#telomerase — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #telomerase, aggregated by home.social.
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Vitamin D May Help Slow Aging, Study Finds
Could a simple vitamin help slow the ticking of our biological clocks? A new study suggests vitamin D may protect the delicate chromosome caps linked to aging, potentially lowering the risk of age-related diseases. Credit: Stock A clinical trial suggests vitamin …
#dining #cooking #diet #food #Nutrition #aging #longevity #nutrition #Telomerase #TheConversation #Vitamins
https://www.diningandcooking.com/2283295/vitamin-d-may-help-slow-aging-study-finds/ -
Vitamin D May Help Slow Aging, Study Finds
Could a simple vitamin help slow the ticking of our biological clocks? A new study suggests vitamin D may protect the delicate chromosome caps linked to aging, potentially lowering the risk of age-related diseases. Credit: Stock A clinical trial suggests vitamin …
#dining #cooking #diet #food #Nutrition #aging #longevity #nutrition #Telomerase #TheConversation #Vitamins
https://www.diningandcooking.com/2283295/vitamin-d-may-help-slow-aging-study-finds/ -
Vitamin D May Help Slow Aging, Study Finds https://www.diningandcooking.com/2283295/vitamin-d-may-help-slow-aging-study-finds/ #aging #longevity #nutrition #Telomerase #TheConversation #Vitamins
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Vitamin D May Help Slow Aging, Study Finds https://www.diningandcooking.com/2283295/vitamin-d-may-help-slow-aging-study-finds/ #aging #longevity #nutrition #Telomerase #TheConversation #Vitamins
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"Unexpectedly, approximately 15% of the steady state population of hTR has a CR4/5 conformation lacking features required for hTERT binding. Mutagenesis demonstrates that stabilization of the alternative CR4/5 conformation is detrimental to telomerase assembly and activity. We propose that this misfolded portion of the cellular hTR pool is either slowly refolded or degraded."
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"Unexpectedly, approximately 15% of the steady state population of hTR has a CR4/5 conformation lacking features required for hTERT binding. Mutagenesis demonstrates that stabilization of the alternative CR4/5 conformation is detrimental to telomerase assembly and activity. We propose that this misfolded portion of the cellular hTR pool is either slowly refolded or degraded."
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The Advances Neuroblastoma Research meeting #anr2023 has kicked off, Lisa Werr showing the role of #telomerase / #TERT in #neuroblastoma in mice and humans in the first talk.
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@WhatisBiotechnology More on #telomerase 🧬 ⬇️
“Chemical Eye 👁️ on Motherly 👵 Love 💕” 👉 http://www.sitnews.us/MacDougall/050705_macdougall.html
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@WhatisBiotechnology More on #telomerase 🧬 ⬇️
“Chemical Eye 👁️ on Motherly 👵 Love 💕” 👉 http://www.sitnews.us/MacDougall/050705_macdougall.html
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'To study TERT deregulation and its downstream consequences, we generated a Tert mutant promoter mouse model via CRISPR/Cas9 engineering of the murine equivalent locus (Tert-123C>T) and crossed it with thyroid-specific BrafV600E-mutant mice.'
#Preprint #Telomeres #telomerase
https://www.biorxiv.org/content/10.1101/2023.01.24.525280v1?med=mas
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'To study TERT deregulation and its downstream consequences, we generated a Tert mutant promoter mouse model via CRISPR/Cas9 engineering of the murine equivalent locus (Tert-123C>T) and crossed it with thyroid-specific BrafV600E-mutant mice.'
#Preprint #Telomeres #telomerase
https://www.biorxiv.org/content/10.1101/2023.01.24.525280v1?med=mas
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A paper that I was not aware of in @embojournal that scientific editor @HVodermaier mentioned in the #telomerase independent immortalisation discussion on the latest #EMBOPodcast episode is the finding from Lackner, Karlseder et al in #EMBOJournal 2012 of a very interesting ALT system in #Celegans
🎧 to the episode
https://www.embo.org/podcasts/alternative-immortality/Read the paper (#OpenAccess)
https://www.embopress.org/doi/full/10.1038/emboj.2012.61 -
A paper that I was not aware of in @embojournal that scientific editor @HVodermaier mentioned in the #telomerase independent immortalisation discussion on the latest #EMBOPodcast episode is the finding from Lackner, Karlseder et al in #EMBOJournal 2012 of a very interesting ALT system in #Celegans
🎧 to the episode
https://www.embo.org/podcasts/alternative-immortality/Read the paper (#OpenAccess)
https://www.embopress.org/doi/full/10.1038/emboj.2012.61 -
Just Published!
"Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity"
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Just Published!
"Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity"
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The latest episode of the EMBO Podcast #EMBOPodcast is out 🎧
I spoke with Roger Reddel & Tracy Bryan at Sydney's Children's Medical Research Institute about their classic 1995 @embojournal paper describing #telomerase independent #telomere lengthening in immortalised cell lines. It challenged conventional wisdom at the time - and it was Bryan's PhD project, quite a way to get started in science.
@miguelgf provided some perspective on the work and its enduring significance and editor @HVodermaier explained #EMBOJournal's interest in studies with striking findings that may not provide a full mechanistic description.
You can listen to "ALTernative immortality" at the link below or on your preferred podcast app. Special thanks to Igor Jukic & audio producer extraordinaire @marcoantonio
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The latest episode of the EMBO Podcast #EMBOPodcast is out 🎧
I spoke with Roger Reddel & Tracy Bryan at Sydney's Children's Medical Research Institute about their classic 1995 @embojournal paper describing #telomerase independent #telomere lengthening in immortalised cell lines. It challenged conventional wisdom at the time - and it was Bryan's PhD project, quite a way to get started in science.
@miguelgf provided some perspective on the work and its enduring significance and editor @HVodermaier explained #EMBOJournal's interest in studies with striking findings that may not provide a full mechanistic description.
You can listen to "ALTernative immortality" at the link below or on your preferred podcast app. Special thanks to Igor Jukic & audio producer extraordinaire @marcoantonio
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Including comments from #telomerase researcher Miguel Godinho Ferreira at IRCAN Nice and @embojournal genome stability & dynamics editor @HVodermaier
Re-read the original article for free in our #anniversary collection:
https://www.embopress.org/page/journal/14602075/focus/40th-anniversary -
Including comments from #telomerase researcher Miguel Godinho Ferreira at IRCAN Nice and @embojournal genome stability & dynamics editor @HVodermaier
Re-read the original article for free in our #anniversary collection:
https://www.embopress.org/page/journal/14602075/focus/40th-anniversary -
#Telomeres #Telomerase #tumorigenesis #Preprint from Charles Kinzig, Titia de Lange et al
"Here, we aimed to determine whether telomerase can add telomeric DNA to DSBs in human cells and how this process is regulated. The data indicate that telomerase can create a functional neotelomere at a Cas9-induced DSB that bears the TS sequence at one 3′ end. The frequency of neotelomere formation is increased upon overexpression of telomerase, suggesting that the low level of telomerase in most human cells minimizes these deleterious events. In addition, neotelomere formation is inhibited by ATR signaling at resected DSBs. We discuss these findings in the context of genome instability during tumorigenesis, where neotelomere formation by telomerase might end BFB cycles as originally proposed by McClintock."