New #polyQ #preprint from our colleagues in the Onck lab at @[email protected] : “A two-bead-per-aminoacid coarse-grained MD model with hydrogen bonding (2BPA-HB) to probe DNAJB6b-mediated suppression of #polyglutamine aggregation in #Huntingtonsdisease ” doi.org/10.64898/202...
doi.org/10.64898/2026....
#huntingtonsdisease — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #huntingtonsdisease, aggregated by home.social.
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Save the date: the #huntingtonsdisease CHDI Foundation will have its 22nd annual HD therapeutics conference on April 26-29 2027. It will again come to Europe, to Dubrovnik, Croatia!
chdifoundation.org
CHDI Foundation -
Leicester Psychologist Draws on Family Huntington’s Diagnosis in New Mental Health Book
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Leicester Psychologist Draws on Family Huntington’s Diagnosis in New Mental Health Book
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The Researcher Who Didn’t Want to Know
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Teva’s Data on AUSTEDO® (deutetrabenazine) tablets and AUSTEDO XR® (deutetrabenazine) extended-release tablets Highlight Long-Term Advances in Tardive Dyskinesia Treatment and Care
Teva Pharmaceutical Industries Ltd New analysis from the IMPACT-TD Registry demonstrates that tre…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Medication #AUSTEDO #Health #huntingtonsdisease #tardivedyskinesia #TevaPharmaceuticalIndustriesLtd #tevapharmaceuticals
https://www.newsbeep.com/us/694693/ -
It arrived. Looking forward to reading this book after hearing good things about it. #huntingtonsdisease
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Once again… Feb 28 is Rare Diseases Day ( www.rarediseaseday.org ). A bit over 15 years ago, my lab got involved in research into the mechanisms behind one such disease: #huntingtonsdisease. Indeed, almost exactly 15 years ago (March 2011) we published our first article from this research line …
Homepage -
New article @hdbuzzfeed.bsky.social about AMT-130: “UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130” en.hdbuzz.net/uniqure-and-... #huntingtonsdisease #polyQ
UniQure and FDA No Longer in A... -
New review article “Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle” by Esmeralda Villavicencio Gonzalez and Huda Zoghbi in the Journal of Experimental Medicine: doi.org/10.1084/jem.... #polyQ #huntingtonsdisease #ataxia
Pathogenesis of polyglutamine ... -
FuRST 2.0 tracks subtle HD changes; FOCUS-HD takes ~20 mins.
More here ⤵️
https://www.karmactive.com/huntingtons-furst-2-0-amt-130-validation-update-2025/Follow @karmactive
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✨🧠 "The Hunt for Huntington's" is a gripping tale of familial phone calls and birthday surprises! 🎉🚀 In a twist of fate, one daughter's epic battle against destiny allegedly sparked a "scientific revolution"—or so the legend goes! Because who knew flying home for Dad's birthday could lead to Nobel-worthy breakthroughs? 🏆✈️
https://nehalslearnings.substack.com/p/the-hunt-for-huntingtons #HuntingtonsDisease #FamilyStories #ScientificRevolution #NobelPrize #BirthdaySurprises #HackerNews #ngated -
UTHealth Houston has several patients included in a study showing promising results in delaying the debilitating symptoms of Huntington's disease.
#HealthScience #Local #News #HuntingtonSDisease #HuntingtonSDiseaseSocietyOfAmerica #UTHealthHouston
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Huntington's disease successfully treated for first time | BBC News
https://youtu.be/bhExSMZt1zs#Science #Medicine #Health #Neuroscience #HuntingtonsDisease #GeneTherapy
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Exogenous Huntingtin-Exon1 Aggregates Exhibit Distinct Levels of Toxicity to Caenorhabditis elegans | ACS Chemical Neuroscience pubs.acs.org/doi/abs/10.1... Interesting new paper on fundamental mechanisms in #huntingtonsdisease by Justin Legleiter’s team at the Univ of Nevada #polyQ
Exogenous Huntingtin-Exon1 Agg... -
Huntington's disease successfully treated for first time. #HuntingtonsDisease
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This is a great documentary about one woman's plight with #Huntington'sDisease. It is movie length though. It is a great watch. #Medicine #Health #GeneticDiseases #Huntington'sDisease youtu.be/si1tAtTWjqA?...
HUNTINGTONS DANCE - The Film -
Some good news for a change. I’ll hold off on celebrating until the studies are further peer-reviewed and reproduced, but for anyone with family or friends affected by this terrible hereditary disease, this is brilliant news.
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Huntington's disease treated for first time
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It means the decline you would normally expect in one year would take four years after treatment, [..].The first symptoms of Huntington's disease tend to appear in your 30s or 40s and is normally fatal within two decades.
"""Wow, one might then very well merely die "with" it, instead of "from" it.
https://www.bbc.com/news/articles/cevz13xkxpro
via @kottke
#medicine #healthcare #HuntingtonsDisease #Huntingtons #kottke
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From The Guardian: Huntington’s disease treated successfully for first time in UK gene therapy trial
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Some actual #GoodNews… #HuntingtonsDisease successfully treated for the first time! https://www.bbc.co.uk/news/articles/cevz13xkxpro
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This is the biggest medical breakthrough in ages, and will dramatically impact a small portion of the population with inherited #HuntingtonsDisease - a truly horrible terminal condition that attacks the brain and CNS. A huge deal for families affected. Really GOOD news, this is… #Disease #PublicHealth #Science #Research
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Huntington's disease, a fatal genetic condition, has been successfully treated for the first time. @BBCNews reports on a type of gene therapy developed at University College London that slows the disease by 75% in patients. It offers the first signs of hope for sufferers of this brutal and terrible condition, which kills brain cells, leading to symptoms that resemble dementia, Parkinson's and motor neurone disease, and is usually fatal within two decades of diagnosis.
#Huntingtons #HuntingtonsDisease #Medicine #Health #Science #Genetics #GeneTherapy #GoodNews
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"One of the cruellest and most devastating diseases – Huntington's – has been successfully treated for the first time, say doctors.
The disease runs through families, relentlessly kills brain cells and resembles a combination of dementia, Parkinson's and motor neurone disease.
An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients.
It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of good quality life', Prof Sarah Tabrizi told BBC News.
The new treatment is a type of gene therapy given during 12 to 18 hours of delicate brain surgery."
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What #science can do. This is a spectacular accomplishment. If only our #eugenicists-in-chief believed in the value of #research instead of #fascism and its relentless pursuit of suffering.
"There was every chance that we would never see a result like this, so to be living in a world where we know this is not only possible, but the actual magnitude of the effect is breathtaking, it's very difficult to fully encapsulate the emotion."
https://www.bbc.com/news/articles/cevz13xkxpro?at_medium=RSS&at_campaign=rss
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Huntington’s disease treated successfully for first time in gene therapy trial
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🚨 BREAKING: Scientists finally find a way to treat Huntington's disease, just in time for the BBC to bury it under 37 tabs of geopolitical drama and penguin documentaries. 🌍🐧✨ Meanwhile, the rest of us are left wondering if they can treat our addiction to scrolling past #news about yet another war. 📰🔄
https://www.bbc.com/news/articles/cevz13xkxpro #HuntingtonsDisease #Breakthrough #Science #MediaCriticism #GeopoliticalDrama #HackerNews #ngated -
Online: doi.org/10.1002/chem... “Probing How Anti-huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid-State #NMR” - continuing our research on #huntingtonsdisease and in particular the aggregated #polyQ proteins involved. Here we looked at antibodies binding to the latter. #nmrchat
Probing How Anti‐huntingtin An... -
@Thorn @actuallyautistic As someone who was for a decade a caregiver for a wife with #HuntingtonsDisease, I have learned to expect that those baby steps won't lead to my feeling seen any time in this life. Anger and grief.
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Huntington’s Disease – eine seltene, aber verheerende genetische Erkrankung. Auch einige prominente Persönlichkeiten waren betroffen oder haben das Thema öffentlich gemacht. 🧠💔 Ein kurzer Überblick: #HuntingtonsDisease #Neuroscience #Awareness
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Our latest paper on #huntingtonsdisease research has posted at @natcomms.nature.com today: “Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress” ( see doi.org/10.1038/s414... ) …
Inhibitor-based modulation of ... -
Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease.
#HuntingtonsDisease #CAGrepeat #SomaticExpansion #SingleCell
https://www.cell.com/cell/fulltext/S0092-8674(24)01379-5 -
Secondary nucleation is increasing recognized as a dominant process in protein aggregation, and in particular also for pathogenic (disease causing) proteins. Still, many questions remain about how this process works, and what implications it has for pathogenic mechanisms. Here we show the unique power of HS-AFM to actually visualize this process directly. Check it out!
#amyloid #AFM #huntingtonsdisease (2/2)
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Looking forward to the European #huntingtonsdisease network ( #EHDN) meeting next week, in beautiful Strasbourg (https://ehdn.org/ehdn2024/ ). It looks like a great line-up of speakers and topics, and offers a chance to catch up with fellow HD researchers (and collaborators). Are you there too? #polyQ
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We're all in this together #research #cures #cureHD #HDawarenessmonth #HuntingtonsDisease
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We're all in this together #research #cures #cureHD #HDawarenessmonth #HuntingtonsDisease
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Our latest (review) article is now available online: https://doi.org/10.1042/BST20230731 in the journal Biochemical Transactions. In this invited article “Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation”, I have reviewed the contributions that solid-state #NMR #SSNMR has made to our understanding of the mutant protein aggregates in #huntingtonsdisease and related #polyQ disorders. (1/2)
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Yay! It is now online: our latest paper on the use #NMR spectroscopy to look at #amyloid formation by #polyQ peptides outfitted with a backbone modification, which allows photochemical control over beta-hairpin formation. Together with the groups of Szymanski and Feringa in #Groningen. A great new tool for studies of #amyloid formation mechanisms.
https://pubs.acs.org/doi/10.1021/jacs.3c11155
#photochemistry #NMR #huntingtonsdisease #amyloid
