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#estradiol — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #estradiol, aggregated by home.social.

  1. SleepyCatten (Melting Arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Uneventful, which was great, as we're exhausted and far too warm 🩷

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  2. SleepyCatten (Melting Arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Managed to do it early for once (!!!) about an hour ago or so without any major issues: just general tiredness, lack of focus, executive dysfunction etc. Must have picked a near-ideal site.

    On a tangent, for reasons we won't go into right now, we're not sure whether we're going to keep doing these weekly injection posts any more, or at least for much longer. We know we've been doing them for a couple of years now, but... yeah...

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  3. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Managed to do it early for once (!!!) about an hour ago or so without any major issues: just general tiredness, lack of focus, executive dysfunction etc. Must have picked a near-ideal site.

    On a tangent, for reasons we won't go into right now, we're not sure whether we're going to keep doing these weekly injection posts any more, or at least for much longer. We know we've been doing them for a couple of years now, but... yeah...

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  4. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Managed to do it early for once (!!!) about an hour ago or so without any major issues: just general tiredness, lack of focus, executive dysfunction etc. Must have picked a near-ideal site.

    On a tangent, for reasons we won't go into right now, we're not sure whether we're going to keep doing these weekly injection posts any more, or at least for much longer. We know we've been doing them for a couple of years now, but... yeah...

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  5. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Managed to do it early for once (!!!) about an hour ago or so without any major issues: just general tiredness, lack of focus, executive dysfunction etc. Must have picked a near-ideal site.

    On a tangent, for reasons we won't go into right now, we're not sure whether we're going to keep doing these weekly injection posts any more, or at least for much longer. We know we've been doing them for a couple of years now, but... yeah...

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #autostabber #unionmedico #lgbtqia2s #lgbtqia #lgbtq #queer
  6. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Managed to do it early for once (!!!) about an hour ago or so without any major issues: just general tiredness, lack of focus, executive dysfunction etc. Must have picked a near-ideal site.

    On a tangent, for reasons we won't go into right now, we're not sure whether we're going to keep doing these weekly injection posts any more, or at least for much longer. We know we've been doing them for a couple of years now, but... yeah...

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  7. SleepyCatten (Melting Arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Overly tired, overstimulated / overloaded, and struggling this evening, and doing the injection with 2 layers of hand supports (compression gloves and thumb splints), so it's little wonder it took us even longer to do and that our leg didn't want to let us pull the bleeping needle out! No blood when we finally managed it though, and no pain... though that may also be due to other meds we're on 😅

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  8. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Overly tired, overstimulated / overloaded, and struggling this evening, and doing the injection with 2 layers of hand supports (compression gloves and thumb splints), so it's little wonder it took us even longer to do and that our leg didn't want to let us pull the bleeping needle out! No blood when we finally managed it though, and no pain... though that may also be due to other meds we're on 😅

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  9. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Overly tired, overstimulated / overloaded, and struggling this evening, and doing the injection with 2 layers of hand supports (compression gloves and thumb splints), so it's little wonder it took us even longer to do and that our leg didn't want to let us pull the bleeping needle out! No blood when we finally managed it though, and no pain... though that may also be due to other meds we're on 😅

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  10. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Overly tired, overstimulated / overloaded, and struggling this evening, and doing the injection with 2 layers of hand supports (compression gloves and thumb splints), so it's little wonder it took us even longer to do and that our leg didn't want to let us pull the bleeping needle out! No blood when we finally managed it though, and no pain... though that may also be due to other meds we're on 😅

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #autostabber #unionmedico #lgbtqia2s #lgbtqia #lgbtq #queer
  11. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Overly tired, overstimulated / overloaded, and struggling this evening, and doing the injection with 2 layers of hand supports (compression gloves and thumb splints), so it's little wonder it took us even longer to do and that our leg didn't want to let us pull the bleeping needle out! No blood when we finally managed it though, and no pain... though that may also be due to other meds we're on 😅

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  12. SleepyCatten (Melting Arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection (after midnight)

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Why 6 mg instead of 5? Because we needed more estradiol for the coming week and fuck our gatekeeping NHS gender clinic 🖕

    Didn't even feel the needle go in, or when we pushed down the syringe, or pulled it out. Did a triple check to make sure we'd actually injected. Teeniest dot of blood came out. Couldn't have asked for an easier or better injection 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  13. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection (after midnight)

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Why 6 mg instead of 5? Because we needed more estradiol for the coming week and fuck our gatekeeping NHS gender clinic 🖕

    Didn't even feel the needle go in, or when we pushed down the syringe, or pulled it out. Did a triple check to make sure we'd actually injected. Teeniest dot of blood came out. Couldn't have asked for an easier or better injection 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  14. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection (after midnight)

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Why 6 mg instead of 5? Because we needed more estradiol for the coming week and fuck our gatekeeping NHS gender clinic 🖕

    Didn't even feel the needle go in, or when we pushed down the syringe, or pulled it out. Did a triple check to make sure we'd actually injected. Teeniest dot of blood came out. Couldn't have asked for an easier or better injection 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  15. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection (after midnight)

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Why 6 mg instead of 5? Because we needed more estradiol for the coming week and fuck our gatekeeping NHS gender clinic 🖕

    Didn't even feel the needle go in, or when we pushed down the syringe, or pulled it out. Did a triple check to make sure we'd actually injected. Teeniest dot of blood came out. Couldn't have asked for an easier or better injection 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #autostabber #unionmedico #lgbtqia2s #lgbtqia #lgbtq #queer
  16. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection (after midnight)

    ~6 mg (~0.12 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Why 6 mg instead of 5? Because we needed more estradiol for the coming week and fuck our gatekeeping NHS gender clinic 🖕

    Didn't even feel the needle go in, or when we pushed down the syringe, or pulled it out. Did a triple check to make sure we'd actually injected. Teeniest dot of blood came out. Couldn't have asked for an easier or better injection 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  17. SleepyCatten (Melting Arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Felt it go in, but wouldn't describe it as pain really: more like a mild moment of pressure. Teensiest amount of blood leakage, but very easy injection, especially for a left leg 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  18. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Felt it go in, but wouldn't describe it as pain really: more like a mild moment of pressure. Teensiest amount of blood leakage, but very easy injection, especially for a left leg 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  19. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Felt it go in, but wouldn't describe it as pain really: more like a mild moment of pressure. Teensiest amount of blood leakage, but very easy injection, especially for a left leg 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  20. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Felt it go in, but wouldn't describe it as pain really: more like a mild moment of pressure. Teensiest amount of blood leakage, but very easy injection, especially for a left leg 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #autostabber #unionmedico #lgbtqia2s #lgbtqia #lgbtq #queer
  21. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Felt it go in, but wouldn't describe it as pain really: more like a mild moment of pressure. Teensiest amount of blood leakage, but very easy injection, especially for a left leg 🩹 :TransButterfly: :NonBinaryButterfly: :TransFemHeart:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  22. SleepyCatten (Melting Arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Late one tonight, as lots of other tiring stuff took priority, but it was an easy and painless injection at least :TransButterfly:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  23. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Late one tonight, as lots of other tiring stuff took priority, but it was an easy and painless injection at least :TransButterfly:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  24. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Late one tonight, as lots of other tiring stuff took priority, but it was an easy and painless injection at least :TransButterfly:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  25. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Late one tonight, as lots of other tiring stuff took priority, but it was an easy and painless injection at least :TransButterfly:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #autostabber #unionmedico #lgbtqia2s #lgbtqia #lgbtq #queer
  26. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Late one tonight, as lots of other tiring stuff took priority, but it was an easy and painless injection at least :TransButterfly:

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  27. PregNuki Raccoon: Shitposting for 2 (at least!) @[email protected] ·

    #PSA for young #MTF #Transwomen getting #Estrogen / #Estradiol via pills...

    I don't recommend pills over Patches or Injections, but if you take them, you need to let them dissolve under your tongue: do not swallow them whole. You want estradiol solutes in your mouth/esophagus that your flesh will absorb directly with the water, not to go through your digestive system which will either break it down or filter it out.

    Again, most people who've been doing this a while recommend Injections or Patches over pills, simply because those have easier and better absorbtion.

    #transgender #gender

    #psa #mtf #transwomen #estrogen #estradiol #transgender
  28. PregNuki Raccoon: Shitposting for 2 (at least!) @[email protected] ·

    #PSA for young #MTF #Transwomen getting #Estrogen / #Estradiol via pills...

    I don't recommend pills over Patches or Injections, but if you take them, you need to let them dissolve under your tongue: do not swallow them whole. You want estradiol solutes in your mouth/esophagus that your flesh will absorb directly with the water, not to go through your digestive system which will either break it down or filter it out.

