#ssnmr — Public Fediverse posts

Slightly delayed due to my holidays, but excited to share this new paper that came out online a little while ago in ACS Applied Materials and Interfaces: https://doi.org/10.1021/acsami.4c08428 In it, PhD student Pushpa Rampratap spearheaded our effort to use MAS #NMR to study ECM-like #hydrogels. In a prior publication (https://doi.org/10.1016/j.carbpol.2023.121063) she described methods for preparing 13C enriched version of the polysaccharide hyaluronic acid…. #glycotime #nmrchat #ssnmr

Busy week coming - but am definitely looking forward to next week visiting #Cambridge (UK) to discuss #amyloid #ssNMR #ECM #polysaccharides and more. Actually my first visit there, although I spent quite a few years in the 'other' Cambridge (MASS/USA). :-)

Well, just got back from the FASEB protein aggregation conference #PACSRC in Ireland. As usual, it was a great event with a never-ending stream of cool science. Quite a few #amyloid structures discusses, based on #ssNMR and #cryoEM . I briefly talked about our own integrative structural biology work on the fibrils made by mutant huntingtin fragments #huntingtonsdisease , as well as our work with aggregation inhibitors (and how they reveal features of the aggregation mechanism) #polyQ

Coming on May 30th: online webinar by Dr. Kaustubh Mote from the Tata Institute of Fundamental Research (TIFR) #hyderabad on the topic of “Measuring dynamics using anisotropic interactions in MAS-NMR”. More info: https://www.globalnmr.org/upcoming-talks Register to attend here: https://www.globalnmr.org/weekly-registration

#NMR #nmrchat #ssNMR #dipoles #dynamics #biophysics

New collaborative article now available online: "A Universal Nanogel‐Based Coating Approach for Medical Implant Materials" in the journal Advanced NanoBiomed Research. With the group of Patrick van Rijn #BME #UMCG and others. See: https://onlinelibrary.wiley.com/doi/10.1002/anbr.202200141 We contributed some #ssNMR analysis of the nanogel to probe its composition and modification. #nmrchat #nanomaterials

A new paper by our colleagues from the Zernike Institute (U. Groningen) has just been published, including some #ssNMR from my group. The paper looks at the process of polydopamine formation the presence and absence of halloysite #nanotubes. See the paper here: https://doi.org/10.1038/s41467-023-36303-8 #polymers

(It is in part a follow-up on our earlier collaborative paper, more focused on the #DNP #SSNMR analysis of unlabeled #polyQ #protein #amyloids - https://pubs.acs.org/doi/10.1021/jacs.8b09002 )

Now online in pre-proof status, at the journal #SSNMR : a new collaborative paper on #DNP ssNMR at 13C natural abundance: "Fast magic angle spinning for the characterization of milligram quantities of organic and biological solids at natural isotopic abundance by 13C–13C correlation DNP-enhanced #NMR" . With Gaël De Paëpe, Snorri Sigurdsson and Sabine Hediger. Includes some new data of unlabeled #polyQ #amyloid aggregates. https://www.sciencedirect.com/science/article/pii/S0926204022000790 #nmrchat