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49 results for “nikita_squirrel”
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@annagrigoryan @PChoate I thoroughly enjoyed seeing #ThinSkinned #ToxicMasculinity taking such a tremendous fall to an #IntelligentYoungWoman. That Musk accidentally did good by enabling this #FarRightBigot to blow his cover & get arrested by the authorities for alleged crimes related to his toxic masculinity was a priceless moment of joy in the otherwise dreary decline of discourse on the bird site. I milked it there but not here. I appreciate the qualitative differences between the sites.
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Former race car driver Nikita Mazepin may become the owner of the Russian game developer behind ‘World of Tanks’ and ‘World of Ships’
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… and the books I purchased on my holidays (lucked out and they're all signed copies):
• Nikita Gill's Styx: The River
• Natalie Jayne Clark's The Malt Whisky Murders
• Len Pennie’s two poetry collections: poyums, and poyums annaw -
CEO Jensen Huang Offers Candid Advice to Departing Nvidia Staff
As they were preparing to leave Nvidia, David Hoeller and Nikita Rudin anxiously hopped on a late-night call…
#EuropeSays #Korea #KR #SK #bingxu #ceojensenhuang #Comment #communication #email #flexionrobotics #Huang #intendedname #nikitarudin #NVIDIA #other #SKGroup #startup #time #year #zurich-basedcompany
https://www.europesays.com/korea/153001/ -
#Läuft !! #Putin kommt aus dem #Feiern nicht mehr raus !
"Wir werden #Amerika einnehmen - ohne einen
einzigen #Schuss abzufeuern - Wir müssen
die #USA nicht #angreifen - Wir werden
Euch von #innen heraus #zerstören !“
#Zitat angeblich #Nikita #Chruschtschow
Regierungschef #Sowjetunion 1958-1964 -
Das #chinesisch #sowjetische #Zerwürfnis 1969 sei nur deshalb der #Eskalation zu einem #Atomkrieg entgangen, weil die #Regierung der #USA unter #Nixon der #Sowjetunion die #Warnung ausgesprochen habe, nicht #untätig zuzusehen, wenn #Atomwaffen abgefeuert würden.
Nikita #Chruschtschow; #Mao #Zedong; #Russland; #China
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AI Is Moving Past Chatbots. Claude Cowork Shows What’s Next – TIME
Claude on a smart phone.Photo illustration by Cheng Xin — Getty ImagesUpdated: Jan 15, 2026 9:36 AM PT
AI Is Moving Beyond Chatbots. Claude Cowork Shows What Comes Next
Claude on a smart phone.Photo illustration by Cheng Xin—Getty ImagesThe DNA file had been gathering dust in Pietro Schirano’s computer for years. Then, earlier this month, he gave it to Claude Code—an “agentic coding tool” developed by Anthropic—for analysis. “I’m attaching my raw DNA file from Ancestry DNA,” he told the tool.
The AI spawned copies of itself on Schirano’s computer, each one simulating an expert in a different part of the genome—one expert on cardiovascular disease, another on aging, a third on autoimmune disease. “There were a lot of things that resonated with my life,” says Schirano, who was an engineer at Anthropic prior to founding MagicPath, an AI product design startup. “I always thought that I could deal with caffeine better than all of my friends. It was always this inside joke: I can just drink seven espressos because I’m Italian.” Claude Code’s analysis revealed that Schirano does, in fact, have a gene that allows him to metabolize caffeine better than the average person, that he’s predisposed to Alzheimer’s, and suggested supplements to take based on his genetic profile.
Claude Code, released in February 2025, was Anthropic’s first successful attempt at building an AI agent—a system that takes actions on the user’s behalf, rather than merely conversing in a chat interface. Claude Code can access files and programs on a user’s computer, and even run “sub-agents” for specific tasks, such as those that analyzed different parts of Schirano’s genome. It has steadily accrued a devoted following of tinkerers using it to file their taxes, design knitting patterns, and even autonomously grow a tomato plant.
