#aav — Public Fediverse posts

#NanoCas, a smaller version of #CRISPR tested with a single #AAV, delivers on-target results.

https://phys.org/news/2025-02-nanocas-smaller-version-crispr-aav.html

I always love learning about new plasmid technologies (maybe I am biased from my Addgene days). Researchers from the University of Rochester developed a dual AAV vector system called StitchR that can deliver plasmids containing gene fragments that can be subsequently cut out and assembled into a functional gene. This helps overcome the small packaging capacity of AAVs.

Find out more from Drug Discovery News : https://buff.ly/4hwaxPb

#AAV #GeneTherapy

Enfermedades virales y fertilidad, revisión sobre el efecto en la calidad seminal. Muchas de ellas tienen un efecto negativo, especialmente adenovirus, hepatitis B y papiloma. https://buff.ly/3ZyjUay #bianorbiotech #MaleInfertility #HPV #AAV #HBV

buff.ly/3ZyjUay

Enfermedades virales y fertilidad, revisión sobre el efecto en la calidad seminal. Muchas de ellas tienen un efecto negativo, especialmente adenovirus, hepatitis B y papiloma. https://buff.ly/3ZyjUay #bianorbiotech #MaleInfertility #HPV #AAV #HBV

buff.ly/3ZyjUay

Enfermedades virales y fertilidad, revisión sobre el efecto en la calidad seminal. Muchas de ellas tienen un efecto negativo, especialmente adenovirus, hepatitis B y papiloma. https://buff.ly/3ZyjUay #bianorbiotech #MaleInfertility #HPV #AAV #HBV

buff.ly/3ZyjUay

Enfermedades virales y fertilidad, revisión sobre el efecto en la calidad seminal. Muchas de ellas tienen un efecto negativo, especialmente adenovirus, hepatitis B y papiloma. https://buff.ly/3ZyjUay #bianorbiotech #MaleInfertility #HPV #AAV #HBV

buff.ly/3ZyjUay

Enfermedades virales y fertilidad, revisión sobre el efecto en la calidad seminal. Muchas de ellas tienen un efecto negativo, especialmente adenovirus, hepatitis B y papiloma. https://buff.ly/3ZyjUay #bianorbiotech #MaleInfertility #HPV #AAV #HBV

buff.ly/3ZyjUay

What #AAV dose will be needed for optogenetic brain implants aimed at restoring vision in humans? https://www.thetransmitter.org/spectrum/whats-next-for-brain-directed-gene-therapy-after-death-in-neurogene-trial/ What's next for brain-directed gene therapy after death in Neurogene trial.

Harrison bird foods has scholarships for #avian vet students.

Harrison’s Bird Foods Veterinary College Program -
$2,000 Avian Medicine Scholarship
Application Closes November 15th, 2024, 11:59 PM EST

https://harrisonsbirdfoods.com/wp-content/uploads/2024/09/HBD-Scholarship.pdf

#avianmedicinescholarship #scholarships #avianmedicinestudents
#aav #avianvets #avianveterinarians #avianmedicine #associationofavianveterinarians #avianhealth #parrothealth #chickenhealth #birdhealth #parrot #veterinarian

Existing #Cas12a nucleases are too large for #AAV-based #GeneTherapy. @grimmlab explores a #PLOSBiology study of a new Cas12a variant, compatible with in vivo #GenomeEditing via all-in-one AAV delivery. Paper: https://plos.io/3UWqpjC Primer: https://plos.io/4fmjk5F

Gene therapy death was caused by an unknown risk of the virus used, study suggests
#AAV #GeneTherapy
https://www.statnews.com/2023/09/27/gene-therapy-death-was-caused-by-an-unknown-risk-of-the-virus-used-study-suggests/

Q for my fellow neuroscience peeps. Is there a way to stabilize the expression of cre if its under the control of a promoter that is active only transiently during development?

Is it possible to cross a cre line with a cre-dependent cre-expressing reporter mouse so that cre become permanently expressed in the population of interest, and amenable for e.g. virus injection in the adult?

Are there tried and true solutions?

#AAV #cre #MouseModels #neuroscience

thinking about making a set of dlx creOFF AAV constructs a la @JDimidschstein and @sohallab. before i do - has anyone got a stash? initially gfp / chr2 but also likely switch gfp/dtomato too. for some 'NOT x' experiments. would be nice if they already existed! #neuroscience #neuromethods #aav #mouse #interneurons HT @elduvelle for the hashtags!

Gene Therapy Reverses Age-Related Hearing Loss in Mice

The efficacy of adeno-associated virus (AAV) vectors in reversing genetic hearing loss in aged animal models has been demonstrated.

#Biomedicine #GeneTherapy #ViralVector #AAV #HearingLoss #AuditoryNeuroscience #Neuroscience

https://neurosciencenews.com/gene-therapy-hearing-loss-23354/

Someone did an angry voice bot

@angry_voice

#AAV #AnotherAngryVoice

It's something I suppose, but I'd rather have his Facebook posts crossposted here.

Investigadores españoles prueban una técnica no invasiva para la terapia génica del Parkinson

#Neurociencia #Cerebro #Encéfalo #Neurología #EnfermedadesNeurológicas #EnfermedadesNeurodegenerativas #Parkinson #BarreraHematoEncefálica #TerapiaGénica #VectoresVirales #AAV #Neuroimagen #PET

https://www.infosalus.com/salud-investigacion/noticia-investigadores-espanoles-prueban-tecnica-no-invasiva-terapia-genica-parkinson-20230420104742.html

Una nueva técnica abre la puerta del cerebro a tratamientos neurológicos sin precedentes

Un estudio en monos y pacientes muestra cómo atravesar la inexpugnable muralla biológica que protege al encéfalo y tratar así el párkinson u otras dolencias

#Neurociencia #Cerebro #Encéfalo #Neurología #EnfermedadesNeurológicas #EnfermedadesNeurodegenerativas #Parkinson #BarreraHematoEncefálica #TerapiaGénica #VectoresVirales #AAV #Neuroimagen #PET

https://elpais.com/ciencia/2023-04-19/una-nueva-tecnica-abre-la-puerta-del-cerebro-a-tratamientos-neurologicos-sin-precedentes.html#Echobox=1681927454-2

BBB opening with focused ultrasound in nonhuman primates and Parkinson’s disease patients:
Targeted AAV vector delivery and PET imaging

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #BoodBrainBarrier #BBB #BBBopening #FocusedUltrasound #GeneTherapy #AAV #AAVvector #ViralVector #Parkinson #Neuroimaging #PET

https://www.science.org/doi/10.1126/sciadv.adf4888

#AAV #AnotherAngryVoice #Labour #Starmer #RedToryism

#AAV #AnotherAngryVoice #Labour #Starmer

#AAV #AnotherAngryVoice #Water #Sewerage #WaterCompanies #UK #England

#AAV #AnotherAngryVoice
#UK #racism #Starmer #Antisemitism #Tories

#AAV #AnotherAngryVoice #UK #Nuclear #Babcock #RoyalNavy #Tories #Privatisation

I don't see #AnotherAngryVoice #AAV posting so much anymore. He doesn't #blog much anymore.

Do you think he's giving up because the #Facebook algorithms are strangling him?

It seems he's always relied too heavily on that hellsite.

#AAV #AnotherAngryVoice

#MeghanMarkle #JeremyClarkson #Media #Hypocrisy #Misogyny

PRPF31 #RetinitisPigmentosa is a #retinal disease caused by haploinsufficiency. #PRPF31 mutations are also homozygous lethal, which makes creating an animal model challenging. We tackled this problem by knocking out PRPF31 using a #CRISPR construct in adults using #AAV – and then showed that #GeneTherapy could prevent retinal degeneration in vivo. Out now in #NatureCommunications. https://www.nature.com/articles/s41467-022-35361-8

Great story about gene therapy cures and insurance from Wired. Will insurers pay current costs?
#genetherapy #hemophilia #AAV #medicine #Costofgoods #medmastodon #bigpharma #medicine
https://www.wired.com/story/the-era-of-one-shot-multi-million-dollar-genetic-cures-is-here/

What are people doing for custom #AAV preps for Addgene plasmids that are not packaged?

Many in vitro #CRISPR knock-in approaches use small molecule drugs to improve the efficiency of homology-directed repair, but these drugs may or may not be safe in vivo. In this paper from #NatureBiotechnology, the authors find that an FDA-approved therapy, fludarabine, can be used for a similar purpose. Still a long ways to go before any genetic knock-ins are routinely done in vivo, but making progress toward doing so safely: https://www.nature.com/articles/s41587-022-01240-2 #science #medicine #GeneEditing #AAV