#ssnmr — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #ssnmr, aggregated by home.social.
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Interesting new paper by Daniel Huster and colleagues, looking at #cardiolipin lipids, how they affect enzymes and membranes, and the role of (NMR-detected) dynamics: doi.org/10.1021/jacs...
#nmrchat #ssNMR
Cardiolipin Modulates the Acti... -
Awarded this time to Tuo Wang for his cool #glycotime by #ssNMR work
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Great to host @[email protected] in Groningen for his colloquium today: Ultra-Low Temperature NMR and #DNP using cryogenic Helium MAS: New insights on advanced nanomaterials from cellulose nanofibrils to perovskite #nanocrystals #ssNMR #nmrchat #glycotime @[email protected]
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Spent today at Radboud University in Nijmegen for the PhD defense of Angel Wong. Great job with lots of cool #ssNMR and a very detailed scientific discussion. Congrats to Dr Wong!
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These are both coming from some of #biophysics oriented research groups of the @[email protected] of the @[email protected] . With special thanks to committee member Henrike Heise who came from Germany for Raffaella’s defense and treated us to a great #ssNMR and DNP talk yesterday
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.. it is from a very nice collaboration with the group of Alessandra Operamolla from the University of Pisa. We looked at cellulose nanocrystals with conjugated lipase enzymes, using #ssNMR and other techniques. The #ssNMR was supported by @[email protected] transnational access (TNA).
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New collaborative paper from the lab: “Candida rugosa Lipase Bioconjugation to Cellulose Nanocrystals with High Immobilization Efficiency: Comparison with Nonspecific Approach” in the @[email protected] journal Biomacromolecules. doi.org/10.1021/acs.... Another #glycotime by #ssNMR project…
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Reminder: the deadline for this #ssNMR job application closes on 15 Dec!
RE: https://bsky.app/profile/did:plc:iqx4eqgwvohrhiu2dzh4f6se/post/3m62vnnajx22h -
With funding from the Dutch NWO, we are looking for a postdoc with expertise in #DNP and/or #ssNMR experiments/hardware. One focus in the work will be to follow-up on our work on in-situ illuminated ssNMR for studying #photochemistry processes. #nmrchat werkenbij.rug.nl/vacature/pos...
Postdoc SSNMR - Rijksuniversit... -
Today is the day: the 60th Dutch #NMRDG meeting bringing together the magnetic resonance community of the Netherlands. This time hosted at Radboud University in Nijmegen. See: sac.kncv.nl/nmr #nmrchat #epr #ssnmr Huge thanks to the local organizers at Radboud and to our sponsors.
The Dutch NMR Discussion Group... -
All in all, we hope that the information about the probe/methods can be useful to other #ssNMR groups interested in this topic. Moreover, we expect this approach to be useful for many other applications and studies, with some more of our own work coming…. #nmrchat #photochemistry #optogenetics
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In this paper we describe how we used in-situ illumination during #ssNMR to probe photochemical processes. This is enabled by a modified MAS NMR probe from Bruker Biospin @brukercorporation.bsky.social in which a light fiber enables sample irradiation using a LED light source. ….
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Well, it’s a wrap! The 2025 Alpine meeting on magnetic resonance in solids has concluded today. As usual I really enjoyed it (and learned some interesting new things). Thanks to all speakers from all over the world, as well as the organizers! #ssNMR
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Traveling to Chamonix for the Alpine meeting on magnetic resonance in solids today. See you there? #ssnmr
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New paper from the Griffin lab: “Diamond rotors for high magic angle spinning frequencies” How to make and use diamond 0.7 mm rotors for #ssNMR doi.org/10.1016/j.jm...
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.. (We did some #ssNMR analysis of labeled ala-based peptides in the #coacervates. )
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… I will be there, to discuss our recent paper on #ssNMR studies of antibodies binding to #polyQ protein fibrils ( #huntingtonsdisease ). (ref. dx.doi.org/10.1002/chem... ) …
Probing How Anti‐huntingtin An... -
The start of the upcoming Alpine Conference on Magnetic Resonance in Solids (in #Chamonix) is just a month away. Really looking forward to it - a nice variety of interesting science coming up, looking at the program and abstracts! ghttps://alpine-conference.org #ssNMR (and more) …
Alpine Conference on Magnetic ... -
… and Dr Alessia Lasorsa from the group will discuss our latest preprint on #ssNMR in context of #photochemistry (ref. dx.doi.org/10.26434/che... )... See you there?
Probing photochemically-induce... -
Our latest preprint is now online at @chemrxiv.org : “Probing photochemically-induced dynamic transitions by magic-angle-spinning #NMR combined with in-situ irradiation.” See: doi.org/10.26434/che... This is part of our effort toward using in situ irradiation in our #ssNMR studies. ..
