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1000 results for “organic_chemistry”
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Molecular glues induce degradation of proteins, but rational design remains challenging. A #Science study scan human proteins for CRBN-binding motifs, exploring hundreds of targets including non-canonical ones like VAV1. The study highlights the potential of hundreds of protein domains that could be used in future drug design campaigns, making it possible to target the ‘undruggable space’.
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Okay, so I had to learn this quickly, and my head is hurting.
#OrganicChemistry #Chemistry -
Organic Chemistry, 4th Edition provides a comprehensive yet accessible treatment of all the essential organic chemistry concepts covered in a two-semester course.
Klein's eBook in PDF 👉 https://lttr.ai/AnJvF
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RE: https://mastodon.social/@theperpetuallycurious8/115108379857787897
✨ New insights added
The article on esterification now includes a FAQ block that explores why esters smell fruity, how the reaction works, and where these molecules appear in everyday life.
From bananas and strawberries to biodiesel and polymers, this reaction links chemistry to familiar experiences. 🍌🍓⚗️
✍️ Explore: https://TPC8.short.gy/dUnO3dI7
A small reminder that even simple scents carry the quiet work of chemistry. ✨
#Chemistry #Science #Fruit #OrganicChemistry #Perfume #STEM #SciComm #TPC8
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Organic Chemistry, 9th Edition – Bruice – eBook
▸ https://lttr.ai/AlzytPaula Yurkanis Bruice
Pearson; Ninth Edition
978-0138223670, 978-0138223571, 978-0138223663, 978-0138223731, 978-0138223564, 978-0138223656
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Submission deadline extended to 📅 Oct. 1, 2024
You are cordially invited to submit your latest research to the thematic issue in “Emerging directions in #SupramolecularChemistry” edited by Joseph W. Meisel, The George Washington University, and Amar H. Flood, Indiana University, in the Beilstein Journal of Organic Chemistry.
➡️ https://www.beilstein-journals.org/bjoc/series/138?M=y
#BJOC 💎🔓 -
You are cordially invited to submit your latest research to the new thematic issue in “Emerging directions in #SupramolecularChemistry” edited by Joseph W. Meisel, The George Washington University, and Amar H. Flood, Indiana University, in the Beilstein Journal of Organic Chemistry.
➡️ https://www.beilstein-journals.org/bjoc/series/138?M=y
Submission deadline: 📅 July 1, 2024
#BJOC 💎🔓
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I just created a bot 🤖 for Mastodon at https://mstdn.science/@Molecular_Cages that will search the literature and post regularly publications in the field of #MolecularCages, including organic cages, metal-organic cages, nanocages, etc.
#Chemistry #ChemiVerse #SupramolecularChemistry
#Science #ScienceMastodon -
Australia's Massive Wildfires Shredded the Ozone Layer--Now Scientists Know Why
Massive wildfires that raged across southeast Australia in 2019–20 unleashed chemicals that chewed through the ozone layer, expanding and prolonging the ozone hole.
A study, published today in Nature, describes how smoke combined with chlorine-containing molecules in the stratosphere — remnants of chemicals that are now banned — to cause the destruction.
The Australian fires produced the largest smoke plume on record, releasing roughly one million tonnes of smoke to heights of up to 30 kilometers.
That’s well into the stratosphere, the portion of the atmosphere that contains the ozone layer, which protects Earth from harmful ultraviolet rays, says study co-author Kane Stone, an atmospheric chemist at the Massachusetts Institute of Technology (MIT) in Cambridge.
In the months after the wildfires, the hole in the ozone layer, which appears annually over Antarctica, was larger and lasted longer than in previous years.
About 80% of the chlorine in the atmosphere is a legacy of #chlorofluorocarbons, chemicals used in aerosol sprays and as refrigerants starting in the 1930s.
Their use has mostly been phased out since an international treaty was implemented in 1987. Remnant chlorine is bound up as #hydrochloric #acid and #chlorine #nitrate, which are harmless to the ozone layer.
