#systemsneuro — Public Fediverse posts

🧠 “Correlation ≠ causation”? This new study put it to the test: activity in posterior parietal #cortex not only correlates with navigation choices, it is causal. Using a #BrainMachineInterface, mice could steer solely from these signals.

🌍 https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00633-3

#Neuroscience #SystemsNeuro #Causality #DecisionMaking #BMI #correlation

» #neuroscience has become so broad & technically sophisticated that individual researchers can no longer fully understand the technical foundations of their experiments.

The average #systemsneuroscience project, for example, requires in-depth knowledge of animal #surgery #mechanical #optical & #electrical #engineering #statistics and #computerscience «

https://www.thetransmitter.org/systems-neuroscience/why-and-how-we-need-to-professionalize-neuroscience/

#neurodon
#neurobuzz
#systemsneuro

@knutson_brain @beneuroscience @PessoaBrain @axoaxonic @debivort @NicoleCRust @MolemanPeter @DrYohanJohn

Not #systemsneuro but #systemsbiology
#NickLane
top-down middle-down
organism to cell:

» quite strong argument is the other way around, metabolism comes first, quite spontaneous
…
fairly controversial still, work from 10y «

https://youtu.be/svlXbmO1qcs?t=386s

Happy & proud to share our latest work with the #bluespot community, #locuscoeruleus enthusiasts, and anyone else willing to read 😉

https://www.biorxiv.org/content/10.1101/2023.10.16.562534v1

4 years ago, we had the idea that endogenous neuromodulatory systems are in place that control LC activity, thereby promoting adaptive behavioral responses in challenging environments.

We examined the role of Neuropeptide Y, as a possible candidate system for this, and identified a new population of #NPY-expressing neurons, distributed in the pericoerulean space.

We showed that peri-LC NPY cells innervate the region, providing #NPY input onto #noradrenergic neurons of the LC, and strongly inhibiting their activity, via Y1Rs.

Next, we showed that chemogenetic stimulation of NPY cells led to anxiety-relief, via Y1Rs, and conversely, inhibition of NPY neurons triggered an anxiogenic phenotype.

Together, we showed a novel role for NPY-mediated #neuromodulation of the LC in adaptive behaviors.

We re happy to hear your thoughts /ideas /feedback on our data.

Please share/boost. Happy reading 🔵

#preprint #neuroscience #systemsneuro #ephys #stress

An especially cool new paper in @PLOSBiology, on spatial navigation in goldfish and the role(s) of a somewhat unique cell type in the goldfish brain. The cells are a kind of boundary vector cell, that respond when the animal is moving away from a boundary. Really interesting experimental design, fun paper to read.

Now the subject of a great little piece in the #nytimes!
https://www.nytimes.com/2023/04/25/science/goldfish-brain-computer-navigation.html

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001747

#neuroscience
#behavior
#systemsneuro
#plosbiology

TIL @MolemanPeter blog:

Enjoyed reading first two of such clearly written short posts style, and with handful complementary key references!

» I do believe in how I fill in the gaps in my knowledge «

https://breininactie.com/who-is-a-believer/

» Every human trait is heritable as well as acquired «

https://breininactie.com/obesity-heritability/

#neuroscience
#complexSystems
#systemsNeuro
#neuroTheory
#neuroBlog
#neurodon

Another not-to-be-missed talk from the WWN series, tomorrow @ 5pm CET

Cagla Eroglu | How do Astrocytes Sculpt Synaptic Circuits?
https://www.world-wide.org/seminar/8674/

#neuroscience #synapse #Astrocyte #systemsneuro #circuits

Another cool seminar from WWN tomorrow (4pm NL time), tune in!

Dr. Nadine Gogolla | Two sides of emotion expressions: readouts and regulators
https://www.world-wide.org/seminar/8778/

#neuroscience #systemsneuro #insula #emotion

Lateral hypothalamus, vPAG, leptin, high fat diet, binge, early life stress... this paper has it all! #stressfeeding #systemsneuro #circuits

Early adversity promotes binge-like eating habits by remodeling a leptin-responsive lateral hypothalamus–brainstem pathway | Nature Neuroscience
https://www.nature.com/articles/s41593-022-01208-0

Is there anything the #LC can't do.?

“...activation of LC NEergic signaling during CFC memory encoding mediates engram early tagging in the mPFC and systems consolidation of remote memory“

Noradrenergic signaling mediates cortical early tagging and storage of remote memory | Nature Communications
https://www.nature.com/articles/s41467-022-35342-x

#systemsneuro #noradrenaline

A series of extremely cool #locuscoeruleus manuscripts have been put out there recently, and I wanna take the opportunity to highlight them in this🧵

Would love input from other #bluespot enthusiasts, since I'm definitely missing papers!

Maybe we can keep adding by replying, and eventually create an easily accessible list of publications that currently shape the #LC field

🔵

#systemsneuro #neuroscience #noradrenaline #preprints

Applying to PhD programs? Check out the #UCSanDiego Cognitive Science dept! We are very interdisciplinary, with research in #cognition, #language, #neuroscience, #development, #computation, #design, #EEG, #fMRI, #machinelearning, #oscillations, #systemsneuro, #cogneuro, and more! Feel free to reach out with questions.

https://cogsci.ucsd.edu/graduates/phd-program/admissions/index.html#Admission-Information