Probing photochemically-induce... -
.. in #huntingtonsdisease but may also find effective use in studies of other aggregating #amyloid proteins, from #alzheimers to #parkinsons and beyond. Read it all at the journal: doi.org/10.1002/chem... (where it is part of the “Hot Topic: amyloids” collection. #nmrchat #polyQ #ssNMR
Probing How Anti‐huntingtin An... -
.. In the paper we speculate that this may impact on the properties of the fibrils, through a variety of mechanisms. This remains to be studied in more detail. For now, we hope that these types of #ssNMR studies may be useful not only for understanding conformation-selective antibodies …
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.. Despite the importance of understanding and visualizing such antibody-fibril interactions, this remains challenging. We deployed our #ssNMR toolkit to see whether we can shed light on how a well-known huntingtin-binding antibody finds its epitope in the fuzzy coat of huntingtin clumps ..
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This is for a new #ssNMR and #DNP based facility that serves the needs of a national consortium of researchers. The instrumentation will be housed at the @rug.nl in the @zernike-institute.bsky.social , but the science behind it is coming from our entire consortium across the Netherlands.
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New preprint now on #bioRxiv: “Probing How Anti-Huntingtin Antibodies Bind The Fibrillar Fuzzy Coat Using Solid-State NMR” by Raffaella Parlato and colleagues.” We used #ssNMR to look how antibodies selectively bind aggregated HTTex1 #amyloid fibrils. doi.org/10.1101/2025...
Probing How Anti-Huntingtin An... -
Mark the date! The next Alpine conference on magnetic resonance in solids is planned for Sept 14-18 2025, as usual in beautiful #Chamonix-Mont-Blanc in the Alps. The invited speakers are listed on the conference website already: https://alpine-conference.org The registration opens early next year. #NMRchat #ssNMR
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Mark the date! The next Alpine conference on magnetic resonance in solids is planned for Sept 14-18 2025, as usual in beautiful #Chamonix-Mont-Blanc in the Alps. The invited speakers are listed on the conference website already: https://alpine-conference.org The registration opens early next year. #NMRchat #ssNMR
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Mark the date! The next Alpine conference on magnetic resonance in solids is planned for Sept 14-18 2025, as usual in beautiful #Chamonix-Mont-Blanc in the Alps. The invited speakers are listed on the conference website already: https://alpine-conference.org The registration opens early next year. #NMRchat #ssNMR
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Mark the date! The next Alpine conference on magnetic resonance in solids is planned for Sept 14-18 2025, as usual in beautiful #Chamonix-Mont-Blanc in the Alps. The invited speakers are listed on the conference website already: https://alpine-conference.org The registration opens early next year. #NMRchat #ssNMR
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Slightly delayed due to my holidays, but excited to share this new paper that came out online a little while ago in ACS Applied Materials and Interfaces: https://doi.org/10.1021/acsami.4c08428 In it, PhD student Pushpa Rampratap spearheaded our effort to use MAS #NMR to study ECM-like #hydrogels. In a prior publication (https://doi.org/10.1016/j.carbpol.2023.121063) she described methods for preparing 13C enriched version of the polysaccharide hyaluronic acid…. #glycotime #nmrchat #ssnmr
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Slightly delayed due to my holidays, but excited to share this new paper that came out online a little while ago in ACS Applied Materials and Interfaces: https://doi.org/10.1021/acsami.4c08428 In it, PhD student Pushpa Rampratap spearheaded our effort to use MAS #NMR to study ECM-like #hydrogels. In a prior publication (https://doi.org/10.1016/j.carbpol.2023.121063) she described methods for preparing 13C enriched version of the polysaccharide hyaluronic acid…. #glycotime #nmrchat #ssnmr
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Slightly delayed due to my holidays, but excited to share this new paper that came out online a little while ago in ACS Applied Materials and Interfaces: https://doi.org/10.1021/acsami.4c08428 In it, PhD student Pushpa Rampratap spearheaded our effort to use MAS #NMR to study ECM-like #hydrogels. In a prior publication (https://doi.org/10.1016/j.carbpol.2023.121063) she described methods for preparing 13C enriched version of the polysaccharide hyaluronic acid…. #glycotime #nmrchat #ssnmr
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Slightly delayed due to my holidays, but excited to share this new paper that came out online a little while ago in ACS Applied Materials and Interfaces: https://doi.org/10.1021/acsami.4c08428 In it, PhD student Pushpa Rampratap spearheaded our effort to use MAS #NMR to study ECM-like #hydrogels. In a prior publication (https://doi.org/10.1016/j.carbpol.2023.121063) she described methods for preparing 13C enriched version of the polysaccharide hyaluronic acid…. #glycotime #nmrchat #ssnmr
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Our latest (review) article is now available online: https://doi.org/10.1042/BST20230731 in the journal Biochemical Transactions. In this invited article “Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation”, I have reviewed the contributions that solid-state #NMR #SSNMR has made to our understanding of the mutant protein aggregates in #huntingtonsdisease and related #polyQ disorders. (1/2)
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Among many other topics, you can find discussion of how #SSNMR is particularly useful to understand the surface features of protein aggregates (their fuzzy coat), which are often hard to see by cryo-EM and other techniques. (2/2)