But when #hydrochloric #acid dissolves in #water droplets, it forms reactive ozone-depleting molecules.
That doesn’t usually happen away from the poles, because the air is too #warm, says Stone.
The team used a computer model to predict how various organic acids contained in smoke particles would alter the solubility of hydrochloric acid.
The changes produced in the simulations mirrored the changes to stratospheric chemistry that were observed after the fires.
Solomon says that #hydrochloric #acid latches onto the #surface of the #smoke #particles and reacts with other molecules to produce #molecular #chlorine, which is broken down in sunlight to highly reactive ‘ozone-eating’ chlorine #ions.
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Australia's Massive Wildfires Shredded the Ozone Layer--Now Scientists Know Why
Massive wildfires that raged across southeast Australia in 2019–20 unleashed chemicals that chewed through the ozone layer, expanding and prolonging the ozone hole.
A study, published today in Nature, describes how smoke combined with chlorine-containing molecules in the stratosphere — remnants of chemicals that are now banned — to cause the destruction.
The Australian fires produced the largest smoke plume on record, releasing roughly one million tonnes of smoke to heights of up to 30 kilometers.
That’s well into the stratosphere, the portion of the atmosphere that contains the ozone layer, which protects Earth from harmful ultraviolet rays, says study co-author Kane Stone, an atmospheric chemist at the Massachusetts Institute of Technology (MIT) in Cambridge.
In the months after the wildfires, the hole in the ozone layer, which appears annually over Antarctica, was larger and lasted longer than in previous years.
About 80% of the chlorine in the atmosphere is a legacy of #chlorofluorocarbons, chemicals used in aerosol sprays and as refrigerants starting in the 1930s.
Their use has mostly been phased out since an international treaty was implemented in 1987. Remnant chlorine is bound up as #hydrochloric #acid and #chlorine #nitrate, which are harmless to the ozone layer.
But when #hydrochloric #acid dissolves in #water droplets, it forms reactive ozone-depleting molecules.
That doesn’t usually happen away from the poles, because the air is too #warm, says Stone.
The team used a computer model to predict how various organic acids contained in smoke particles would alter the solubility of hydrochloric acid.
The changes produced in the simulations mirrored the changes to stratospheric chemistry that were observed after the fires.
Solomon says that #hydrochloric #acid latches onto the #surface of the #smoke #particles and reacts with other molecules to produce #molecular #chlorine, which is broken down in sunlight to highly reactive ‘ozone-eating’ chlorine #ions.
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Australia's Massive Wildfires Shredded the Ozone Layer--Now Scientists Know Why
Massive wildfires that raged across southeast Australia in 2019–20 unleashed chemicals that chewed through the ozone layer, expanding and prolonging the ozone hole.
A study, published today in Nature, describes how smoke combined with chlorine-containing molecules in the stratosphere — remnants of chemicals that are now banned — to cause the destruction.
The Australian fires produced the largest smoke plume on record, releasing roughly one million tonnes of smoke to heights of up to 30 kilometers.
That’s well into the stratosphere, the portion of the atmosphere that contains the ozone layer, which protects Earth from harmful ultraviolet rays, says study co-author Kane Stone, an atmospheric chemist at the Massachusetts Institute of Technology (MIT) in Cambridge.
In the months after the wildfires, the hole in the ozone layer, which appears annually over Antarctica, was larger and lasted longer than in previous years.
About 80% of the chlorine in the atmosphere is a legacy of #chlorofluorocarbons, chemicals used in aerosol sprays and as refrigerants starting in the 1930s.
Their use has mostly been phased out since an international treaty was implemented in 1987. Remnant chlorine is bound up as #hydrochloric #acid and #chlorine #nitrate, which are harmless to the ozone layer.
But when #hydrochloric #acid dissolves in #water droplets, it forms reactive ozone-depleting molecules.
That doesn’t usually happen away from the poles, because the air is too #warm, says Stone.
The team used a computer model to predict how various organic acids contained in smoke particles would alter the solubility of hydrochloric acid.
The changes produced in the simulations mirrored the changes to stratospheric chemistry that were observed after the fires.
Solomon says that #hydrochloric #acid latches onto the #surface of the #smoke #particles and reacts with other molecules to produce #molecular #chlorine, which is broken down in sunlight to highly reactive ‘ozone-eating’ chlorine #ions.
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Australia's Massive Wildfires Shredded the Ozone Layer--Now Scientists Know Why
Massive wildfires that raged across southeast Australia in 2019–20 unleashed chemicals that chewed through the ozone layer, expanding and prolonging the ozone hole.
A study, published today in Nature, describes how smoke combined with chlorine-containing molecules in the stratosphere — remnants of chemicals that are now banned — to cause the destruction.
The Australian fires produced the largest smoke plume on record, releasing roughly one million tonnes of smoke to heights of up to 30 kilometers.
That’s well into the stratosphere, the portion of the atmosphere that contains the ozone layer, which protects Earth from harmful ultraviolet rays, says study co-author Kane Stone, an atmospheric chemist at the Massachusetts Institute of Technology (MIT) in Cambridge.
In the months after the wildfires, the hole in the ozone layer, which appears annually over Antarctica, was larger and lasted longer than in previous years.
About 80% of the chlorine in the atmosphere is a legacy of #chlorofluorocarbons, chemicals used in aerosol sprays and as refrigerants starting in the 1930s.
Their use has mostly been phased out since an international treaty was implemented in 1987. Remnant chlorine is bound up as #hydrochloric #acid and #chlorine #nitrate, which are harmless to the ozone layer.
But when #hydrochloric #acid dissolves in #water droplets, it forms reactive ozone-depleting molecules.
That doesn’t usually happen away from the poles, because the air is too #warm, says Stone.
The team used a computer model to predict how various organic acids contained in smoke particles would alter the solubility of hydrochloric acid.
The changes produced in the simulations mirrored the changes to stratospheric chemistry that were observed after the fires.
Solomon says that #hydrochloric #acid latches onto the #surface of the #smoke #particles and reacts with other molecules to produce #molecular #chlorine, which is broken down in sunlight to highly reactive ‘ozone-eating’ chlorine #ions.
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Modular Strategy for the Synthesis of Chiral Thiooxazolidinones:
Pd-catalyzed asymmetric [3+2] annulations of vinylethylene carbonates and sulfinylanilineshttps://www.chemistryviews.org/modular-strategy-for-the-synthesis-of-chiral-thiooxazolidinones/
#chemistry #chemistryviews #chemviews #chemiverse #research #chemicalsynthesis #PdCat #organicchemistry
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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Starting TOMORROW: 📅 March 28, 2024 🕒 3–4 pm CET
Online #BeilsteinTalk "Molecular #nanographenes: the search for #enantioselectivity" with Nazario Martín, IMDEA Nanoscience and Universidad Complutense de Madrid.
Participate for FREE – just register: 🔗 https://www.beilstein-institut.de/en/talks/organic-chemistry-molecular-nanographenes-the-search-for-enantioselectivity?M=y
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Save the date: 📅 March 28, 2024 🕒 3–4 pm CET
Online #BeilsteinTalk "Molecular #nanographenes: the search for #enantioselectivity" with Nazario Martín, IMDEA-Nanoscience Institute and Universidad Complutense Madrid.
Participate for FREE – just register: 🔗 https://www.beilstein-institut.de/en/talks/organic-chemistry-molecular-nanographenes-the-search-for-enantioselectivity?M=y
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Save the date: 📅 March 28, 2024 🕒 3–4 pm CET
Online #BeilsteinTalk "Molecular #nanographenes: the search for #enantioselectivity" with Nazario Martín IMDEA-Nanoscience Institute and Universidad Complutense Madrid.
Participation is FREE – just register: 🔗 https://www.beilstein-institut.de/en/talks/organic-chemistry-molecular-nanographenes-the-search-for-enantioselectivity?M=y
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MOF Confinement Shifts Critical Temperature of Water:
Supercritical transition in highly hydrophobic metal–organic framework (MOF) cavities observed at about 250 K below the bulk value
https://www.chemistryviews.org/mof-confinement-shifts-critical-temperature-of-water/
#supercriticalwater #physicalchemistry #chemistry #science #chemistryviews
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There’s still time to submit to the thematic issue “Advances in asymmetric #organocatalysis II” edited by Radovan Sebesta, Comenius University Bratislava, in the Beilstein Journal of Organic Chemistry:
➡️ https://www.beilstein-journals.org/bjoc/series/136?M=y
Submission deadline 📅August 15, 2024
#GreenChemistry #greensolvents #catalysis
#DiamondOpenAccess 💎🔓 #BJOC -
Submission deadline extended to 📅 August 15, 2024
You are cordially invited to submit to the thematic issue “Advances in asymmetric #organocatalysis II” edited by Radovan Šebesta, Comenius University Bratislava, in the Beilstein Journal of Organic Chemistry ➡️ https://www.beilstein-journals.org/bjoc/series/136?M=y
#GreenChemistry #greensolvents #catalysis #DiamondOpenAccess 💎🔓 #BJOC -
New thematic issue in the Beilstein Journal of Organic Chemistry:
“Advances in asymmetric #organocatalysis II” edited by Radovan Šebesta, Comenius University Bratislava.Submit your latest research by 📅 April 30, 2024
➡️ https://www.beilstein-journals.org/bjoc/series/136?M=y
#GreenChemistry #greensolvents #catalysis
#DiamondOpenAccess 💎🔓 #BJOC -
Save the date: 📅 Oct. 12, 2023 🕒 3–4 pm CEST
Online #BeilsteinTalk "Designing secondary-sphere modifications in #organocatalysis" with Anat Milo, Ben-Gurion University of the Negev, Israel 🇮🇱.
Participation is FREE – just register ➡️ https://www.beilstein-institut.de/en/talks/organic-chemistry-organocatalysis/?M=y
#BeilsteinTalks #carbenes #benzoin reaction #AminoCatalysts #AldolReaction #BoronicAcids
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In this #ChemSciPicks David Schultz et al. present the photoinduced electron spin polarisation (ESP) of a spin- ½ organic radical (nitronyl nitroxide), in a series of Pt(II) complexes comprised of 4,4’-di-tert-butyl-2,2’-bipyridine and 3-tert-butylcatecholate (CAT) ligands, where the CAT ligand is substituted with (CH3)n-meta-phenyl-NN groups.
You can read the work here, for free: https://pubs.rsc.org/en/content/articlelanding/2023/sc/d3sc03049k -
#Monoterpenes were the most abundant volatile organic compound ( #VOC ) emitted from the tree.
They peaked during the first day before diminishing significantly by the third day.
Their concentration was initially at the same level of a plug-in air freshener or newly constructed house before it quickly dropped by nearly 10 times its original amount, said Poppendieck.
The researchers detected 52 distinct types of monoterpenes.Researchers then injected #ozone into the chamber to see how it affected indoor air chemistry. They found that ozone reacted with the monoterpenes, forming byproducts such as formaldehyde, another type of VOC, as well as other reactive chemicals.
The monoterpene concentration diminished even more with the introduction of ozone, while formaldehyde levels rose, which showed an impact on indoor air chemistry.
However, the amount of formaldehyde created was relatively small at around one part per billion. Typical U.S. houses have formaldehyde concentrations ranging from 20 to 30 parts per billion.For people who are sensitive to VOCs, Christmas trees could be one possible cause for watery eyes and noses, especially when initially brought indoors.
In that case, Poppendieck suggests, opening a window near the tree will reduce exposure. In addition, newly cut trees can be left outdoors or in a garage for three days before bringing them into the home as the emission strength naturally decays over time."But for most people," Poppendieck said, "this shouldn't be a major concern. I'm still going to have a Christmas tree in my house."
https://www.sciencedirect.com/science/article/pii/S2950362023000024 -
#Monoterpenes were the most abundant volatile organic compound ( #VOC ) emitted from the tree.
