#spliceosome — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #spliceosome, aggregated by home.social.
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Variations in U4 and U6 snRNA genes lead to retinitis pigmentosa.
🧬 153 RP cases found with RNU4-2 and RNU6 variants in 67 families
🧬 Variants located in U4/U6 duplex's vital junction
🧬 ~1.4% of undiagnosed RP cases explained by these variants
🧬 Potential impact on tri-snRNP splicing factors#Genomics #Spliceosome #RetinitisPigmentosa #NoncodingRNA #Pub2Post
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U2 is more than just a mid band. :xenia_blep: It is a key player in biological processes and critical to life as we know it!
#biology #spliceosome -
U2 is more than just a mid band. :xenia_blep: It is a key player in biological processes and critical to life as we know it!
#biology #spliceosome -
U2 is more than just a mid band. :xenia_blep: It is a key player in biological processes and critical to life as we know it!
#biology #spliceosome -
U2 is more than just a mid band. :xenia_blep: It is a key player in biological processes and critical to life as we know it!
#biology #spliceosome -
U2 is more than just a mid band. :xenia_blep: It is a key player in biological processes and critical to life as we know it!
#biology #spliceosome -
The minor #spliceosome: Researchers reveal new structural insights into an essential #RNA-protein complex
https://phys.org/news/2025-02-minor-spliceosome-reveal-insights-essential.html
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The minor #spliceosome: Researchers reveal new structural insights into an essential #RNA-protein complex
https://phys.org/news/2025-02-minor-spliceosome-reveal-insights-essential.html
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The minor #spliceosome: Researchers reveal new structural insights into an essential #RNA-protein complex
https://phys.org/news/2025-02-minor-spliceosome-reveal-insights-essential.html
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The minor #spliceosome: Researchers reveal new structural insights into an essential #RNA-protein complex
https://phys.org/news/2025-02-minor-spliceosome-reveal-insights-essential.html
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The minor #spliceosome: Researchers reveal new structural insights into an essential #RNA-protein complex
https://phys.org/news/2025-02-minor-spliceosome-reveal-insights-essential.html
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The #spliceosome: An atomic-level look into how #cells avoid errors when manufacturing #mRNA.
https://phys.org/news/2025-02-spliceosome-atomic-cells-errors-mrna.html
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The #spliceosome: An atomic-level look into how #cells avoid errors when manufacturing #mRNA.
https://phys.org/news/2025-02-spliceosome-atomic-cells-errors-mrna.html
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The #spliceosome: An atomic-level look into how #cells avoid errors when manufacturing #mRNA.
https://phys.org/news/2025-02-spliceosome-atomic-cells-errors-mrna.html
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The #spliceosome: An atomic-level look into how #cells avoid errors when manufacturing #mRNA.
https://phys.org/news/2025-02-spliceosome-atomic-cells-errors-mrna.html
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The #spliceosome: An atomic-level look into how #cells avoid errors when manufacturing #mRNA.
https://phys.org/news/2025-02-spliceosome-atomic-cells-errors-mrna.html
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A complex #molecular machine, the #spliceosome, ensures that the #genetic information from the #genome, after being transcribed into ##mRNA precursors, is correctly assembled into mature mRNA.
#Biomolecular #Biochemistry #Genetics #sflorg
https://www.sflorg.com/2025/02/bmod02072501.html -
A complex #molecular machine, the #spliceosome, ensures that the #genetic information from the #genome, after being transcribed into ##mRNA precursors, is correctly assembled into mature mRNA.
#Biomolecular #Biochemistry #Genetics #sflorg
https://www.sflorg.com/2025/02/bmod02072501.html -
A complex #molecular machine, the #spliceosome, ensures that the #genetic information from the #genome, after being transcribed into ##mRNA precursors, is correctly assembled into mature mRNA.
#Biomolecular #Biochemistry #Genetics #sflorg
https://www.sflorg.com/2025/02/bmod02072501.html -
A complex #molecular machine, the #spliceosome, ensures that the #genetic information from the #genome, after being transcribed into ##mRNA precursors, is correctly assembled into mature mRNA.
#Biomolecular #Biochemistry #Genetics #sflorg
https://www.sflorg.com/2025/02/bmod02072501.html -
A complex #molecular machine, the #spliceosome, ensures that the #genetic information from the #genome, after being transcribed into ##mRNA precursors, is correctly assembled into mature mRNA.
#Biomolecular #Biochemistry #Genetics #sflorg
https://www.sflorg.com/2025/02/bmod02072501.html -
When your body turns your DNA into one of many alternate protein forms, it uses this finely tuned biomachinery for a rope dance with the mRNA strand to carry out very coordinated cuts and joins.
Absolutely incredible to see it animated with this level of detail :0
#RNA #spliceosome #structuralbiology #animation #exons #introns #alessoninthelariat
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When your body turns your DNA into one of many alternate protein forms, it uses this finely tuned biomachinery for a rope dance with the mRNA strand to carry out very coordinated cuts and joins.
Absolutely incredible to see it animated with this level of detail :0
#RNA #spliceosome #structuralbiology #animation #exons #introns #alessoninthelariat
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When your body turns your DNA into one of many alternate protein forms, it uses this finely tuned biomachinery for a rope dance with the mRNA strand to carry out very coordinated cuts and joins.
Absolutely incredible to see it animated with this level of detail :0
#RNA #spliceosome #structuralbiology #animation #exons #introns #alessoninthelariat
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When your body turns your DNA into one of many alternate protein forms, it uses this finely tuned biomachinery for a rope dance with the mRNA strand to carry out very coordinated cuts and joins.
