#RNA
#mRNA
#mRNALocalization
#ribosome #P_bodies #StressGranules
#Transcription #Translation #mRNADegradation
#CellBiology #MolecularBiology
#TunnelingNanotubes
#EndoplasmicReticulum #mitochondria #Peroxisome
#Microscopy #fluorescent #FluorescentProteins
#PeerReview #StaffScientist
#Reproducibility
#LabLife -
So, after lurking here for a couple of days, I realized that hashtags are important here. So here are a few of my interests:
#RNA
#mRNA
#mRNALocalization
#ribosome #P_bodies #StressGranules
#Transcription #Translation #mRNADegradation
#CellBiology #MolecularBiology
#TunnelingNanotubes
#EndoplasmicReticulum #mitochondria #Peroxisome
#Microscopy #fluorescent #FluorescentProteins
#PeerReview #StaffScientist
#Reproducibility
#LabLife