#astrocyte — Public Fediverse posts

https://www.europesays.com/ie/679706/ Astrocyte changes may explain how stress affects mental health #Amygdala #anxiety #Astrocyte #Brain #BrainCell #Cell #Cilia #Depression #Éire #Gene #Health #IE #Ireland #Neurons #Receptor #Research #Stress

Newly mapped #brain networks link far-flung regions
#Astrocyte networks in #mice link distant brain regions in ways nerve cell wiring does not.
This system, made of star-shaped cells called #astrocytes, is no relic, a new study reports. It’s operational, linking locales near and far in flexible, mysterious ways.
What’s more, astrocyte networks may also have roles in disorders such as #Alzheimer’s disease, traumatic brain injuries and stroke.
https://www.sciencenews.org/article/astrocytes-brain-networks-communicate
https://archive.ph/MKkcZ

To capture this local heterogeneity, the authors developed a #multiphoton #FLIM approach with the Na⁺ indicator ING-2 and #astrocyte labeling, enabling quantitative Na⁺ measurements in individual #astrocytes and their processes. This is important because astrocytic Na⁺ is not just a bulk somatic variable. It varies locally across branches and subdomains, where K⁺ uptake and #glutamate-linked Na⁺ influx are regulated.

#Neuroscience #Imaging

🧠🎨 New paper by Meyer et al: #astrocytic #sodium #homeostasis is not uniform. Using multiphoton #FLIM in #mouse #brain slices and #invivo, they show strong #cellular and #subcellular heterogeneity in astrocytic Na⁺ levels.

Processes contain more Na⁺ than somata, Na⁺ varies between #astrocyte branches, and distinct Na⁺/K⁺-ATPase subunit patterns help tune local K⁺ uptake and #glutamate-linked Na⁺ influx.

🌍 https://doi.org/10.1038/s41467-026-73435-z

#Neuroscience #Astrocytes #Neurobiology #NeuralDynamics

Magnetic Cell Sorter 🇺🇸

#Astrocytes #CellsandOrganelles #GLAST #GLAST+ #Magnetic #Sorter #astrocyte #brain

⏩ 2 new pictures from NIH BioArt https://commons.wikimedia.org/wiki/Special:ListFiles?limit=22&user=OptimusPrimeBot&ilshowall=1&offset=20251216025720

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #CognitiveDecline #CognitiveDysfunction #MemoryLoss #BetaAmyloid #AmyloidFibrils #Aβ #AβFibrils #Immunotherapy #Lecanemab

https://www.cell.com/neuron/fulltext/S0896-6273(23)00269-6

Alzheimer’s Drug Lecanemab Shields Brain from Free-Roaming Amyloid Fibrils

Amyloid beta protein forms small aggregates that disrupt brain function in Alzheimer’s disease.
Lecanemab, a recently FDA-approved Alzheimer’s treatment, can neutralize these disruptive aggregates, hinting at its potential to slow down the disease’s cognitive decline.

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #CognitiveDecline #CognitiveDysfunction #MemoryLoss #BetaAmyloid #AmyloidFibrils #Immunotherapy #Lecanemab

https://neurosciencenews.com/amyloid-fibril-neuropharmacology-23207/