#proteostasis — Public Fediverse posts

🧬 Ubiquitin Precursor: A Key to Healthy Aging?
Researchers from the #UniCologne and the Heinrich-Heine-Universität Düsseldorf have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging. This discovery opens up potentially new perspectives for the treatment of cancer and age-related diseases.

Read more ▶️ https://uni.koeln/BLXJA

📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373

#uniköln #unicologne #Research #Ubiquitin #Cancer #Aging #Health #proteostasis

Hi #ScienceMastodon! I am happy to share the final #ResearchHighlight from Issue 18 of JCS. Song-Kun Shyue and colleagues at the Institute of Biomedical Sciences, Academia Sinica, Taiwan, unravel the upstream protein machinery required for ER-associated degradation (ERAD) of the crucial enzyme cyclooxygenase-2.
#cellbiology #proteostasis

Derlins and Surf4 work together to ERADicate COX-2
https://journals.biologists.com/jcs/article/136/18/e136_e1804/330714/Derlins-and-Surf4-work-together-to-ERADicate-COX-2

New paper! Great collaboration between our group and the @mz at @biozentrum @unibasel - supported by a Sinergia grant of the @snsf_ch.

Aberrant #proteostasis (balance between protein synthesis and degradation, centrally regulated by #mTOR) and mitochondrial dysfunction are two of the most prominent and reproducible processes associated with #aging in skeletal #muscle (and other tissues).

1/2

https://www.pnas.org/doi/10.1073/pnas.2302360120

Postdoctoral Research Fellow in Proteostasis and Aging

UNC Charlotte

Postdoctoral research position available to study gut-to-muscle stress signaling and its role in aging #chaperones #Proteostasis #C. elegans

See the full job description on jobRxiv: https://jobrxiv.org/job/unc-charlotte-27778-postdoctoral-research-fellow-in-proteostasis-and-aging/?feed_id=54832

#ScienceJobs ...
https://jobrxiv.org/job/unc-charlotte-27778-postdoctoral-research-fellow-in-proteostasis-and-aging/?feed_id=54832

PhD in Ubiquitin and Immune Signalling

RWTH Aachen University

PhD to study cross-talk between receptor-triggered and ubiquitin signalling in plants #proteostasis #PlantSci #PlantSciJobs

See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-phd-in-ubiquitin-and-immune-signalling/?feed_id=52601

#ScienceJobs #hiring #research
Aachen #Germany #P...
https://jobrxiv.org/job/rwth-aachen-university-27778-phd-in-ubiquitin-and-immune-signalling/?feed_id=52601

Check out the latest paper from my buddy @TheVilchezLab on aging. The third paper today from my smart friends! V r doing well.
---
RT @TheVilchezLab
New work from the lab @NatureAging!❄️Lowering body temperature extends #longevity. We find that cold-induced #proteostasis prevents #aging and aggregation of proteins that cause age-related diseases #ALS #HuntingtonDisease in C. elegans and human cells https://www.nature.com/articles/s43…
https://twitter.com/TheVilchezLab/status/1642908783327207426

Check out the latest paper from my buddy @TheVilchezLab on aging. The third paper today from my smart friends! V r doing well.
---
RT @TheVilchezLab
New work from the lab @NatureAging!❄️Lowering body temperature extends #longevity. We find that cold-induced #proteostasis prevents #aging and aggregation of proteins that cause age-related diseases #ALS #HuntingtonDisease in C. elegans and human cells https://www.nature.com/articles/s43…
https://twitter.com/TheVilchezLab/status/1642908783327207426

Check out the latest paper from my buddy @TheVilchezLab on aging. The third paper today from my smart friends! V r doing well.
---
RT @TheVilchezLab
New work from the lab @NatureAging!❄️Lowering body temperature extends #longevity. We find that cold-induced #proteostasis prevents #aging and aggregation of proteins that cause age-related diseases #ALS #HuntingtonDisease in C. elegans and human cells https://www.nature.com/articles/s43…
https://twitter.com/TheVilchezLab/status/1642908783327207426

Check out the latest paper from my buddy @TheVilchezLab on aging. The third paper today from my smart friends! V r doing well.
---
RT @TheVilchezLab
New work from the lab @NatureAging!❄️Lowering body temperature extends #longevity. We find that cold-induced #proteostasis prevents #aging and aggregation of proteins that cause age-related diseases #ALS #HuntingtonDisease in C. elegans and human cells https://www.nature.com/articles/s43…
https://twitter.com/TheVilchezLab/status/1642908783327207426

Another neat worskhop @DGZ_info, talks by @IgnatovaLab @FranziskaOttens @_ilgink @TheVilchezLab.

I loved the story ER associated degradation & the "smurf assay" in #celegans by @Soto_Ef @FranziskaOttens, Shutter, et al.

Full: https://www.nature.com/articles/s41556-022-01025-4 #ER_literature #scicomm
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RT @DGZ_info
Join us for the next #DGZ Focus Workshop on Cellular and Organismal #Proteostasis on March 28, featuring @_ilgink, @TheVil…
https://twitter.com/DGZ_info/status/1633025784968359943

Postdoc position in Biology of Aging at NUS (Sorrentino lab) @Vinz_Sorrentino

My lab is opening position for #postdoc at NUS in #biology of #aging, #mitochondria, #proteostasis #translationalresearch
http://lnkd.in/gcVu3m_R

...
https://jobrxiv.org/job/national-university-of-singapore-centre-for-healthy-longevity-27778-postdoc-position-in-biology-of-aging-at-nus-sorrentino-lab/?feed_id=41436

Postdoc position in Biology of Aging at NUS (Sorrentino lab) @Vinz_Sorrentino

My lab is opening position for #postdoc at NUS in #biology of #aging, #mitochondria, #proteostasis #translationalresearch
http://lnkd.in/gcVu3m_R

...
https://jobrxiv.org/job/national-university-of-singapore-centre-for-healthy-longevity-27778-postdoc-position-in-biology-of-aging-at-nus-sorrentino-lab/?feed_id=39666

Postdoc position in Biology of Aging at NUS (Sorrentino lab) @Vinz_Sorrentino

My lab is opening position for #postdoc at NUS in #biology of #aging, #mitochondria, #proteostasis #translationalresearch
http://lnkd.in/gcVu3m_R

...
https://jobrxiv.org/job/national-university-of-singapore-centre-for-healthy-longevity-27778-postdoc-position-in-biology-of-aging-at-nus-sorrentino-lab/?feed_id=39486

A Year at the Forefront of Proteostasis and Aging

@Co_Biologists @BiologyOpen

#review #aging #proteostasis

https://journals.biologists.com/bio/article/12/2/bio059750/287042/A-Year-at-the-Forefront-of-Proteostasis-and-Aging

Are you ready for your reading list for the week?

Check out this week's edition of publications on #MembraneContactSites!

http://biomed.news/bims-mecosi/2023-01-29

Thanks to #BioMedNews, an abstract-selection tool based on #ArtificialIntelligence and #MachineLearning!

#MAMs #MCS #Mitochondria #Lysosome #Proteostasis

Are you ready for your reading list for the week?

Check out this week's edition of publications on #MembraneContactSites!

http://biomed.news/bims-mecosi/2023-01-29

Thanks to #BioMedNews, an abstract-selection tool based on #ArtificialIntelligence and #MachineLearning!

#MAMs #MCS #Mitochondria #Lysosome #Proteostasis

Are you ready for your reading list for the week?

Check out this week's edition of publications on #MembraneContactSites!

http://biomed.news/bims-mecosi/2023-01-29

Thanks to #BioMedNews, an abstract-selection tool based on #ArtificialIntelligence and #MachineLearning!

#MAMs #MCS #Mitochondria #Lysosome #Proteostasis

Are you ready for your reading list for the week?

Check out this week's edition of publications on #MembraneContactSites!

http://biomed.news/bims-mecosi/2023-01-29

Thanks to #BioMedNews, an abstract-selection tool based on #ArtificialIntelligence and #MachineLearning!

#MAMs #MCS #Mitochondria #Lysosome #Proteostasis

"We have discovered the Caenorhabditis elegans homeodomain-interacting protein kinase (HPK-1) acts as a key transcriptional effector to preserve neuronal integrity, function, and #proteostasis during #aging."

#Celegans #preprint

https://www.biorxiv.org/content/10.1101/2023.01.11.523661v1

What happens to the #ubiquitin-#proteasome system in cells that cannot form #stressgranules?
Nico Dantuma & coworkers at Karolinska Institute find surprising #nucleolar relocalization of DRiP #peptides, compromising #proteostasis in the nucleus
https://www.embopress.org/doi/10.15252/embj.2022111802

Intercellular Mitochondrial Transfer as a Rescue Mechanism in Response to Protein Import Failure

#mitochondria #proteostasis #preprint

https://www.biorxiv.org/content/10.1101/2022.11.30.518494v2

#Introduction:

Hello #ScienceMastodon.