    Again, most people who've been doing this a while recommend Injections or Patches over pills, simply because those have easier and better absorbtion.

    #transgender #gender

    #psa #mtf #transwomen #estrogen #estradiol #transgender
  29. PregNuki Raccoon: Shitposting for 2 (at least!) @[email protected] ·

    #PSA for young #MTF #Transwomen getting #Estrogen / #Estradiol via pills...

    I don't recommend pills over Patches or Injections, but if you take them, you need to let them dissolve under your tongue: do not swallow them whole. You want estradiol solutes in your mouth/esophagus that your flesh will absorb directly with the water, not to go through your digestive system which will either break it down or filter it out.

    Again, most people who've been doing this a while recommend Injections or Patches over pills, simply because those have easier and better absorbtion.

    #transgender #gender

    #psa #mtf #transwomen #estrogen #estradiol #transgender
  30. PregNuki Raccoon: Shitposting for 2 (at least!) @[email protected] ·

    #PSA for young #MTF #Transwomen getting #Estrogen / #Estradiol via pills...

    I don't recommend pills over Patches or Injections, but if you take them, you need to let them dissolve under your tongue: do not swallow them whole. You want estradiol solutes in your mouth/esophagus that your flesh will absorb directly with the water, not to go through your digestive system which will either break it down or filter it out.

    Again, most people who've been doing this a while recommend Injections or Patches over pills, simply because those have easier and better absorbtion.

    #transgender #gender

    #gender #transgender #estradiol #estrogen #transwomen #mtf
  31. PregNuki Raccoon: Shitposting for 2 (at least!) @[email protected] ·

    #PSA for young #MTF #Transwomen getting #Estrogen / #Estradiol via pills...

    I don't recommend pills over Patches or Injections, but if you take them, you need to let them dissolve under your tongue: do not swallow them whole. You want estradiol solutes in your mouth/esophagus that your flesh will absorb directly with the water, not to go through your digestive system which will either break it down or filter it out.

    Again, most people who've been doing this a while recommend Injections or Patches over pills, simply because those have easier and better absorbtion.

    #transgender #gender

    #psa #mtf #transwomen #estrogen #estradiol #transgender
  32. SleepyCatten (Melting Arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Only the teeniest dot of blood after. Not even a blob. Painless injection (insertion and removal) too.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  33. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Only the teeniest dot of blood after. Not even a blob. Painless injection (insertion and removal) too.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  34. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Only the teeniest dot of blood after. Not even a blob. Painless injection (insertion and removal) too.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  35. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Only the teeniest dot of blood after. Not even a blob. Painless injection (insertion and removal) too.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #autostabber #unionmedico #lgbtqia2s #lgbtqia #lgbtq #queer
  36. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Only the teeniest dot of blood after. Not even a blob. Painless injection (insertion and removal) too.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  37. biyokea @[email protected] ·

    C'est pas techniquement un papier lié à la santé trans mais c'est pertinent ; sont sortis de nouveaux résultats des cohortes PATCH et STAMPEDE-1 sur l'utilisation de l'estradiol en patch dans le cancer de la prostate[1].

    L'utilisation des oestro dans le cancer de la prostate c'est pas nouveau, ça se fait depuis les années 1960, mais ça avait été assez largement abandonné notamment à cause du risque cardiovasculaire (en même temps quand on utilise du DES oui c'est sûr 😬) et de l'arrivée des analogues de la GnRH, plus sûrs. (Au passage oui ça veut dire qu'à un moment dans l'histoire, l'alternative établie à l'orchidectomie/la "castration chimique" c'était des oestro, et pas que des anti-androgènes. Et maintenant t'as des médecins qui essaient de t'expliquer que la monothérapie ça marche pas, 🤦)
    Relativement récemment il y a un regain d'intérêt pour l'utilisation de l'estradiol, mais plutôt par voie transdermique (en patch), car bien moins risqué d'un point de vue thromboembolique et pouvant apporter des bénéfices niveau qualité de vie (la thérapie de déprivation androgénique pendant des années, c'est souvent mal vécu par les patients) et niveau risque fracturaire.

