home.social

#zepbound — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #zepbound, aggregated by home.social.

  1. Merely a few conditions now being pursued for secondary prevention or treatment with #GLP-1/GIP/glucagon drugs like #Ozempic or #Zepbound

    Alzheimer disease
    Parkinson disease
    Stroke
    Heart failure
    CKD
    MASLD/MASH
    Type 2 diabetes
    Sleep apnea
    Psoriasis
    Osteoarthritis
    Substance use disorder
    ALS
    And more 🤗

    We may be watching the emergence of an entirely new class of systems-level disease modifiers, not just “weight loss drugs.”

  2. Longevity Cocktail based on Science 👍

    Cholesterol (LDL)
    -Statin (low dose rosuvastatin)
    -Zetia (ezetimibe)

    Gut Health
    -Psyllium 10-12 gm/day

    Muscle (and maybe Brain)
    -Creatine

    Cognitive/Biologic Aging
    -Multivitamin (generic Centrum Silver)

    Metabolic, Insulin Resistance, Anti-inflammatory
    -Low dose Zepbound/Mounjaro (tirzepatide)

    substance-over-noise.beehiiv.c

    #longevity #rosuvastatin #zetia #psyllium #creatine #Zepbound #Mounjaro #tirzepatide #cholesterol #ldl #glp1

  3. Update: New Options for Weight Loss

    The landscape of metabolic medicine is shifting beneath our feet. For the last few years, the conversation has been dominated by weekly injections like #Zepbound (#tirzepatide), #Wegovy (#semaglutide), #Foundayo (#orforglipron) and #retatrutide.

    bit.ly/4sbhJVl
    #obesity #WeightLoss

  4. There may not be a safe way to stop taking GLP-1 drugs such as Zepbound, a prescription weight loss medicine #health #science #data #Zepbound arstechnica.com/health/2025/...

    There may not be a safe off-ra...

  5. “Our findings raise the possibility that this delta–theta band oscillation could serve as a target engagement biomarker, but its relationship to food preoccupation warrants more controlled investigation," the authors of the study conclude. #DNA #ISOGG #mounjaro #zepbound #diabetes #tirzepetide #epigenetics
    nature.com/articles/s41591-025

  6. Eli Lilly said Thursday that it would increase the prices of medicines in Europe and other developed markets “in order to make them lower” in the U.S., in an apparent response to the Trump administration’s calls to do so.

    statnews.com/2025/08/14/eli-li

    #health #healthcare #medicine #obesity #GLP1 #biotech #pharma #zepbound #mounjaro #weightloss

  7. 📈📉📈😩For those struggling with their weight and related health problems: Below I wrote up a thread about my brief experience so far with being prescribed the GLP1-agonist drugs #semaglutide (aka #Ozempic / #Wegovy) and #tirzepatide (aka #Mounjaro / #Zepbound), and my struggle to get insurance coverage (boo #FEPBlue! You suck!).

    🧪🥼I also talk light science about a related experimental drug called #bimagrumab that I *might* be helping to test via a #ClinicalTrial. It's pretty fascinating stuff!
    hachyderm.io/@mogul/1148442347

  8. Unique new drug for #Obesity?

    BAM15, semaglutide, rosiglitazone, and pioglitazone in diet-induced obese mice 

    The study compares #BAM15 with #Semaglutide, rosiglitazone, and pioglitazone in obese mice. BAM15 outperformed the others in reducing body weight, improving insulin sensitivity, enhancing glucose tolerance, and reducing liver fat and inflammation.

    Its unique mechanism—mitochondrial uncoupling—increases energy expenditure rather than altering insulin pathways.

    No major side effects were observed. Human research is needed.
    #wegovy #ozempic #mounjaro #zepbound
    sciencedirect.com/science/arti

  9. Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs

    “The point of these medications is to improve health,” he said. “The majority of people won’t need the most effective medication.”

    sentinelcolorado.com/a-town-ma

    #wegovy #Zepbound

  10. New Review and Meta-Analysis confirms weight gain with discontinuance of #Semaglutide and #Tirzepatide

    Discontinuing GLP1 medications led to a pooled overall mean weight regain of 9.69 kg (or about 22 lbs in patients prescribed semaglutide/tirzepatide. The proportion of weight regained was proportional to the amount originally lost.

    Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to #Obesity.