My name is Verena Kohler and I am a #FirstGen #scientist, currently working as independent senior #postdoc at #UniGraz in Austria.

I am interested, how age influences #proteostasis, the balance between protein production, folding and degradation, and how #ageing affects cellular #communication routes.
For that, I am using my favourite #ModelOrganism, the baker’s #yeast, a lot of #FluorescenceMicroscopy and #HighThroughput screens.

Let’s talk #science !

#Introduction:

Hello #ScienceMastodon.

My name is Verena Kohler and I am a #FirstGen #scientist, currently working as independent senior #postdoc at #UniGraz in Austria.

I am interested, how age influences #proteostasis, the balance between protein production, folding and degradation, and how #ageing affects cellular #communication routes.
For that, I am using my favourite #ModelOrganism, the baker’s #yeast, a lot of #FluorescenceMicroscopy and #HighThroughput screens.

Let’s talk #science !

#Introduction:

Hello #ScienceMastodon.

My name is Verena Kohler and I am a #FirstGen #scientist, currently working as independent senior #postdoc at #UniGraz in Austria.

I am interested, how age influences #proteostasis, the balance between protein production, folding and degradation, and how #ageing affects cellular #communication routes.
For that, I am using my favourite #ModelOrganism, the baker’s #yeast, a lot of #FluorescenceMicroscopy and #HighThroughput screens.

Let’s talk #science !

#Introduction:

Hello #ScienceMastodon.

My name is Verena Kohler and I am a #FirstGen #scientist, currently working as independent senior #postdoc at #UniGraz in Austria.

I am interested, how age influences #proteostasis, the balance between protein production, folding and degradation, and how #ageing affects cellular #communication routes.
For that, I am using my favourite #ModelOrganism, the baker’s #yeast, a lot of #FluorescenceMicroscopy and #HighThroughput screens.

Let’s talk #science !

#Introduction:

Hello #ScienceMastodon.

My name is Verena Kohler and I am a #FirstGen #scientist, currently working as independent senior #postdoc at #UniGraz in Austria.

I am interested, how age influences #proteostasis, the balance between protein production, folding and degradation, and how #ageing affects cellular #communication routes.
For that, I am using my favourite #ModelOrganism, the baker’s #yeast, a lot of #FluorescenceMicroscopy and #HighThroughput screens.

Let’s talk #science !

Shift of the insoluble content of the proteome in aging mouse brain

#proteostasis #aging #brain

https://www.biorxiv.org/content/10.1101/2022.12.13.520290v1

I’m still not sure how this 🐘 works, but I guess the best is to start with an #introduction
Here I will be posting about stuff from our lab at the CECAD. We want to understand #aging and #proteostasis to prevent multiple age-related diseases such as #ALS, #Alzheimer, #Parkinson and #huntington

#introduction

Hello! I'm an assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the retina. I also work in developing novel AAV systems with expanded capabilities.

My interests are in #ProteinFolding, #proteostasis, #chaperones, #retina #AAV, #StructuralBiology, #Biophysics, #cryoEM, and #CRISPRi screens.

#introduction

Hello! I'm an assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the retina. I also work in developing novel AAV systems with expanded capabilities.

My interests are in #ProteinFolding, #proteostasis, #chaperones, #retina #AAV, #StructuralBiology, #Biophysics, #cryoEM, and #CRISPRi screens.

#introduction

Hello! I'm a research assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the #retina.

Before Pitt I was at #UCSF in the Biophysics program.

My interests are in #ProteinFolding, #Proteostasis, #StructuralBiology, #Biophysics, #cryoEM and #CRISPRi screens.

#introduction

Hello! I'm an assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the retina. I also work in developing novel AAV systems with expanded capabilities.

My interests are in #ProteinFolding, #proteostasis, #chaperones, #retina #AAV, #StructuralBiology, #Biophysics, #cryoEM, and #CRISPRi screens.

#introduction

Hello! I'm a research assistant professor at #Pitt. I do research on the molecular mechanisms of protein homeostasis in the #retina.

Before Pitt I was at #UCSF in the Biophysics program.

My interests are in #ProteinFolding, #Proteostasis, #StructuralBiology, #Biophysics, #cryoEM and #CRISPRi screens.