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25 results for “Silke_Bischoff”
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Sometimes it’s easy
Sometimes it is hard
To play all these games
With a broken heart -
Demnach sollten alle, die eine Monatsblutung haben, in der ersten Zyklushälfte eher Kraftsport machen und in der zweiten eher Dehnübungen und leichteres Ausdauertraining – abgestimmt auf die Wirkung, die die #Hormone #Östrogen und #Progesteron auf Muskulatur und andere Gewebe im Körper haben.
2/5
#CycleSyncing #zyklusbasiert #Sport -
Demnach sollten alle, die eine Monatsblutung haben, in der ersten Zyklushälfte eher Kraftsport machen und in der zweiten eher Dehnübungen und leichteres Ausdauertraining – abgestimmt auf die Wirkung, die die #Hormone #Östrogen und #Progesteron auf Muskulatur und andere Gewebe im Körper haben.
2/5
#CycleSyncing #zyklusbasiert #Sport -
Demnach sollten alle, die eine Monatsblutung haben, in der ersten Zyklushälfte eher Kraftsport machen und in der zweiten eher Dehnübungen und leichteres Ausdauertraining – abgestimmt auf die Wirkung, die die #Hormone #Östrogen und #Progesteron auf Muskulatur und andere Gewebe im Körper haben.
2/5
#CycleSyncing #zyklusbasiert #Sport -
Demnach sollten alle, die eine Monatsblutung haben, in der ersten Zyklushälfte eher Kraftsport machen und in der zweiten eher Dehnübungen und leichteres Ausdauertraining – abgestimmt auf die Wirkung, die die #Hormone #Östrogen und #Progesteron auf Muskulatur und andere Gewebe im Körper haben.
2/5
#CycleSyncing #zyklusbasiert #Sport -
Demnach sollten alle, die eine Monatsblutung haben, in der ersten Zyklushälfte eher Kraftsport machen und in der zweiten eher Dehnübungen und leichteres Ausdauertraining – abgestimmt auf die Wirkung, die die #Hormone #Östrogen und #Progesteron auf Muskulatur und andere Gewebe im Körper haben.
2/5
#CycleSyncing #zyklusbasiert #Sport -
French-born Spanish film director on Silk Road's cultural legacy - CGTN
https://news.cgtn.com/news/2026-09-22/French-born-Spanish-film-director-on-Silk-Road-s-cultural-legacy-1QEbHYxlgo8/share_amp.html
Drawing on his roots in Galicia and …
#WayOfStJames
#StJamesWay
#caminodesantiago
#BuenCamino -
https://www.europesays.com/pl/705768/ Żużel. Unia może zapomnieć o medalu? Mówi o sile Motoru Lublin – PoBandzie #ekstraliga #GoogleNews #GoogleUpday #Googleżużel #lublin #MotorLublin #MSN #News #PGEEkstraliga #PL #PoBandzie #pobandzie #PobandziePortal #Pobandzieżużel #Poland #Polish #Polska #Polski #Speedway #SpeedwayNews #Sportżużlowy #UniaLeszno #upday #Updayżużel #zuzel #Zuzel2026 #żużelEkstraliga #żużelGoogle #żużelNews #żużelPobandzie #żużelTv #żużelUpday #żużelWiadomości #żużelWyniki
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CW: NSFW 18+
Model: Aubrey Belle
From: alsscan.comWrapped in the warm silence of the bath, she offers a gaze of pure, intimate desire. Her hands gently cup her thigh, highlighting a tiny star tattoo and hinting at the silky pleasure to come. She is the definition of tempting relaxation—a portrait of serene, seductive allure.
#nsfw #lewd #sexy #tits #pussy #beautiful #dildo #redhead #cute #ass #bathtub #erotic #glamour #sexuality
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CW: NSFW 18+
Model: Aubrey Belle
From: alsscan.comWrapped in the warm silence of the bath, she offers a gaze of pure, intimate desire. Her hands gently cup her thigh, highlighting a tiny star tattoo and hinting at the silky pleasure to come. She is the definition of tempting relaxation—a portrait of serene, seductive allure.
#nsfw #lewd #sexy #tits #pussy #beautiful #dildo #redhead #cute #ass #bathtub #erotic #glamour #sexuality
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CW: NSFW 18+
Model: Aubrey Belle
From: alsscan.comWrapped in the warm silence of the bath, she offers a gaze of pure, intimate desire. Her hands gently cup her thigh, highlighting a tiny star tattoo and hinting at the silky pleasure to come. She is the definition of tempting relaxation—a portrait of serene, seductive allure.
#nsfw #lewd #sexy #tits #pussy #beautiful #dildo #redhead #cute #ass #bathtub #erotic #glamour #sexuality
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Canadian job & contract leads (any duration), I'm not affiliated with any of these companies:
Nutrien is hiring a full-time network engineer in either Calgary, AB or Saskatoon, SK. No salary range listed. Job description at https://jobs.nutrien.com/North-America/job/Network-Engineer/34197-en_US.
Silk & Snow is hiring an E-Commerce Coordinator in Toronto, Ontario. Salary range is $50,000.00 - $65,000.00. Apply at https://eklv.fa.ca3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_3003/job/925.
Wawanesa Insurance is hiring an Application Developer II - Digital Platforms. "We offer a hybrid work environment that offers flexibility to our employees in balancing in-office (2 days per week OR 15 hours per week in a Wawanesa office) and remote work. You may work from any of the following locations: Winnipeg, MB; Wawanesa, MB; Vancouver, BC; Calgary, AB; Edmonton, AB; Lethbridge, AB; Toronto (North York), ON; Kitchener, ON; Ottawa, ON; Montreal, QC; Quebec City, QC, Moncton, NB; Dartmouth; NS." Salary range is $80,000 - $105,000 ("Candidates with salary expectations outside of the range are still encouraged to apply.") They are looking for someone with "Hands-on experience with TypeScript, React, Node.js, REST APIs, and Git-based source control." Apply now at https://jobs.wawanesa.com/job/Winnipeg%2C-MB-%28Hybrid%29-Application-Developer-II-Digital-Platforms-MB/606233817/.
Global Watch Company is hiring a web developer in Vancouver, BC. Hourly pay is $35 - $45. All the details are at https://globalwatchco.com/careers/web-developer.
Stripe is hiring for many roles (including backend & frontend engineers, engineering manager, and more). Some of the roles are remote in Canada, while others are in their Toronto office. Salary range is listed in each job description. See all their openings at https://stripe.com/careers/search?locations=North+America--Canada.
If you're still reading this, and have found any of the leads I've found helpful, please consider donating to the Terry Fox Foundation at https://terryfox.org/learn-more-ways-to-give/.
#WPJobs #WPCareers #WordPressJobs #CanadaJobs #CanadianJobs #DevJobs #WebDevJobs #WordPress #FediHired #GetFediHired #hiring #RemoteJobs #FediJobs #ITJobs #JobAlert #TechJobs #ToJobs #TorontoJobs #CalgaryJobs #WinnipegJobs #RemoteWork #FediHire #Job #Jobs #JobOpenings #OpenRoles
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Canadian job & contract leads (any duration), I'm not affiliated with any of these companies:
Nutrien is hiring a full-time network engineer in either Calgary, AB or Saskatoon, SK. No salary range listed. Job description at https://jobs.nutrien.com/North-America/job/Network-Engineer/34197-en_US.
Silk & Snow is hiring an E-Commerce Coordinator in Toronto, Ontario. Salary range is $50,000.00 - $65,000.00. Apply at https://eklv.fa.ca3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_3003/job/925.