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Our latest (review) article is now available online: https://doi.org/10.1042/BST20230731 in the journal Biochemical Transactions. In this invited article “Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation”, I have reviewed the contributions that solid-state #NMR #SSNMR has made to our understanding of the mutant protein aggregates in #huntingtonsdisease and related #polyQ disorders. (1/2)
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Among many other topics, you can find discussion of how #SSNMR is particularly useful to understand the surface features of protein aggregates (their fuzzy coat), which are often hard to see by cryo-EM and other techniques. (2/2)
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Our latest (review) article is now available online: https://doi.org/10.1042/BST20230731 in the journal Biochemical Transactions. In this invited article “Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation”, I have reviewed the contributions that solid-state #NMR #SSNMR has made to our understanding of the mutant protein aggregates in #huntingtonsdisease and related #polyQ disorders. (1/2)
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Our latest (review) article is now available online: https://doi.org/10.1042/BST20230731 in the journal Biochemical Transactions. In this invited article “Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation”, I have reviewed the contributions that solid-state #NMR #SSNMR has made to our understanding of the mutant protein aggregates in #huntingtonsdisease and related #polyQ disorders. (1/2)
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Among many other topics, you can find discussion of how #SSNMR is particularly useful to understand the surface features of protein aggregates (their fuzzy coat), which are often hard to see by cryo-EM and other techniques. (2/2)
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Call for papers! Solid-State NMR and DNP of Heterogeneous Biomaterials and Cellular Systems https://www.sciencedirect.com/journal/solid-state-nuclear-magnetic-resonance/about/call-for-papers#solid-state-nmr-and-dnp-of-heterogeneous-biomaterials-and-cellular-systems -… #NMRchat #SSNMR
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Call for papers! Solid-State NMR and DNP of Heterogeneous Biomaterials and Cellular Systems https://www.sciencedirect.com/journal/solid-state-nuclear-magnetic-resonance/about/call-for-papers#solid-state-nmr-and-dnp-of-heterogeneous-biomaterials-and-cellular-systems -… #NMRchat #SSNMR
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Call for papers! Solid-State NMR and DNP of Heterogeneous Biomaterials and Cellular Systems https://www.sciencedirect.com/journal/solid-state-nuclear-magnetic-resonance/about/call-for-papers#solid-state-nmr-and-dnp-of-heterogeneous-biomaterials-and-cellular-systems -… #NMRchat #SSNMR
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Busy week coming - but am definitely looking forward to next week visiting #Cambridge (UK) to discuss #amyloid #ssNMR #ECM #polysaccharides and more. Actually my first visit there, although I spent quite a few years in the 'other' Cambridge (MASS/USA). :-)
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Busy week coming - but am definitely looking forward to next week visiting #Cambridge (UK) to discuss #amyloid #ssNMR #ECM #polysaccharides and more. Actually my first visit there, although I spent quite a few years in the 'other' Cambridge (MASS/USA). :-)
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Chamonix hike during the #alpineMR2023 conference #ssNMR #nmrchat
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Chamonix hike during the #alpineMR2023 conference #ssNMR #nmrchat
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Don’t miss the #iupacchains2023 parallel session 10 on Structural Biology and Protein Design at 10:20am - see the talk by my PhD student Raffaella Parlato! She will talk about our work with Wiktor Szymanski’s team (also University of #Groningen) - enabling #photochemical control over #polyQ #amyloid formation & structure. #ssNMR #chemistry
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Don’t miss the #iupacchains2023 parallel session 10 on Structural Biology and Protein Design at 10:20am - see the talk by my PhD student Raffaella Parlato! She will talk about our work with Wiktor Szymanski’s team (also University of #Groningen) - enabling #photochemical control over #polyQ #amyloid formation & structure. #ssNMR #chemistry
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Don’t miss the #iupacchains2023 parallel session 10 on Structural Biology and Protein Design at 10:20am - see the talk by my PhD student Raffaella Parlato! She will talk about our work with Wiktor Szymanski’s team (also University of #Groningen) - enabling #photochemical control over #polyQ #amyloid formation & structure. #ssNMR #chemistry
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… using in-depth #moleculardynamics simulation to integrate various experimental constraint provides an unprecedented view of the structure of the misfolded protein aggregates, with a central role (of course) for new and existing #ssNMR data. These #polyQ protein fibrils are tough for #cryoEM due to structural and dynamic heterogeneity.
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… using in-depth #moleculardynamics simulation to integrate various experimental constraint provides an unprecedented view of the structure of the misfolded protein aggregates, with a central role (of course) for new and existing #ssNMR data. These #polyQ protein fibrils are tough for #cryoEM due to structural and dynamic heterogeneity.
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Cool new paper from Joern Schmedt auf der Guenne and coworkers, in the journal #SSNMR: “High resolution solid-state #NMR on the desktop”, presenting a conical MAS rotor design for use in permanent magnets. Looks cool! The team includes Oliver Pecher and Marco Braun from the NMR-service company, which is doing various other interesting things when it comes to #ssNMR hardware! https://www.sciencedirect.com/science/article/pii/S0926204023000346