Yet most people have never heard of Claude Code. That’s because the primary way of accessing the tool is through a command line interface—the old-school computer terminal that went out of fashion among the general public some time in the last millennium. That obscurity might be about to change. On Monday, Anthropic announced Claude Cowork, which the company calls “Claude Code for the rest of your work.”
“It’s gonna blow a lot of people’s minds who are not coders,” says Martin DeVido, the developer behind the experiment using Claude Code to grow a tomato plant.
Claude Cowork aims to bring Claude Code’s agentic capabilities to a broader audience by supplying it with a friendlier user interface and hiding some of the complexity that has made Claude Code daunting to the uninitiated. The tool, initially available as a research preview for customers paying $100 a month for the Max plan, has “rough edges,” according to Felix Reiseberg, its lead engineer. One user found that the app gave her “scary error messages” and wouldn’t connect to her calendar.
Continue/Read Original Article Here: AI Is Moving Past Chatbots. Claude Cowork Shows What’s Next | TIME
Tags: Agentic Coding Tool, AI, Anthropic, artificial intelligence, Claude, Claude Code, Claude Cowork, Command Line Interface, February 2025, Time, Time Magazine
#AgenticCodingTool #AI #Anthropic #artificialIntelligence #Claude #ClaudeCode #ClaudeCowork #CommandLineInterface #February2025 #Time #TimeMagazine -
DATE: September 15, 2026 at 08:00AM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: Common antidepressants might help liver cells clear a dangerous type of cholesterol
Common antidepressants might help lower a stubborn, disease-causing type of cholesterol by helping liver cells absorb it from the bloodstream. This unintended side effect could eventually provide a dual-purpose treatment for patients facing both depression and an elevated risk of heart disease. The findings were published in the Journal of Lipid Research.
Lipoprotein(a) is a complex particle in the blood that carries fats and cholesterol throughout the body. It is structurally similar to low-density lipoprotein, commonly known as bad cholesterol. However, it contains an extra protein called apolipoprotein(a) that makes it particularly prone to causing blockages in arteries. High levels of this molecule are genetic and affect at least a fifth of the population of European descent.
Traditional cholesterol-lowering medications, such as statins, fail to reduce these specific particles in the blood. The lack of targeted clinical treatments leaves a major gap in preventing cardiovascular disease for many patients. Researchers are actively trying to understand exactly how the human body clears this molecule from circulation.
Cells absorb molecules from their environment through a process called endocytosis, which involves the cell membrane folding inward to swallow outside material. A specific type of endocytosis called macropinocytosis, or cellular drinking, handles the uptake of this particular cholesterol particle. During cellular drinking, the cell membrane extends outward to gulp large amounts of surrounding fluid and particles.
Researchers from the University of Otago and the University of New South Wales, led by Nikita Deo, Sally P. A. McCormick, and Gregory M. I. Redpath, wanted to map the mechanics of this cellular drinking. They sought to identify exactly what stimulates liver cells to absorb the particles.
The research team initially tested a drug called imipramine on human liver cells grown in a laboratory. Imipramine is an older tricyclic antidepressant that previous laboratory studies identified as a blocker of cellular drinking. The researchers treated the liver cells with the drug overnight and then introduced the cholesterol particles into the fluid bathing the cells.
After a short incubation period, the team measured how much of the substance the cells had absorbed. Instead of blocking the process, the drug caused the cells to absorb nearly three times as much of the cholesterol. The researchers confirmed this was an isolated effect by testing regular bad cholesterol, which the drug did not affect.
This unexpected outcome prompted the team to test newer, more frequently prescribed antidepressants known as selective serotonin reuptake inhibitors. These drugs treat depression by blocking a specific transport protein from pulling serotonin back into cells. This mechanism leaves more of the mood-regulating chemical active in the space outside the cells.
The researchers repeated the cell culture experiment using the common drugs citalopram, sertraline, and fluoxetine. Citalopram increased the cholesterol uptake in the liver cells to a degree similar to imipramine. Sertraline and fluoxetine did not alter the uptake levels. A later test with paroxetine showed it also boosted cellular absorption of the particles.
To figure out how imipramine and citalopram caused this effect, the researchers looked at the outer boundary of the liver cells. The cholesterol molecules must anchor to the cell surface before the cell can swallow them. The team cooled the cells to temporarily halt the swallowing process, added the cholesterol, and used fluorescent tags to measure how much stuck to the outside of the cells.
Both imipramine and citalopram roughly doubled the amount of cholesterol anchored to the cell surface. The drugs did not change the cells’ ability to bind to standard sugar molecules used as a control. This confirmed that the medications specifically enhanced the cell’s grip on this exact type of cholesterol.
Because these drugs increase the availability of serotonin outside the cells, the researchers hypothesized that serotonin itself might be driving the surface binding. They added pure serotonin to the liver cell cultures overnight and tracked the cholesterol particles. The serotonin treatment produced the same outcome as the medications.
The serotonin drastically increased both the amount of cholesterol sticking to the cell surface and the amount the cells eventually absorbed. This suggests the antidepressants enhance cholesterol absorption by increasing local serotonin levels. The serotonin then somehow alters the cell surface to make it more receptive to the passing cholesterol particles.
The team also explored why sertraline failed to enhance the absorption process despite being in the same class of drugs. Some forms of cellular drinking rely on a specific structural protein called dynamin. Dynamin acts like a lasso, pinching off the newly formed internal pouches so they can detach and drop into the cell interior.
Previous research shows sertraline can interfere with dynamin, preventing it from pinching off the pouches. The researchers tested this by tracking a different molecule known to require dynamin for absorption. Sertraline blocked this control molecule from entering the cells. Its interference with dynamin likely prevents it from enhancing cholesterol uptake.
To understand the mechanics of the surface binding, the researchers examined specific anchor proteins on the liver cells. They used fluorescent tags to measure the presence of a receptor known to grab the cholesterol particles. Treating the cells with imipramine or serotonin increased the amount of this receptor on the cell surface.
Citalopram did not increase this specific receptor. However, it did boost the presence of an accessory protein that helps orchestrate the swallowing process. The precise mechanism linking citalopram, serotonin, and this accessory protein requires further mapping.
Finally, the team tracked where the cholesterol went after the cells swallowed it. They used chemical markers to see if the cells sent the particles to internal compartments meant for degradation or compartments meant for recycling material back outside the cell. The cells treated with imipramine and citalopram routed the extra cholesterol into the recycling compartments.
The researchers suspect this recycling process strips the harmful lipid component from the particle before sending the harmless protein portion back into the bloodstream. If true, the overall impact would still be a reduction in cardiovascular risk.
This study relied exclusively on isolated cells in a laboratory. The behavior of these drugs and the cholesterol particles might differ inside a living human body. The liver interacts with many different tissues and chemical signals that a petri dish cannot replicate.
Additionally, the concentration of citalopram used in the main experiments was roughly twice the maximum dose prescribed to human patients. The serotonin levels tested were also much higher than typical biological conditions. While the paroxetine tests matched clinical doses, animal studies or human trials are needed to verify if these medications can safely lower this dangerous cholesterol in patients.
People suffering from depression often exhibit higher levels of this specific cholesterol, elevating their risk of heart attacks and strokes. Identifying an existing, affordable medication that manages both mood and cardiovascular risk could simplify treatment regimens for vulnerable patients.
The study, “Antidepressants stimulate lipoprotein(a) macropinocytosis via serotonin-enhanced cell surface binding,” was authored by Nikita Deo, Halima Siddiqui, Katie Peppercorn, Golnoush Madani, Alexandria Rutherford-Blyth, Malcolm Rutledge, Michael J. A. Williams, Sally P. A. McCormick, and Gregory M. I. Redpath.
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Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #Lipoprotein(a) #antidepressants #serotonin #macropinocytosis #liverhealth #cardiovascularrisk #cholesterollowering #statinsfail #dualtherapy #lipidresearch
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Ich bin fast 27 Jahre alt, und ich habe heute das erste Mal wählen können. Nicht einfach ein Kreuz irgendwo setzen, sondern meine Meinung ausdrücken, ohne die Angst zu haben, dass alles eh geklaut und belogen wird.
