#m6a — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #m6a, aggregated by home.social.
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N6-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93.
#RNA #RNAbiology #NuclearExport #m6A #NuclearPoreComplex #MethylTransferase #Nucleoporin #NefroticSyndrome
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N6-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93.
#RNA #RNAbiology #NuclearExport #m6A #NuclearPoreComplex #MethylTransferase #Nucleoporin #NefroticSyndrome
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Single-molecule #m6A profiling reveals position-dependent #mRNA regulation and non-canonical roles for Ythdf2 in early embryogenesis
#zebrafish #nanopore #paper
https://www.biorxiv.org/content/10.64898/2026.07.03.736379v1 -
Single-molecule #m6A profiling reveals position-dependent #mRNA regulation and non-canonical roles for Ythdf2 in early embryogenesis
#zebrafish #nanopore #paper
https://www.biorxiv.org/content/10.64898/2026.07.03.736379v1 -
Single-molecule #m6A profiling reveals position-dependent #mRNA regulation and non-canonical roles for Ythdf2 in early embryogenesis
#zebrafish #nanopore #paper
https://www.biorxiv.org/content/10.64898/2026.07.03.736379v1 -
Single-molecule #m6A profiling reveals position-dependent #mRNA regulation and non-canonical roles for Ythdf2 in early embryogenesis
#zebrafish #nanopore #paper
https://www.biorxiv.org/content/10.64898/2026.07.03.736379v1 -
Single-molecule #m6A profiling reveals position-dependent #mRNA regulation and non-canonical roles for Ythdf2 in early embryogenesis
#zebrafish #nanopore #paper
https://www.biorxiv.org/content/10.64898/2026.07.03.736379v1 -
Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. In this #PLOSBiology Unsolved Mystery, Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation.
https://plos.io/3VjfjWI -
Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. In this #PLOSBiology Unsolved Mystery, Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation.
https://plos.io/3VjfjWI -
Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. In this #PLOSBiology Unsolved Mystery, Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation.
https://plos.io/3VjfjWI -
Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. In this #PLOSBiology Unsolved Mystery, Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation.
https://plos.io/3VjfjWI -
Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. In this #PLOSBiology Unsolved Mystery, Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation.
https://plos.io/3VjfjWI -
RNA methylation in retrotransposon control.
#Transposons #N6methyladenosine #m6A
https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00105-2
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RNA methylation in retrotransposon control.
#Transposons #N6methyladenosine #m6A
https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00105-2
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beloved #Mettl3 is involved in DNA repair by placing #m6A in #DNA
#modifications
https://elifesciences.org/articles/101626 -
beloved #Mettl3 is involved in DNA repair by placing #m6A in #DNA
#modifications
https://elifesciences.org/articles/101626 -
beloved #Mettl3 is involved in DNA repair by placing #m6A in #DNA
#modifications
https://elifesciences.org/articles/101626 -
beloved #Mettl3 is involved in DNA repair by placing #m6A in #DNA
#modifications
https://elifesciences.org/articles/101626 -
beloved #Mettl3 is involved in DNA repair by placing #m6A in #DNA
#modifications
https://elifesciences.org/articles/101626 -
An #m6A-independent function of #YTHDC1: its expression delays cellular #senescence and pulmonary #fibrosis by interacting with #TopBP1 to activate ATR
https://www.embopress.org/doi/full/10.1038/s44318-023-00003-2 -
An #m6A-independent function of #YTHDC1: its expression delays cellular #senescence and pulmonary #fibrosis by interacting with #TopBP1 to activate ATR
https://www.embopress.org/doi/full/10.1038/s44318-023-00003-2 -
An #m6A-independent function of #YTHDC1: its expression delays cellular #senescence and pulmonary #fibrosis by interacting with #TopBP1 to activate ATR
https://www.embopress.org/doi/full/10.1038/s44318-023-00003-2 -
An #m6A-independent function of #YTHDC1: its expression delays cellular #senescence and pulmonary #fibrosis by interacting with #TopBP1 to activate ATR
https://www.embopress.org/doi/full/10.1038/s44318-023-00003-2 -
An #m6A-independent function of #YTHDC1: its expression delays cellular #senescence and pulmonary #fibrosis by interacting with #TopBP1 to activate ATR
https://www.embopress.org/doi/full/10.1038/s44318-023-00003-2 -
More good news: coincidentally (or not) #nanopore release new dorado v0.43 with support for #m6A in DRACH context for RNA004
https://github.com/nanoporetech/dorado/releases/tag/v0.4.3RNA model is called: [email protected]_m6A_DRACH@v1
Binaries for Linux are available through their ONT community (website still not updated): https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.4.3-linux-x64.tar.gz
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More good news: coincidentally (or not) #nanopore release new dorado v0.43 with support for #m6A in DRACH context for RNA004
https://github.com/nanoporetech/dorado/releases/tag/v0.4.3RNA model is called: [email protected]_m6A_DRACH@v1
Binaries for Linux are available through their ONT community (website still not updated): https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.4.3-linux-x64.tar.gz
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More good news: coincidentally (or not) #nanopore release new dorado v0.43 with support for #m6A in DRACH context for RNA004
https://github.com/nanoporetech/dorado/releases/tag/v0.4.3RNA model is called: [email protected]_m6A_DRACH@v1
Binaries for Linux are available through their ONT community (website still not updated): https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.4.3-linux-x64.tar.gz
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Can you imagine calling #m6A modifications from raw #RNA #nanopore reads just with #basecalling?
Let me introduce you to #m6ABasecaller
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Can you imagine calling #m6A modifications from raw #RNA #nanopore reads just with #basecalling?
Let me introduce you to #m6ABasecaller
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Can you imagine calling #m6A modifications from raw #RNA #nanopore reads just with #basecalling?
Let me introduce you to #m6ABasecaller
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Can you imagine calling #m6A modifications from raw #RNA #nanopore reads just with #basecalling?
Let me introduce you to #m6ABasecaller
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Can you imagine calling #m6A modifications from raw #RNA #nanopore reads just with #basecalling?
Let me introduce you to #m6ABasecaller
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🎯🐠 I've been away for a while. But here:
I wrote a blog post on "Imaging mRNA modifications in situ"Featuring: m6AISH-PLA, ARPLA (on #glycoRNA) & DART-FISH.
#smFISH #m6A #RNA #mRNA #RNAmodifications #microscopy #imaging #singlemolecule
https://greenfluorescentblog.wordpress.com/2023/10/31/imaging-mrna-modifications-in-situ/
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🎯🐠 I've been away for a while. But here:
I wrote a blog post on "Imaging mRNA modifications in situ"Featuring: m6AISH-PLA, ARPLA (on #glycoRNA) & DART-FISH.
#smFISH #m6A #RNA #mRNA #RNAmodifications #microscopy #imaging #singlemolecule
https://greenfluorescentblog.wordpress.com/2023/10/31/imaging-mrna-modifications-in-situ/
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🎯🐠 I've been away for a while. But here:
I wrote a blog post on "Imaging mRNA modifications in situ"Featuring: m6AISH-PLA, ARPLA (on #glycoRNA) & DART-FISH.
#smFISH #m6A #RNA #mRNA #RNAmodifications #microscopy #imaging #singlemolecule
https://greenfluorescentblog.wordpress.com/2023/10/31/imaging-mrna-modifications-in-situ/
-
🎯🐠 I've been away for a while. But here:
I wrote a blog post on "Imaging mRNA modifications in situ"Featuring: m6AISH-PLA, ARPLA (on #glycoRNA) & DART-FISH.
#smFISH #m6A #RNA #mRNA #RNAmodifications #microscopy #imaging #singlemolecule
https://greenfluorescentblog.wordpress.com/2023/10/31/imaging-mrna-modifications-in-situ/
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In our issue 18:
Reviews on ubiquitin-targeted bacterial effectors, and on satellite RNAsHighlights on #ribonucleotide salvage for #mitochondrial #transcription, and plant defense against #m6A-RNA-containing viruses
Further articles on #intraflagellar transport, #replication initiation within #chromatin, #integrin-dependent cancer cell invasion…
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In our issue 18:
Reviews on ubiquitin-targeted bacterial effectors, and on satellite RNAsHighlights on #ribonucleotide salvage for #mitochondrial #transcription, and plant defense against #m6A-RNA-containing viruses
Further articles on #intraflagellar transport, #replication initiation within #chromatin, #integrin-dependent cancer cell invasion…
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In our issue 18:
Reviews on ubiquitin-targeted bacterial effectors, and on satellite RNAsHighlights on #ribonucleotide salvage for #mitochondrial #transcription, and plant defense against #m6A-RNA-containing viruses
Further articles on #intraflagellar transport, #replication initiation within #chromatin, #integrin-dependent cancer cell invasion…
-
In our issue 18:
Reviews on ubiquitin-targeted bacterial effectors, and on satellite RNAsHighlights on #ribonucleotide salvage for #mitochondrial #transcription, and plant defense against #m6A-RNA-containing viruses
Further articles on #intraflagellar transport, #replication initiation within #chromatin, #integrin-dependent cancer cell invasion…
-
In our issue 18:
Reviews on ubiquitin-targeted bacterial effectors, and on satellite RNAsHighlights on #ribonucleotide salvage for #mitochondrial #transcription, and plant defense against #m6A-RNA-containing viruses
Further articles on #intraflagellar transport, #replication initiation within #chromatin, #integrin-dependent cancer cell invasion…
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Are there roles of DNA-incorporated N6-#methyldeoxyadenosine in animals?