Wawanesa Insurance is hiring an Application Developer II - Digital Platforms. "We offer a hybrid work environment that offers flexibility to our employees in balancing in-office (2 days per week OR 15 hours per week in a Wawanesa office) and remote work. You may work from any of the following locations: Winnipeg, MB; Wawanesa, MB; Vancouver, BC; Calgary, AB; Edmonton, AB; Lethbridge, AB; Toronto (North York), ON; Kitchener, ON; Ottawa, ON; Montreal, QC; Quebec City, QC, Moncton, NB; Dartmouth; NS." Salary range is $80,000 - $105,000 ("Candidates with salary expectations outside of the range are still encouraged to apply.") They are looking for someone with "Hands-on experience with TypeScript, React, Node.js, REST APIs, and Git-based source control." Apply now at https://jobs.wawanesa.com/job/Winnipeg%2C-MB-%28Hybrid%29-Application-Developer-II-Digital-Platforms-MB/606233817/.
Global Watch Company is hiring a web developer in Vancouver, BC. Hourly pay is $35 - $45. All the details are at https://globalwatchco.com/careers/web-developer.
Stripe is hiring for many roles (including backend & frontend engineers, engineering manager, and more). Some of the roles are remote in Canada, while others are in their Toronto office. Salary range is listed in each job description. See all their openings at https://stripe.com/careers/search?locations=North+America--Canada.
If you're still reading this, and have found any of the leads I've found helpful, please consider donating to the Terry Fox Foundation at https://terryfox.org/learn-more-ways-to-give/.
#WPJobs #WPCareers #WordPressJobs #CanadaJobs #CanadianJobs #DevJobs #WebDevJobs #WordPress #FediHired #GetFediHired #hiring #RemoteJobs #FediJobs #ITJobs #JobAlert #TechJobs #ToJobs #TorontoJobs #CalgaryJobs #WinnipegJobs #RemoteWork #FediHire #Job #Jobs #JobOpenings #OpenRoles
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Canadian job & contract leads (any duration), I'm not affiliated with any of these companies:
Nutrien is hiring a full-time network engineer in either Calgary, AB or Saskatoon, SK. No salary range listed. Job description at https://jobs.nutrien.com/North-America/job/Network-Engineer/34197-en_US.
Silk & Snow is hiring an E-Commerce Coordinator in Toronto, Ontario. Salary range is $50,000.00 - $65,000.00. Apply at https://eklv.fa.ca3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_3003/job/925.
Wawanesa Insurance is hiring an Application Developer II - Digital Platforms. "We offer a hybrid work environment that offers flexibility to our employees in balancing in-office (2 days per week OR 15 hours per week in a Wawanesa office) and remote work. You may work from any of the following locations: Winnipeg, MB; Wawanesa, MB; Vancouver, BC; Calgary, AB; Edmonton, AB; Lethbridge, AB; Toronto (North York), ON; Kitchener, ON; Ottawa, ON; Montreal, QC; Quebec City, QC, Moncton, NB; Dartmouth; NS." Salary range is $80,000 - $105,000 ("Candidates with salary expectations outside of the range are still encouraged to apply.") They are looking for someone with "Hands-on experience with TypeScript, React, Node.js, REST APIs, and Git-based source control." Apply now at https://jobs.wawanesa.com/job/Winnipeg%2C-MB-%28Hybrid%29-Application-Developer-II-Digital-Platforms-MB/606233817/.
Global Watch Company is hiring a web developer in Vancouver, BC. Hourly pay is $35 - $45. All the details are at https://globalwatchco.com/careers/web-developer.
Stripe is hiring for many roles (including backend & frontend engineers, engineering manager, and more). Some of the roles are remote in Canada, while others are in their Toronto office. Salary range is listed in each job description. See all their openings at https://stripe.com/careers/search?locations=North+America--Canada.
If you're still reading this, and have found any of the leads I've found helpful, please consider donating to the Terry Fox Foundation at https://terryfox.org/learn-more-ways-to-give/.
#WPJobs #WPCareers #WordPressJobs #CanadaJobs #CanadianJobs #DevJobs #WebDevJobs #WordPress #FediHired #GetFediHired #hiring #RemoteJobs #FediJobs #ITJobs #JobAlert #TechJobs #ToJobs #TorontoJobs #CalgaryJobs #WinnipegJobs #RemoteWork #FediHire #Job #Jobs #JobOpenings #OpenRoles
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🦖 Zdá se, že T. rex měl teplotu skoro JAKO ČLOVĚK! Analýza chemických stop ve sklovině tyranosauřích zubů TOTIŽ NAZNAČUJE, že měl průměrnou tělesnou teplotu kolem 36 °C! O tom, jakou měli dinoši teplotu, se lidi nehádají jenom z nějakého bizarního důvodu – tělesná teplota je i náznak toho, jak to daný biočich má s TERMOREGULACÍ… 🫦 Dřív se dinoši často líčili jako pomalí, těžkopádní a STUDENOKREVNÍ tvorové.
