#lncrna — Public Fediverse posts

Unser Heft 11/2024 ist draußen!

Mit großem Special "Stammzell-#Forschung"

Außerdem:
- #Corona-#Impfstoff;
- Kontroverse #UMAP-Plots;
- #Forschungskandale;
- #Krebsforschung;
- #lncRNA;
- #Protein-#Sequenzierung;
- #Antibiotika-Inkubator
- u.v.m.

Das ganze Heft online: https://www.laborjournal.de/rubric/aktuell/index.php

Plant shade avoidance syndrome is controlled by APOLO #lncRNA regulation of #auxin-related genes in #Arabidopsis
Federico Ariel and colleagues
https://www.embopress.org/doi/full/10.15252/embj.2023113941

Cool story: xenografting of human #neurons into mouse #Alzheimers model resulted in their death by #necroptosis. This process involves #lncRNA MEG3, possibly via TNF inflammatory signaling. This study revealed human-specific vulnerability in AD.
#neuroscience
https://www.science.org/doi/10.1126/science.abp9556

We are pleased to announce that registration to this year's annual meeting in memory of Prof. Yossi Sperling is now open, at the link below. The meeting will take place in the Lopatie Hall at the Weizmann Institute on 16 Oct, 2023. We will be celebrating local RNA science, and enjoy contributions from our two wonderful keynote speakers for this year - Marvin Tannenabum and Christin Mayr (see attached poster)

#RNA #mRNA #lncRNA #translation #splicing #transcription

https://erez.weizmann.ac.il/apx/r/ws1/101/101/?P101_PKNS_CODE=2604

LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis

Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8

https://www.embopress.org/doi/10.15252/embj.2022110921

A new paper from @wu_xuebing 's lab just published @Nature
"Noncoding translation mitigation"

https://www.nature.com/articles/s41586-023-05946-4

Here are my thoughts:
It is a very interesting paper, and important to anyone working on #translation, particularly from #ncRNAs, but not only.
In brief, they screened short sequences originating from #lncRNA or from non coding regions ( #UTR #intron) (and #mRNA CDS as control) which they fused to GFP at the C-term and looked at GFP expression level.
>>

#LncRNA LITATS1 suppresses #TGF-β-induced #EMT and #cancer cell plasticity by potentiating TβRI degradation

Chuannan Fan, Peter ten Dijke et al

https://www.embopress.org/doi/10.15252/embj.2022112806

This is neat!
A paper in @eLife from Anne-Catherine Prats lab (U Toulouse) looking at #IRES regulation.
They show that #mRNA with IRES in #cardiomyocytes interactes with #lncRNA NEAT1 in nuclear paraspeckles, and suggest an assembly of an "IRESome" -with paraspeckle-related proteins - that regulates IRES-dependent translation (here - upon hypoxia).

https://elifesciences.org/articles/69162

How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT

How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT

How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT