#sk — Public Fediverse posts

https://www.europesays.com/sk/150166/ Ministerstvo životného prostredia ohrozuje záväzky Slovenska voči EÚ #Košice #SK #Slovak #Slovakia #Slovenčina #Slovensko

https://www.europesays.com/sk/150164/ Slovenský metrologický ústav sa ohradil voči slovám Matúša Šutaja Eštoka #Headlines #HlavnéSprávy #News #SK #Slovak #Slovakia #Slovenčina #Slovensko #Správy #Titulky #TopStories

https://www.europesays.com/sk/150162/ Perzeidy 2026 prichádzajú! Táto noc bude extra dobrá- TECHBOX.sk #SK #Slovak #SlovakRepublic #Slovakia #Slovenčina #SlovenskáRepublika #Slovensko #vesmír

https://www.europesays.com/sk/150160/ Zrútil sa armádny vrtuľník: Tragická smrť posádky a plamene pri obytných domoch! #News #SK #Slovak #Slovenčina #Správy #Svet #World #WorldNews

https://www.europesays.com/sk/150158/ Európa starne. Kto bude o 20 rokov platiť naše dôchodky? #DemografickáSituácia #DemografickéZmeny #dôchodok #Ekonomika #EU #Európa #Europe #SK #Slovak #Slovenčina

https://www.europesays.com/sk/150156/ Carey Price – Montreal patrí medzi uchádzačov o Stanley Cup / NHL #CareyPrice #MontrealCanadiens #NHL #SK #Slovak #Slovakia #Slovenčina #Slovensko #Šport #Sports

https://www.europesays.com/sk/150154/ Krásna influencerka († 25) spáchala samovraždu počas živého vysielania: Jej rodina posiela odkaz, ktorý by si mali prečítať všetci! #Entertainment #SK #Slovak #Slovakia #Slovenčina #Slovensko #Zábava

https://www.europesays.com/sk/150152/ Meninová pesnička: ĽUBOMÍR | Fun rádio #Entertainment #Hudba #Music #SK #Slovak #Slovakia #Slovenčina #Slovensko #Zábava

https://www.europesays.com/sk/150150/ Belgičan Doku predĺžil zmluvu s Manchestrom City. Na ako dlho? #Bratislava #SK #Slovak #Slovakia #Slovenčina #Slovensko

https://www.europesays.com/sk/150146/ Archeológovia hľadajú v Čertovej peci posledných neandertálcov #archeológovia #ČertovaPec #neandrtálci #Radošina #SK #Slovak #SlovakRepublic #Slovakia #Slovenčina #SlovenskáRepublika #Slovensko #zaujimavosti

https://www.europesays.com/sk/150144/ Prebudenie polárneho medveďa ho stálo draho. Prečo za obyčajné zatrúbenie prišiel taký vysoký trest? – Svet – Správy #News #SK #Slovak #Slovenčina #Správy #Svet #World #WorldNews

https://www.europesays.com/sk/150142/ ME v atletike 2026: Nórska štafeta odmietla zlaté medaily #SK #Slovak #Slovakia #Slovenčina #Slovensko #Šport #Sports

https://www.europesays.com/sk/150140/ Rok po smrti hviezdy zo Šou Billa Cosbyho boj o majetok neutícha: Vdova zostala na mizine a ešte aj toto! #BojOPeniaze #dedičstvo #Entertainment #MalcolJamalWarner #SK #Slovak #Slovakia #Slovenčina #Slovensko #SmrťHerca #SporSoSvokrou #Zábava

Can Micron’s AI Memory Focus Help It Outpace SK Hynix and Sandisk? – August 13, 2026

