#fibroblasts — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #fibroblasts, aggregated by home.social.
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New #mechanobiology paper on #cancer #microenvironment. The authors show that cancer-associated #fibroblasts (CAFs) compress tumors with actomyosin supracellular contractility supported by #fibronectin deposition. This induces #YAP nuclear exit in cancer cells, limits cancer growth, and induces tumor reorganization.
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`Tail blastema, but not limb, #fibroblasts express sulf1 and form #cartilage under Hedgehog signaling regulation. Depletion of phagocytes inhibits blastema formation, but treatment with pericytic phagocyte-conditioned media rescues blastema chondrogenesis and cartilage formation in amputated limbs... These properties..indicate potential actionable targets for inducing #regeneration in other species, including humans`
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#Collagen is mainly synthesized by #Fibroblasts, strengthening #Arteriole and #Capillary vessel wall. #Ultrastructure shows #fibripositors where #collagenfibril #tripelhelixes are made and #fibrils that reach across the #PerivascularSpace (8/15)