Jenže novější objevy tenhle obraz dávno narušily. Dnes se obecně počítá s tím, že řada dinosaurů byla TEPLOKREVNÁ a dokázala si regulovat tělesnou teplotu – včetně T. rexe. 😏
Problém je, že vyhynulému zvířeti nejde strčit teploměr do tlamy – respektive jde, ale moc z toho nevyčtete! Vědátoři proto zkoušeli různé nepřímé metody – šmírují růst, vývoj, strukturu kostí. Tentokrát pomohly zuby. Atomy ve sklovině se totiž shlukují do různých vzorců podle teploty těla zvířete, VE KTERÉM sklovina vznikala… 🙃
Tři zkoumané zuby proto ve výsledku ukazují na průměr asi 36 °C. To je podobné dnešním slonům a v podstatě stejné jako u lidí, jejichž běžná tělesná teplota se pohybuje zhruba mezi 36 až 37 °C. Někteří odborníci přitom čekali, že T. rex BUDE TEPLEJŠÍ, podobně jako moderní ptáci! 🧐
Stabilních 36 °C přitom silně naznačuje, že to mohlo T. rexovi pomáhat prosperovat v různých částech tehdejší Severní Ameriky – v CHLADNĚJŠÍCH I TEPLEJŠÍCH oblastech. A také napovídá, kolik energie potřeboval a jakou kořist musel lovit, aby jeho obří tělo fungovalo.
Prostě jsme měli mnoho společného – snad tedy brzy nebudeme mít společný i… VYHYNULÝ status T. rexů! 🥲
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DATE: September 23, 2026 at 06:00PM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: Alzheimer’s proteins predict early brain shrinkage before dementia symptoms appear
An analysis of the AMYPAD Prognostic and Natural History Study data found that, in older individuals with preserved cognition, amyloid-beta accumulation in the brain can predict future brain atrophy. In women, the association was stronger for predicting atrophy of the temporal region of the brain. It was also stronger in the frontal and lateral-temporal regions as well as the hippocampus in carriers of at least one version (allele) of the APOE-ε4 gene, a gene associated with increased risk of Alzheimer’s disease. The paper was published in NeuroImage: Clinical.
As people reach advanced age, their memory, attention, and mental processing speed tend to gradually worsen. This is a normal part of aging. However, in some people these changes can be more severe, indicating that some type of dementia or neurodegenerative disease might be developing.
Alzheimer’s disease is the most common cause of dementia. It gradually disrupts memory, reasoning, language, and the ability to function independently. Other forms of dementia, such as vascular dementia, Lewy body dementia, and frontotemporal dementia, produce similar symptoms but arise from partly different biological processes.
One of the hallmark features of Alzheimer’s disease is the accumulation of amyloid-beta protein into plaques between brain cells. Another important change is the buildup of abnormal tau protein inside neurons, which is closely associated with neuronal damage and brain atrophy. These pathological processes can begin many years before noticeable cognitive symptoms appear.
Study author Leonard Pieperhoff and his colleagues wanted to explore the influence of global accumulation levels of amyloid-beta in the brain on regional brain atrophy. To do this, they examined regional changes in brain volume and thickness in a large research sample composed of older adults without dementia.
They also explored whether the relationship between amyloid-beta accumulation and subsequent brain atrophy depends on an individual’s sex and on whether the person is a carrier of the APOE-ε4 gene. APOE-ε4 is a gene variant that increases a person’s genetic risk of developing Alzheimer’s disease. People with this gene variant also tend to develop Alzheimer’s disease earlier in life.
