#celegans — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #celegans, aggregated by home.social.
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Some #bacteria polymerize excess carbon into polyhydroxybutyrate (PHB), a biodegradable storage polymer. This study shows that #PHB -producing bacteria kill #Celegans nematodes by disrupting pharyngeal & intestinal function @PLOSBiology https://plos.io/4cFAwDz
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Some #bacteria polymerize excess carbon into polyhydroxybutyrate (PHB), a biodegradable storage polymer. This study shows that #PHB -producing bacteria kill #Celegans nematodes by disrupting pharyngeal & intestinal function @PLOSBiology https://plos.io/4cFAwDz
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Can changes in the #proteome be transmitted from parents to offspring? @betowbin &co study #intergenerational effects of #DietaryRestriction in #Celegans, showing that maternal mTORC1 governs transfer of #ribosomes, so modulating growth & development @PLOSBiology https://plos.io/4tMpQJe
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Can changes in the #proteome be transmitted from parents to offspring? @betowbin &co study #intergenerational effects of #DietaryRestriction in #Celegans, showing that maternal mTORC1 governs transfer of #ribosomes, so modulating growth & development @PLOSBiology https://plos.io/4tMpQJe
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Aharonoff et al. show that dosage compensation mechanisms continue to evolve in species with shared X chromosome ancestry, and that the process of evolving chromosome-wide gene regulatory mechanisms is constrained.
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Aharonoff et al. show that dosage compensation mechanisms continue to evolve in species with shared X chromosome ancestry, and that the process of evolving chromosome-wide gene regulatory mechanisms is constrained.
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NeuroSC is a new #OpenAccess tool that lets researchers interactively explore neuronal morphology, membrane contacts and synaptic connectivity across #CElegans development.
https://elifesciences.org/articles/103977?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
NeuroSC is a new #OpenAccess tool that lets researchers interactively explore neuronal morphology, membrane contacts and synaptic connectivity across #CElegans development.
https://elifesciences.org/articles/103977?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
"The dopaminergic system of Caenorhabditis elegans", Muralidhara and Hardege, 2025
https://royalsocietypublishing.org/doi/10.1098/rsos.250843That's the review I was waiting for – finally I have the field laid out to write the reinterpretation of part of the worm's pharyngeal ring – aka the brain – as an antennal lobe and a mushroom body.
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"The dopaminergic system of Caenorhabditis elegans", Muralidhara and Hardege, 2025
https://royalsocietypublishing.org/doi/10.1098/rsos.250843That's the review I was waiting for – finally I have the field laid out to write the reinterpretation of part of the worm's pharyngeal ring – aka the brain – as an antennal lobe and a mushroom body.
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For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.
Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.
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For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.
Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.
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When its meal turns toxic, the tiny worm #CElegans shuts down digestion thanks to a single protein that links its “taste” neurons to the gut.
https://elifesciences.org/digests/104028/gut-feeling?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
When its meal turns toxic, the tiny worm #CElegans shuts down digestion thanks to a single protein that links its “taste” neurons to the gut.
https://elifesciences.org/digests/104028/gut-feeling?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
Nicotine exposure elicits diverse behavioral changes. This study shows that in #Celegans, chronic #nicotine exposure couples reversal behaviors to rhythmic body contractions by modulating the sensitivity of a mechanosensory-motor circuit
@PLOSBiology plos.io/4o2CWyS -
Nicotine exposure elicits diverse behavioral changes. This study shows that in #Celegans, chronic #nicotine exposure couples reversal behaviors to rhythmic body contractions by modulating the sensitivity of a mechanosensory-motor circuit
@PLOSBiology plos.io/4o2CWyS -
How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @PLOSBiology https://plos.io/4nU79QF
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How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @PLOSBiology https://plos.io/4nU79QF
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Xanthine dehydrogenase mutations can cause #xanthinuria in humans. This study in #Celegans provides new insights into the mechanisms of #xanthine #KidneyStone accumulation, implicating sulfate imbalance & osmotic stress in disease progression @PLOSBiology https://plos.io/4pXOCFh
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Xanthine dehydrogenase mutations can cause #xanthinuria in humans. This study in #Celegans provides new insights into the mechanisms of #xanthine #KidneyStone accumulation, implicating sulfate imbalance & osmotic stress in disease progression @PLOSBiology https://plos.io/4pXOCFh
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Postdoc available in Iris Hardege in Cambridge University, UK:
On dopamine receptors in C. elegans:
https://www.cam.ac.uk/jobs/research-associate-neuroscience-research-group-fixed-term-pf47153 -
Postdoc available in Iris Hardege in Cambridge University, UK:
On dopamine receptors in C. elegans:
https://www.cam.ac.uk/jobs/research-associate-neuroscience-research-group-fixed-term-pf47153 -
"High-Speed Microscope for Biological Imaging"
https://www.optica-opn.org/home/newsroom/2025/august/high-speed_microscope_for_biological_imaging/Sara Abrahamsson's lab delivers again!