Wählen können ist ein Privileg. Also wenn ihr in #Niedersachsen wohnt und ein:e EU-Bürger:in seid, geht und macht Gebrauch von eurem Privileg 🗳️
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I am having fun trying to write simple edu cross-platform app. And after trying to do it with xilem, than tauri and sycamore, I am doing my last hope attempt with flutter and rift.
Mobile gods, help me 🙏
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Niitä ruutuleita tulikin sitten jokunen enempi
#Pyysaari #Kruunuvuorenselkä #Haakoninlahti #Vasikkasaarenriutta #Vasikkasaari #Koivusaari #Varisluoto #Varisluodonkari #Varisluodonlahti #itähelsinki #Ruutulit #Jäätalvi
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Analyysi: Suomi kiinnostui Ranskan ydinaseista – kriisiaikana niitä saatettaisiin periaatteessa tuoda Suomeenkin
Suomi pohti perusteellisesti, miten Yhdysvallat suhtautuu Ranskan ydinpelotteeseen, kirjoittaa Ylen Nato-erikoistoimittaja Maria Stenroos.
#Turvallisuus #Nato #Euroopanunioni #Kansainvälinenpolitiikka #Politiikka #Ydinaseet #Ukraina #Ulkomaat
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Skatanniemessä kasvaa vaahtera ja pihlaja. Aina niitä katsoessani muistan Lumikurun pihlajan. Skatanniemi on hieno paikka, mutta Lumikuru on yliluonnollinen.
#ItäHelsinki #pihlaja #Saariselkä -
#Alko n valikoimassa on hämmentävänkin monta vegaanista #samppanja a, ja jaksoin selata niitä vähän reilun satasen pulloihin asti. Siihen mennessä ei #nimittäin ollut ensimmäinenkään #Porvoo n #Handel ien valikoimassa.
Että ehkä minä "tyydyn" #Alsace laiseen kuohariin sitten hallituksenkaatumissamppanjana, jos niikseen. Rakastan alsacelaisia viinejä, mut olishan tämä ollut aidon samppanjan paikka.
#hallitus #sinimustahallitus #laitaoikeistohallitus #politiikka #viini #juhlat #RKP #SFP
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How Britain's kings and queens powered the slave trade – video
By Morgan Ofori, Stephanie Windeler, Albert Villa Alsina and Nikhita ChulaniEnslaved African people were seared with hot metal brands bearing the royal crown, according to research by historians who have documented the monarchy’s centuries-long involvement in Britain’s slave trade.
#Slavery #Monarchy #Colonialism #Africa #KingCharlesIII #TheGuardian #MorganOfori #StephanieWindeler #AlbertVillaAlsina #NikhitaChulani
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Viime päivinä on näkynyt paljon kauriita. Niiden ympärillä on joka kerta ollut ihmisiä vain tuijottamassa tai valokuvaamassa niitä. a) On hienoa että eläimet ovat niin maagisia, että ihmiset pysähtyvät niiden eteen. b) Säälittää kun arkana eläimenä kauris ei uskalla liikkua kun sitä tuijotetaan vaan se seisoo jähmettyneenä paikoillaan ja odottaa että ihminen kääntäisi katseen pois.
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Saarioinen on uusinut ruokapakkauksensa ja se uusi punainen väri on siis aivan törkeän hirveä. En tiedä, mikä siinä on niin kauheaa, mutta en pysty edes katsomaan sitä. Ostin niitä perinteisiä kasvispyöryköitä, mutta kun se punainen pakkaus oli jääkaapissani, se vei ruokahalun ja kuvotti aina kun näin sen. Jatkossa ei siis Saarioista (tai sitten pitää siirtää pyörykät kotona johonkin säilystysrasiaan).
Myös kursiivin käyttö tuotenimessä on kammottava valinta.
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No joo ei kyllä...