They peaked during the first day before diminishing significantly by the third day.
Their concentration was initially at the same level of a plug-in air freshener or newly constructed house before it quickly dropped by nearly 10 times its original amount, said Poppendieck.
The researchers detected 52 distinct types of monoterpenes.Researchers then injected #ozone into the chamber to see how it affected indoor air chemistry. They found that ozone reacted with the monoterpenes, forming byproducts such as formaldehyde, another type of VOC, as well as other reactive chemicals.
The monoterpene concentration diminished even more with the introduction of ozone, while formaldehyde levels rose, which showed an impact on indoor air chemistry.
However, the amount of formaldehyde created was relatively small at around one part per billion. Typical U.S. houses have formaldehyde concentrations ranging from 20 to 30 parts per billion.For people who are sensitive to VOCs, Christmas trees could be one possible cause for watery eyes and noses, especially when initially brought indoors.
In that case, Poppendieck suggests, opening a window near the tree will reduce exposure. In addition, newly cut trees can be left outdoors or in a garage for three days before bringing them into the home as the emission strength naturally decays over time."But for most people," Poppendieck said, "this shouldn't be a major concern. I'm still going to have a Christmas tree in my house."
https://www.sciencedirect.com/science/article/pii/S2950362023000024 -
#Monoterpenes were the most abundant volatile organic compound ( #VOC ) emitted from the tree.
They peaked during the first day before diminishing significantly by the third day.
Their concentration was initially at the same level of a plug-in air freshener or newly constructed house before it quickly dropped by nearly 10 times its original amount, said Poppendieck.
The researchers detected 52 distinct types of monoterpenes.Researchers then injected #ozone into the chamber to see how it affected indoor air chemistry. They found that ozone reacted with the monoterpenes, forming byproducts such as formaldehyde, another type of VOC, as well as other reactive chemicals.
The monoterpene concentration diminished even more with the introduction of ozone, while formaldehyde levels rose, which showed an impact on indoor air chemistry.
However, the amount of formaldehyde created was relatively small at around one part per billion. Typical U.S. houses have formaldehyde concentrations ranging from 20 to 30 parts per billion.For people who are sensitive to VOCs, Christmas trees could be one possible cause for watery eyes and noses, especially when initially brought indoors.
In that case, Poppendieck suggests, opening a window near the tree will reduce exposure. In addition, newly cut trees can be left outdoors or in a garage for three days before bringing them into the home as the emission strength naturally decays over time."But for most people," Poppendieck said, "this shouldn't be a major concern. I'm still going to have a Christmas tree in my house."
https://www.sciencedirect.com/science/article/pii/S2950362023000024 -
#Monoterpenes were the most abundant volatile organic compound ( #VOC ) emitted from the tree.
They peaked during the first day before diminishing significantly by the third day.
Their concentration was initially at the same level of a plug-in air freshener or newly constructed house before it quickly dropped by nearly 10 times its original amount, said Poppendieck.
The researchers detected 52 distinct types of monoterpenes.Researchers then injected #ozone into the chamber to see how it affected indoor air chemistry. They found that ozone reacted with the monoterpenes, forming byproducts such as formaldehyde, another type of VOC, as well as other reactive chemicals.
The monoterpene concentration diminished even more with the introduction of ozone, while formaldehyde levels rose, which showed an impact on indoor air chemistry.
However, the amount of formaldehyde created was relatively small at around one part per billion. Typical U.S. houses have formaldehyde concentrations ranging from 20 to 30 parts per billion.For people who are sensitive to VOCs, Christmas trees could be one possible cause for watery eyes and noses, especially when initially brought indoors.
In that case, Poppendieck suggests, opening a window near the tree will reduce exposure. In addition, newly cut trees can be left outdoors or in a garage for three days before bringing them into the home as the emission strength naturally decays over time."But for most people," Poppendieck said, "this shouldn't be a major concern. I'm still going to have a Christmas tree in my house."
https://www.sciencedirect.com/science/article/pii/S2950362023000024