#mrnas — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #mrnas, aggregated by home.social.
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Messenger #RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several #COVID-19 #vaccines. But #mRNAs, which are genetic sequences that instruct the body to produce proteins, are also being developed as a new class of drugs.
#Biotechnology , #Bioengineering #Biology #sflorg
https://www.sflorg.com/2024/03/btec03222401.html -
Watching worm #RNA: @mango_s_lab adapt the MS2-MCP system to visualize endogenous #mRNAs in #Celegans. Inactivating #NMD & expressing low levels of cytoplasmic MCP allows live imaging of functional transcripts in #nematodes @biozentrum #PLOSBiology https://plos.io/3wBaMpA
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The World Antimicrobial Resistance Awareness Week (#WAAW) starts tomorrow, but at the #HIRI, the battle against #AntibioticResistance is a year-round task. 🦠 We are searching for new targets in various germs, as conventional antibiotics are becoming increasingly ineffective: https://www.helmholtz-hiri.de/en/newsroom/features-stories/the-silent-pandemic/
One promising solution are programmable antibiotics, ASOs, studied by the laboratory of HIRI Director Jörg Vogel. They target #mRNAs needed by bacteria to synthesize new proteins & replicate. 🧬
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ADENOVIRUS VS RNA
Un nuovo studio ha messo a confronto, in assenza di infezioni pregresse, il vaccino di Astra Zeneca con quello di Pfizer.
I dati ottenuti sono interessanti, soprattutto in vista dello sviluppo di futuri prodotti. -
MRNA was discovered in the early 1960's, John Hopkins states. Some were used to fight the Ebola virus. Researchers are also currently working to use mRNA to prevent other respiratory viruses.
According to the National Cancer Institute, mRNA vaccines are being studied to treat people with various types of cancer. The research that was done to treat people with cancer before the pandemic struck helped spearhead the COVID vaccine, the NCI says.
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How do select pre-#mRNAs escape 3’ end-processing inhibition by #DNAdamage?
Stephan Vagner and colleagues (Institut Curie) invoke rescue by a #cotranscriptional cleavage that allows subsequent #posttranscriptional #polyadenylation site processing in the nucleoplasmNow published, previously a #RefereedPreprint via @ReviewCommons
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How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
#CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basisTranslational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding
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How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
#CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basisTranslational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding
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How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
#CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basisTranslational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding
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How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
#CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basisTranslational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding
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Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: https://pubmed.ncbi.nlm.nih.gov/30218101/
Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
https://www.biorxiv.org/content/10.1101/2022.02.05.479257v1.full -
Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: https://pubmed.ncbi.nlm.nih.gov/30218101/
Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
https://www.biorxiv.org/content/10.1101/2022.02.05.479257v1.full -
Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: https://pubmed.ncbi.nlm.nih.gov/30218101/
Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
https://www.biorxiv.org/content/10.1101/2022.02.05.479257v1.full -
Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: https://pubmed.ncbi.nlm.nih.gov/30218101/
Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
https://www.biorxiv.org/content/10.1101/2022.02.05.479257v1.full