Febrimarsa, Uri Frank et al #UniOfGalway show that its recycling from #m6A-containing RNA in #cnidarian embryos can delay #zygotic genome activation
https://www.embopress.org/doi/full/10.15252/embj.2022112934 -
Are there roles of DNA-incorporated N6-#methyldeoxyadenosine in animals?
Febrimarsa, Uri Frank et al #UniOfGalway show that its recycling from #m6A-containing RNA in #cnidarian embryos can delay #zygotic genome activation
https://www.embopress.org/doi/full/10.15252/embj.2022112934 -
Are there roles of DNA-incorporated N6-#methyldeoxyadenosine in animals?
Febrimarsa, Uri Frank et al #UniOfGalway show that its recycling from #m6A-containing RNA in #cnidarian embryos can delay #zygotic genome activation
https://www.embopress.org/doi/full/10.15252/embj.2022112934 -
Are there roles of DNA-incorporated N6-#methyldeoxyadenosine in animals?
Febrimarsa, Uri Frank et al #UniOfGalway show that its recycling from #m6A-containing RNA in #cnidarian embryos can delay #zygotic genome activation
https://www.embopress.org/doi/full/10.15252/embj.2022112934 -
Is there N6-methyl-2’adenine DNA incorporation derived from decay of #m6A-RNA in cells?
Hailin Wang and colleagues show that mammalian ADAL deaminase sanitizes 2’-#deoxynucleotide pools to prevent AK1-dependent misincorporation
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Is there N6-methyl-2’adenine DNA incorporation derived from decay of #m6A-RNA in cells?
Hailin Wang and colleagues show that mammalian ADAL deaminase sanitizes 2’-#deoxynucleotide pools to prevent AK1-dependent misincorporation
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Is there N6-methyl-2’adenine DNA incorporation derived from decay of #m6A-RNA in cells?
Hailin Wang and colleagues show that mammalian ADAL deaminase sanitizes 2’-#deoxynucleotide pools to prevent AK1-dependent misincorporation
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Is there N6-methyl-2’adenine DNA incorporation derived from decay of #m6A-RNA in cells?
Hailin Wang and colleagues show that mammalian ADAL deaminase sanitizes 2’-#deoxynucleotide pools to prevent AK1-dependent misincorporation
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Study reveals pivotal #RNA modification in mouse #embryos.
https://phys.org/news/2023-04-reveals-pivotal-rna-modification-mouse.html
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Nice!
Another "uncharacterized" gene (YGL036W) in yeast is now characterized - as encoding a protein (re-named Vir1) that is part of the mRNA m6A methyltransferase complex required during meiosis.The deletion mutant is defective in meiosis and has zero m6A, just like ime4 deletion.
"Vir1p, the Yeast Homolog of Virilizer, is Required for mRNA m6A Methylation and Meiosis"
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Nice!
Another "uncharacterized" gene (YGL036W) in yeast is now characterized - as encoding a protein (re-named Vir1) that is part of the mRNA m6A methyltransferase complex required during meiosis.The deletion mutant is defective in meiosis and has zero m6A, just like ime4 deletion.
"Vir1p, the Yeast Homolog of Virilizer, is Required for mRNA m6A Methylation and Meiosis"
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Nice!
Another "uncharacterized" gene (YGL036W) in yeast is now characterized - as encoding a protein (re-named Vir1) that is part of the mRNA m6A methyltransferase complex required during meiosis.The deletion mutant is defective in meiosis and has zero m6A, just like ime4 deletion.
"Vir1p, the Yeast Homolog of Virilizer, is Required for mRNA m6A Methylation and Meiosis"
-
Nice!
Another "uncharacterized" gene (YGL036W) in yeast is now characterized - as encoding a protein (re-named Vir1) that is part of the mRNA m6A methyltransferase complex required during meiosis.The deletion mutant is defective in meiosis and has zero m6A, just like ime4 deletion.
"Vir1p, the Yeast Homolog of Virilizer, is Required for mRNA m6A Methylation and Meiosis"
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Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
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Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
-
Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
-
Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
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Role of #PCIF1-mediated 5′-cap N6-#methyladeonsine #m6A #mRNA #methylation in #colorectalcancer and anti-#PD1 #immunotherapy
New article by Tariq Rana and colleagues at UCSD
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Role of #PCIF1-mediated 5′-cap N6-#methyladeonsine #m6A #mRNA #methylation in #colorectalcancer and anti-#PD1 #immunotherapy
New article by Tariq Rana and colleagues at UCSD