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#adverseevents — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #adverseevents, aggregated by home.social.

  1. The claim is circulating that antidepressants can cause overheating and dehydration. This is a genuine public health message, but it's not so simple: diuretics, beta blockers, ACE inhibitors, antipsychotics, and some antihistamines may also interact badly with hot weather.
    nytimes.com/2024/06/15/well/li (excerpt in a reply)

    There's even doubt about antidepressants having this effect. A recent paper in eClinicalMedicine looked at all the studies they could find and concluded that there wasn't evidence of antidepressants causing overheating in hot weather - though some other medicines do.

    "Current evidence supports strong anticholinergics, non-selective beta-blockers, adrenaline, and anti-Parkinson’s agents impairing thermoregulation during heat stress ... physicians should interpret with caution conventional public health messaging related to the thermoregulatory effects of some drugs (e.g., antidepressants) during hot weather."
    thelancet.com/journals/eclinm/

    #Antidepressants #Diuretics #AnticholinergicMedications #MedMastodon #BetaBlockers #HeatWaves #Thermoregulation #OverHeating #Dehydration #SideEffects #AdverseEffects #AdverseEvents #DrugSideEffects #DrugSafety #HeatStress #HotWeather #HotWeatherSafety #PublicHealth #ACEinhibitors #Antipsychotics

  2. A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment of Drug-Resistant Tuberculosis. doi.org/10.20411/pai.v9i2.705

  3. Given my earlier work on the reporting of harms researchgate.net/profile/Tom-K I was informed of an upcoming special issue of Trials on assessing #harms in clinical trials, "The collection, analysis and reporting of adverse events in randomised controlled trials"

    biomedcentral.com/collections/

    These days I focus on @IrishMECFSAssociation but perhaps of interest to somebody. With all the exercise and other #LongCovid trials, it remains important

    #MECFS #adverseevents