Saa jäädä huomiseen, kun kukaan käyttäjä ei ole valittanut / arvaan sen perusteella, ettei kukaan ole myöskään käyttänyt
Tääkin on taas niitä dedaripaineessa / lähdön lähestyessä tehtyjen ensimmäisten uusien versioiden haasteita, molen kyllä melko varma et toi / noi arvot oli jossain kohtaan tai versiossa oikein tunteissa
Pardon
o/ mun vika
#Ruska26 #Ruska2026 #Ruska26seuranta
#Cycling #Pyöräily #Randoneuring #pitkänmatkanpyöräily #BikeToot -
No joo ei kyllä...
Saa jäädä huomiseen, kun kukaan käyttäjä ei ole valittanut / arvaan sen perusteella, ettei kukaan ole myöskään käyttänyt
Tääkin on taas niitä dedaripaineessa / lähdön lähestyessä tehtyjen ensimmäisten uusien versioiden haasteita, molen kyllä melko varma et toi / noi arvot oli jossain kohtaan tai versiossa oikein tunteissa
Pardon
o/ mun vika
#Ruska26 #Ruska2026 #Ruska26seuranta
#Cycling #Pyöräily #Randoneuring #pitkänmatkanpyöräily #BikeToot -
Päätyykö #ruska2026 reitit jotenkin esim keskinopeuksista pääteltynä ajettaviin tietoihin OSM:ssä tms? Kun noita viivoja kattelen ja muistelen kaikkia niitä sekoboltseiluja mihin itse olen (lähinnä Salon seutuvilla) eksynyt peräteillä…
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Nokkelittaako?
"Loisnokkeli (Buphagus erythrorhynchus) puhdisti nokkaansa sarvikuonon ihoa vasten eteläafrikkalaisella Manyeletin riistansuojelualueella. Loisnokkelit syövät sarvikuonojen iholle tulevia loiseläimiä ja ovat muutenkin hyödyksi sarvikuonoille, esimerkiksi varoittamalla niitä lähestyvistä vihollisista."
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Nokkelittaako?
"Loisnokkeli (Buphagus erythrorhynchus) puhdisti nokkaansa sarvikuonon ihoa vasten eteläafrikkalaisella Manyeletin riistansuojelualueella. Loisnokkelit syövät sarvikuonojen iholle tulevia loiseläimiä ja ovat muutenkin hyödyksi sarvikuonoille, esimerkiksi varoittamalla niitä lähestyvistä vihollisista."
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Nokkelittaako?
"Loisnokkeli (Buphagus erythrorhynchus) puhdisti nokkaansa sarvikuonon ihoa vasten eteläafrikkalaisella Manyeletin riistansuojelualueella. Loisnokkelit syövät sarvikuonojen iholle tulevia loiseläimiä ja ovat muutenkin hyödyksi sarvikuonoille, esimerkiksi varoittamalla niitä lähestyvistä vihollisista."
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Nokkelittaako?
"Loisnokkeli (Buphagus erythrorhynchus) puhdisti nokkaansa sarvikuonon ihoa vasten eteläafrikkalaisella Manyeletin riistansuojelualueella. Loisnokkelit syövät sarvikuonojen iholle tulevia loiseläimiä ja ovat muutenkin hyödyksi sarvikuonoille, esimerkiksi varoittamalla niitä lähestyvistä vihollisista."
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Nokkelittaako?
"Loisnokkeli (Buphagus erythrorhynchus) puhdisti nokkaansa sarvikuonon ihoa vasten eteläafrikkalaisella Manyeletin riistansuojelualueella. Loisnokkelit syövät sarvikuonojen iholle tulevia loiseläimiä ja ovat muutenkin hyödyksi sarvikuonoille, esimerkiksi varoittamalla niitä lähestyvistä vihollisista."
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🎠 JUHANNUStotuuksia🎠
1. jos on juhannuksena vettä lätäköissä,
on sitä teltassakin.
2. ei juhannus ongelmia ratkaise,
mutta kyllä se niitä siirtää.
3. jos ystävä antaa sinulle juhannuksena,
anna samalla mitalla takaisin.
4. juhannuslupausten ja -unohdusten
määrä on vakio.
5. jos ei juhli juhannuksena,
ei tarvitse juhlia koko kesänä.
