#locuscoeruleus — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #locuscoeruleus, aggregated by home.social.
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DATE: August 29, 2026 at 06:00PM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: Brain network rhythms reveal why some people are better at keeping their focus
A person’s ability to maintain focus and resist distractions is embedded in the stable, large-scale dynamic rhythms of their brain. A new study published in PNAS reveals that individuals with better attention control naturally coordinate activity across major brain networks more effectively, both while resting and when cognitive demands rise.
Attention control is the cognitive ability to concentrate on relevant information while filtering out distractions. Psychologists often distinguish between momentary fluctuations in focus, like getting distracted because you are tired, and a person’s baseline capacity to pay attention over time. As a stable characteristic, this baseline capacity reliably predicts academic performance, career success, and general physical health.
Despite its importance, the neurological foundation of this enduring mental trait has remained somewhat elusive. Past neuroimaging research has mostly focused on how the average brain responds to momentary tasks or examined resting brains in isolation. Few researchers have looked at how stable, individual differences in attention control dictate the way brain networks shift their behavior from a state of rest to a state of high cognitive demand.
Psychologists Dolly T. Seeburger and Randall W. Engle from the Georgia Institute of Technology led a team to investigate this gap. They suspected that attention control relies on the frontoparietal control network, a distributed brain system that acts like a central executive. This network spans regions in the prefrontal and parietal cortices, managing goals by communicating with other systems in the brain.
Specifically, the control network frequently interacts with the default mode network, which handles internally directed thoughts like daydreaming, and the dorsal attention network, which directs focus toward the outside world. The researchers hypothesized that people with strong attention control are simply better at managing these neural connections as their environment demands more mental effort.
To test this, the research team recruited nearly 200 adults for a multi-day experiment. During the first two sessions, participants completed a battery of computerized behavioral tests. These tests measured their baseline attention control, their working memory capacity, and their general problem solving skills, known as fluid intelligence.
Because these three cognitive abilities are highly correlated, the researchers used statistical modeling to isolate attention control. This mathematical step ensured that any brain activity they observed later was uniquely associated with the ability to focus, rather than general intelligence or memory limits.
During a third session, participants underwent functional magnetic resonance imaging. Researchers recorded their brain activity under three different conditions. First, participants lay awake with their eyes open for ten minutes to establish a resting baseline.
Next, they completed a low-load memory task that required them to press a button when a shape on the screen matched the one shown immediately before it. Finally, participants completed a high-load memory task. In this difficult condition, they had to remember if a shape matched the one shown three steps back in the sequence, requiring continuous updating of their mental workspace while resisting distractions.
To analyze the brain scans, the researchers looked for quasi-periodic patterns. These are slow, rhythmic waves of brain activity that repeat over time. By tracking these low-frequency signals, the team could observe how different brain networks synchronized or decoupled as the participants moved from resting to the easy task and then to the hard task.
The analysis revealed distinct differences between individuals based on their attention control abilities. For the network associated with internal thought, people with lower attention control showed a strong positive connection with the manager network while at rest. This connection dropped abruptly as soon as they started the easy task.
In contrast, highly attentive people showed a different rhythm. Their connection between the manager network and the internal thought network changed very little between rest and the easy task. When the hard task began, however, their brains strongly segregated the two networks, suggesting they successfully pushed away internal distractions only when maximum focus was required.
A similar pattern emerged for the external attention network. People with lower attention control showed their largest shift in connectivity when moving from rest to the easy task. Those with higher attention control experienced their biggest boost in connectivity under the highest cognitive load, recruiting their goal-directed attention systems exactly when the difficulty peaked.
The researchers also tracked the ventral attention network, which acts as an alert system for unexpected or important events. At rest, highly attentive individuals exhibited a positive connection between the central manager and this alert network. As cognitive load increased, this connection gradually faded.
Individuals with lower attention control showed a much more erratic pattern in this alert system. Their brain activity shifted from negative coupling at rest to positive coupling under low load, and back to negative under high load.
The researchers also examined the locus coeruleus, a small structure in the brainstem that produces norepinephrine. This chemical messenger regulates physical arousal and helps coordinate global brain states. Traditionally linked to basic alertness, the locus coeruleus is increasingly recognized for its role in complex cognition.
During the most difficult memory task, highly attentive individuals showed positive synchronization between the brain’s control manager and the locus coeruleus. Conversely, people with low attention control showed a negative correlation between these regions during the hard task. This suggests that people with lower focus may have reduced their mental effort, or partially disengaged, when the demands exceeded their capacity.
While the results provide a deep look at the physical nature of attention, the study has several limitations. The locus coeruleus is tiny and varies physically from person to person. Standard brain imaging techniques are somewhat imprecise when measuring such small structures, meaning specialized scans could provide greater accuracy in the future.
Additionally, the low-load and high-load memory tasks may not simply represent different difficulties of the same mental process. Participants often adopt entirely different mental strategies to handle the harder memory sequences, which could influence the observed brain rhythms in ways unrelated to pure attention.
Because the study relies on observational data, the results cannot establish that these brain network patterns directly generate attention control. Interventions using noninvasive brain stimulation could help determine if altering these neural pathways actively changes a person’s ability to focus.
The study, “Attention control ability is associated with frontoparietal control network interactions,” was authored by Dolly T. Seeburger, Jason S. Tsukahara, Nan Xu, Vishwadeep Ahluwalia, Shella D. Keilholz, and Randall W. Engle.
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #AttentionControl #FrontoparietalNetwork #BrainRhythms #Neuroscience #CognitiveControl #DefaultModeNetwork #DorsalAttentionNetwork #LocusCoeruleus #BrainConnectivity #FocusAndDistraction
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This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @PLOSBiology https://plos.io/3IehTKb
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Happy & proud to share our latest work with the #bluespot community, #locuscoeruleus enthusiasts, and anyone else willing to read 😉
https://www.biorxiv.org/content/10.1101/2023.10.16.562534v1
4 years ago, we had the idea that endogenous neuromodulatory systems are in place that control LC activity, thereby promoting adaptive behavioral responses in challenging environments.
We examined the role of Neuropeptide Y, as a possible candidate system for this, and identified a new population of #NPY-expressing neurons, distributed in the pericoerulean space.
We showed that peri-LC NPY cells innervate the region, providing #NPY input onto #noradrenergic neurons of the LC, and strongly inhibiting their activity, via Y1Rs.
Next, we showed that chemogenetic stimulation of NPY cells led to anxiety-relief, via Y1Rs, and conversely, inhibition of NPY neurons triggered an anxiogenic phenotype.
Together, we showed a novel role for NPY-mediated #neuromodulation of the LC in adaptive behaviors.
We re happy to hear your thoughts /ideas /feedback on our data.
Please share/boost. Happy reading 🔵
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Postdoc position in locus coeruleus connectomics of resilience at MGH
Massachusetts General Hospital / Harvard Medical School
Exciting postdoc on #locuscoeruleus functional networks project in #Alzheimers in #Boston? Come join our fun, collaborative lab at MGH!
See the full job description on jobRxiv: https://jobrxiv.org/j...
https://jobrxiv.org/job/massachusetts-general-hospital-harvard-medical-school-27778-postdoc-position-in-locus-coeruleus-connectomics-of-resilience-at-mgh/?feed_id=57015 -
Postdoc position in locus coeruleus connectomics of resilience at MGH
Massachusetts General Hospital / Harvard Medical School
Exciting postdoc on #locuscoeruleus functional networks project in #Alzheimers in #Boston? Come join our fun, collaborative lab at MGH!
See the full job description on jobRxiv: https://jobrxiv.org/j...
https://jobrxiv.org/job/massachusetts-general-hospital-harvard-medical-school-27778-postdoc-position-in-locus-coeruleus-connectomics-of-resilience-at-mgh/?feed_id=53370 -
Postdoc position in locus coeruleus connectomics of resilience at MGH
Massachusetts General Hospital / Harvard Medical School
Exciting postdoc on #locuscoeruleus functional networks project in #Alzheimers in #Boston? Come join our fun, collaborative lab at MGH!
See the full job description on jobRxiv: https://jobrxiv.org/j...
https://jobrxiv.org/job/massachusetts-general-hospital-harvard-medical-school-27778-postdoc-position-in-locus-coeruleus-connectomics-of-resilience-at-mgh/?feed_id=52961 -
Plugging here for fellow #bluespot member & #locuscoeruleus enthusiast, Greyson Sipe:
"the Sipe lab officially started at Penn State in March, 2023 and we are actively recruiting graduate students and postdoctoral fellows! Please feel free to spread the news to anybody interested in studying neurons, astrocytes, and neuromodulators in arousal, stress and addiction. The lab is pretty much set up with a cutting-edge 2-photon microscope, a custom 1-photon widefield scope, two dual-color fiber photometry rigs, and a suite of behavioral rigs with optogenetics (mini-scopes are on the way)".
For inquiries check:
https://www.sipelab.com/openings -
New instance, new #introduction!
I am a psychologist, turned behavioral neuroscientist, turned electrophysiologist. Finishing my postdoc @ https://meyelab.net/ and soon to start @ http://mcn.cncr.nl/ NLI am interested in all things #circuits, #patching, #stress and the incredible #locuscoeruleus
You ll find me knitting, baking & complaining, most times, simultaneously.
Looking forward to meet, listen & learn.
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A series of extremely cool #locuscoeruleus manuscripts have been put out there recently, and I wanna take the opportunity to highlight them in this🧵
Would love input from other #bluespot enthusiasts, since I'm definitely missing papers!
Maybe we can keep adding by replying, and eventually create an easily accessible list of publications that currently shape the #LC field
🔵
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Hello,
I am a neuroscientist studying how specific regions in the brain are vulnerable to Alzheimer's disease (#AD). We are mainly interested in the neurons of entorhinal cortex and hippocampal since they are affected early in AD and important for memory. We use in vivo electrophysiology to understand the population dynamics of neurons affected by amyloid beta and tau pathologies. More recently, we've been interested in how locus coeruleus pathology impacts downstream regions.
Was awesome meeting so many fellow scientists at the #neuroscience meeting #sfn2022#neurodon #memory #alzheimers #dementia #entorhinalcortex #hippocampus #locuscoeruleus #sfn22
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Oh hello there, my beautiful cells! #neuroscience #neuropeptide #locuscoeruleus #RNAscope #IHC
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Alright, time for an #introduction :)
I am an "assistant" professor at the University of Nottingham, but will be moving to the University of Tilburg in two months.
My main interest is the #locuscoeruleus - both its role in adaptively modulating #cognition and its degeneration as an early step in #Alzheimers disease.
The methods I use include #pupillometry, #mri, #eeg and naturalistic driving tasks.
I also write software in #Java, #Python, and #Matlab.
My site: https://andrew.modelgui.org/
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First post, talking to the void: looking to connect with fellow neuroscientists, interested in all things #stress, #locuscoeruleus #neuropeptides #ephys Particularly invested in dialogue, open science & equity