#hypercholesterolemia — Public Fediverse posts

OMG! I shot myself! With my PC...

"Yeah, yeah. It was with your PCSK9 inhibitor."

Yeah... my cholesterol medicine.

"Old news."

😭

#FamilialHypercholesterolemia #hypercholesterolemia #PCSK9Inhibitor

OMG! I shot myself! With my PC...

"Yeah, yeah. It was with your PCSK9 inhibitor."

Yeah... my cholesterol medicine.

"Old news."

😭

#FamilialHypercholesterolemia #hypercholesterolemia #PCSK9Inhibitor

OMG! I shot myself! With my PC...

"Yeah, yeah. It was with your PCSK9 inhibitor."

Yeah... my cholesterol medicine.

"Old news."

😭

#FamilialHypercholesterolemia #hypercholesterolemia #PCSK9Inhibitor

OMG! I shot myself! With my PC...

"Yeah, yeah. It was with your PCSK9 inhibitor."

Yeah... my cholesterol medicine.

"Old news."

😭

#FamilialHypercholesterolemia #hypercholesterolemia #PCSK9Inhibitor

busybee: fluffy rambles: Medications are expensive https://beesbuzz.biz/blog/8443-Medications-are-expensive #Hypercholesterolemia #ClottingDisorder #Fibromyalgia #Medication #Blog #HRT

Today is Rare Disease Day.

I've got two of those. :catjam:

First is familial hypercholesterolemia. This is not your run--of-the-mill hypercholesterolemia. No. This cannot be just treated with diet and exercise. Even the statins aren't great at treating it. The state of the art is a PCSK9 inhibitor. This, this does wonders.

Then, there's the PCNS lymphoma. Lymphomas are already considered rare. The PCNS form is even rarer. I'm over 5 years in remission and doing fine.

May we eradicate all diseases, from the commonest to the rarest.

#RareDiseaseDay2026 #RareDiseaseDay #hypercholesterolemia #FamilialHypercholesterolemia #PCSK9Inhibitor #lymphoma #cancer #PCNSLymphoma #CancerSurvivor #HeartAttackSurvivor

Today is Rare Disease Day.

I've got two of those. :catjam:

First is familial hypercholesterolemia. This is not your run--of-the-mill hypercholesterolemia. No. This cannot be just treated with diet and exercise. Even the statins aren't great at treating it. The state of the art is a PCSK9 inhibitor. This, this does wonders.

Then, there's the PCNS lymphoma. Lymphomas are already considered rare. The PCNS form is even rarer. I'm over 5 years in remission and doing fine.

May we eradicate all diseases, from the commonest to the rarest.

#RareDiseaseDay2026 #RareDiseaseDay #hypercholesterolemia #FamilialHypercholesterolemia #PCSK9Inhibitor #lymphoma #cancer #PCNSLymphoma #CancerSurvivor #HeartAttackSurvivor

Today is Rare Disease Day.

I've got two of those. :catjam:

First is familial hypercholesterolemia. This is not your run--of-the-mill hypercholesterolemia. No. This cannot be just treated with diet and exercise. Even the statins aren't great at treating it. The state of the art is a PCSK9 inhibitor. This, this does wonders.

Then, there's the PCNS lymphoma. Lymphomas are already considered rare. The PCNS form is even rarer. I'm over 5 years in remission and doing fine.

May we eradicate all diseases, from the commonest to the rarest.

#RareDiseaseDay2026 #RareDiseaseDay #hypercholesterolemia #FamilialHypercholesterolemia #PCSK9Inhibitor #lymphoma #cancer #PCNSLymphoma #CancerSurvivor #HeartAttackSurvivor

Today is Rare Disease Day.

I've got two of those. :catjam:

First is familial hypercholesterolemia. This is not your run--of-the-mill hypercholesterolemia. No. This cannot be just treated with diet and exercise. Even the statins aren't great at treating it. The state of the art is a PCSK9 inhibitor. This, this does wonders.

Then, there's the PCNS lymphoma. Lymphomas are already considered rare. The PCNS form is even rarer. I'm over 5 years in remission and doing fine.

May we eradicate all diseases, from the commonest to the rarest.

#RareDiseaseDay2026 #RareDiseaseDay #hypercholesterolemia #FamilialHypercholesterolemia #PCSK9Inhibitor #lymphoma #cancer #PCNSLymphoma #CancerSurvivor #HeartAttackSurvivor

https://www.europesays.com/ie/293254/ Genomic screening uncovers hidden cancer and heart disease risk in young adults #cancer #Cholesterol #Diagnostic #DNA #Éire #FamilialHypercholesterolemia #Genes #Genetic #Genetics #Genomic #Health #Healthcare #Heart #HeartDisease #Hypercholesterolemia #IE #Ireland #LynchSyndrome #medicine #OvarianCancer #Research #Syndrome

So I was on the phone with some sort of patient advocate. We talked about my hypercholesterolemia, then we move on to my cancer.

Her: "You've had a gastric lymphoma. What's the medicine you take for it?"

My: "My lymphoma was not gastric."

Her: "Sir, we talked about your heart problem. We're talking about your cancer."

My: "Yes, I kn..."

Her: "Sir, first, I asked you about your heart problem. We're done with it. Now I'm asking you about your cancer."

Me: "Yes, I know this."

Her: [talking over me.] "Sir..."

Rinse and fucking repeat. We spent a good five minutes with her explaining to me, as if I were a damn baby, I might add, what I fucking already knew!!!

When finally, she asked me again for the medicine. I told her, "your diagnosis is wrong: my lymphoma was not gastric."

Her: "Oh...."

:headache:

#ActuallyAutistic #PatientAdvocate #hypercholesterolemia #cancer

So I was on the phone with some sort of patient advocate. We talked about my hypercholesterolemia, then we move on to my cancer.

Her: "You've had a gastric lymphoma. What's the medicine you take for it?"

My: "My lymphoma was not gastric."

Her: "Sir, we talked about your heart problem. We're talking about your cancer."

My: "Yes, I kn..."

Her: "Sir, first, I asked you about your heart problem. We're done with it. Now I'm asking you about your cancer."

Me: "Yes, I know this."

Her: [talking over me.] "Sir..."

Rinse and fucking repeat. We spent a good five minutes with her explaining to me, as if I were a damn baby, I might add, what I fucking already knew!!!

When finally, she asked me again for the medicine. I told her, "your diagnosis is wrong: my lymphoma was not gastric."

Her: "Oh...."

:headache:

#ActuallyAutistic #PatientAdvocate #hypercholesterolemia #cancer

So I was on the phone with some sort of patient advocate. We talked about my hypercholesterolemia, then we move on to my cancer.

Her: "You've had a gastric lymphoma. What's the medicine you take for it?"

My: "My lymphoma was not gastric."

Her: "Sir, we talked about your heart problem. We're talking about your cancer."

My: "Yes, I kn..."

Her: "Sir, first, I asked you about your heart problem. We're done with it. Now I'm asking you about your cancer."

Me: "Yes, I know this."

Her: [talking over me.] "Sir..."

Rinse and fucking repeat. We spent a good five minutes with her explaining to me, as if I were a damn baby, I might add, what I fucking already knew!!!

When finally, she asked me again for the medicine. I told her, "your diagnosis is wrong: my lymphoma was not gastric."

Her: "Oh...."

:headache:

#ActuallyAutistic #PatientAdvocate #hypercholesterolemia #cancer

So I was on the phone with some sort of patient advocate. We talked about my hypercholesterolemia, then we move on to my cancer.

Her: "You've had a gastric lymphoma. What's the medicine you take for it?"

My: "My lymphoma was not gastric."

Her: "Sir, we talked about your heart problem. We're talking about your cancer."