    #wegovy #ozempic #mounjaro #zepbound
    onlinelibrary.wiley.com/doi/10

  11. GLP-1s Are Crazy Effective — Just Not Cost-Effective

    I’ll make the argument that the most effective drugs in the past decade are the GLP-1 receptor agonists, drugs like semaglutide and tirzepatide. At least in terms of weight loss, they are truly unparalleled. They are clearly effective. But are they worth it? Are they cost-effective? That is a much harder question, and, as you’ll see in a minute, despite their amazing effects, the answer — for now, at least — is no.

    #mounjaro #ozempic #zepbound #wegovy #glp1
    medscape.com/viewarticle/glp-1

  12. Thinking about the newly approved apnea drug, #zepbound - my theory has long been that pharma companies have a group of science fiction and fantasy writers locked in a basement, generating new drug names.

  13. What Ozempic Really Does to Your Brain

    “IF YOU TAKE a GLP-1 agonist like #Ozempic or #Zepbound, you can see changes to your waistline and your blood sugar within weeks. What might be less obvious is how the drug is affecting your brain. Research suggests these popular weight-loss medications can influence everything from daily behavior to risk of age-related memory loss, and neuroscientists are working overtime to discover exactly how these drugs affect the brain.

    #glp1
    menshealth.com/health/a6324941

  14. Lilly’s Zepbound Beats Wegovy in First Head-to-Head Study

    Eli Lilly’s Zepbound #Obesity drug helped people lose significantly more weight than its main competitor, Novo Nordisk’s Wegovy.

    People taking Zepbound lost 20.2% of their body weight on average after 72 weeks of treatment in the Lilly-sponsored study, compared with a 13.7% loss for Wegovy patients, Lilly said Wednesday.

    That translated into an average 50-pound loss for people who took Zepbound, while Wegovy users lost 33 pounds.

    PS: #Zepbound and #Mounjaro are the same drug with different brand names, as are #Ozempic and #Wegovy.

    apple.news/Acy6MzE4uRrORN59ldO

  15. #goodnewsfriday Don't have time to read all of the articles? Search for the hashtag to find this and all of my previous posts again. Time for the good news about #LakeTrout, #Salmon, Human aging, Dancing for free coffee and those weight loss that might become a covered medical expense.

    After nearly being wiped out in the mid-20th century, one of the Great Lakes' top native fish species has "fully recovered.
    jsonline.com/story/sports/outd

    Not two months have passed since a series of four dams were demolished on the Klamath River, and salmon are already spawning in creeks and tributaries far upriver
    goodnewsnetwork.org/salmon-hav

    Within 5 years will reach a point where our life expectancies lengthen by more than one year per year
    popularmechanics.com/science/a

    Walk in and give us your BEST dance moves for 5 seconds
    goodnewsnetwork.org/massachuse

    The new rule would dramatically expand access to anti-obesity medications such as #Ozempic, #Wegovy, #Mounjaro and #Zepbound
    nbcnews.com/health/health-news

    Have a great weekend!

  16. Is this the FDA‘s backdoor to reduce the cost of drugs in America?

    This opinion piece by Dr Scott Gottlieb, a Pfizer board member, may be biased towards the pharmaceutical industry 🤔

    #FDA’s permissive stance on the compounding of GLP-1 drugs used for weight loss. Initially, the agency cited shortages of #semaglutide and #tirzepatide — the active ingredients in the popular drugs #Wegovy and #Zepbound — and allowed pharmacies to compound these drugs under a provision for addressing drug shortages.

    #obesity #glp1
    statnews.com/2024/11/19/fda-gl

  17. Amazing!

    GLP-1 medications like #Ozempic and #Mounjaro are reducing ‘all cause’ hospitalizations and bariatric surgery.

    Researchers recently found a 132.6% increase in #GLP1 prescriptions and a 25.6% decline in bariatric surgeries between 2022 and 2023. The results add empirical evidence to a trend of declining operations that bariatric surgeons have been noticing for months.

    A Novo Nordisk trial also discovered an association between Wegovy prescriptions and fewer hospitalizations for any cause”

    #obesity #wegovy #zepbound
    beckershospitalreview.com/phar

  18. #Obesity Drug Shows Promise in Easing Knee #Osteoarthritis Pain

    As a practicing physician, I've seen up close the remarkable benefits of the #GLP1 class of medications, including #semaglutide (#Ozempic, #Wegovy) and #tirzepatide (#Mounjaro, #Zepbound.)

    Reduction in weight (and inflammation) are game changers.

    Better control of #Diabetes, reduced #Cardiovascular and #Stroke risk, maybe lower incident of #Dementia, #MultipleSclerosis and other diseases which have an 'inflammatory' component.

