#vte — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #vte, aggregated by home.social.
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@adredish Interesting connection, especially the parallel to hippocampal theta sweeps and #VTE. And yes, your last point is particularly interesting: Most paradigms reduce decisions to binary choices. It would be nice to see whether these dynamics still hold once animals choose between multiple alternatives instead of just two.
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Reading the paper this points to, I find that this is remarkably similar to the theta-cycling (7 Hz) that's been seen in rats making decisions, where the signal oscillates between alternatives in hippocampally-driven theta sweeps at 7 Hz. #VTE
One of the big debates in the hippocampal space right now is whether the sequences are ubiquitously alternating or whether they are randomly shifting.
Importantly, no one (to my knowledge) has successfully looked at sweeps "deliberating" between more than two options.
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C'est pas techniquement un papier lié à la santé trans mais c'est pertinent ; sont sortis de nouveaux résultats des cohortes PATCH et STAMPEDE-1 sur l'utilisation de l'estradiol en patch dans le cancer de la prostate[1].
L'utilisation des oestro dans le cancer de la prostate c'est pas nouveau, ça se fait depuis les années 1960, mais ça avait été assez largement abandonné notamment à cause du risque cardiovasculaire (en même temps quand on utilise du DES oui c'est sûr 😬) et de l'arrivée des analogues de la GnRH, plus sûrs. (Au passage oui ça veut dire qu'à un moment dans l'histoire, l'alternative établie à l'orchidectomie/la "castration chimique" c'était des oestro, et pas que des anti-androgènes. Et maintenant t'as des médecins qui essaient de t'expliquer que la monothérapie ça marche pas, 🤦)
Relativement récemment il y a un regain d'intérêt pour l'utilisation de l'estradiol, mais plutôt par voie transdermique (en patch), car bien moins risqué d'un point de vue thromboembolique et pouvant apporter des bénéfices niveau qualité de vie (la thérapie de déprivation androgénique pendant des années, c'est souvent mal vécu par les patients) et niveau risque fracturaire.Bref, là on a des résultats assez solides qui montrent une non-infériorité des patchs d'estradiol aux analogues de la GnRH (médicaments type décapeptyl) dans le cancer de la prostate (avancé localement) dans la survie sans métastase à 3 ans (et dans la survie globale à 5 ans).
C'est cool pour les personnes qui ont un cancer de la prostate qui pourront s'en servir pour advocate auprès de leurs médecins pour ce traitement si ça les intéresse (cf https://estradiolinitiative.org/).C'est aussi intéressant pour les personnes transféminines parce que ça prouve encore fois l'efficacité de la monothérapie, et parce que ça continue à montrer la bonne sécurité cardiovasculaire/thromboembolique de l'estradiol à relative haute dose (300-400µg/j en patch, taux d'estradiol dans les 250 pg/mL).
Précédemment on avait cette analyse[2] des résultats de l'étude PATCH qui va un peu plus dans les détails sur le sujet qui trouve pas plus de mortalité ou de morbidité cardiovasculaire chez les personnes sous oestro.
(Ce qui à mon avis s'ajoute aux diverses preuves que le surrisque cardiovasculaire et thromboembolique chez les personnes transfem ce n'est pas entièrement ni même principalement un fait du THS, mais c'est plutôt lié aux conditions socio-économiques défavorables et au stress minoritaire).[1] : Transdermal Estradiol Patches in Locally Advanced Prostate Cancer. Langley RE et al., 2026. https://doi.org/10.1056%2FNEJMoa2511781
[2] : Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme. Langley RE et al., 2021. https://doi.org/10.1016/S0140-6736(21)00100-8
#prostatecancer #e2 #estradiol #ADT #VTE #cardiovascular #monotherapy
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Aviation weather for Wattay International airport in Vientiane area (Lao) is “METAR VLVT 240400Z 04002KT 9999 FEW020 33/28 Q1010 NOSIG” : See what it means on https://www.bigorre.org/aero/meteo/vlvt/en #wattayinternationalairport #airport #vientiane #lao #vlvt #vte #metar #aviation #aviationweather #avgeek vl
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Aviation weather for Wattay International airport in Vientiane area (Lao) is “VLVT 180530Z 18002KT 8000 FEW020 33/28 Q1012 NOSIG” : See what it means on https://www.bigorre.org/aero/meteo/vlvt/en #wattayinternationalairport #airport #vientiane #lao #vlvt #vte #metar #aviation #aviationweather #avgeek vl
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Aviation weather for Wattay International airport in Vientiane area (Lao) is “VLVT 180430Z 04002KT 7000 NSC 32/27 Q1013 NOSIG” : See what it means on https://www.bigorre.org/aero/meteo/vlvt/en #wattayinternationalairport #airport #vientiane #lao #vlvt #vte #metar #aviation #aviationweather #avgeek vl
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Aviation weather for Wattay International airport in Vientiane area (Lao) is “VLVT 160400Z 04002KT 8000 NSC 27/22 Q1014 NOSIG” : See what it means on https://www.bigorre.org/aero/meteo/vlvt/en #wattayinternationalairport #airport #vientiane #lao #vlvt #vte #metar #aviation #aviationweather #avgeek vl
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🥊 State of Terminal Emulators in 2025: The Errant Champions / Jeff Quast
https://www.jeffquast.com/post/state-of-terminal-emulation-2025/
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Since I'm big on emojis, this bug has been extremely annoying but I never felt entitled to complain about it because I hadn't filed an issue yet. Now that changes :)
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TIL: On peut faire des liens avec des ancres dans un terminal (l'équivalent de la balise HTML `<a>`) 🤯
Je suis tombé là-dessus en regardant la sortie de la commande `hostnamectl` qui faisait pointer le texte `Ubuntu 24.10` vers le site d'Ubuntu…
J'avoue que je ne sais pas trop quoi en pense mais si jamais vous êtes curieux, la spec est par là 😅 :
➡️ https://gist.github.com/egmontkob/eb114294efbcd5adb1944c9f3cb5feda
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Also, by the way, this paper contains the history of #VTE that I often use in my talks. (Updated to include not just the technological breakthroughs in experimental techniques and the mathematical sciences, but also the theoretical breakthroughs that were necessary to get us to see rats "thinking about the future".)
I think this speaks to why science is slow and why we have to look at science over a long time scale
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@dimokaramanlis @elduvelle_neuro @jessetm
It is important to distinguish the computations going on within the subject.
Technically, #VTE is a behavior of pausing attentively, orienting and re-orienting (as originally defined by Gentry, Muenzinger, and Tolman in the 1930s). But what we really care about are the neurophysiological computations that behavior is reflecting at the moment.
(We want to take the subject's POV, not the experimenter's.)There are currently (to my knowledge) two computations that have been shown to create attentive pause and reorientation behaviors (i.e. VTE).
(1) Sensory discrimination --- the subject is turning to focus sensory signals on sensory receptors.
(2) Planning systems --- the subject pauses to send hippocampal sweeps down the two options. What causes the reorientation is unknown, but I suspect that it is action chains that are halted.
Both the timing of each of these (in what situations they appear) and the neural circuits involved in each are different.
See the paper @elduvelle cites (https://www.nature.com/articles/nrn.2015.30) for a review, including a discussion of this issue. A good example of the distinction is in Bett et al (https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2012.00070/full).
PS. Yes, mice and rats both definitely do VTE. Primates do a thing called SFS (saccade-fixate-saccade), which appears similar (likely with two meanings, much like rodents).
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For our next #NeuroESC #JournalClub I will read this paper from @jessetm :
get the PDF at: https://drive.google.com/file/d/1qmfyeNkOwe_R-tvCOc0uSq3AX2WkMt4I/view?usp=sharing
Anyone else interested? We could all pledge to read it and then discuss it here afterwards (Next Friday) 👀
#Neuroscience #VTE #FlexibleDecisions #SpatialCognition #mPFC #NavigationStrategies
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#VTE detection: what's the best algorithm out there to detect Rat VTEs from 2D head position data (no HD data)?
By "best" I mean least effortful for the user...I know that @adredish has the D-phil method (explained in Interactions between deliberation and delay-discounting in rats #RedishLab which is used quite a lot.
But also just found out about a different method from @jessetm explained in A Machine Learning Approach for Detecting Vicarious Trial and Error Behaviors #MizumoriLab - Jesse, I haven't checked the details yet but as its creator, would you recommend it? Would you have code for it somewhere? I couldn't see a repo link in the paper but maybe I missed it. 🙏
Edit: Jeff Stott added this one to the list, which uses a "Curvature" measure (also from #RedishLab): A functional difference in information processing between orbitofrontal cortex and ventral striatum during decision-making behaviour
Any other ones out there?
#Neuroscience #NeuroMethods #SpatialCognition -
.: :terminal: Sakura Terminal :terminal: :.
Is a terminal emulator based on GTK+ and VTE. It's a terminal emulator with few dependencies, so you don't need a full GNOME desktop installed to have a decent terminal emulator.
Being trying and I like it a lot.
https://www.mankier.com/1/sakura
Surely I replace it for Xterm...
I like Xterm also, but Sakura is more powerful.
Cheers!
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I released the new version of one of my oldest projects!
🐸 **kermit**: A froggy terminal emulator.
🐸 Not written in Rust - don't *frog* out.
🎨 Supports tabs and customization.
⭐ GitHub: https://github.com/orhun/kermit
#terminal #emulator #opensource #release #project #linux #vte
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@Andrewpapale @elduvelle_neuro @BrianMSweis
Sweeps are theta sequences. 100% They do tend to go farther during VTE than during normal running, but they are definitely relatively normal theta sequences.
As you may know, there is this paper by Papale et al (2016 Neuron 😉) that definitively showed that animals are in theta through VTE. This can also be seen in the original Johnson and Redish 2007 JNeurosci paper as well as in the Kay et al 2020 Cell paper, and all the other ones that have looked.
What is more controversial is whether #VTE = #Deliberation. My view is that VTE is a subset of Deliberation. You can see Deliberation without VTE, but not VTE without Deliberation.
In general, what we see is three stages of theta sequences.
(1) When an animal knows the maze, but not what to do on it, you see alternating sweeps to the goal in theta and commonly VTE (although sometimes just pausing or slowing through the choice point). [Deliberation]
(2) When an animal knows the maze and what to do, but is still in "hippocampal" mode, you see sweeps to one side (the next goal). [Planning/Checking]
(3) When an animal has automated what to do, sweeps drop down to very small (not going all the way to the goal), and task bracketing shows up in dorsal striatum. [Habit/Automation]
See Redish 2016 Nature Reviews Neuroscience for a thorough review. This story has been confirmed by many papers since. Most recently see Ugurcan Mugan's 2024 bioRxiv paper.
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Mice definitely do #VTE (Vicarious Trial and Error) behaviors. We've seen them in our Restaurant Row task. (Take a look at the various @BrianMSweis papers. They VTE in the offer zone as they learn to precommit to avoid the sunk costs.)
Primates do as well, but in primates they are generally saccade-fixate-saccade sequences rather than actual head movements.
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@edeno cool thanks! Putting some screenshots for illustration.. it definitely seems like a lot of events happen at the choice point, but strangely, most if not all of the replay examples shown in the paper are from the reward locations.
Also, as you say, it is not clear that those events were during SWRs and not theta - the theta/delta ratio around “replays” does seem quite similar to the rest of behaviour... it would have been nice if they had made this figure separately for reward vs choice point events. Actually they even say that their choice point events could be similar to @adredish ‘s #VTE activity, which is definitely #ThetaSequences. 🤔
(For reference, here is the paper:
Awake replay of remote experiences in the hippocampus) -
FLAME Study, too good to be true? #VTE #PE #thrombectomy https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.123.013406
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@eRatt Ahaha I think this is a documented behaviour in the rat scientific literature called “Vicarious Trial-and-Error” (#VTE) - they do this a lot at choice points in mazes! But it’s supposed to be helping them know where to go next, not figure out where they currently are… super interesting to see it in a “natural” setting!
It would be so cool to see a video if you ever did it again! 👀 -
Big Data Study Debunks One of The Most Common Fears Surrounding COVID-19 Vaccinations
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@elduvelle Behavior is inherently equifinal. Many neurophysiological processes can lead to the same behavior.
The physical path of #VTE (pause and orient back and forth) is *correlated* with but not identical to the neurophysiological process of #VTE (vicariously trying out options; planning; deliberation).
Other pause and reorient behaviors include trying to see better cues [visual discrimination] (Bett et al 2012: https://www.frontiersin.org/articles/10.3389/fnbeh.2012.00070/full) and identifying new events/positions to put onto the map (Monaco et al 2014: https://www.nature.com/articles/nn.3687). The Monaco et al head-scanning includes a lot of rearing events.
Interestingly, the pause-and-reorient behaviors (PARs) in this paper (George et al 2023: https://www.sciencedirect.com/science/article/abs/pii/S0166432823001286) include rearing, which deliberative VTE doesn't seem to.
Nevertheless, a fascinating contribution to the literature. I'm particularly intrigued by the evidence that these behaviors predict future performance.
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Very excited to release the first version of Workbench - A sandbox to learn and prototype with #GNOME technologies.
Featuring #GTK / #CSS live preview
https://github.com/sonnyp/Workbench
Built with #libadwaita #gtk4 #vte #gtksourceview #gjs