My: "Yes, I kn..."

Her: "Sir, first, I asked you about your heart problem. We're done with it. Now I'm asking you about your cancer."

Me: "Yes, I know this."

Her: [talking over me.] "Sir..."

Rinse and fucking repeat. We spent a good five minutes with her explaining to me, as if I were a damn baby, I might add, what I fucking already knew!!!

When finally, she asked me again for the medicine. I told her, "your diagnosis is wrong: my lymphoma was not gastric."

Her: "Oh...."

:headache:

#ActuallyAutistic #PatientAdvocate #hypercholesterolemia #cancer

OMG! I shot myself!

"What happened?"

I shot myself with my alirocumab.

"Your ali-what?"

My praluent.

"Your what?"

My PCSK9 inhibitor.

"What does it do?"

As the name says, it inhibits the PCSK9.

"What's the PCSK9?"

Hell if I know. A protein, I guess.

"What's a protein?"

Did you fail biology class?

"Yes."

Well...

#PCSK9inhibitor #alirocumab #praluent #FamilialHypercholesterolemia #hypercholesterolemia #protein #biology

OMG! I shot myself!

"What happened?"

I shot myself with my alirocumab.

"Your ali-what?"

My praluent.

"Your what?"

My PCSK9 inhibitor.

"What does it do?"

As the name says, it inhibits the PCSK9.

"What's the PCSK9?"

Hell if I know. A protein, I guess.

"What's a protein?"

Did you fail biology class?

"Yes."

Well...

#PCSK9inhibitor #alirocumab #praluent #FamilialHypercholesterolemia #hypercholesterolemia #protein #biology

OMG! I shot myself!

"What happened?"

I shot myself with my alirocumab.

"Your ali-what?"

My praluent.

"Your what?"

My PCSK9 inhibitor.

"What does it do?"

As the name says, it inhibits the PCSK9.

"What's the PCSK9?"

Hell if I know. A protein, I guess.

"What's a protein?"

Did you fail biology class?

"Yes."

Well...

#PCSK9inhibitor #alirocumab #praluent #FamilialHypercholesterolemia #hypercholesterolemia #protein #biology

OMG! I shot myself!

"What happened?"

I shot myself with my alirocumab.

"Your ali-what?"

My praluent.

"Your what?"

My PCSK9 inhibitor.

"What does it do?"

As the name says, it inhibits the PCSK9.

"What's the PCSK9?"

Hell if I know. A protein, I guess.

"What's a protein?"

Did you fail biology class?

"Yes."

Well...

#PCSK9inhibitor #alirocumab #praluent #FamilialHypercholesterolemia #hypercholesterolemia #protein #biology

"We show that Aster-B and Aster-C are critical for nonvesicular #cholesterol movement in enterocytes...Enterocytes lacking Asters accumulate PM cholesterol and show endoplasmic reticulum cholesterol depletion. Aster-deficient mice have impaired cholesterol absorption and are protected against diet-induced #hypercholesterolemia. Finally, the #Aster pathway can be targeted with a small-molecule inhibitor to manipulate cholesterol uptake."

https://www.science.org/doi/10.1126/science.adf0966

Here's a good example of how the US health care system is messed up.

I have a genetic defect. This defect causes hypercholesterolemia. So I have what is called *familial* hypercholesterolemia, because the cause is my genes.

I've been approved for a PCSK9 inhibitor. This is a drug that works only for people who have familial hypercholesterolemia. If you give it to a random guy without my disease, it is going to do nothing to them. (Perhaps hurt them, I'm not sure.)

I've received a letter from my health insurance saying that my approval is expiring soon.

Why? :why:

This is a genetic defect. A PCSK9 inhibitor is not gene therapy. It does not modify my genetic makeup. That's why I have to keep taking this drug.

Because it is a genetic defect, I'm going to have to be on this drug until I die. Or maybe they are going to find something better, but I expect this "something better" will also require approval because we're wading into highly specialized territory here.

