#introns — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #introns, aggregated by home.social.
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When your body turns your DNA into one of many alternate protein forms, it uses this finely tuned biomachinery for a rope dance with the mRNA strand to carry out very coordinated cuts and joins.
Absolutely incredible to see it animated with this level of detail :0
#RNA #spliceosome #structuralbiology #animation #exons #introns #alessoninthelariat
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"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
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Long-standing #genomics mystery about the origins of #introns explained in new study
https://phys.org/news/2022-11-long-standing-genomic-mystery-introns.html#TransposableElements drive #intron gain in diverse eukaryotes https://www.pnas.org/doi/10.1073/pnas.2209766119
The researchers believe that #introners (specialized #transposons) are the only likely explanation for intron burst events, in which thousands of introns show up in a #genome seemingly all at once, and they find evidence of this in species across the eukaryotic tree of life.