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#ms2 — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #ms2, aggregated by home.social.

  1. Alexander Hogrebe, PhD @[email protected] ·

    📐 Fig 4: CHIMERYS quantifies peptides directly from chimeric #MS2 spectra. How? Deconvolution!
    → #PRM-level precision with r = 0.99 vs Skyline
    → CV performance on par with established DIA algorithms
    No libraries. No manual curation. Straight from data to insights.
    5/7

    #ms2 #prm
  2. Alexander Hogrebe, PhD @[email protected] ·

    📐 Fig 4: CHIMERYS quantifies peptides directly from chimeric #MS2 spectra. How? Deconvolution!
    → #PRM-level precision with r = 0.99 vs Skyline
    → CV performance on par with established DIA algorithms
    No libraries. No manual curation. Straight from data to insights.
    5/7

    #prm #ms2
  3. Cosmin Saveanu @[email protected] ·

    Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: pubmed.ncbi.nlm.nih.gov/302181

    Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
    biorxiv.org/content/10.1101/20

    #pab1 #erf3 #rna #ms2 #utr #mrnas
  4. Cosmin Saveanu @[email protected] ·

    Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: pubmed.ncbi.nlm.nih.gov/302181

    Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
    biorxiv.org/content/10.1101/20

    #pab1 #erf3 #rna #ms2 #utr #mrnas
  5. Cosmin Saveanu @[email protected] ·

    Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: pubmed.ncbi.nlm.nih.gov/302181

    Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
    biorxiv.org/content/10.1101/20

    #pab1 #erf3 #rna #ms2 #utr #mrnas
  6. Cosmin Saveanu @[email protected] ·

    Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: pubmed.ncbi.nlm.nih.gov/302181

    Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
    biorxiv.org/content/10.1101/20

    #mrnas #utr #ms2 #rna #erf3 #pab1