So, again, why ask for approvals every year? It is not like my genetic code is going to fix itself magically.

:headache:

#PCSK9Inhibitor #USHealthcare #healthcare #approval #hypercholesterolemia #genes #GeneticDefect

Here's a good example of how the US health care system is messed up.

I have a genetic defect. This defect causes hypercholesterolemia. So I have what is called *familial* hypercholesterolemia, because the cause is my genes.

I've been approved for a PCSK9 inhibitor. This is a drug that works only for people who have familial hypercholesterolemia. If you give it to a random guy without my disease, it is going to do nothing to them. (Perhaps hurt them, I'm not sure.)

I've received a letter from my health insurance saying that my approval is expiring soon.

Why? :why:

This is a genetic defect. A PCSK9 inhibitor is not gene therapy. It does not modify my genetic makeup. That's why I have to keep taking this drug.

Because it is a genetic defect, I'm going to have to be on this drug until I die. Or maybe they are going to find something better, but I expect this "something better" will also require approval because we're wading into highly specialized territory here.

So, again, why ask for approvals every year? It is not like my genetic code is going to fix itself magically.

:headache:

#PCSK9Inhibitor #USHealthcare #healthcare #approval #hypercholesterolemia #genes #GeneticDefect

Here's a good example of how the US health care system is messed up.

I have a genetic defect. This defect causes hypercholesterolemia. So I have what is called *familial* hypercholesterolemia, because the cause is my genes.

I've been approved for a PCSK9 inhibitor. This is a drug that works only for people who have familial hypercholesterolemia. If you give it to a random guy without my disease, it is going to do nothing to them. (Perhaps hurt them, I'm not sure.)

I've received a letter from my health insurance saying that my approval is expiring soon.

Why? :why:

This is a genetic defect. A PCSK9 inhibitor is not gene therapy. It does not modify my genetic makeup. That's why I have to keep taking this drug.

Because it is a genetic defect, I'm going to have to be on this drug until I die. Or maybe they are going to find something better, but I expect this "something better" will also require approval because we're wading into highly specialized territory here.

So, again, why ask for approvals every year? It is not like my genetic code is going to fix itself magically.

:headache:

#PCSK9Inhibitor #USHealthcare #healthcare #approval #hypercholesterolemia #genes #GeneticDefect

Here's a good example of how the US health care system is messed up.

I have a genetic defect. This defect causes hypercholesterolemia. So I have what is called *familial* hypercholesterolemia, because the cause is my genes.

I've been approved for a PCSK9 inhibitor. This is a drug that works only for people who have familial hypercholesterolemia. If you give it to a random guy without my disease, it is going to do nothing to them. (Perhaps hurt them, I'm not sure.)

I've received a letter from my health insurance saying that my approval is expiring soon.

Why? :why:

This is a genetic defect. A PCSK9 inhibitor is not gene therapy. It does not modify my genetic makeup. That's why I have to keep taking this drug.

Because it is a genetic defect, I'm going to have to be on this drug until I die. Or maybe they are going to find something better, but I expect this "something better" will also require approval because we're wading into highly specialized territory here.

So, again, why ask for approvals every year? It is not like my genetic code is going to fix itself magically.

:headache:

#PCSK9Inhibitor #USHealthcare #healthcare #approval #hypercholesterolemia #genes #GeneticDefect

-Time for a short #Introduction-

I am a group leader in #MedicinalChemistry at the University of Parma. My lab combines #chemical & #computational techniques to develop novel pharmacological tools to study different Chronic Diseases (#CysticFibrosis, #IBD, #Hypercholesterolemia, #Alzheimer, #Cancer) and Infective Agents (#SARSCoV2, #Enterovirus, #Flavivirus, #Monkeypox, #HIV).
We are particularly interested in the development of #MultiTarget inhibitors and open to new #collaborations in #DrugDiscovery.
#Tooting (sooner or later) about the #chemistry and #science