#cohesin — Public Fediverse posts

Separase plays a key role in cleaving #cohesin complexes that hold #chromosomes together during cell division. Martin Anger explores a @PLOSBiology study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2). Paper: https://plos.io/3RAoccz Primer: https://plos.io/43L91UR

🚨 Job alert 🚨

We're hiring a postdoc (computational or wet-lab) to work on genetic diseases of chromatin! 🧬

Come work with us at the Centre for Human Genetics in the beautiful University of Oxford

🗓️ Closing date September 13th 2024

Further details at beagrielab.com/join

Pls boost!

#PostdocJobs #GeneticsJobs #genomics #cohesin

#Centromere research yields new insights into the mechanisms of #chromosome #segregation errors.

#mitosis #cohesin

https://phys.org/news/2024-05-centromere-yields-insights-mechanisms-chromosome.html

Super happy to share my first co-authored publication, a review on loop extrusion modeling by cohesins! @golobor, Flavia Corsi and I review recent discoveries made by the modeling of loop extrusion, the "rules" behind these models and propose future enhancements to models based on recent insights on the mechanism and regulation of cohesin-driven loop extrusion. Give it a read: https://authors.elsevier.com/c/1hIIR,LqAZXo9S #review #computationalBiology #3Dgenome #loopExtrusion #cohesin

#Cohesin can resolve sister #chromatids already in G2 phase independent of #condensin - suggesting DNA #loopextrusion as generic mechanism for segregating #replicated genomes shared across different Structural Maintenance of #Chromosomes (SMC) protein complexes

Paul Batty, Daniel Gerlich et al #viennabiocenter
https://www.embopress.org/doi/10.15252/embj.2023113475

Another fruitful @viennabiocenter collaboration, in this case with @golobor @IMBA_Vienna. #cohesin #immunoglobolin #DNA #chromatin #antibody

CTCF binds to DNA and acts as a barrier to #cohesin, regulating its activity and restraining loop extrusion to specific areas of the genome. But how?
Read our news release to find out.👀⏬ (2/)
https://www.imp.ac.at/news/article/architects-of-the-genome

The labs of Jan-Michael Peters and @leonidmirny @MIT have found how #genetranscription interferes with #cohesin-mediated loop extrusion. Transcription shapes genome organisation in unexpected ways!
The paper: https://www.pnas.org/doi/10.1073/pnas.2210480120
Our news article: https://www.imp.ac.at/news/article/gene-transcription-hampers-cohesins-travel-along-chromosomes

Our latest work on computer simulation of #chromatin appeared in its final form today. Fully extruded loops mediated by #cohesin and #CTCF have increased contact probabilities within loops. Microloops manifest without additional factors. Effects depend on nucleosome positions. It is freely available online until end of the year with https://authors.elsevier.com/a/1g4Hg1SPT0FkK

I am excited to be at genomic.social #introduction. I am interested in understanding the spatial structure of #chromatin and its regulation e.g. by nucleosome positions or #cohesin. My lab uses Monte Carlo simulations with a resolution of single nucleosomes of regions up to 1 Mbp.