#senolytics — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #senolytics, aggregated by home.social.
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FOXO4-DRI = senescent cell eliminator
How it works:
→ FOXO4 normally binds p53 in senescent cells
→ FOXO4-DRI peptide displaces FOXO4
→ Free p53 triggers apoptosis
→ Senescent cells eliminated
Mouse studies: restored fur, kidney function, fitness
Selective killing = safe
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Senolytics clear senescent cells—the "zombie cells" that accumulate with age and drive inflammation + disease.
The challenge: delivering them precisely to target cells, not healthy tissue.
Solution: nanoparticles + targeting ligands = drugs delivered only where needed.
Result: efficacy at lower doses, reduced toxicity.
Tested in: fibrosis, atherosclerosis, neurodegeneration.
Precision aging medicine is here.
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I want to call out from a #UX perspective how amazing the email newsletter is from #TallyHealth.
Out of 100s of trashbin emails, Tally is the one with so much useful info in it, it feels like a time saver since I would search for it anyways
#TallyHealth #Tally #DavidSinclair
#Longevity #Senolytics #Healthspan -
A pill to live to 150? 🧬🍇
Shenzhen’s Lonvi Biosciences is selling a grapeseed-derived PCC1 capsule it says clears “zombie cells” and could make 150-year lifespans realistic.
Our Biotech IE piece separates mouse data from marketing: senolytics, China’s longevity push, and what regulators might do next.
🔗 https://biotech.industryexaminer.com/china-150-year-grapeseed-longevity-pill-pcc1/
#Biotech #Longevity #Senolytics #AgingResearch #China #Geroscience #TechNews
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Is it possible to stop cellular #senescence? That’s the aim of senolytic drugs.
This #PLOSBiology Perspective looks at how discovery of the senescence-associated secretory phenotype enabled the development of #senolytics.
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Senescent Cells in Aged Tissues May Use Immune Checkpoints to Prevent Immune Clearance https://www.fightaging.org/archives/2024/08/senescent-cells-in-aged-tissues-may-use-immune-checkpoints-to-prevent-immune-clearance/
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OK, so in essence dasatinib+quercetin does work, we just need to up the dosage.
Also, note that there is a dasatinib 1:1 equivalence in piperlongumine (https://www.nature.com/articles/s41598-024-55870-4/tables/3) that can be bought from here (https://www.mcsformulas.com/vitamins-supplements/piperlongumine-liposomal/).
I'm doing this as we speak.
Results from a Phase 2 Trial of Senolytic Therapy Dasatinib and Quercetin for Osteoporosis https://www.fightaging.org/archives/2024/07/results-from-a-phase-2-trial-of-senolytic-therapy-dasatinib-and-quercetin-for-osteoporosis/
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Interesting venue of research . Not thought of that before. #medicine #aging #senolytics
Why Are Extraocular Muscles So Resilient to Aging? https://www.fightaging.org/archives/2024/05/why-are-extraocular-muscles-so-resilient-to-aging/
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Really good stuff here, a lot of new companies and therapies coming up that I didn't know of before. Good read.
#medicine #senolytics #biology
Notes from the Rejuvenation Startup Summit in Berlin, May 2024 https://www.fightaging.org/archives/2024/05/notes-from-the-rejuvenation-startup-summit-in-berlin-may-2024/
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OK, interesting.. It is a bit hard to get hold of Dasatinib for sure.
In Search of Natural Senolytics to Substitute for Dasatinib https://www.fightaging.org/archives/2024/05/in-search-of-natural-senolytics-to-substitute-for-dasatinib/
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Predicting the Order of Arrival of the First Rejuvenation Therapies https://www.fightaging.org/archives/2024/03/predicting-the-order-of-arrival-of-the-first-rejuvenation-therapies-2/
(SOme good pointers to existing and soon to come stuff)
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SENS Research Foundation's Senotherapeutic Screening Project is Now Crowdfunding at Experiment https://www.fightaging.org/archives/2023/06/sens-research-foundations-senotherapeutic-screening-project-is-now-crowdfunding-at-experiment/
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Deep learning AIs are proving indispensable in medicine and chemistry research for finding new compounds for treatments.