These researchers analyzed data from the Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) Prognostic Natural History Study (PNHS). The study included 1,329 participants who were all required to have no history of dementia and be above 50 years of age at the start. Participants’ average age was 68.2 years. 56% were women. 40% had at least one version of the APOE-ε4 gene.
All participants completed magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging of their brains. A subgroup of 684 participants completed these scans at least once again in the years after the start. The median follow-up time for these scans was 3.4 years later.
Results showed that participants’ brain volumes generally shrank over time, suggesting that there was widespread atrophy of the brain due to aging-related factors. This effect was the most prominent in temporal and parietal regions of the brain as well as in the hippocampus and amygdala. Similar reductions were seen in cortical thickness, although the posterior and anterior cingulate cortices showed thickening over time.
Higher amyloid-beta concentrations were associated with lower volumes of multiple regions of the brain including the lateral-temporal lobes, precuneus, posterior cingulate, amygdala, and hippocampus. Cortical thickness of these regions was also associated with amyloid-beta concentrations in the same way.
Across time, higher amyloid-beta concentrations in the cortex were associated with widespread decrease of volume and thickness at follow-up scans, across different brain regions. The strongest effects were observed in the posterior cingulate, fusiform, and parahippocampal gyri, as well as the hippocampus and amygdala. Notably, atrophy in the fusiform gyrus was predicted by amyloid-beta independently of tau protein levels. This association was stronger in women when temporal regions of the brain were concerned. For carriers of at least one variant of the APOE-ε4 gene, these associations were stronger in frontal and lateral-temporal regions and the hippocampus.
“Our findings suggest that in older adults with mostly preserved cognition, baseline Aβ-PET [amyloid-beta concentrations assessed using PET] predicts future brain atrophy, with fusiform atrophy showing independence from tau pathology [accumulation of tau proteins in the brain] and Aβ-dependent atrophy being exacerbated in region-dependent manners in females and APOE-ε4 carriers. Regional cortical volume and thickness may serve as sensitive markers for early Aβ-related neurodegeneration and aid in stratifying risk in AD [Alzheimer’s disease] prevention trials,” the study authors concluded.
The study contributes to the scientific understanding of the neural correlates of dementia and age-related brain atrophy. However, it should be noted that the design of the study does not allow any causal inferences to be derived from the results.
The paper, “Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study,” was authored by Leonard Pieperhoff, Luigi Lorenzini, Sophie Mastenbroek, Mario Tranfa, Mahnaz Shekari, Alle Meije Wink, Robin Wolz, Sylke Grootoonk, Craig Ritchie, Mercè Boada, Marta Marquié, Wiesje van der Flier, Rik Vandenberghe, Bernard J. Hanseeuw, Pablo Martínez-Lage, Pierre Payoux, Pieter Jelle Visser, Michael Schöll, Giovanni B. Frisoni, Andrew Stephens, Christopher Buckley, Gill Farrar, Frank Jessen, Oriol Grau-Rivera, Juan Domingo Gispert, David Vállez García, Henk Mutsaerts, Frederik Barkhof, and Lyduine E. Collij, on behalf of the AMYPAD consortium.
-------------------------------------------------
Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot
-------------------------------------------------
#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #AlzheimersDisease #AmyloidBeta #AβAtlas #APOE4 #BrainAtrophy #AmyloidPET #Neurodegeneration #FusiformGyrus #Hippocampus #AMYPAD
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DATE: September 23, 2026 at 06:00PM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: Alzheimer’s proteins predict early brain shrinkage before dementia symptoms appear
An analysis of the AMYPAD Prognostic and Natural History Study data found that, in older individuals with preserved cognition, amyloid-beta accumulation in the brain can predict future brain atrophy. In women, the association was stronger for predicting atrophy of the temporal region of the brain. It was also stronger in the frontal and lateral-temporal regions as well as the hippocampus in carriers of at least one version (allele) of the APOE-ε4 gene, a gene associated with increased risk of Alzheimer’s disease. The paper was published in NeuroImage: Clinical.
As people reach advanced age, their memory, attention, and mental processing speed tend to gradually worsen. This is a normal part of aging. However, in some people these changes can be more severe, indicating that some type of dementia or neurodegenerative disease might be developing.
Alzheimer’s disease is the most common cause of dementia. It gradually disrupts memory, reasoning, language, and the ability to function independently. Other forms of dementia, such as vascular dementia, Lewy body dementia, and frontotemporal dementia, produce similar symptoms but arise from partly different biological processes.
One of the hallmark features of Alzheimer’s disease is the accumulation of amyloid-beta protein into plaques between brain cells. Another important change is the buildup of abnormal tau protein inside neurons, which is closely associated with neuronal damage and brain atrophy. These pathological processes can begin many years before noticeable cognitive symptoms appear.
Study author Leonard Pieperhoff and his colleagues wanted to explore the influence of global accumulation levels of amyloid-beta in the brain on regional brain atrophy. To do this, they examined regional changes in brain volume and thickness in a large research sample composed of older adults without dementia.
They also explored whether the relationship between amyloid-beta accumulation and subsequent brain atrophy depends on an individual’s sex and on whether the person is a carrier of the APOE-ε4 gene. APOE-ε4 is a gene variant that increases a person’s genetic risk of developing Alzheimer’s disease. People with this gene variant also tend to develop Alzheimer’s disease earlier in life.
These researchers analyzed data from the Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) Prognostic Natural History Study (PNHS). The study included 1,329 participants who were all required to have no history of dementia and be above 50 years of age at the start. Participants’ average age was 68.2 years. 56% were women. 40% had at least one version of the APOE-ε4 gene.
All participants completed magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging of their brains. A subgroup of 684 participants completed these scans at least once again in the years after the start. The median follow-up time for these scans was 3.4 years later.
Results showed that participants’ brain volumes generally shrank over time, suggesting that there was widespread atrophy of the brain due to aging-related factors. This effect was the most prominent in temporal and parietal regions of the brain as well as in the hippocampus and amygdala. Similar reductions were seen in cortical thickness, although the posterior and anterior cingulate cortices showed thickening over time.
Higher amyloid-beta concentrations were associated with lower volumes of multiple regions of the brain including the lateral-temporal lobes, precuneus, posterior cingulate, amygdala, and hippocampus. Cortical thickness of these regions was also associated with amyloid-beta concentrations in the same way.
Across time, higher amyloid-beta concentrations in the cortex were associated with widespread decrease of volume and thickness at follow-up scans, across different brain regions. The strongest effects were observed in the posterior cingulate, fusiform, and parahippocampal gyri, as well as the hippocampus and amygdala. Notably, atrophy in the fusiform gyrus was predicted by amyloid-beta independently of tau protein levels. This association was stronger in women when temporal regions of the brain were concerned. For carriers of at least one variant of the APOE-ε4 gene, these associations were stronger in frontal and lateral-temporal regions and the hippocampus.
“Our findings suggest that in older adults with mostly preserved cognition, baseline Aβ-PET [amyloid-beta concentrations assessed using PET] predicts future brain atrophy, with fusiform atrophy showing independence from tau pathology [accumulation of tau proteins in the brain] and Aβ-dependent atrophy being exacerbated in region-dependent manners in females and APOE-ε4 carriers. Regional cortical volume and thickness may serve as sensitive markers for early Aβ-related neurodegeneration and aid in stratifying risk in AD [Alzheimer’s disease] prevention trials,” the study authors concluded.
The study contributes to the scientific understanding of the neural correlates of dementia and age-related brain atrophy. However, it should be noted that the design of the study does not allow any causal inferences to be derived from the results.
The paper, “Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study,” was authored by Leonard Pieperhoff, Luigi Lorenzini, Sophie Mastenbroek, Mario Tranfa, Mahnaz Shekari, Alle Meije Wink, Robin Wolz, Sylke Grootoonk, Craig Ritchie, Mercè Boada, Marta Marquié, Wiesje van der Flier, Rik Vandenberghe, Bernard J. Hanseeuw, Pablo Martínez-Lage, Pierre Payoux, Pieter Jelle Visser, Michael Schöll, Giovanni B. Frisoni, Andrew Stephens, Christopher Buckley, Gill Farrar, Frank Jessen, Oriol Grau-Rivera, Juan Domingo Gispert, David Vállez García, Henk Mutsaerts, Frederik Barkhof, and Lyduine E. Collij, on behalf of the AMYPAD consortium.
