#lncrna — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #lncrna, aggregated by home.social.
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#Makrophagen sind die „Fresszellen“ des #Immunsystems, doch manche Erreger machen sich gerade diese Zellen als Versteck zunutze. Ein Team des @Helmholtz_HIRI hat mit Partnern nun eine #RNA gefunden, die ein "Notausschalter" für infizierte Immunzellen ist. #lncRNA
https://www.helmholtz-hzi.de/media-center/newsroom/news-detailseite/notausschalter-fuer-fresszellen/ -
#Makrophagen sind die „Fresszellen“ des #Immunsystems, doch manche Erreger machen sich gerade diese Zellen als Versteck zunutze. Ein Team des @Helmholtz_HIRI hat mit Partnern nun eine #RNA gefunden, die ein "Notausschalter" für infizierte Immunzellen ist. #lncRNA
https://www.helmholtz-hzi.de/media-center/newsroom/news-detailseite/notausschalter-fuer-fresszellen/ -
Unser Heft 11/2024 ist draußen!
Mit großem Special "Stammzell-#Forschung"
Außerdem:
- #Corona-#Impfstoff;
- Kontroverse #UMAP-Plots;
- #Forschungskandale;
- #Krebsforschung;
- #lncRNA;
- #Protein-#Sequenzierung;
- #Antibiotika-Inkubator
- u.v.m.Das ganze Heft online: https://www.laborjournal.de/rubric/aktuell/index.php
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Unser Heft 11/2024 ist draußen!
Mit großem Special "Stammzell-#Forschung"
Außerdem:
- #Corona-#Impfstoff;
- Kontroverse #UMAP-Plots;
- #Forschungskandale;
- #Krebsforschung;
- #lncRNA;
- #Protein-#Sequenzierung;
- #Antibiotika-Inkubator
- u.v.m.Das ganze Heft online: https://www.laborjournal.de/rubric/aktuell/index.php
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Expanding and Enriching the LncRNA Gene–Disease Landscape Using the GeneCaRNA Database. https://doi.org/10.3390/biomedicines12061305 #NonCodingRna #LongNonCodingRna #HumanNoncodingRna #Ncrna #Lncrna
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Expanding and Enriching the LncRNA Gene–Disease Landscape Using the GeneCaRNA Database. https://doi.org/10.3390/biomedicines12061305 #NonCodingRna #LongNonCodingRna #HumanNoncodingRna #Ncrna #Lncrna
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I’m happy to share our preprint
“Flawed machine-learning confounds coding sequence annotation“
https://doi.org/10.1101/2024.05.16.594598
A collaboration with @OtagoBiochemist and @plantandfood scientists @mikblacknz @TingHsuanTHC #Genomics #Bioinformatics #ncRNA #lncRNA #protein 1/n -
I’m happy to share our preprint
“Flawed machine-learning confounds coding sequence annotation“
https://doi.org/10.1101/2024.05.16.594598
A collaboration with @OtagoBiochemist and @plantandfood scientists @mikblacknz @TingHsuanTHC #Genomics #Bioinformatics #ncRNA #lncRNA #protein 1/n -
A new tool for #plant long non-coding #RNA identification.
https://phys.org/news/2024-05-tool-coding-rna-identification.html
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#CRISPRlnc: New #lncRNA-specific #SgRNA design method proposed.
https://phys.org/news/2024-03-crisprlnc-lncrna-specific-sgrna-method.html
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Plant shade avoidance syndrome is controlled by APOLO #lncRNA regulation of #auxin-related genes in #Arabidopsis
Federico Ariel and colleagues
https://www.embopress.org/doi/full/10.15252/embj.2023113941 -
Plant shade avoidance syndrome is controlled by APOLO #lncRNA regulation of #auxin-related genes in #Arabidopsis
Federico Ariel and colleagues
https://www.embopress.org/doi/full/10.15252/embj.2023113941 -
🥳 Happy to share the publication of the last part of Thomas Roule's Ph.D. at IPS2 on the role of ARES #lncRNA 🧬 in the modulation of Arabidopsis 🌱 root architecture. https://doi.org/10.1002/iub.2761
A great collaboration with the group of Federico Ariel 🧪
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Cool story: xenografting of human #neurons into mouse #Alzheimers model resulted in their death by #necroptosis. This process involves #lncRNA MEG3, possibly via TNF inflammatory signaling. This study revealed human-specific vulnerability in AD.
#neuroscience
https://www.science.org/doi/10.1126/science.abp9556 -
Just Published!
Structure and Function of the H19 Long Non-coding RNA in Cancer
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Just Published!
