#polyq — Public Fediverse posts

New review article “Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle” by Esmeralda Villavicencio Gonzalez and Huda Zoghbi in the Journal of Experimental Medicine: doi.org/10.1084/jem.... #polyQ #huntingtonsdisease #ataxia

Pathogenesis of polyglutamine ...

Looking forward to the European #huntingtonsdisease network ( #EHDN) meeting next week, in beautiful Strasbourg (https://ehdn.org/ehdn2024/ ). It looks like a great line-up of speakers and topics, and offers a chance to catch up with fellow HD researchers (and collaborators). Are you there too? #polyQ

Our latest (review) article is now available online: https://doi.org/10.1042/BST20230731 in the journal Biochemical Transactions. In this invited article “Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation”, I have reviewed the contributions that solid-state #NMR #SSNMR has made to our understanding of the mutant protein aggregates in #huntingtonsdisease and related #polyQ disorders. (1/2)

Yay! It is now online: our latest paper on the use #NMR spectroscopy to look at #amyloid formation by #polyQ peptides outfitted with a backbone modification, which allows photochemical control over beta-hairpin formation. Together with the groups of Szymanski and Feringa in #Groningen. A great new tool for studies of #amyloid formation mechanisms.

https://pubs.acs.org/doi/10.1021/jacs.3c11155
#photochemistry #NMR #huntingtonsdisease #amyloid

Sign up now! HDF Foundation webinar about the protein that is mutated in #huntingtonsdisease. Presented by J. Frydman and N. Barbosa from Stanford University - happening tomorrow!! https://www.hdfoundation.org/webinars #polyQ #amyloid #biophysics

Interesting webinar about #HuntingtonsDisease is coming on Sept 28th 2023, via the #HDF foundation: https://www.hdfoundation.org/webinars
An online presentation by Judith Frydman and Natalia Barbosa (#Stanford) talking about “How expanding our knowledge of the Huntington's protein can unlock new therapies”. (A statement I fully agree with - to address a protein misfolding disease like HD, we need to understand what this #misfolding process really is!) #polyQ #huntingtondisease #biophysics

Don’t miss the #iupacchains2023 parallel session 10 on Structural Biology and Protein Design at 10:20am - see the talk by my PhD student Raffaella Parlato! She will talk about our work with Wiktor Szymanski’s team (also University of #Groningen) - enabling #photochemical control over #polyQ #amyloid formation & structure. #ssNMR #chemistry

… using in-depth #moleculardynamics simulation to integrate various experimental constraint provides an unprecedented view of the structure of the misfolded protein aggregates, with a central role (of course) for new and existing #ssNMR data. These #polyQ protein fibrils are tough for #cryoEM due to structural and dynamic heterogeneity.
….

Well, just got back from the FASEB protein aggregation conference #PACSRC in Ireland. As usual, it was a great event with a never-ending stream of cool science. Quite a few #amyloid structures discusses, based on #ssNMR and #cryoEM . I briefly talked about our own integrative structural biology work on the fibrils made by mutant huntingtin fragments #huntingtonsdisease , as well as our work with aggregation inhibitors (and how they reveal features of the aggregation mechanism) #polyQ

(It is in part a follow-up on our earlier collaborative paper, more focused on the #DNP #SSNMR analysis of unlabeled #polyQ #protein #amyloids - https://pubs.acs.org/doi/10.1021/jacs.8b09002 )

Our department at the Zernike Institute for Advanced Materials of the University of #Groningen is highlighting Raffaella Parlato from my #SSNMR group in this year's advent calendar: Raffaella's research focuses on #HuntingtonsDisease, a rare and neurodegenerative disease caused by #polyQ #protein aggregation into #amyloid fibrils . Read more: https://www.rug.nl/research/zernike/news/newsitems/20221220-day20-parlato

Now online in pre-proof status, at the journal #SSNMR : a new collaborative paper on #DNP ssNMR at 13C natural abundance: "Fast magic angle spinning for the characterization of milligram quantities of organic and biological solids at natural isotopic abundance by 13C–13C correlation DNP-enhanced #NMR" . With Gaël De Paëpe, Snorri Sigurdsson and Sabine Hediger. Includes some new data of unlabeled #polyQ #amyloid aggregates. https://www.sciencedirect.com/science/article/pii/S0926204022000790 #nmrchat