Key Takeaways Micron’s fiscal Q3 2026 revenues surged 346% year over year to $41.46 billion amid strong AI…
#EuropeSays #Korea #KR #SK #financial #financialplanning #investing #investment #investmentadvice #onlineinvestment #onlinestocktrading #onlinetrading #quote #quotes #SKGroup #stock #stockmarket #stockquotes #stocks
https://www.europesays.com/korea/118208/

https://www.europesays.com/sk/150138/ Petržalka začala s komplexnou obnovou bytového domu na Medveďovej #Bratislava #bytový #dom #komplexná #obnova #Petržalka #SK #Slovak #Slovakia #Slovenčina #Slovensko

https://www.europesays.com/sk/150136/ Izraelská armáda zadržala palestínskeho novinára podozrivého z podpory Hamasu #Košice #SK #Slovak #Slovakia #Slovenčina #Slovensko

https://www.europesays.com/sk/150134/ Slávny herec (58) čaká tretie dieťa: Paparazzi FOTO vás pobavia! #Headlines #HlavnéSprávy #JamieFoxx #News #SK #Slovak #Slovakia #Slovenčina #Slovensko #Správy #Titulky #TopStories

https://www.europesays.com/sk/150132/ MŽP zachová iba jednu akceleračnú zónu na východe SR, rozdelí ju na dve #AkceleračnáZóna #MinisterstvoživotnéhoProstredia(MŽP)SR #SK #Slovak #SlovakRepublic #Slovakia #Slovenčina #SlovenskáRepublika #Slovensko #TomášTaraba #VeternéParky

https://www.europesays.com/sk/150130/ Najkrajšia farba nechtov konca leta? Tento jemný odtieň vytláča klasické nude tóny #dokonalosť #krása #lak #leto #Leto2026 #manikúra #nechty #News #odtiene #SK #Slovak #Slovenčina #Správy #Svet #trendy #World #WorldNews #žena

SK Hynix’s Korean workers launch unified union amid stalled wage talks

SEOUL, Aug 13 : Workers at SK Hynix on Thursday launched a new labour union in South Korea,…
#EuropeSays #Korea #KR #SKHynix #SK #SKhynix
https://www.europesays.com/korea/118198/

https://www.europesays.com/sk/150128/ ME v atletike 2026: Ján Volko nepostúpil z rozbehov na 200 m (výsledky) #SK #Slovak #Slovakia #Slovenčina #Slovensko #Šport #Sports

https://www.europesays.com/sk/150126/ Biedny dôchodok Jozefa Golonku? Legenda to nenechá len tak: Má tajný plán, ktorý nikto nečakal #Entertainment #SK #Slovak #Slovakia #Slovenčina #Slovensko #Zábava

https://www.europesays.com/sk/150124/ Cez víkend budú dopravné obmedzenia na Jarošovej v Bratislave #BAX #Bratislava #polícia #SK #Slovak #Slovakia #Slovenčina #Slovensko #SR #VZI

SK’s Yoon to Lead SK hynix Global Growth Push

Yoon Poong-young, president of SK’s SUPEX Council, has been appointed to lead a dedicated unit at SK hynix…
#EuropeSays #Korea #KR #SK #AIDataCenters #GlobalGrowthTaskForce #Nasdaqlisting #PenguinSolutions #SKGroup #SKhynix #SKSquare #YoonPoong-young
https://www.europesays.com/korea/118178/

https://www.europesays.com/sk/150120/ Najvyššia kvalita života na Slovensku je v malej obci (REBRÍČEK) #Bratislava #Kvalitaživota #obce #SK #Slovak #SlovakRepublic #Slovakia #Slovenčina #SlovenskáRepublika #Slovensko

https://www.europesays.com/sk/150118/ Prúd z motorov lietadla zmietol turistku na Skiathose, vážne sa zranila #grécko #letisko #lietadlo #News #SK #Skiathos #Slovak #Slovenčina #Správy #štart #Svet #turisti #World #WorldNews

https://www.europesays.com/sk/150116/ ME v atletike 2026: Emma Zapletalová reaguje po zisku zlatej medaily #SK #Slovak #Slovakia #Slovenčina #Slovensko #Šport #Sports

https://www.europesays.com/sk/150114/ Silný odkaz Jána Dobríka po synovej chorobe: Niekto sa vôbec nedokázal o tom rozprávať, opýtať… #Entertainment #SK #Slovak #Slovakia #Slovenčina #Slovensko #Zábava