Structure and Function of the H19 Long Non-coding RNA in Cancer
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#LncRNA NRON promotes #tumorigenesis by regulating #MDM2/#MDMX heterodimerization and enhancing their #ubiquitin-dependent degradation of multiple #tumorsuppressor proteins
Erwei Song, Man-Li Luo and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022112414 -
#LncRNA NRON promotes #tumorigenesis by regulating #MDM2/#MDMX heterodimerization and enhancing their #ubiquitin-dependent degradation of multiple #tumorsuppressor proteins
Erwei Song, Man-Li Luo and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022112414 -
We are pleased to announce that registration to this year's annual meeting in memory of Prof. Yossi Sperling is now open, at the link below. The meeting will take place in the Lopatie Hall at the Weizmann Institute on 16 Oct, 2023. We will be celebrating local RNA science, and enjoy contributions from our two wonderful keynote speakers for this year - Marvin Tannenabum and Christin Mayr (see attached poster)
#RNA #mRNA #lncRNA #translation #splicing #transcriptionhttps://erez.weizmann.ac.il/apx/r/ws1/101/101/?P101_PKNS_CODE=2604
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LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis
Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8
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LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis
Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8
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A new paper from @wu_xuebing 's lab just published @Nature
"Noncoding translation mitigation"https://www.nature.com/articles/s41586-023-05946-4
Here are my thoughts:
It is a very interesting paper, and important to anyone working on #translation, particularly from #ncRNAs, but not only.
In brief, they screened short sequences originating from #lncRNA or from non coding regions ( #UTR #intron) (and #mRNA CDS as control) which they fused to GFP at the C-term and looked at GFP expression level.
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@marcrr “Over 20 years after the original publication of the human genome, the number of protein-coding genes is stabilizing around 19,500, although the number of isoforms of these genes is still a subject of intensive study and discussion. …
In contrast, noncoding RNA genes, particularly lncRNAs, are at an earlier stage of understanding, and are still increasing in number, with current catalogs containing 17,000-20,000 lncRNAs or more.”
#genetics #lncRNA #genes -
'When presented to the immune system as either ex vivo-loaded dendritic cells or expressed from a viral vector, lncRNA-derived peptides drove a potent antigen-specific CD8 T lymphocyte response, which translated into a significant delay in tumour growth.'
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'When presented to the immune system as either ex vivo-loaded dendritic cells or expressed from a viral vector, lncRNA-derived peptides drove a potent antigen-specific CD8 T lymphocyte response, which translated into a significant delay in tumour growth.'
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This is neat!
A paper in @eLife from Anne-Catherine Prats lab (U Toulouse) looking at #IRES regulation.
They show that #mRNA with IRES in #cardiomyocytes interactes with #lncRNA NEAT1 in nuclear paraspeckles, and suggest an assembly of an "IRESome" -with paraspeckle-related proteins - that regulates IRES-dependent translation (here - upon hypoxia). -
Ein neuer Mechanismus, wie Gene entstehen, spielte bei der Entwicklung des menschlichen Gehirns eine Schlüsselrolle. Entscheidend dafür war eine neue Rolle der RNA.
Umfunktionierte RNA ließ das menschliche Gehirn wachsen
#RNA #Gehirn #Hirnentwicklung #Evolution #Zellkern #Gene #Genregulation #Spleißen #Lncrna #Mrna #PsychologieHirnforschung -
Ein neuer Mechanismus, wie Gene entstehen, spielte bei der Entwicklung des menschlichen Gehirns eine Schlüsselrolle. Entscheidend dafür war eine neue Rolle der RNA.
Umfunktionierte RNA ließ das menschliche Gehirn wachsen
#RNA #Gehirn #Hirnentwicklung #Evolution #Zellkern #Gene #Genregulation #Spleißen #Lncrna #Mrna #PsychologieHirnforschung -
The post below reminded me of a visit to the HQ of IonTorrent, then in beta stage
The building was RIGHT on Long Island sound, with a spectacular view
The road crossed a bridge that was slanted and underwater at high tidehttps://vis.social/@[email protected]ston/109563813071400521
#labwork #ngs #molecularbio #sequencing #transcriptomics #lncRNA #epigenetic
#bioinformatics #NGS -
After some ☕, we carry on with the talk of our own #RegRNALab member, Dr. Jose Antonio Corona (@[email protected]) talking about his work on the conservation of #lncRNA structure in plants 🌱. #AcademicDays2022
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After some ☕, we carry on with the talk of our own #RegRNALab member, Dr. Jose Antonio Corona (@[email protected]) talking about his work on the conservation of #lncRNA structure in plants 🌱. #AcademicDays2022
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More than time for an #introduction.
I am a #CNRS researcher working at IPS2 (Université Paris-Saclay, 🇫🇷 ) interested in long non-coding RNAs (#lncRNAs) and how they regulate other genes and could provide adaptative behaviour to #plants (🌱, 🍅).
I combine different #quantitative 📈 approaches spanning several scales such as molecular biology 🧬🥼, #genomics, #ImageAnalysis 🔬🎥📷 .
Expect scientific toots covering #lncRNA #GeneRegulation #epigenetic #root #bioinformatics #transcriptomics #LabLife
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More than time for an #introduction.
I am a #CNRS researcher working at IPS2 (Université Paris-Saclay, 🇫🇷 ) interested in long non-coding RNAs (#lncRNAs) and how they regulate other genes and could provide adaptative behaviour to #plants (🌱, 🍅).
I combine different #quantitative 📈 approaches spanning several scales such as molecular biology 🧬🥼, #genomics, #ImageAnalysis 🔬🎥📷 .
Expect scientific toots covering #lncRNA #GeneRegulation #epigenetic #root #bioinformatics #transcriptomics #LabLife
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How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
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How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
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How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
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How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
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How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
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How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT