#inducedproximity — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #inducedproximity, aggregated by home.social.
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Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)
#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success
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Interesting bioRxiv preprint by the groups of Liron Bar-Peled and A. John Iafrate. They introduce COUPLrs - structurally diverse molecules with 2 electrophilic warheads and an alkyne - to identify proteins that can be linked to other proteins. https://www.biorxiv.org/content/10.1101/2024.07.16.603666v1
#Chemistry #ChemBio #ChemPro #InducedProximity -
Great talk by Nathanael Gray at #ISCPDD. He presented his group’s work on induced proximity to regulate transcription. Exciting data on recruiting a transcriptional activator (e.g. BRD4 or CDK9) to replace co-repressors on the death regulator BCL6 to induce cell death.
https://www.nature.com/articles/s41586-023-06348-2
#Chemistry #ChemBio #InducedProximity -
Chemical Biology Postdoc in the Ferguson Lab at UCSD
University of California, San Diego
Join our team working on #TPD #InducedProximity as a Postdoctoral fellow in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=91...
https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=91018 -
Chemical Biology Postdoc in the Ferguson Lab at UCSD
University of California, San Diego
Join our team working on #TPD #InducedProximity as a Postdoctoral fellow in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=90...
https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=90738 -
Crabtree and Gray labs introduce #TCIPs! Demonstrating that chemical induced proximity between transcription factor #BCL6 and #BRD4, activates downstream #BCL6 target gene expression and results in potent apoptosis. Go go marvels of #inducedproximity! https://www.biorxiv.org/content/10.1101/2022.12.04.517548v1