#neuropeptide — Public Fediverse posts

An organism's internal state & behavioral outcomes are shaped by experience. This study reveals a #neuropeptide relay pathway, neuronal & non-neuronal, which orchestrates #SynapticPlasticity & context-dependent shifts in #mating duration in male #Drosophila @PLOSBiology https://plos.io/4n8aUSV

Some female #ants display #PhenotypicPlasticity related to #reproduction, e.g. gyne <--> queen. This study shows that #neuropeptide neuroparsin A mediates physiological changes in response to insemination across ant species #PLOSBiology https://plos.io/3WZCRS8

The version of record of our #Nematostella #GPCR #neuropeptide paper has now been published
https://elifesciences.org/articles/90674#content

For #cnidarian #neuroscience there are lots of new deorphanised receptors described in the paper. We also identified orthologs across cnidarian species, including corals, #Exaiptasia etc. so the resource is not limited to Nematostella.

The version of record of our #Nematostella #GPCR #neuropeptide paper has now been published
https://elifesciences.org/articles/90674#content

For #cnidarian #neuroscience there are lots of new deorphanised receptors described in the paper. We also identified orthologs across cnidarian species, including corals, #Exaiptasia etc. so the resource is not limited to Nematostella.

The version of record of our #Nematostella #GPCR #neuropeptide paper has now been published
https://elifesciences.org/articles/90674#content

For #cnidarian #neuroscience there are lots of new deorphanised receptors described in the paper. We also identified orthologs across cnidarian species, including corals, #Exaiptasia etc. so the resource is not limited to Nematostella.

For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look!

For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look!

For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look!

For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look!

The 31 new deorphanized #neuropeptide #GPCRs from #Nematostella and the #phylogenetic trees also allowed us to predict the ligand for many receptors across #cnidarians. We hope that cnidarian researchers will functionally characterising these e.g. by #CRISPR, as the Houliston lab has done for the MIH receptor.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000614
#evolution #neuroscience

Previously, only one #GPCR with a ligand was known in #cnidaria, the receptor for the #Clytia Maturation-Inducing-Hormone. This receptor was found by Gonzalo Quiroga Artigas and Philipp Bauknecht in our lab, in a collaboration with Evelyn Houliston.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000614
#cnidaria #neuropeptide #evolution #neuroscience

Previously, only one #GPCR with a ligand was known in #cnidaria, the receptor for the #Clytia Maturation-Inducing-Hormone. This receptor was found by Gonzalo Quiroga Artigas and Philipp Bauknecht in our lab, in a collaboration with Evelyn Houliston.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000614
#cnidaria #neuropeptide #evolution #neuroscience

Previously, only one #GPCR with a ligand was known in #cnidaria, the receptor for the #Clytia Maturation-Inducing-Hormone. This receptor was found by Gonzalo Quiroga Artigas and Philipp Bauknecht in our lab, in a collaboration with Evelyn Houliston.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000614
#cnidaria #neuropeptide #evolution #neuroscience

By phylogenetic reconstruction, Daniel Thiel and Luis Yanez could show that #cnidarian #neuropeptide receptors diversified independent from #GPCRs in bilateria. This parallel #evolution and expansion confirms that cnidarians do not represent the ancestral state in neuronal signalling (as implied by terms like 'pre-bilaterian') any more than bilaterians.
#receptor #evolution #neuroscience #phylogeny

In our new preprint we characterise neuropeptide signalling in the cnidarian #Nematostella.
https://www.biorxiv.org/content/10.1101/2023.07.03.547448v1
Daniel Thiel and Luis Yanez-Guerra screened 64 neuropeptides against 161 G-protein coupled receptors (#GPCR) and found activating peptide ligands for 31 receptors.
#cnidaria #neuropeptide #evolution #neuroscience

In our new preprint we characterise neuropeptide signalling in the cnidarian #Nematostella.
https://www.biorxiv.org/content/10.1101/2023.07.03.547448v1
Daniel Thiel and Luis Yanez-Guerra screened 64 neuropeptides against 161 G-protein coupled receptors (#GPCR) and found activating peptide ligands for 31 receptors.
#cnidaria #neuropeptide #evolution #neuroscience

In our new preprint we characterise neuropeptide signalling in the cnidarian #Nematostella.
https://www.biorxiv.org/content/10.1101/2023.07.03.547448v1
Daniel Thiel and Luis Yanez-Guerra screened 64 neuropeptides against 161 G-protein coupled receptors (#GPCR) and found activating peptide ligands for 31 receptors.
#cnidaria #neuropeptide #evolution #neuroscience

For #neuropeptide afficionados:
Interesting new paper from James Checco's lab on two #Aplysia #allatotropin / #orexin receptors, one activated by a D-peptide the other one by an L-peptide.
Conversion of an L-stereoisomer to a D-stereoisomer is a big mystery in peptide biology - but it matters for rec specificity and lifetime.
https://www.pnas.org/doi/10.1073/pnas.2217604120

New research from Herring lab researchers shows that routine testing for the #stress hormone #Neuropeptide Y (#NPY) in the hours after a #heart attack has the potential to save thousands of lives.
#HeartAttack #Medical #sflorg
https://www.sflorg.com/2023/01/med01312301.html

Oh hello there, my beautiful cells! #neuroscience #neuropeptide #locuscoeruleus #RNAscope #IHC

Oh hello there, my beautiful cells! #neuroscience #neuropeptide #locuscoeruleus #RNAscope #IHC

Oh hello there, my beautiful cells! #neuroscience #neuropeptide #locuscoeruleus #RNAscope #IHC

Oh hello there, my beautiful cells! #neuroscience #neuropeptide #locuscoeruleus #RNAscope #IHC