Paper at:
"High-speed 3D imaging with a 25-camera multifocus microscope", Miyasaki et al. 2025
https://opg.optica.org/optica/fulltext.cfm?uri=optica-12-8-1230&id=575640#neuroscience #GCaMP #CaImaging #Drosophila #Celegans #DrosophilaLarva
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"High-Speed Microscope for Biological Imaging"
https://www.optica-opn.org/home/newsroom/2025/august/high-speed_microscope_for_biological_imaging/Sara Abrahamsson's lab delivers again!
Paper at:
"High-speed 3D imaging with a 25-camera multifocus microscope", Miyasaki et al. 2025
https://opg.optica.org/optica/fulltext.cfm?uri=optica-12-8-1230&id=575640#neuroscience #GCaMP #CaImaging #Drosophila #Celegans #DrosophilaLarva
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🧬June's most-read Genetics paper independently validates previous research showing that #CElegans can inherit learned pathogen avoidance: https://elifesciences.org/reviewed-preprints/107034?utm_source=mastodon&utm_medium=social&utm_campaign=submissions_organic&utm_content=top_paper
Have a paper people should see? See what our Editors look for: https://elifesciences.org/about/aims-scope?utm_source=mastodon&utm_medium=social&utm_campaign=submissions_organic&utm_content=top_paper#genetics-and-genomics
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🧬June's most-read Genetics paper independently validates previous research showing that #CElegans can inherit learned pathogen avoidance: https://elifesciences.org/reviewed-preprints/107034?utm_source=mastodon&utm_medium=social&utm_campaign=submissions_organic&utm_content=top_paper
Have a paper people should see? See what our Editors look for: https://elifesciences.org/about/aims-scope?utm_source=mastodon&utm_medium=social&utm_campaign=submissions_organic&utm_content=top_paper#genetics-and-genomics
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Adapting to a deficiency of polyunsaturated fatty acids
Defects in the synthesis of polyunsaturated fatty acids in #CElegans cannot be compensated for by mutations in other pathways.
https://elifesciences.org/articles/104181?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
Adapting to a deficiency of polyunsaturated fatty acids
Defects in the synthesis of polyunsaturated fatty acids in #CElegans cannot be compensated for by mutations in other pathways.
https://elifesciences.org/articles/104181?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
Position available: Post Doctoral Research Associate in Whole Organism Neuroscience – lab of Iris Hardege, University of Cambridge, UK.
Deadline for application: August 3rd, 2025.
"This BBSRC-funded project aims to understand the interplay between excitatory and inhibitory metabotropic and ionotropic dopamine receptors and how they contribute to the regulation of complex behaviours."
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Position available: Post Doctoral Research Associate in Whole Organism Neuroscience – lab of Iris Hardege, University of Cambridge, UK.
Deadline for application: August 3rd, 2025.
"This BBSRC-funded project aims to understand the interplay between excitatory and inhibitory metabotropic and ionotropic dopamine receptors and how they contribute to the regulation of complex behaviours."
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In #CElegans, the protein FLWR-1 helps manage calcium levels and vesicle recycling at the neuromuscular junction, challenging old models of its role in #endocytosis.
Video: Time series of a fluorescent particle travelling along commissures.
https://elifesciences.org/articles/103870?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
In #CElegans, the protein FLWR-1 helps manage calcium levels and vesicle recycling at the neuromuscular junction, challenging old models of its role in #endocytosis.
Video: Time series of a fluorescent particle travelling along commissures.
https://elifesciences.org/articles/103870?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
The nematode Caenorhabditis elegans builds towers and catches a ride on passing insects. This behaviour was seen in the lab, but has now been filmed in the wild.
https://www.ab.mpg.de/681130/news_publication_24804370_transferred
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@SciMag @news-from-science-SciMag
Original paper is open access and will show you the movies:
"Towering behavior and collective dispersal in Caenorhabditis nematodes", Perez et al. 2025
https://www.cell.com/current-biology/fulltext/S0960-9822(25)00601-3 -
@SciMag @news-from-science-SciMag
Original paper is open access and will show you the movies:
"Towering behavior and collective dispersal in Caenorhabditis nematodes", Perez et al. 2025
https://www.cell.com/current-biology/fulltext/S0960-9822(25)00601-3 -
#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? This study shows that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @PLOSBiology https://plos.io/3HfH8LN
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#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? This study shows that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @PLOSBiology https://plos.io/3HfH8LN
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Cells reallocate their limited energy for cellular maintenance in response to nutrient scarcity, but how? This study shows that the nucleolar RNA #exosome surveillance mechanism can be temporarily inhibited, reducing translation in #Celegans to adapt to starvation @PLOSBiology https://plos.io/3Zs1B6c
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Cells reallocate their limited energy for cellular maintenance in response to nutrient scarcity, but how? This study shows that the nucleolar RNA #exosome surveillance mechanism can be temporarily inhibited, reducing translation in #Celegans to adapt to starvation @PLOSBiology https://plos.io/3Zs1B6c
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Song et al. show that nematodes evolved novel telomeric repeat motifs in spite of the specificity of telomere-binding proteins, highlighting co-evolution between DNA repeats and their interacting proteins.
🔗 doi.org/10.1093/gbe/evaf085
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Song et al. show that nematodes evolved novel telomeric repeat motifs in spite of the specificity of telomere-binding proteins, highlighting co-evolution between DNA repeats and their interacting proteins.
🔗 doi.org/10.1093/gbe/evaf085
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Comparative transcriptomics of nematodes C. elegans and Brugia malayi supports Ohno’s hypothesis of X-linked genes showing upregulation following Y degeneration, which depends on the dosage-sensitive gene content of proto-X.
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Comparative transcriptomics of nematodes C. elegans and Brugia malayi supports Ohno’s hypothesis of X-linked genes showing upregulation following Y degeneration, which depends on the dosage-sensitive gene content of proto-X.
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Whole-transcriptome profiling in C. briggsae and C. elegans reveals a post-reproductive shift in gene expression, indicating a dynamic regulation of aging-associated pathways linked to reproduction.
Link: doi.org/10.1093/gbe/...
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Whole-transcriptome profiling in C. briggsae and C. elegans reveals a post-reproductive shift in gene expression, indicating a dynamic regulation of aging-associated pathways linked to reproduction.
Link: doi.org/10.1093/gbe/...
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Even worms can minimize effort when they have the choice – here, assessed when feeding:
"C. elegans food choice exhibits effort discounting-like behavior", Millet et al. 2025 (Shawn Lockery's lab)
https://www.biorxiv.org/content/10.1101/2025.03.10.641934v1.full-text
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Even worms can minimize effort when they have the choice – here, assessed when feeding:
"C. elegans food choice exhibits effort discounting-like behavior", Millet et al. 2025 (Shawn Lockery's lab)
https://www.biorxiv.org/content/10.1101/2025.03.10.641934v1.full-text
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How do worms navigate based on learned experience? @AndrewLeifer &co reveal flexible behavioral strategies & distributed neural computations underlying learning-dependent odor #navigation in #Celegans #plosbiology https://plos.io/4bYZs7c
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How do worms navigate based on learned experience? @AndrewLeifer &co reveal flexible behavioral strategies & distributed neural computations underlying learning-dependent odor #navigation in #Celegans #plosbiology https://plos.io/4bYZs7c
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A review: "C. elegans wired and wireless connectome: insights into principles of nervous system structure and function", by K Venkatesh, L Ripoll-Sánchez, I Beets, WR Schafer 2025
https://link.springer.com/article/10.1007/s12038-025-00513-7 -
A review: "C. elegans wired and wireless connectome: insights into principles of nervous system structure and function", by K Venkatesh, L Ripoll-Sánchez, I Beets, WR Schafer 2025
https://link.springer.com/article/10.1007/s12038-025-00513-7 -
#SmallRNA pathways can regulate eukaryotic antiviral defense. This study in #Celegans shows that a subunit of the dREAM complex regulates antiviral RNAi in response to Orsay #virus infection; if mutated it can generate a constitutive state of antiviral readiness #plosbiology https://plos.io/4hziGlf
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#SmallRNA pathways can regulate eukaryotic antiviral defense. This study in #Celegans shows that a subunit of the dREAM complex regulates antiviral RNAi in response to Orsay #virus infection; if mutated it can generate a constitutive state of antiviral readiness #plosbiology https://plos.io/4hziGlf
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@katchwreck For sure we won't understand how the brain works until the role of astrocytes and other glial cells is fully understood.
The #connectome though is understood as the wiring diagram where neurons are nodes and edges are synaptic connections. For additional interactions there's the "#neuromodulome" for e.g., neuropeptide/neuromodulator vs. the corresponding receptor, like in this paper by Lidia Ripoll-Sánchez et al. 2023 on C. elegans:
"The neuropeptidergic connectome of C. elegans" https://www.cell.com/neuron/fulltext/S0896-6273(23)00756-0
#neuroscience #Celegans #connectomics -
@katchwreck For sure we won't understand how the brain works until the role of astrocytes and other glial cells is fully understood.
The #connectome though is understood as the wiring diagram where neurons are nodes and edges are synaptic connections. For additional interactions there's the "#neuromodulome" for e.g., neuropeptide/neuromodulator vs. the corresponding receptor, like in this paper by Lidia Ripoll-Sánchez et al. 2023 on C. elegans:
"The neuropeptidergic connectome of C. elegans" https://www.cell.com/neuron/fulltext/S0896-6273(23)00756-0
#neuroscience #Celegans #connectomics -
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated #plosbiology plos.io/3W7OQMs
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bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated #plosbiology plos.io/3W7OQMs
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ULP-2 is a conserved SUMO protease required for embryonic development in #Celegans, but what does it do? This study shows that ULP-2 controls germline development by regulating #SUMOylation levels (and so activity) of H3K4me3 reader SET-26 #plosbiology https://plos.io/403ixQ5