    Bref, là on a des résultats assez solides qui montrent une non-infériorité des patchs d'estradiol aux analogues de la GnRH (médicaments type décapeptyl) dans le cancer de la prostate (avancé localement) dans la survie sans métastase à 3 ans (et dans la survie globale à 5 ans).
    C'est cool pour les personnes qui ont un cancer de la prostate qui pourront s'en servir pour advocate auprès de leurs médecins pour ce traitement si ça les intéresse (cf estradiolinitiative.org/).

    C'est aussi intéressant pour les personnes transféminines parce que ça prouve encore fois l'efficacité de la monothérapie, et parce que ça continue à montrer la bonne sécurité cardiovasculaire/thromboembolique de l'estradiol à relative haute dose (300-400µg/j en patch, taux d'estradiol dans les 250 pg/mL).
    Précédemment on avait cette analyse[2] des résultats de l'étude PATCH qui va un peu plus dans les détails sur le sujet qui trouve pas plus de mortalité ou de morbidité cardiovasculaire chez les personnes sous oestro.
    (Ce qui à mon avis s'ajoute aux diverses preuves que le surrisque cardiovasculaire et thromboembolique chez les personnes transfem ce n'est pas entièrement ni même principalement un fait du THS, mais c'est plutôt lié aux conditions socio-économiques défavorables et au stress minoritaire).

    [1] : Transdermal Estradiol Patches in Locally Advanced Prostate Cancer. Langley RE et al., 2026. doi.org/10.1056%2FNEJMoa2511781

    [2] : Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme. Langley RE et al., 2021. doi.org/10.1016/S0140-6736(21)

    #prostatecancer #e2 #estradiol #ADT #VTE #cardiovascular #monotherapy

    #prostatecancer #e2 #estradiol #adt #vte #cardiovascular
  38. biyokea @[email protected] ·

    C'est pas techniquement un papier lié à la santé trans mais c'est pertinent ; sont sortis de nouveaux résultats des cohortes PATCH et STAMPEDE-1 sur l'utilisation de l'estradiol en patch dans le cancer de la prostate[1].

    L'utilisation des oestro dans le cancer de la prostate c'est pas nouveau, ça se fait depuis les années 1960, mais ça avait été assez largement abandonné notamment à cause du risque cardiovasculaire (en même temps quand on utilise du DES oui c'est sûr 😬) et de l'arrivée des analogues de la GnRH, plus sûrs. (Au passage oui ça veut dire qu'à un moment dans l'histoire, l'alternative établie à l'orchidectomie/la "castration chimique" c'était des oestro, et pas que des anti-androgènes. Et maintenant t'as des médecins qui essaient de t'expliquer que la monothérapie ça marche pas, 🤦)
    Relativement récemment il y a un regain d'intérêt pour l'utilisation de l'estradiol, mais plutôt par voie transdermique (en patch), car bien moins risqué d'un point de vue thromboembolique et pouvant apporter des bénéfices niveau qualité de vie (la thérapie de déprivation androgénique pendant des années, c'est souvent mal vécu par les patients) et niveau risque fracturaire.

    Bref, là on a des résultats assez solides qui montrent une non-infériorité des patchs d'estradiol aux analogues de la GnRH (médicaments type décapeptyl) dans le cancer de la prostate (avancé localement) dans la survie sans métastase à 3 ans (et dans la survie globale à 5 ans).
    C'est cool pour les personnes qui ont un cancer de la prostate qui pourront s'en servir pour advocate auprès de leurs médecins pour ce traitement si ça les intéresse (cf estradiolinitiative.org/).

    C'est aussi intéressant pour les personnes transféminines parce que ça prouve encore fois l'efficacité de la monothérapie, et parce que ça continue à montrer la bonne sécurité cardiovasculaire/thromboembolique de l'estradiol à relative haute dose (300-400µg/j en patch, taux d'estradiol dans les 250 pg/mL).
    Précédemment on avait cette analyse[2] des résultats de l'étude PATCH qui va un peu plus dans les détails sur le sujet qui trouve pas plus de mortalité ou de morbidité cardiovasculaire chez les personnes sous oestro.
    (Ce qui à mon avis s'ajoute aux diverses preuves que le surrisque cardiovasculaire et thromboembolique chez les personnes transfem ce n'est pas entièrement ni même principalement un fait du THS, mais c'est plutôt lié aux conditions socio-économiques défavorables et au stress minoritaire).