Samsung Electronics, SK Hynix Extend Rebound to Third Day as Foreign Investors Return

Forecast Trend Report by Period See more mid- to long-term trend analysis‘Excessive selloff’ view gains traction as Samsung…
#EuropeSays #Korea #KR #SKHynix #bitcoin #bitcoincommunity #blockchain #bloomingbit #coincommunity #coininfo #coininvest #coinnews #coinreview #coinstats #cryptocurrency #ethereum #SK #SKhynix #solana
https://www.europesays.com/korea/118170/

https://www.europesays.com/sk/150112/ Výluka na Špitálskej sa predlžuje. Potrvá až do 28. augusta #Bratislava #doprava #DopravaVŽiline #DopravaŽilina #DopravnýServisŽilina #HliadkyŽilina #KolónaStrečno #KolónaŽilina #NehodaStrečno #NehodaVŽiline #NehodaŽilina #ObmedzenieŽilina #PolicajnéHliadkyARadaryŽilina #SK #Slovak #Slovakia #Slovenčina #Slovensko #UzávierkaŽilina #UzavretáCestaŽilina

Random bird observation: I saw a tiny, tiny bird land on the rim of a flowerpot outside my kitchen window that I don't recall seeing before. Looking through the usual references for southern Saskatchewan, it appears to have been an American Redstart. Doesn't even ring a bell.

#Redstart #AmericanRedstart #SK #bird

Random bird observation: I saw a tiny, tiny bird land on the rim of a flowerpot outside my kitchen window that I don't recall seeing before. Looking through the usual references for southern Saskatchewan, it appears to have been an American Redstart. Doesn't even ring a bell.

#Redstart #AmericanRedstart #SK #bird

Random bird observation: I saw a tiny, tiny bird land on the rim of a flowerpot outside my kitchen window that I don't recall seeing before. Looking through the usual references for southern Saskatchewan, it appears to have been an American Redstart. Doesn't even ring a bell.

#Redstart #AmericanRedstart #SK #bird

Random bird observation: I saw a tiny, tiny bird land on the rim of a flowerpot outside my kitchen window that I don't recall seeing before. Looking through the usual references for southern Saskatchewan, it appears to have been an American Redstart. Doesn't even ring a bell.

#Redstart #AmericanRedstart #SK #bird

DATE: August 8, 2026 at 02:00PM
SOURCE: PSYPOST.ORG

** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------

TITLE: Foldable synthetic molecules could infiltrate and bust apart the toxic protein clumps causing Parkinson’s

URL: https://www.psypost.org/foldable-synthetic-molecules-could-infiltrate-and-bust-apart-the-toxic-protein-clumps-causing-parkinsons/

Current therapies for Parkinson’s disease and related conditions primarily treat symptoms but don’t stop the underlying process causing the disease.

Increasing evidence suggests that toxic clumps of proteins called alpha-synuclein are among the primary drivers of damage to neurons. My team and I developed a synthetic molecule that can block these proteins from clumping and spreading in the brains of mice, ultimately reducing symptoms of disease.

This molecule, called SK-129, acts like a molecular brace: It binds to several parts of alpha-synuclein and holds the protein in a shape that makes it less likely to stick to other ones. It binds especially strongly to early forms of these toxic clumps, preventing them from growing and forming new ones.

Why it matters

Beyond SK-129, our research highlights the broader potential of the class of molecules to which it belongs: foldamers.

Foldamers are laboratory-designed molecules that fold into predictable shapes, much like natural proteins. Because they’re so stable, scientists can tailor them to recognize and bind to specific biological targets.

