#adverseevents — Public Fediverse posts

The claim is circulating that antidepressants can cause overheating and dehydration. This is a genuine public health message, but it's not so simple: diuretics, beta blockers, ACE inhibitors, antipsychotics, and some antihistamines may also interact badly with hot weather.
https://www.nytimes.com/2024/06/15/well/live/heat-weather-medication-safety.html (excerpt in a reply)

There's even doubt about antidepressants having this effect. A recent paper in eClinicalMedicine looked at all the studies they could find and concluded that there wasn't evidence of antidepressants causing overheating in hot weather - though some other medicines do.

"Current evidence supports strong anticholinergics, non-selective beta-blockers, adrenaline, and anti-Parkinson’s agents impairing thermoregulation during heat stress ... physicians should interpret with caution conventional public health messaging related to the thermoregulatory effects of some drugs (e.g., antidepressants) during hot weather."
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00465-6/fulltext

#Antidepressants #Diuretics #AnticholinergicMedications #MedMastodon #BetaBlockers #HeatWaves #Thermoregulation #OverHeating #Dehydration #SideEffects #AdverseEffects #AdverseEvents #DrugSideEffects #DrugSafety #HeatStress #HotWeather #HotWeatherSafety #PublicHealth #ACEinhibitors #Antipsychotics

The claim is circulating that antidepressants can cause overheating and dehydration. This is a genuine public health message, but it's not so simple: diuretics, beta blockers, ACE inhibitors, antipsychotics, and some antihistamines may also interact badly with hot weather.
https://www.nytimes.com/2024/06/15/well/live/heat-weather-medication-safety.html (excerpt in a reply)

There's even doubt about antidepressants having this effect. A recent paper in eClinicalMedicine looked at all the studies they could find and concluded that there wasn't evidence of antidepressants causing overheating in hot weather - though some other medicines do.

"Current evidence supports strong anticholinergics, non-selective beta-blockers, adrenaline, and anti-Parkinson’s agents impairing thermoregulation during heat stress ... physicians should interpret with caution conventional public health messaging related to the thermoregulatory effects of some drugs (e.g., antidepressants) during hot weather."
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00465-6/fulltext

#Antidepressants #Diuretics #AnticholinergicMedications #MedMastodon #BetaBlockers #HeatWaves #Thermoregulation #OverHeating #Dehydration #SideEffects #AdverseEffects #AdverseEvents #DrugSideEffects #DrugSafety #HeatStress #HotWeather #HotWeatherSafety #PublicHealth #ACEinhibitors #Antipsychotics

A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment of Drug-Resistant Tuberculosis. https://doi.org/10.20411/pai.v9i2.705 #AdverseEvents #Linezolid #Neurotoxicity #PrecisionMedicine #Sbsn

A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment of Drug-Resistant Tuberculosis. https://doi.org/10.20411/pai.v9i2.705 #AdverseEvents #Linezolid #Neurotoxicity #PrecisionMedicine #Sbsn

Given my earlier work on the reporting of harms https://www.researchgate.net/profile/Tom-Kindlon/research I was informed of an upcoming special issue of Trials on assessing #harms in clinical trials, "The collection, analysis and reporting of adverse events in randomised controlled trials"

https://www.biomedcentral.com/collections/CART

These days I focus on @IrishMECFSAssociation but perhaps of interest to somebody. With all the exercise and other #LongCovid trials, it remains important

#MECFS #adverseevents

Given my earlier work on the reporting of harms https://www.researchgate.net/profile/Tom-Kindlon/research I was informed of an upcoming special issue of Trials on assessing #harms in clinical trials, "The collection, analysis and reporting of adverse events in randomised controlled trials"

https://www.biomedcentral.com/collections/CART

These days I focus on @IrishMECFSAssociation but perhaps of interest to somebody. With all the exercise and other #LongCovid trials, it remains important

#MECFS #adverseevents

Our main paper reporting the results of our #MultiSite observational study investigating the effectiveness of #psychotherapy in patients with #MedicallyUnexplained #PhysicalSymptoms in #CzechRepublic services has been published:
https://link.springer.com/article/10.1007/s10879-023-09597-4
#Rstats codes and materials: https://osf.io/dfrma/

This completes the trio, w prev papers looking at #NegativeEffects https://discovery.dundee.ac.uk/en/publications/negative-effects-during-multicomponent-group-based-treatment-a-mu #AdverseEvents

and our exploration of potential mechanisms of change
https://discovery.dundee.ac.uk/en/publications/mechanisms-of-change-in-multicomponent-group-based-treatment-for-

#ISRCTN

"Pfizer knew . . ."
Dr Naomi Wolf - Pfizer Docs, Miscarriages and the War on Life

📺 WATCH
https://rumble.com/v1j886t-dr-naomi-wolf-pfizer-docs-miscarriages-and-the-war-on-life.html
📻 LISTEN
https://www.podbean.com/ew/pb-9kd9k-12baba5
Hit play for a clip ⏯️ #AdverseEvents