    All we need now is to lower the cost (about $1,000/month in the US; heard the price is $59 in EU!)

    nytimes.com/2024/10/30/health/

  19. Remember Noom's full-page ad in the Wall Street Journal a couple weeks ago begging Congress to keep compounded weight-loss drugs on the market (even though that's not allowed by law?)

    @STAT's obesity drugs expert @elaineywchen has more about the patients caught in the fight between Lilly and compounders

    statnews.com/2024/10/11/eli-li

    #zepbound #mounjaro #wegovy #ozempic #bigpharma #healthcare #medicine

  20. Who needs a #GLP1 when you have this? Move over Ozempic!

    "We've developed a molecule that can mimic the body's natural metabolic response to strenuous exercise and fasting.

    In practice, the molecule brings the body into a metabolic state corresponding to running 10 kilometers at high speed on an empty stomach," explains Professor Thomas Poulsen from the Department of Chemistry at Aarhus University"

    #ozempic #mounjaro #zepbound #wegovy #tirezepatide #semaglutide #obesity #weightloss #longevity
    phys.org/news/2024-10-molecule

  21. @3x10to8mps
    Sorry for all the trouble you've had 🙁

    As I've seen in my practice, most of the side effects can be dealt with dietary changes.

    And as usual, in the crazy American #Healthcare system, we have two names for one drug:

    #Ozempic (diabetes) and #Wegovy (obesity, with slight difference in dose) = #semaglutide

    #Mounjaro (#diabetes) and #Zepbound (#obesity, same exact dose) = #tirezepatide.

    I've created this informational instruction page with dietary hints for my patients:

    cnmri.com/mounjaro/

  22. From 29 Aug: Eli Lilly raises price of Zepbound while trumpeting discount on starter vials - Enlarge / An Eli Lilly & Co. Zepbound injection pen arranged in the Brooklyn borough o... arstechnica.com/science/2024/0 #bernie-sanders #drug-prices #eli-lilly #glp-1 #health-insurance #lilly #prescription-drugs #sanders #science #weight-loss-drugs #zepbound

  23. #Wegovy®, #Zepbound®, and similar medications continue to gain attention for effectively treating #obesity, and now there is discussion—with research underway—about their potential for improving certain #surgical outcomes.

    The brand-name medications mentioned above belong to a class called GLP-1 (glucagon-like peptide-1) agonists. #GLP-1s mimic the actions of the GLP-1 hormone, which is secreted in the gut and sends an “I’m full” signal to the brain after you eat.

    GLP-1 medications aren’t new. @Ozempic® (generic name: #semaglutide) received approval from the U.S. Food and Drug Administration (FDA) to treat type 2 diabetes in 2017.

    After its weight-loss effects were studied, semaglutide (at a higher dose and sold under the name Wegovy) was approved by the FDA as an anti-obesity medication in 2021, and others have since followed.

    Most recently, the FDA approved Wegovy for patients with #cardiovascular #disease and obesity or overweight after a study showed that those taking the medication had a lower overall risk of major cardiac events, such as heart attack, stroke, or cardiovascular-related death.

    Now, some Yale Medicine surgeons believe, based on their ongoing research, that taking anti-obesity medications before and sometimes after total #joint #replacement and #bariatric #surgery can be beneficial.

    “These medications have been transformative, in terms of expanding the pool of people who can safely undergo joint replacement surgery,” says Daniel Wiznia, MD, a Yale Medicine orthopaedic surgeon and co-director of the Avascular Necrosis Program.

    “These anti-obesity medications are game-changers; they are changing the way people practice medicine.”

    Often, patients who need a total hip or knee replacement must delay surgery until they lose enough weight to meet specific body mass index ( #BMI ) standards.
    This is important in protecting the patient’s health.

    “Weight increases a patient’s risk of postoperative complications, including wound-healing problems, stroke, heart attack, blood clots, and infection,” he says.

    However, having patients take a GLP-1 medication before surgery, as well as improving their diet, has allowed more patients to reach a safe preoperative BMI, Dr. Wiznia says.

    yalemedicine.org/news/anti-obe

  24. Let's hope a big price war!

    #Novo has reaped mega-profits from its obesity drug #Wegovy by selling it for a premium price of $1,349 a month in the US — significantly higher than its diabetes drug, #Ozempic, even though the two contain the exact same active ingredient.

    On Wednesday, Lilly undercut that price with its newly approved weight-loss drug #Zepbound. The drugmaker said it plans to charge more than 21% less — or about $1,060 a month.
    #obesity
    bloomberg.com/news/articles/20