#degron — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #degron, aggregated by home.social.
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My technical wish for 2025 is that experiments done over the years in slow-growing gene #deletion strains will be repeated under rapid depletion of the corresponding proteins (#degron).
Especially in the field of #mRNA degradation, it is an illusion that the results obtained in cells growing at different rates are not strongly influenced by the different metabolic levels of the studied cells.
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EMBO Journal Issue 4/23:
- Commentary on #creativity needs in research
- #Degron recognition in orphan complex subunits by CLR4-DCAF12 E3 #ubiquitin #ligase
- #Plasmamembrane topography of #IgM #Bcell receptors
- #YAP roles and regulation in #tumorigenesis
- #Brassinosteroid interplay with #katanin #microtubule severingCover by Satarupa Bhaduri, Analine Aguayo, Sonya Neal et al
https://www.embopress.org/toc/14602075/2023/42/4 -
Protein complex assembly #qualitycontrol in action:
#cryoEM structures by Nico Thomä at FMI and colleagues show how #CRL4-#DCAF12 #ubiquitin E3 #ligase engages a C-terminal di-Glu #degron in CCT5 recognizable only when this subunit is not incorporated into the #TRiC/#CCT #chaperone complex
https://www.embopress.org/doi/10.15252/embj.2022112253