#crispri — Public Fediverse posts

#HIRI researchers deployed #CRISPRi for the first time for the functional characterization of the gut mutualist Bacteroides thetaiotaomicron. They identified an sRNA that modulates the microorganisms' growth in the presence of bile. The findings should contribute to a better understanding of the bacterium’s lifestyle in its native environment, the human intestine, and to the development of clinical applications. The study was published in @PNASNews: https://www.helmholtz-hiri.de/en/newsroom/news/detail/news/bacteroides-thetaiotaomicron-physiology-under-bile-stress/

#HIRI researchers deployed #CRISPRi for the first time for the functional characterization of the gut mutualist Bacteroides thetaiotaomicron. They identified an sRNA that modulates the microorganisms' growth in the presence of bile. The findings should contribute to a better understanding of the bacterium’s lifestyle in its native environment, the human intestine, and to the development of clinical applications. The study was published in @PNASNews: https://www.helmholtz-hiri.de/en/newsroom/news/detail/news/bacteroides-thetaiotaomicron-physiology-under-bile-stress/

#HIRI researchers deployed #CRISPRi for the first time for the functional characterization of the gut mutualist Bacteroides thetaiotaomicron. They identified an sRNA that modulates the microorganisms' growth in the presence of bile. The findings should contribute to a better understanding of the bacterium’s lifestyle in its native environment, the human intestine, and to the development of clinical applications. The study was published in @PNASNews: https://www.helmholtz-hiri.de/en/newsroom/news/detail/news/bacteroides-thetaiotaomicron-physiology-under-bile-stress/

#HIRI researchers deployed #CRISPRi for the first time for the functional characterization of the gut mutualist Bacteroides thetaiotaomicron. They identified an sRNA that modulates the microorganisms' growth in the presence of bile. The findings should contribute to a better understanding of the bacterium’s lifestyle in its native environment, the human intestine, and to the development of clinical applications. The study was published in @PNASNews: https://www.helmholtz-hiri.de/en/newsroom/news/detail/news/bacteroides-thetaiotaomicron-physiology-under-bile-stress/

#HIRI researchers deployed #CRISPRi for the first time for the functional characterization of the gut mutualist Bacteroides thetaiotaomicron. They identified an sRNA that modulates the microorganisms' growth in the presence of bile. The findings should contribute to a better understanding of the bacterium’s lifestyle in its native environment, the human intestine, and to the development of clinical applications. The study was published in @PNASNews: https://www.helmholtz-hiri.de/en/newsroom/news/detail/news/bacteroides-thetaiotaomicron-physiology-under-bile-stress/

Bar-coding #bacteriophages: New method could unleash powerful #biotechnology applications.

#CRISPRi #genomics

https://phys.org/news/2024-01-bar-coding-bacteriophages-method-unleash.html

Bar-coding #bacteriophages: New method could unleash powerful #biotechnology applications.

#CRISPRi #genomics

https://phys.org/news/2024-01-bar-coding-bacteriophages-method-unleash.html

#Bioinformatics: Researchers develop a new #machine_learning approach.

#CRISPRi #bacteria #AI

https://phys.org/news/2024-01-bioinformatics-machine-approach.html

#Bioinformatics: Researchers develop a new #machine_learning approach.

#CRISPRi #bacteria #AI

https://phys.org/news/2024-01-bioinformatics-machine-approach.html

How pioneer #transcription_factors blaze the one trail that determines #cell_fate.

#transcriptomics #CRISPRi #FOXA #OCT4 #epigenetics

https://phys.org/news/2024-01-transcription-factors-blaze-trail-cell.html

How pioneer #transcription_factors blaze the one trail that determines #cell_fate.

#transcriptomics #CRISPRi #FOXA #OCT4 #epigenetics

https://phys.org/news/2024-01-transcription-factors-blaze-trail-cell.html

#Phages are key drivers of #MicrobialEvolution, but many #phage genes are poorly understood. @denish_piya @AdamArkinLab @vivek_mutalik &co use arrayed genome-wide #CRISPRi to map gene the essentiality landscape in the iconic coliphages λ & P1. #PLOSBiology https://plos.io/3uLtzgU

#Phages are key drivers of #MicrobialEvolution, but many #phage genes are poorly understood. @denish_piya @AdamArkinLab @vivek_mutalik &co use arrayed genome-wide #CRISPRi to map gene the essentiality landscape in the iconic coliphages λ & P1. #PLOSBiology https://plos.io/3uLtzgU

#Phages are key drivers of #MicrobialEvolution, but many #phage genes are poorly understood. @denish_piya @AdamArkinLab @vivek_mutalik &co use arrayed genome-wide #CRISPRi to map gene the essentiality landscape in the iconic coliphages λ & P1. #PLOSBiology https://plos.io/3uLtzgU

#Phages are key drivers of #MicrobialEvolution, but many #phage genes are poorly understood. @denish_piya @AdamArkinLab @vivek_mutalik &co use arrayed genome-wide #CRISPRi to map gene the essentiality landscape in the iconic coliphages λ & P1. #PLOSBiology https://plos.io/3uLtzgU

#Phages are key drivers of #MicrobialEvolution, but many #phage genes are poorly understood. @denish_piya @AdamArkinLab @vivek_mutalik &co use arrayed genome-wide #CRISPRi to map gene the essentiality landscape in the iconic coliphages λ & P1. #PLOSBiology https://plos.io/3uLtzgU

Today, Dr. Rosa Mino shared her beautiful work on clathrin-mediated endocytosis, a key process that regulates availability of cell surface molecules in the central nervous system, cancer & other cell types. Thank you, Dr. Mino!
#CRISPRi #tirfmicroscopy
@Nous_MRE
@HustonTillotson

#introduction

Hello! I'm an assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the retina. I also work in developing novel AAV systems with expanded capabilities.

My interests are in #ProteinFolding, #proteostasis, #chaperones, #retina #AAV, #StructuralBiology, #Biophysics, #cryoEM, and #CRISPRi screens.

#introduction

Hello! I'm an assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the retina. I also work in developing novel AAV systems with expanded capabilities.

My interests are in #ProteinFolding, #proteostasis, #chaperones, #retina #AAV, #StructuralBiology, #Biophysics, #cryoEM, and #CRISPRi screens.

#introduction

Hello! I'm a research assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the #retina.

Before Pitt I was at #UCSF in the Biophysics program.

My interests are in #ProteinFolding, #Proteostasis, #StructuralBiology, #Biophysics, #cryoEM and #CRISPRi screens.

#introduction

Hello! I'm an assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the retina. I also work in developing novel AAV systems with expanded capabilities.

My interests are in #ProteinFolding, #proteostasis, #chaperones, #retina #AAV, #StructuralBiology, #Biophysics, #cryoEM, and #CRISPRi screens.

#introduction

Hello! I'm a research assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the #retina.

Before Pitt I was at #UCSF in the Biophysics program.

My interests are in #ProteinFolding, #Proteostasis, #StructuralBiology, #Biophysics, #cryoEM and #CRISPRi screens.

New paper now published in #mSystems by Pascal Hols' lab with some help from us (Johann Mignolet) where 3 cool genome-wide #CRISPRi screens are used to study competence in #Streptococcus #salivarius. It finds that #competence increases upon cell wall impairment with a role for #StkP
https://journals.asm.org/doi/10.1128/msystems.00735-22

New paper now published in #mSystems by Pascal Hols' lab with some help from us (Johann Mignolet) where 3 cool genome-wide #CRISPRi screens are used to study competence in #Streptococcus #salivarius. It finds that #competence increases upon cell wall impairment with a role for #StkP
https://journals.asm.org/doi/10.1128/msystems.00735-22

New paper now published in #mSystems by Pascal Hols' lab with some help from us (Johann Mignolet) where 3 cool genome-wide #CRISPRi screens are used to study competence in #Streptococcus #salivarius. It finds that #competence increases upon cell wall impairment with a role for #StkP
https://journals.asm.org/doi/10.1128/msystems.00735-22

New paper now published in #mSystems by Pascal Hols' lab with some help from us (Johann Mignolet) where 3 cool genome-wide #CRISPRi screens are used to study competence in #Streptococcus #salivarius. It finds that #competence increases upon cell wall impairment with a role for #StkP
https://journals.asm.org/doi/10.1128/msystems.00735-22