Alpha-synuclein make up the Lewy bodies (darker spots) that form in neurons in Parkinson’s.
Suraj Rajan/Wikimedia Commons, CC BY-SA

This versatility is particularly important, because many proteins involved in neurodegenerative diseases have long been considered “undruggable.” Unlike other disease proteins with pockets that conventional drugs can bind to, proteins involved in neurodegenerative diseases, such as alpha-synuclein, are highly flexible and lack well-defined binding sites. Synthetic foldamers offer larger surfaces that can engage these difficult targets and disrupt the abnormal protein interactions that lead to toxic aggregation.

Foldamers could open new treatment avenues not only for Parkinson’s disease, but also for other neurodegenerative disorders driven by toxic protein aggregation, including Alzheimer’s disease and ALS.

What still isn’t known

Although SK-129 showed strong promise in its ability to target Parkinson’s in cell and animal models, we have yet to test its effectiveness in people.

Important questions remain regarding its long-term safety, optimal dosing and how it travels through and interacts with the human body. Additional studies are needed to understand how the molecule works and how to further optimize it to stop or slow Parkinson’s disease from worsening in people.

More broadly, researchers are still working to fully understand how different forms of alpha-synuclein drive neurodegeneration and disease spread. My team is also investigating how selectively targeting these toxic protein clumps influences their spread, inflammation in the nervous system and brain cell survival across different brain regions.

What other research is being done

Researchers are actively developing other therapies that target the toxic alpha-synuclein clumps that cause Parkinson’s and related diseases.

These approaches include molecules designed to clear these protein clumps or reduce their production, as well as molecules that can stop them from aggregating. Several of these strategies have advanced into clinical trials.

Each major approach to treatment has important limitations. Some struggle to selectively bind to the toxic proteins, while others are unable to penetrate the brain.

Through the collaboration of neuroscientists, biophysicists, clinicians and translational researchers, researchers like me hope to develop new ways to treat diseases that conventional drugs haven’t been able to before.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

URL: https://www.psypost.org/foldable-synthetic-molecules-could-infiltrate-and-bust-apart-the-toxic-protein-clumps-causing-parkinsons/

-------------------------------------------------

Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org

Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot

-------------------------------------------------

#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #ParkinsonsDisease #alphaSynuclein #foldamers #SK-129 #proteinAggregation #neurodegeneration #drugdesign #clinicaltrials #neuroscience #neuroprotectiveCOURSE

DATE: August 8, 2026 at 02:00PM
SOURCE: PSYPOST.ORG

** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------

TITLE: Foldable synthetic molecules could infiltrate and bust apart the toxic protein clumps causing Parkinson’s

URL: https://www.psypost.org/foldable-synthetic-molecules-could-infiltrate-and-bust-apart-the-toxic-protein-clumps-causing-parkinsons/

Current therapies for Parkinson’s disease and related conditions primarily treat symptoms but don’t stop the underlying process causing the disease.

Increasing evidence suggests that toxic clumps of proteins called alpha-synuclein are among the primary drivers of damage to neurons. My team and I developed a synthetic molecule that can block these proteins from clumping and spreading in the brains of mice, ultimately reducing symptoms of disease.

This molecule, called SK-129, acts like a molecular brace: It binds to several parts of alpha-synuclein and holds the protein in a shape that makes it less likely to stick to other ones. It binds especially strongly to early forms of these toxic clumps, preventing them from growing and forming new ones.

Why it matters

Beyond SK-129, our research highlights the broader potential of the class of molecules to which it belongs: foldamers.

Foldamers are laboratory-designed molecules that fold into predictable shapes, much like natural proteins. Because they’re so stable, scientists can tailor them to recognize and bind to specific biological targets.

Alpha-synuclein make up the Lewy bodies (darker spots) that form in neurons in Parkinson’s.
Suraj Rajan/Wikimedia Commons, CC BY-SA

This versatility is particularly important, because many proteins involved in neurodegenerative diseases have long been considered “undruggable.” Unlike other disease proteins with pockets that conventional drugs can bind to, proteins involved in neurodegenerative diseases, such as alpha-synuclein, are highly flexible and lack well-defined binding sites. Synthetic foldamers offer larger surfaces that can engage these difficult targets and disrupt the abnormal protein interactions that lead to toxic aggregation.

