#peptidoglycan — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #peptidoglycan, aggregated by home.social.
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New #studies show that a #bacterial molecule, #peptidoglycan, is present in the #brain and fluctuates with #sleep patterns. This challenges the idea that sleep is solely brain-driven, instead suggesting it’s a #collaborative process between our #bodies and #microbiomes. The theory links #microbes not only to sleep but also to #cognition, #appetite, and #behavior, pointing to a profound #evolutionary relationship
https://www.sciencedaily.com/releases/2025/09/250925025336.htm
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Archaea-on-bacteria action! This study shows that many #archaea encode #peptidoglycan hydrolases, which specifically target #bacterial cell walls, experimentally confirming the killing capacity of 2 of these enzymes @PLOSBiology https://plos.io/4lrJBBa
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As already indicated by previous experiments, not only #V_cholerae reacts to purified #peptidoglycan but this behaviour can also be observed in different biofilm-forming species.
So Sanika has "demonstrated that exogenous PG released by cellular lysis is a general danger signal to which several bacterial species respond by forming biofilms. The resulting biofilms serves as a refuge that protects against phage predation or other biotic and abiotic stresses that can lyse bacterial cells."
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Still, the signal was missing ... and the signal hunt was on ... and escalated quickly. While some experiments with differently threated lysates showed that biofilm-inducing molecules had a wide range of sizes, but they have to be larger than 3 kDa. Others pointed into the direction of exogenously cell wall fragments. Indeed, the exposure of #V_cholerae to purified #peptidoglycan triggered the biofilm formation!
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The septal #peptidoglycan hydrolysis machinery is crucial for #CellDivision in #bacteria. This study uses #cryoEM & functional analysis of E. coli FtsEX to characterize the molecular basis of FtsEX regulation of peptidoglycan hydrolysis #PLOSBiology https://plos.io/3Vndl8E
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x-posting from twitter...
https://twitter.com/Dr_Lori_Burrows/status/1649421714822950913?s=20
...not Streptomyces, it's a #peptidoglycan biosynthesis mutant of #Pseudomonas aeruginosa. I feel like we still know very little about this crazy #superbug. We took this SEM image 10 years ago and I've been scratching my head over it ever since.
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#Celldivision protein FtsK coordinates bacterial #chromosome segregation and daughter cell separation in #Staphylococcus #aureus
Helena Veiga, Mariana Pinho et al show #FtsK interacts with the #chaperone #Triggerfactor and establishes its gradient towards the #septum to promote stability and export of the #peptidoglycan #hydrolase Sle1. -
#Celldivision protein FtsK coordinates bacterial #chromosome segregation and daughter cell separation in #Staphylococcus #aureus
Helena Veiga, Mariana Pinho et al show #FtsK interacts with the #chaperone #Triggerfactor and establishes its gradient towards the #septum to promote stability and export of the #peptidoglycan #hydrolase Sle1. -
#Celldivision protein FtsK coordinates bacterial #chromosome segregation and daughter cell separation in #Staphylococcus #aureus
Helena Veiga, Mariana Pinho et al show #FtsK interacts with the #chaperone #Triggerfactor and establishes its gradient towards the #septum to promote stability and export of the #peptidoglycan #hydrolase Sle1. -
#Celldivision protein FtsK coordinates bacterial #chromosome segregation and daughter cell separation in #Staphylococcus #aureus
Helena Veiga, Mariana Pinho et al show #FtsK interacts with the #chaperone #Triggerfactor and establishes its gradient towards the #septum to promote stability and export of the #peptidoglycan #hydrolase Sle1. -
How to resist a #phage ...
This fascinating new research explores how Gram positive #bacteria (Listeria monocytogenes) can escape #bacteriophage infection by enzymatic degradation of their own bacterial cell wall #peptidoglycan to form a transient and reversible cell-wall deficient L-form removing cell wall targets used by the phage for attachment.
Learn more in this new paper in Nature Microbiology on: