#spliceosome — Public Fediverse posts

U2 is more than just a mid band. ​:xenia_blep:​ It is a key player in biological processes and critical to life as we know it!
#biology #spliceosome

Biologists discover a new type of control over #RNA #splicing

#spliceosome #U1 #snRNA #LUC7

https://phys.org/news/2025-02-biologists-rna-splicing.html

The minor #spliceosome: Researchers reveal new structural insights into an essential #RNA-protein complex

https://phys.org/news/2025-02-minor-spliceosome-reveal-insights-essential.html

The #spliceosome: An atomic-level look into how #cells avoid errors when manufacturing #mRNA.

https://phys.org/news/2025-02-spliceosome-atomic-cells-errors-mrna.html

A complex #molecular machine, the #spliceosome, ensures that the #genetic information from the #genome, after being transcribed into ##mRNA precursors, is correctly assembled into mature mRNA.
#Biomolecular #Biochemistry #Genetics #sflorg
https://www.sflorg.com/2025/02/bmod02072501.html

When your body turns your DNA into one of many alternate protein forms, it uses this finely tuned biomachinery for a rope dance with the mRNA strand to carry out very coordinated cuts and joins.

https://youtu.be/OuAGeQYjfus

Absolutely incredible to see it animated with this level of detail :0

#RNA #spliceosome #structuralbiology #animation #exons #introns #alessoninthelariat

"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA

https://www.nature.com/articles/s41467-024-48697-0

"Evidence implicates..catalytic activity of the intron lariat spliceosome (ILS) in which the 3′-OH of the lariat tail... attacks the branch, joining the intron 3′ end to the 5′ splice site in a 3′–5′ linked circle. Human U2 and U12 spliceosomes produce analogous full-length and processed circles. Postsplicing catalytic activity of the #spliceosome may promote #intron transposition during eukaryotic #genome #evolution."

http://m.genesdev.cshlp.org/content/early/2024/05/09/gad.351764.124

Researchers study role of #post_transcriptional #splicing in #plant response to #light.

#spliceosome #AtPRMT5 #photosynthesis

https://phys.org/news/2024-02-role-transcriptional-splicing-response.html

LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis

Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8

https://www.embopress.org/doi/10.15252/embj.2022110921

Have any antisense oligonucleotide #ASO experts made it onto mastodon?

I'm trying to find evidence on how much of a role #intron secondary structure remediation plays in splice-switching ASO design. A presentation by an ASO researcher from a biotech stated that the #spliceosome recognizes intron #secstruct, particularly the intron 5' structure, but haven't found published evidence or hypothesis.

#premRNA #splicing