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#mrnas — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #mrnas, aggregated by home.social.

  1. The EMBO Journal @[email protected] ·

    How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
    #CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basis

    Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding

    embopress.org/doi/full/10.1525

    #bacterial #rna #chaperone #hfq #mrnas #cryoem
  2. Cosmin Saveanu @[email protected] ·

    Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: pubmed.ncbi.nlm.nih.gov/302181

    Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
    biorxiv.org/content/10.1101/20

    #pab1 #erf3 #rna #ms2 #utr #mrnas