A primary component of aging is senescent cells that stop dividing, leading to cancer, heart disease, Alzheimer's, and more.
Senolytics cause selective apoptosis (cell death) of these.
Now, researchers have used AI to analyze 800,000 compounds and find 3 new senolytic candidates.
#Aging #Senolytics #AI #DeepLearning #Science #Medicine #Scicomm
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This begins a bit heavy, but skip ahead a bit and you get a very nice up-to-date run-down of what we know today of how senolytics works and which we know are effective.
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What! That's 977 years away. I'll be long dead.
Maybe not. Covid19 has triggered further advances in the study of #senolytics - aging. One investigator from the SENS Foundation believes the first person to live to 1,000 is alive now -
🧬 Cellular Senescence: The Zombie Cells Within Us
Ever wonder why we age? Meet senescent cells - the "zombie cells" that stop dividing but refuse to die.
What happens:
→ Healthy cells become damaged (stress, DNA damage, telomere shortening)
The future of longevity? Senolytics - drugs that selectively eliminate these zombie cells, potentially reversing aspects of aging.
#CellularSenescence #AgingResearch #Longevity #Senolytics #RegenerativeMedicine #Geroscience
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A pill to live to 150? 🧬🍇
Shenzhen’s Lonvi Biosciences is selling a grapeseed-derived PCC1 capsule it says clears “zombie cells” and could make 150-year lifespans realistic.
Our Biotech IE piece separates mouse data from marketing: senolytics, China’s longevity push, and what regulators might do next.
🔗 https://biotech.industryexaminer.com/china-150-year-grapeseed-longevity-pill-pcc1/
#Biotech #Longevity #Senolytics #AgingResearch #China #Geroscience #TechNews
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A pill to live to 150? 🧬🍇
Shenzhen’s Lonvi Biosciences is selling a grapeseed-derived PCC1 capsule it says clears “zombie cells” and could make 150-year lifespans realistic.
Our Biotech IE piece separates mouse data from marketing: senolytics, China’s longevity push, and what regulators might do next.
🔗 https://biotech.industryexaminer.com/china-150-year-grapeseed-longevity-pill-pcc1/
#Biotech #Longevity #Senolytics #AgingResearch #China #Geroscience #TechNews
-
A pill to live to 150? 🧬🍇
Shenzhen’s Lonvi Biosciences is selling a grapeseed-derived PCC1 capsule it says clears “zombie cells” and could make 150-year lifespans realistic.
Our Biotech IE piece separates mouse data from marketing: senolytics, China’s longevity push, and what regulators might do next.
🔗 https://biotech.industryexaminer.com/china-150-year-grapeseed-longevity-pill-pcc1/
#Biotech #Longevity #Senolytics #AgingResearch #China #Geroscience #TechNews
-
A pill to live to 150? 🧬🍇
Shenzhen’s Lonvi Biosciences is selling a grapeseed-derived PCC1 capsule it says clears “zombie cells” and could make 150-year lifespans realistic.
Our Biotech IE piece separates mouse data from marketing: senolytics, China’s longevity push, and what regulators might do next.
🔗 https://biotech.industryexaminer.com/china-150-year-grapeseed-longevity-pill-pcc1/
#Biotech #Longevity #Senolytics #AgingResearch #China #Geroscience #TechNews
-
I want to call out from a #UX perspective how amazing the email newsletter is from #TallyHealth.
Out of 100s of trashbin emails, Tally is the one with so much useful info in it, it feels like a time saver since I would search for it anyways
#TallyHealth #Tally #DavidSinclair
#Longevity #Senolytics #Healthspan -
I want to call out from a #UX perspective how amazing the email newsletter is from #TallyHealth.
Out of 100s of trashbin emails, Tally is the one with so much useful info in it, it feels like a time saver since I would search for it anyways
#TallyHealth #Tally #DavidSinclair
#Longevity #Senolytics #Healthspan -
I want to call out from a #UX perspective how amazing the email newsletter is from #TallyHealth.
Out of 100s of trashbin emails, Tally is the one with so much useful info in it, it feels like a time saver since I would search for it anyways
#TallyHealth #Tally #DavidSinclair
#Longevity #Senolytics #Healthspan