Absolutely incredible to see it animated with this level of detail :0
#RNA #spliceosome #structuralbiology #animation #exons #introns #alessoninthelariat
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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"Evidence implicates..catalytic activity of the intron lariat spliceosome (ILS) in which the 3′-OH of the lariat tail... attacks the branch, joining the intron 3′ end to the 5′ splice site in a 3′–5′ linked circle. Human U2 and U12 spliceosomes produce analogous full-length and processed circles. Postsplicing catalytic activity of the #spliceosome may promote #intron transposition during eukaryotic #genome #evolution."
http://m.genesdev.cshlp.org/content/early/2024/05/09/gad.351764.124
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"Evidence implicates..catalytic activity of the intron lariat spliceosome (ILS) in which the 3′-OH of the lariat tail... attacks the branch, joining the intron 3′ end to the 5′ splice site in a 3′–5′ linked circle. Human U2 and U12 spliceosomes produce analogous full-length and processed circles. Postsplicing catalytic activity of the #spliceosome may promote #intron transposition during eukaryotic #genome #evolution."
http://m.genesdev.cshlp.org/content/early/2024/05/09/gad.351764.124
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"Evidence implicates..catalytic activity of the intron lariat spliceosome (ILS) in which the 3′-OH of the lariat tail... attacks the branch, joining the intron 3′ end to the 5′ splice site in a 3′–5′ linked circle. Human U2 and U12 spliceosomes produce analogous full-length and processed circles. Postsplicing catalytic activity of the #spliceosome may promote #intron transposition during eukaryotic #genome #evolution."
http://m.genesdev.cshlp.org/content/early/2024/05/09/gad.351764.124
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"Evidence implicates..catalytic activity of the intron lariat spliceosome (ILS) in which the 3′-OH of the lariat tail... attacks the branch, joining the intron 3′ end to the 5′ splice site in a 3′–5′ linked circle. Human U2 and U12 spliceosomes produce analogous full-length and processed circles. Postsplicing catalytic activity of the #spliceosome may promote #intron transposition during eukaryotic #genome #evolution."
http://m.genesdev.cshlp.org/content/early/2024/05/09/gad.351764.124
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"Evidence implicates..catalytic activity of the intron lariat spliceosome (ILS) in which the 3′-OH of the lariat tail... attacks the branch, joining the intron 3′ end to the 5′ splice site in a 3′–5′ linked circle. Human U2 and U12 spliceosomes produce analogous full-length and processed circles. Postsplicing catalytic activity of the #spliceosome may promote #intron transposition during eukaryotic #genome #evolution."
http://m.genesdev.cshlp.org/content/early/2024/05/09/gad.351764.124
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Newly identified #protein helps #flowers develop properly.
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Newly identified #protein helps #flowers develop properly.
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Team discovers mechanism that protects tissue after faulty #gene #expression.
https://phys.org/news/2024-02-team-mechanism-tissue-faulty-gene.html
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Team discovers mechanism that protects tissue after faulty #gene #expression.
https://phys.org/news/2024-02-team-mechanism-tissue-faulty-gene.html
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Researchers study role of #post_transcriptional #splicing in #plant response to #light.
#spliceosome #AtPRMT5 #photosynthesis
https://phys.org/news/2024-02-role-transcriptional-splicing-response.html
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#CryoEM models of spliceosomal complexes containing Prp16 show it in its nucleotide-free state: here the first structure of Prp16 in complex with a nucleotide is presented.
@unigoettingen
@ActaCrystF
@IUCr
#DEAHBoxHelicases #Prp16 #spliceosome https://doi.org/10.1107/S2053230X23005721 -
#CryoEM models of spliceosomal complexes containing Prp16 show it in its nucleotide-free state: here the first structure of Prp16 in complex with a nucleotide is presented.
@unigoettingen
@ActaCrystF
@IUCr
#DEAHBoxHelicases #Prp16 #spliceosome https://doi.org/10.1107/S2053230X23005721 -
LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis
Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8
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LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis
Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8
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LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis
Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8
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LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis
Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8
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Excited to announce Eterna has launched our new OpenASO project in collaboration with the Sanford and Stone Labs at UC Santa Cruz.
Our players will be designing short pieces of #RNA to restore proper splicing in pre-mRNA mutated by #genetic disease and learn more about #exon definition.
https://www.youtube.com/watch?v=Iq57MTprHV0
#chemistry #biochemistry #raredisease #hemophilia #spliceosome #crowdsourcing #citizenscience
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Excited to announce Eterna has launched our new OpenASO project in collaboration with the Sanford and Stone Labs at UC Santa Cruz.
Our players will be designing short pieces of #RNA to restore proper splicing in pre-mRNA mutated by #genetic disease and learn more about #exon definition.
https://www.youtube.com/watch?v=Iq57MTprHV0
#chemistry #biochemistry #raredisease #hemophilia #spliceosome #crowdsourcing #citizenscience
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Have any antisense oligonucleotide #ASO experts made it onto mastodon?
I'm trying to find evidence on how much of a role #intron secondary structure remediation plays in splice-switching ASO design. A presentation by an ASO researcher from a biotech stated that the #spliceosome recognizes intron #secstruct, particularly the intron 5' structure, but haven't found published evidence or hypothesis.
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Have any antisense oligonucleotide #ASO experts made it onto mastodon?
I'm trying to find evidence on how much of a role #intron secondary structure remediation plays in splice-switching ASO design. A presentation by an ASO researcher from a biotech stated that the #spliceosome recognizes intron #secstruct, particularly the intron 5' structure, but haven't found published evidence or hypothesis.
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Have any antisense oligonucleotide #ASO experts made it onto mastodon?
I'm trying to find evidence on how much of a role #intron secondary structure remediation plays in splice-switching ASO design. A presentation by an ASO researcher from a biotech stated that the #spliceosome recognizes intron #secstruct, particularly the intron 5' structure, but haven't found published evidence or hypothesis.