Foldamers could open new treatment avenues not only for Parkinson’s disease, but also for other neurodegenerative disorders driven by toxic protein aggregation, including Alzheimer’s disease and ALS.

What still isn’t known

Although SK-129 showed strong promise in its ability to target Parkinson’s in cell and animal models, we have yet to test its effectiveness in people.

Important questions remain regarding its long-term safety, optimal dosing and how it travels through and interacts with the human body. Additional studies are needed to understand how the molecule works and how to further optimize it to stop or slow Parkinson’s disease from worsening in people.

More broadly, researchers are still working to fully understand how different forms of alpha-synuclein drive neurodegeneration and disease spread. My team is also investigating how selectively targeting these toxic protein clumps influences their spread, inflammation in the nervous system and brain cell survival across different brain regions.

What other research is being done

Researchers are actively developing other therapies that target the toxic alpha-synuclein clumps that cause Parkinson’s and related diseases.

These approaches include molecules designed to clear these protein clumps or reduce their production, as well as molecules that can stop them from aggregating. Several of these strategies have advanced into clinical trials.

Each major approach to treatment has important limitations. Some struggle to selectively bind to the toxic proteins, while others are unable to penetrate the brain.

Through the collaboration of neuroscientists, biophysicists, clinicians and translational researchers, researchers like me hope to develop new ways to treat diseases that conventional drugs haven’t been able to before.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

URL: https://www.psypost.org/foldable-synthetic-molecules-could-infiltrate-and-bust-apart-the-toxic-protein-clumps-causing-parkinsons/

-------------------------------------------------

Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org

Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot

-------------------------------------------------

#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #ParkinsonsDisease #alphaSynuclein #foldamers #SK-129 #proteinAggregation #neurodegeneration #drugdesign #clinicaltrials #neuroscience #neuroprotectiveCOURSE

I forgot to mention: if you're in the #YQR / Regina area, tomorrow (Saturday 8 August 2026) is the #Regina Repair Cafe for this month. It's at the Victoria Square Mall, so lots of parking. It runs 10am - 4pm.

If you have stuff that is not working or broken, there's a good chance one of us volunteers can fix it for you. And it's free! We help keep stuff from ending up in the landfill before its time, and save you the expense of having to replace it.

And yes, we fix stuff you can't get fixed "professionally" because no one fixes small appliances and whatnot any more, because everyone says "Just buy a new one, it's cheaper". Not everyone can afford to "just" replace stuff, and there's the whole environment thing.

I guess we're adding a fourth "R" to the circle of life: reduce, re-use, repair, recycle.

I'm just a volunteer, not an organizer or official publicist or anything like that. But come down and say "Hi".

#RepairCafe #repair #environment #CollectiveAction #conservation #SK #fix #broken

I forgot to mention: if you're in the #YQR / Regina area, tomorrow (Saturday 8 August 2026) is the #Regina Repair Cafe for this month. It's at the Victoria Square Mall, so lots of parking. It runs 10am - 4pm.

If you have stuff that is not working or broken, there's a good chance one of us volunteers can fix it for you. And it's free! We help keep stuff from ending up in the landfill before its time, and save you the expense of having to replace it.

And yes, we fix stuff you can't get fixed "professionally" because no one fixes small appliances and whatnot any more, because everyone says "Just buy a new one, it's cheaper". Not everyone can afford to "just" replace stuff, and there's the whole environment thing.

I guess we're adding a fourth "R" to the circle of life: reduce, re-use, repair, recycle.

I'm just a volunteer, not an organizer or official publicist or anything like that. But come down and say "Hi".

#RepairCafe #repair #environment #CollectiveAction #conservation #SK #fix #broken