    [1] : Transdermal Estradiol Patches in Locally Advanced Prostate Cancer. Langley RE et al., 2026. doi.org/10.1056%2FNEJMoa2511781

    [2] : Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme. Langley RE et al., 2021. doi.org/10.1016/S0140-6736(21)

    #prostatecancer #e2 #estradiol #ADT #VTE #cardiovascular #monotherapy

    #prostatecancer #e2 #estradiol #adt #vte #cardiovascular
  39. biyokea @[email protected] ·

    C'est pas techniquement un papier lié à la santé trans mais c'est pertinent ; sont sortis de nouveaux résultats des cohortes PATCH et STAMPEDE-1 sur l'utilisation de l'estradiol en patch dans le cancer de la prostate[1].

    L'utilisation des oestro dans le cancer de la prostate c'est pas nouveau, ça se fait depuis les années 1960, mais ça avait été assez largement abandonné notamment à cause du risque cardiovasculaire (en même temps que on utilise du DES oui c'est sûr 😬) et de l'arrivée des analogues de la GnRH, plus sûrs. (Au passage oui ça veut dire qu'à un moment dans l'histoire, l'alternative établie à l'orchidectomie/la "castration chimique" c'était des oestro, et pas que des anti-androgènes. Et maintenant t'as des médecins qui essaient de t'expliquer que la monothérapie ça marche pas, 🤦)
    Relativement récemment y'a un regain d'intérêt pour l'utilisation de l'estradiol, mais plutôt par voie transdermique (en patch), psk bien moins risqué d'un point de vue thromboembolique, et psk peut apporter des bénéfices niveau qualité de vie (la thérapie de déprivation androgénique/ADT pendant des années, c'est souvent mal vécu par les patients! + niveau risque fracturaire).

    Bref, là on a des résultats assez solides qui montrent une non-infériorité des patchs d'estradiol aux analogues de la GnRH (médicaments type décapeptyl) dans le cancer de la prostate (avancé localement) dans la survie sans métastase à 3 ans (et dans la survie globale à 5 ans).
    C'est cool pour les personnes qui ont un cancer de la prostate qui pourront s'en servir pour advocate auprès de leurs médecins pour ce traitement si ça les intéresse (cf estradiolinitiative.org/).

    C'est aussi intéressant pour les personnes transféminines parce que ça prouve encore fois l'efficacité de la monothérapie, et parce que ça continue à montrer la bonne sécurité cardiovasculaire/thromboembolique de l'estradiol à relative haute dose (300-400µg/j en patch, taux d'estradiol dans les 250 pg/mL).
    Précédemment on avait cette analyse[2] des résultats de l'étude PATCH qui va un peu plus dans les détails sur le sujet qui trouve pas plus de mortalité ou de morbidité cardiovasculaire chez les personnes sous oestro.
    (Ce qui à mon avis s'ajoute aux diverses preuves que le surrisque cardiovasculaire et thromboembolique chez les personnes transfem ce n'est pas entièrement ni même principalement un fait du THS, mais c'est plutôt lié aux conditions socio-économiques défavorables et au stress minoritaire).

    [1] : Transdermal Estradiol Patches in Locally Advanced Prostate Cancer. Langley RE et al., 2026. doi.org/10.1056%2FNEJMoa2511781
    [2] : Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme. Langley RE et al., 2021. doi.org/10.1016/S0140-6736(21)

    #prostatecancer #e2 #estradiol #ADT #VTE #cardiovascular

    #prostatecancer #e2 #estradiol #adt #vte #cardiovascular
  40. biyokea @[email protected] ·

    C'est pas techniquement un papier lié à la santé trans mais c'est pertinent ; sont sortis de nouveaux résultats des cohortes PATCH et STAMPEDE-1 sur l'utilisation de l'estradiol en patch dans le cancer de la prostate[1].

    L'utilisation des oestro dans le cancer de la prostate c'est pas nouveau, ça se fait depuis les années 1960, mais ça avait été assez largement abandonné notamment à cause du risque cardiovasculaire (en même temps que on utilise du DES oui c'est sûr 😬) et de l'arrivée des analogues de la GnRH, plus sûrs. (Au passage oui ça veut dire qu'à un moment dans l'histoire, l'alternative établie à l'orchidectomie/la "castration chimique" c'était des oestro, et pas que des anti-androgènes. Et maintenant t'as des médecins qui essaient de t'expliquer que la monothérapie ça marche pas, 🤦)
    Relativement récemment y'a un regain d'intérêt pour l'utilisation de l'estradiol, mais plutôt par voie transdermique (en patch), psk bien moins risqué d'un point de vue thromboembolique, et psk peut apporter des bénéfices niveau qualité de vie (la thérapie de déprivation androgénique/ADT pendant des années, c'est souvent mal vécu par les patients! + niveau risque fracturaire).

    Bref, là on a des résultats assez solides qui montrent une non-infériorité des patchs d'estradiol aux analogues de la GnRH (médicaments type décapeptyl) dans le cancer de la prostate (avancé localement) dans la survie sans métastase à 3 ans (et dans la survie globale à 5 ans).
    C'est cool pour les personnes qui ont un cancer de la prostate qui pourront s'en servir pour advocate auprès de leurs médecins pour ce traitement si ça les intéresse (cf estradiolinitiative.org/).

    C'est aussi intéressant pour les personnes transféminines parce que ça prouve encore fois l'efficacité de la monothérapie, et parce que ça continue à montrer la bonne sécurité cardiovasculaire/thromboembolique de l'estradiol à relative haute dose (300-400µg/j en patch, taux d'estradiol dans les 250 pg/mL).
    Précédemment on avait cette analyse[2] des résultats de l'étude PATCH qui va un peu plus dans les détails sur le sujet qui trouve pas plus de mortalité ou de morbidité cardiovasculaire chez les personnes sous oestro.
    (Ce qui à mon avis s'ajoute aux diverses preuves que le surrisque cardiovasculaire et thromboembolique chez les personnes transfem ce n'est pas entièrement ni même principalement un fait du THS, mais c'est plutôt lié aux conditions socio-économiques défavorables et au stress minoritaire).

    [1] : Transdermal Estradiol Patches in Locally Advanced Prostate Cancer. Langley RE et al., 2026. doi.org/10.1056%2FNEJMoa2511781
    [2] : Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme. Langley RE et al., 2021. doi.org/10.1016/S0140-6736(21)

    #prostatecancer #e2 #estradiol #ADT #VTE #cardiovascular

    #cardiovascular #vte #adt #estradiol #e2 #prostatecancer
  41. biyokea @[email protected] ·

    C'est pas techniquement un papier lié à la santé trans mais c'est pertinent ; sont sortis de nouveaux résultats des cohortes PATCH et STAMPEDE-1 sur l'utilisation de l'estradiol en patch dans le cancer de la prostate[1].

    L'utilisation des oestro dans le cancer de la prostate c'est pas nouveau, ça se fait depuis les années 1960, mais ça avait été assez largement abandonné notamment à cause du risque cardiovasculaire (en même temps quand on utilise du DES oui c'est sûr 😬) et de l'arrivée des analogues de la GnRH, plus sûrs. (Au passage oui ça veut dire qu'à un moment dans l'histoire, l'alternative établie à l'orchidectomie/la "castration chimique" c'était des oestro, et pas que des anti-androgènes. Et maintenant t'as des médecins qui essaient de t'expliquer que la monothérapie ça marche pas, 🤦)
    Relativement récemment il y a un regain d'intérêt pour l'utilisation de l'estradiol, mais plutôt par voie transdermique (en patch), car bien moins risqué d'un point de vue thromboembolique et pouvant apporter des bénéfices niveau qualité de vie (la thérapie de déprivation androgénique pendant des années, c'est souvent mal vécu par les patients) et niveau risque fracturaire.

    Bref, là on a des résultats assez solides qui montrent une non-infériorité des patchs d'estradiol aux analogues de la GnRH (médicaments type décapeptyl) dans le cancer de la prostate (avancé localement) dans la survie sans métastase à 3 ans (et dans la survie globale à 5 ans).
    C'est cool pour les personnes qui ont un cancer de la prostate qui pourront s'en servir pour advocate auprès de leurs médecins pour ce traitement si ça les intéresse (cf estradiolinitiative.org/).

    C'est aussi intéressant pour les personnes transféminines parce que ça prouve encore fois l'efficacité de la monothérapie, et parce que ça continue à montrer la bonne sécurité cardiovasculaire/thromboembolique de l'estradiol à relative haute dose (300-400µg/j en patch, taux d'estradiol dans les 250 pg/mL).
    Précédemment on avait cette analyse[2] des résultats de l'étude PATCH qui va un peu plus dans les détails sur le sujet qui trouve pas plus de mortalité ou de morbidité cardiovasculaire chez les personnes sous oestro.
    (Ce qui à mon avis s'ajoute aux diverses preuves que le surrisque cardiovasculaire et thromboembolique chez les personnes transfem ce n'est pas entièrement ni même principalement un fait du THS, mais c'est plutôt lié aux conditions socio-économiques défavorables et au stress minoritaire).

    [1] : Transdermal Estradiol Patches in Locally Advanced Prostate Cancer. Langley RE et al., 2026. doi.org/10.1056%2FNEJMoa2511781

    [2] : Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme. Langley RE et al., 2021. doi.org/10.1016/S0140-6736(21)

    #prostatecancer #e2 #estradiol #ADT #VTE #cardiovascular #monotherapy

    #prostatecancer #e2 #estradiol #adt #vte #cardiovascular
  42. [ πɑ@Betty_Fn0rd ~ ]$ :sparkletrans: :v_aroace: @[email protected] ·
    CW: HRT; genitalia

    Considering advice given in my trans* group and cross-referencing :potion_trans: Transfeminine Science, this is day 1 of applying girl juice on my 🎱 🎱 .:

    Consequently, scrotal/neolabial administration of transdermal estradiol gel or cream is likely to be a powerful alternative option for achieving high estradiol levels similarly to scrotal/neolabial application of transdermal estradiol patches. Scrotal/neolabial application of transdermal estradiol preparations may allow for greater efficacy and considerably reduced cost compared to conventional transdermal application of such formulations.

    :neocat_happy: Let's see how genital skin agrees with hydroalcoholic based gel … I wouldn't mind if they'd eventually come off … lol :neocat_floof_owo:

    Any transfemme out there sharing their experience on that?

    #HRT #Estradiol #Genitals #transfem

    #hrt #estradiol #genitals #transfem
  43. [ πɑ@Betty_Fn0rd ~ ]$ :sparkletrans: :v_aroace: @[email protected] ·
    CW: HRT; genitalia

    Considering advice given in my trans* group and cross-referencing :potion_trans: Transfeminine Science, this is day 1 of applying girl juice on my 🎱 🎱 .:

    Consequently, scrotal/neolabial administration of transdermal estradiol gel or cream is likely to be a powerful alternative option for achieving high estradiol levels similarly to scrotal/neolabial application of transdermal estradiol patches. Scrotal/neolabial application of transdermal estradiol preparations may allow for greater efficacy and considerably reduced cost compared to conventional transdermal application of such formulations.

    :neocat_happy: Let's see how genital skin agrees with hydroalcoholic based gel … I wouldn't mind if they'd eventually come off … lol :neocat_floof_owo:

    Any transfemme out there sharing their experience on that?

    #HRT #Estradiol #Genitals #transfem

    #hrt #estradiol #genitals #transfem
  44. SleepyCatten (Melting Arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Small bleed after. No pain or discomfort though, but that's the norm for us now.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  45. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Small bleed after. No pain or discomfort though, but that's the norm for us now.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  46. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Small bleed after. No pain or discomfort though, but that's the norm for us now.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  47. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Small bleed after. No pain or discomfort though, but that's the norm for us now.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #autostabber #unionmedico #lgbtqia2s #lgbtqia #lgbtq #queer
  48. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in our right thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Small bleed after. No pain or discomfort though, but that's the norm for us now.

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht
  49. SleepyCatten (Melting Arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Didn't feel anything at all...

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transgaht #diygaht #diyhrt #gaht #hrt #feminisinggaht
  50. SleepyCatten (referred for ME/CFS, but it's probably P-HSD arc) @[email protected] ·
    CW: Feminising GAHT (HRT) injection

    ~5 mg (~0.10 mL; 50 mg/mL concentration) estradiol enanthate injected intramuscularly into the vastus lateralis in left thigh using our Union Medico auto-stabber and a 25 mm 25G TotalDose low dead space needle 💉

    Didn't feel anything at all...

    #TransDIY #TransHRT #TransGAHT #DIYGAHT #DIYHRT #GAHT #HRT #FeminisingGAHT #FeminisingHRT #EstradiolEnanthate #estradiol #transition #trans #transgender #NonBinary #TransFem #FemEnby #injection #TransHealthcare #queer #LGBTQ+ #LGBTQIA+ #LGBTQIA2S+ #UnionMedico #AutoStabber

    #transdiy #transhrt #transgaht #diygaht #diyhrt #gaht