-------------------------------------------------
Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot
-------------------------------------------------
#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #AlzheimersDisease #AmyloidBeta #AβAtlas #APOE4 #BrainAtrophy #AmyloidPET #Neurodegeneration #FusiformGyrus #Hippocampus #AMYPAD
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DATE: September 23, 2026 at 06:00PM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: Alzheimer’s proteins predict early brain shrinkage before dementia symptoms appear
An analysis of the AMYPAD Prognostic and Natural History Study data found that, in older individuals with preserved cognition, amyloid-beta accumulation in the brain can predict future brain atrophy. In women, the association was stronger for predicting atrophy of the temporal region of the brain. It was also stronger in the frontal and lateral-temporal regions as well as the hippocampus in carriers of at least one version (allele) of the APOE-ε4 gene, a gene associated with increased risk of Alzheimer’s disease. The paper was published in NeuroImage: Clinical.
As people reach advanced age, their memory, attention, and mental processing speed tend to gradually worsen. This is a normal part of aging. However, in some people these changes can be more severe, indicating that some type of dementia or neurodegenerative disease might be developing.
Alzheimer’s disease is the most common cause of dementia. It gradually disrupts memory, reasoning, language, and the ability to function independently. Other forms of dementia, such as vascular dementia, Lewy body dementia, and frontotemporal dementia, produce similar symptoms but arise from partly different biological processes.
One of the hallmark features of Alzheimer’s disease is the accumulation of amyloid-beta protein into plaques between brain cells. Another important change is the buildup of abnormal tau protein inside neurons, which is closely associated with neuronal damage and brain atrophy. These pathological processes can begin many years before noticeable cognitive symptoms appear.
Study author Leonard Pieperhoff and his colleagues wanted to explore the influence of global accumulation levels of amyloid-beta in the brain on regional brain atrophy. To do this, they examined regional changes in brain volume and thickness in a large research sample composed of older adults without dementia.
They also explored whether the relationship between amyloid-beta accumulation and subsequent brain atrophy depends on an individual’s sex and on whether the person is a carrier of the APOE-ε4 gene. APOE-ε4 is a gene variant that increases a person’s genetic risk of developing Alzheimer’s disease. People with this gene variant also tend to develop Alzheimer’s disease earlier in life.
These researchers analyzed data from the Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) Prognostic Natural History Study (PNHS). The study included 1,329 participants who were all required to have no history of dementia and be above 50 years of age at the start. Participants’ average age was 68.2 years. 56% were women. 40% had at least one version of the APOE-ε4 gene.
All participants completed magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging of their brains. A subgroup of 684 participants completed these scans at least once again in the years after the start. The median follow-up time for these scans was 3.4 years later.
Results showed that participants’ brain volumes generally shrank over time, suggesting that there was widespread atrophy of the brain due to aging-related factors. This effect was the most prominent in temporal and parietal regions of the brain as well as in the hippocampus and amygdala. Similar reductions were seen in cortical thickness, although the posterior and anterior cingulate cortices showed thickening over time.
Higher amyloid-beta concentrations were associated with lower volumes of multiple regions of the brain including the lateral-temporal lobes, precuneus, posterior cingulate, amygdala, and hippocampus. Cortical thickness of these regions was also associated with amyloid-beta concentrations in the same way.
Across time, higher amyloid-beta concentrations in the cortex were associated with widespread decrease of volume and thickness at follow-up scans, across different brain regions. The strongest effects were observed in the posterior cingulate, fusiform, and parahippocampal gyri, as well as the hippocampus and amygdala. Notably, atrophy in the fusiform gyrus was predicted by amyloid-beta independently of tau protein levels. This association was stronger in women when temporal regions of the brain were concerned. For carriers of at least one variant of the APOE-ε4 gene, these associations were stronger in frontal and lateral-temporal regions and the hippocampus.
“Our findings suggest that in older adults with mostly preserved cognition, baseline Aβ-PET [amyloid-beta concentrations assessed using PET] predicts future brain atrophy, with fusiform atrophy showing independence from tau pathology [accumulation of tau proteins in the brain] and Aβ-dependent atrophy being exacerbated in region-dependent manners in females and APOE-ε4 carriers. Regional cortical volume and thickness may serve as sensitive markers for early Aβ-related neurodegeneration and aid in stratifying risk in AD [Alzheimer’s disease] prevention trials,” the study authors concluded.
The study contributes to the scientific understanding of the neural correlates of dementia and age-related brain atrophy. However, it should be noted that the design of the study does not allow any causal inferences to be derived from the results.
The paper, “Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study,” was authored by Leonard Pieperhoff, Luigi Lorenzini, Sophie Mastenbroek, Mario Tranfa, Mahnaz Shekari, Alle Meije Wink, Robin Wolz, Sylke Grootoonk, Craig Ritchie, Mercè Boada, Marta Marquié, Wiesje van der Flier, Rik Vandenberghe, Bernard J. Hanseeuw, Pablo Martínez-Lage, Pierre Payoux, Pieter Jelle Visser, Michael Schöll, Giovanni B. Frisoni, Andrew Stephens, Christopher Buckley, Gill Farrar, Frank Jessen, Oriol Grau-Rivera, Juan Domingo Gispert, David Vállez García, Henk Mutsaerts, Frederik Barkhof, and Lyduine E. Collij, on behalf of the AMYPAD consortium.
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #AlzheimersDisease #AmyloidBeta #AβAtlas #APOE4 #BrainAtrophy #AmyloidPET #Neurodegeneration #FusiformGyrus #Hippocampus #AMYPAD
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I must admit that I for the first time have started playing the camera on my Jolla Phone 2026. A new pro camera is being developed. Photos are taken faster, with far more details and with RAW support. That development is still in an early stage. And on GitHub one can see that @jolla has done work on the default camera app as well. Yay! #SailfishOS #Photography #CameraApps #Camera #Bengalcat
https://forum.sailfishos.org/t/jolla-phone-camera-too-many-details-are-lost/32717/102?u=frankps
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I must admit that I for the first time have started playing the camera on my Jolla Phone 2026. A new pro camera is being developed. Photos are taken faster, with far more details and with RAW support. That development is still in an early stage. And on GitHub one can see that @jolla has done work on the default camera app as well. Yay! #SailfishOS #Photography #CameraApps #Camera #Bengalcat
https://forum.sailfishos.org/t/jolla-phone-camera-too-many-details-are-lost/32717/102?u=frankps
-
I must admit that I for the first time have started playing the camera on my Jolla Phone 2026. A new pro camera is being developed. Photos are taken faster, with far more details and with RAW support. That development is still in an early stage. And on GitHub one can see that @jolla has done work on the default camera app as well. Yay! #SailfishOS #Photography #CameraApps #Camera #Bengalcat
https://forum.sailfishos.org/t/jolla-phone-camera-too-many-details-are-lost/32717/102?u=frankps
-
I must admit that I for the first time have started playing the camera on my Jolla Phone 2026. A new pro camera is being developed. Photos are taken faster, with far more details and with RAW support. That development is still in an early stage. And on GitHub one can see that @jolla has done work on the default camera app as well. Yay! #SailfishOS #Photography #CameraApps #Camera #Bengalcat
https://forum.sailfishos.org/t/jolla-phone-camera-too-many-details-are-lost/32717/102?u=frankps
-
I must admit that I for the first time have started playing the camera on my Jolla Phone 2026. A new pro camera is being developed. Photos are taken faster, with far more details and with RAW support. That development is still in an early stage. And on GitHub one can see that @jolla has done work on the default camera app as well. Yay! #SailfishOS #Photography #CameraApps #Camera #Bengalcat
https://forum.sailfishos.org/t/jolla-phone-camera-too-many-details-are-lost/32717/102?u=frankps
